The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition

FASEB Journal

Volumn 30, Issue 4, 2016, Pages 1659-1669

  Moll, Lorna ^a   Ben Gedalya, Tziona ^a,c   Reuveni, Hadas ^b   Cohen, Ehud ^a  

^a HEBREW UNIVERSITY   (Israel)

^b TyrNovo Limited   (Israel)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Aggresome; Chaperones; Neurodegeneration; Protein degradation

Indexed keywords

BAFILOMYCIN A1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHAPERONE; CHAPERONIN 60; CYCLOSPORIN A; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 72; HEAT SHOCK PROTEIN 90; MESSENGER RNA; NT 219; PRION PROTEIN; PROTEASOME; PROTEIN INHIBITOR; PROTEIN P62; SOMATOMEDIN C; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; NT219 COMPOUND; ORGANIC COMPOUND; PRION; PROTEIN; PYROGALLOL; THIOAMIDE;

AGGRESOME; ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL CULTURE; CELL POPULATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CAENORHABDITIS ELEGANS; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HAMSTER; HOMEOSTASIS; METABOLISM; MOUSE; PC12 CELL LINE; PHYSIOLOGY; PRION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; ANIMALS; BLOTTING, WESTERN; CAENORHABDITIS ELEGANS; CELL LINE, TUMOR; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; GENE EXPRESSION; HOMEOSTASIS; INSULIN-LIKE GROWTH FACTOR I; MICE; MOLECULAR CHAPERONES; NEURODEGENERATIVE DISEASES; NIH 3T3 CELLS; ORGANIC CHEMICALS; PC12 CELLS; PRIONS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; PYROGALLOL; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THIOAMIDES;

EID: 84963968499     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-281675     Document Type: Article

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