Expression of APPL1 is correlated with clinicopathologic characteristics and poor prognosis in patients with gastric cancer

Current Oncology

Volumn 23, Issue 2, 2016, Pages e95-e101

  Zhai, J S ^a,b   Song, J G ^b   Zhu, C H ^b   Wu, K ^b   Yao, Y ^b   Li, Nan ^a,b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b 309TH HOSPITAL OF PLA   (China)

Author keywords

Appl1; Gastric cancer; mRNA; Prognosis

Indexed keywords

ADAPTOR PROTEIN; APPL1 PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER;

EID: 84963830481     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: 10.3747/co.23.2775     Document Type: Article

References (38)

1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015;65:87-108.
2. Goh KL. Changing trends in gastrointestinal disease in the Asia-Pacific region. J Dig Dis 2007;8:179-85.
3. Rahman R, Asombang AW, Ibdah JA. Characteristics of gastric cancer in Asia. World J Gastroenterol 2014;20:4483-90.
4. Lu LC, Shao YY, Hsu CH, et al. Metastasectomy of Krukenberg tumors may be associated with survival benefits in patients with metastatic gastric cancer. Anticancer Res 2012;32:3397-401.
5. Aizawa M, Nashimoto A, Yabusaki H, Nakagawa S, Matsuki A. Clinical benefit of surgical management for gastric cancer with synchronous liver metastasis. Hepatogastroenterology 2014;61:1439-45.
6. Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev 2014;23:700-13.
7. 2+mobilization. Endocrinology 2011;152:1691-701.
8. Liu J, Yao F, Wu R, et al. Mediation of the dcc apoptotic signal by dip13 alpha. J Biol Chem 2002;277:26281-5.
9. Zhao Z, Liu XF, Wu HC, et al. Rab5a overexpression promoting ovarian cancer cell proliferation may be associated with appl1-related epidermal growth factor signaling pathway. Cancer Sci 2010;101:1454-62.
10. Tan Y, You H, Wu C, Altomare DA, Testa JR. Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling inmurine embryonic fibroblasts. J Biol Chem 2010;285:6377-89.
11. Bidkhori G, Narimani Z, Hosseini Ashtiani S, Moeini A, Nowzari-Dalini A, Masoudi-Nejad A. Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma. PLoS One 2013;8:e67552.
12. Mauro L, Pellegrino M, De Amicis F, et al. Evidences that estrogen receptor α interferes with adiponectin effects on breast cancer cell growth. Cell Cycle 2014;13:553-64.
13. Bai YQ, Zhang JY, Bai CY, et al. Low EphA7 expression correlated with lymph node metastasis and poor prognosis of patients with esophageal squamous cell carcinoma. Acta Histochem Cytochem 2015;48:75-81.
14. Bauer L, Takacs A, Slotta-Huspenina J, et al. Clinical significance of NOTCH1 and NOTCH2 expression in gastric carcinomas: an immunohistochemical study. Front Oncol 2015;5:94.
15. Gao XH, Yang XQ, Wang BC, Liu SP, Wang FB. Overexpression of Twist and matrix metalloproteinase-9 with metastasis and prognosis in gastric cancer. Asian Pac J Cancer Prev 2013;14:5055-60.
16. Zhang H, Sun K, Ding J, et al. Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. Phytomedicine 2014;21:348-55.
17. Zhang EB, Han L, Yin DD, Kong R, De W, Chen J. c-Myc-​ induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer. Med Oncol 2014;31:914.
18. Alevizos L, Gomatos IP, Smparounis S, Konstadoulakis MM, Zografos G. Review of the molecular profile and modern prognosticmarkers for gastric lymphoma: howdo they affect clinical practice? Can J Surg 2012;55:117-24.
19. Oki E, Hisamatsu Y, Ando K, Saeki H, Kakeji Y, Maehara Y. Clinical aspect andmolecularmechanism of dna aneuploidy in gastric cancers. J Gastroenterol 2012;47:351-8.
20. Johnson IR, Parkinson-Lawrence EJ, Shandala T, Weigert R, Butler LM, Brooks DA. Altered endosome biogenesis in prostate cancer has biomarker potential. Mol Cancer Res 2014;12:1851-62.
21. Sasaki T, Kuniyasu H. Significance of Akt in gastric cancer. Int J Oncol 2014;45:2187-92.
22. Cheng KK, Lam KS, Wu D, et al. appl1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of snare proteins in mice. Proc Natl Acad Sci U S A 2012;109:8919-8924.
23. Schenck A, Goto-Silva L, Collinet C, et al. The endosomal protein appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 2008;133:486-97.
24. Katoh M. Functional proteomics, human genetics and cancer biology of GIPC family members. Exp Mol Med 2013;45:e26.
25. Xu SH, Huang JZ, Xu ML, et al. ack1 promotes gastric cancer epithelial-mesenchymal transition and metastasis through Akt-pou2f1-ecd signalling. J Pathol 2015;236:175-85.
26. Liu J, Zhang Y, Xu R, et al. pi3k/Akt-dependent phosphorylation of gsk3β and activation of RhoA regulateWnt5a-induced gastric cancer cell migration. Cell Signal 2013;25:447-56.
27. Tabata S, Ikeda R, Yamamoto M, et al. Thymidine phosphorylase activates nfκb and stimulates the expression of angiogenic and metastatic factors in human cancer cells. Oncotarget 2014;5:10473-85.
28. Hupalowska A, Pyrzynska B, Miaczynska M. appl1 regulates basal nf-κb activity by stabilizing nik. J Cell Sci 2012;125:4090-102.
29. Tian C, Jin X, Ye X, et al. Long term intake of 0.1% ethanol decreases serumadiponectin by suppressing pparγ expression via p38 mapk pathway. Food Chem Toxicol 2014,65:329-34.
30. Haagenson KK, Zhang JW, Xu Z, Shekhar MP, Wu GS. Functional analysis of mkp-1 andmkp-2 in breast cancer tamoxifen sensitivity. Oncotarget 2014;5:1101-10.
31. Hsu YF, Sheu JR, Lin CH, et al. mapk phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. Biochim Biophys Acta 2011;1810:1160-9.
32. Song J, Su H, Zhou YY, Guo LL. Cyclooxygenase-2 expression is associated with poor overall survival of patients with gastric cancer: a meta-analysis. Dig Dis Sci 2014;59:436-45.
33. Khajeniazi S, Allameh A, Soleimani M, Mortaz E. Changes in cox-2 and oxidative damage factors during differentiation of human mesenchymal stem cells to hepatocyte-like cells is associated with downregulation of P53 gene. Biol Chem 2013;394:1213-22.
34. Kim S, Sato Y, Mohan PS, et al. Evidence that the Rab5 effector appl1 mediates app-βctf-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease. Mol Psychiatry 2015;:[Epub ahead of print].
35. Torres VA. Rab’ing tumor cellmigrationand invasion: focal adhesion disassembly drivenby Rab5. Cell AdhMigr 2014;8:84-7.
36. Chen C, Yang JM, Hu TT, et al. Prognostic role of human epidermal growth factor receptor in gastric cancer: A systematic review and meta-analysis. Arch Med Res 2013;44:380-9.
37. Lee JR, Hahn HS, Kim YH, et al. Adaptor protein containing ph domain, ptb domain and leucine zipper (appl1) regulates the protein level of egfr by modulating its trafficking. Biochem Biophys Res Commun 2011;415:206-211.
38. Hennig J, McShane MP, Cordes N, Eke I. appl proteins modulate dna repair and radiation survival of pancreatic carcinoma cells by regulating atm. Cell Death Dis 2014;5:e1199.