-
1
-
-
79953172571
-
Cutting edge: Distinct glycolytic, and lipid oxidative metabolic programs are essential for effector, and regulatory CD4 + T cell subsets
-
Michalek R. D., et al. Cutting edge: Distinct glycolytic, and lipid oxidative metabolic programs are essential for effector, and regulatory CD4 + T cell subsets. J Immunol 186, 3299-3303, doi: 10.4049/jimmunol.1003613 (2011
-
(2011)
J Immunol
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
-
2
-
-
79960369458
-
HIF1{alpha}-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17, and Treg cells
-
Shi L. Z., et al. HIF1{alpha}-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17, and Treg cells. J Exp Med 208, 1367-1376, doi: 10.1084/jem.20110278 (2011
-
(2011)
J Exp Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
-
3
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang R., et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882, doi: 10.1016/j.immuni.2011.09.021 (2011
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
-
4
-
-
84922080059
-
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
-
Berod L., et al. De novo fatty acid synthesis controls the fate between regulatory T, and T helper 17 cells. Nature medicine 20, 1327-1333, doi: 10.1038/nm.3704 (2014
-
(2014)
Nature Medicine
, vol.20
, pp. 1327-1333
-
-
Berod, L.1
-
5
-
-
84876514626
-
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
-
Sinclair L. V., et al. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 14, 500-508, doi: 10.1038/ni.2556 (2013
-
(2013)
Nat Immunol
, vol.14
, pp. 500-508
-
-
Sinclair, L.V.1
-
6
-
-
84900440370
-
Inflammatory t cell responses rely on amino acid transporter asct2 facilitation of glutamine uptake, and mtorc1 kinase activation
-
Nakaya M., et al. Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake, and mTORC1 Kinase Activation. Immunity 40, 692-705, doi: 10.1016/j.immuni.2014.04.007 (2014
-
(2014)
Immunity
, vol.40
, pp. 692-705
-
-
Nakaya, M.1
-
7
-
-
84904057246
-
The glucose transporter glut1 is selectively essential for cd4 t cell activation, and effector function
-
Macintyre A. N., et al. The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation, and Effector Function. Cell metabolism 20, 61-72, doi: 10.1016/j.cmet.2014.05.004 (2014
-
(2014)
Cell Metabolism
, vol.20
, pp. 61-72
-
-
Macintyre, A.N.1
-
8
-
-
84942850610
-
Glutamine-dependent alpha-ketoglutarate production regulates the balance between T helper 1 cell, and regulatory T cell generation
-
ra97
-
Klysz D., et al. Glutamine-dependent alpha-ketoglutarate production regulates the balance between T helper 1 cell, and regulatory T cell generation. Science signaling 8, ra97, doi: 10.1126/scisignal.aab2610 (2015
-
(2015)
Science Signaling
, vol.8
-
-
Klysz, D.1
-
9
-
-
0034798447
-
Structural analysis of the GLUT1 facilitative glucose transporter (review
-
Hruz P. W., & Mueckler M. M. Structural analysis of the GLUT1 facilitative glucose transporter (review). Mol Membr Biol 18, 183-193 (2001
-
(2001)
Mol Membr Biol
, vol.18
, pp. 183-193
-
-
Hruz, P.W.1
Mueckler, M.M.2
-
10
-
-
0041975825
-
Activated akt promotes increased resting t cell size, cd28-independent t cell growth, and development of autoimmunity, and lymphoma
-
Rathmell J. C., Elstrom R. L., Cinalli R. M., & Thompson C. B. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity, and lymphoma. Eur J Immunol 33, 2223-2232 (2003
-
(2003)
Eur J Immunol
, vol.33
, pp. 2223-2232
-
-
Rathmell, J.C.1
Elstrom, R.L.2
Cinalli, R.M.3
Thompson, C.B.4
-
11
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
Frauwirth K. A., et al. The CD28 signaling pathway regulates glucose metabolism. Immunity 16, 769-777 (2002
-
(2002)
Immunity
, vol.16
, pp. 769-777
-
-
Frauwirth, K.A.1
-
12
-
-
0037370905
-
The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis
-
Manel N., et al. The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis. Blood 101, 1913-1918 (2003
-
(2003)
Blood
, vol.101
, pp. 1913-1918
-
-
Manel, N.1
-
13
-
-
0037450683
-
In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8(+ ) T cells
-
Yu Q., Erman B., Bhandoola A., Sharrow S. O., & Singer A. In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8(+ ) T cells. J Exp Med 197, 475-487 (2003
-
(2003)
J Exp Med
, vol.197
, pp. 475-487
-
-
Yu, Q.1
Erman, B.2
Bhandoola, A.3
Sharrow, S.O.4
Singer, A.5
-
14
-
-
4544331713
-
Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells
-
Barata J. T., et al. Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med 200, 659-669 (2004
-
(2004)
J Exp Med
, vol.200
, pp. 659-669
-
-
Barata, J.T.1
-
15
-
-
77951639702
-
IL-7 is essential for homeostatic control of T cell metabolism in vivo
-
Jacobs S. R., Michalek R. D., & Rathmell J. C. IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol 184, 3461-3469, doi: 10.4049/jimmunol.0902593 (2010
-
(2010)
J Immunol
, vol.184
, pp. 3461-3469
-
-
Jacobs, S.R.1
Michalek, R.D.2
Rathmell, J.C.3
-
16
-
-
41349093966
-
IL-7 promotes Glut1 trafficking, and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
-
Wofford J. A., Wieman H. L., Jacobs S. R., Zhao Y., & Rathmell J. C. IL-7 promotes Glut1 trafficking, and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 111, 2101-2111, doi: 10.1182/blood-2007-06-096297 (2008
-
(2008)
Blood
, vol.111
, pp. 2101-2111
-
-
Wofford, J.A.1
Wieman, H.L.2
Jacobs, S.R.3
Zhao, Y.4
Rathmell, J.C.5
-
17
-
-
33846861326
-
IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway
-
Swainson L., et al. IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway. Blood 109, 1034-1042 (2007
-
(2007)
Blood
, vol.109
, pp. 1034-1042
-
-
Swainson, L.1
-
18
-
-
0028231378
-
Changes in glucose transport, and transporter isoforms during the activation of human peripheral blood lymphocytes by phytohemagglutinin
-
Chakrabarti R., Jung C. Y., Lee T. P., Liu H., & Mookerjee B. K. Changes in glucose transport, and transporter isoforms during the activation of human peripheral blood lymphocytes by phytohemagglutinin. J Immunol 152, 2660-2668 (1994
-
(1994)
J Immunol
, vol.152
, pp. 2660-2668
-
-
Chakrabarti, R.1
Jung, C.Y.2
Lee, T.P.3
Liu, H.4
Mookerjee, B.K.5
-
19
-
-
34249784239
-
Isolated receptor binding domains of HTLV-1, and HTLV-2 envelopes bind Glut-1 on activated CD4+, and CD8+ T cells
-
Kinet S., et al. Isolated receptor binding domains of HTLV-1, and HTLV-2 envelopes bind Glut-1 on activated CD4+, and CD8+ T cells. Retrovirology 4, 31 (2007
-
(2007)
Retrovirology
, vol.4
, pp. 31
-
-
Kinet, S.1
-
20
-
-
84878831880
-
Posttranscriptional control of T cell effector function by aerobic glycolysis
-
Chang C. H., et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, 1239-1251, doi: 10.1016/j. cell.2013.05.016 (2013
-
(2013)
Cell
, vol.153
, pp. 1239-1251
-
-
Chang, C.H.1
-
21
-
-
84885055994
-
Inhibiting glycolytic metabolism enhances CD8+ T cell memory, and antitumor function
-
Sukumar M., et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory, and antitumor function. J Clin Invest 123, 4479-4488, doi: 10.1172/JCI69589 (2013
-
(2013)
J Clin Invest
, vol.123
, pp. 4479-4488
-
-
Sukumar, M.1
-
22
-
-
84941344937
-
Metabolic competition in the tumor microenvironment is a driver of cancer progression
-
Chang C. H., et al. Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. Cell 162, 1229-1241, doi: 10.1016/j.cell.2015.08.016 (2015
-
(2015)
Cell
, vol.162
, pp. 1229-1241
-
-
Chang, C.H.1
-
23
-
-
84941366350
-
Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor t cell responses
-
Ho P. C., et al. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell 162, 1217-1228, doi: 10.1016/j. cell.2015.08.012 (2015
-
(2015)
Cell
, vol.162
, pp. 1217-1228
-
-
Ho, P.C.1
-
24
-
-
55249114228
-
Glucose deprivation inhibits multiple key gene expression events, and effector functions in CD8+ T cells
-
Cham C. M., Driessens G., O?Keefe J. P., & Gajewski T. F. Glucose deprivation inhibits multiple key gene expression events, and effector functions in CD8+ T cells. Eur J Immunol 38, 2438-2450, doi: 10.1002/eji.200838289 (2008
-
(2008)
Eur J Immunol
, vol.38
, pp. 2438-2450
-
-
Cham, C.M.1
Driessens, G.2
Okeefe, J.P.3
Gajewski, T.F.4
-
25
-
-
17044422629
-
Glucose availability regulates IFN-gamma production, and p70S6 kinase activation in CD8+ effector T cells
-
Cham C. M., & Gajewski T. F. Glucose availability regulates IFN-gamma production, and p70S6 kinase activation in CD8+ effector T cells. J Immunol 174, 4670-4677 (2005
-
(2005)
J Immunol
, vol.174
, pp. 4670-4677
-
-
Cham, C.M.1
Gajewski, T.F.2
-
26
-
-
84921309472
-
The energy sensor AMPK regulates T cell metabolic adaptation, and effector responses in vivo
-
Blagih J., et al. The energy sensor AMPK regulates T cell metabolic adaptation, and effector responses in vivo. Immunity 42, 41-54, doi: 10.1016/j.immuni.2014.12.030 (2015
-
(2015)
Immunity
, vol.42
, pp. 41-54
-
-
Blagih, J.1
-
27
-
-
84928641864
-
Normalization of CD4+ T cell metabolism reverses lupus
-
274ra218
-
Yin Y., et al. Normalization of CD4+ T cell metabolism reverses lupus. Science translational medicine 7, 274ra218, doi: 10.1126/scitranslmed.aaa0835 (2015
-
(2015)
Science Translational Medicine
, vol.7
-
-
Yin, Y.1
-
28
-
-
84953335448
-
Glucose oxidation is critical for CD4+ T cell activation in a mouse model of systemic lupus erythematosus
-
Yin Y., et al. Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus. J Immunol, doi: 10.4049/jimmunol.1501537 (2015
-
(2015)
J Immunol
-
-
Yin, Y.1
-
30
-
-
55249095393
-
Hypoxia controls CD4+ CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha
-
Ben-Shoshan J., Maysel-Auslender S., Mor A., Keren G., & George J. Hypoxia controls CD4+ CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol 38, 2412-2418, doi: 10.1002/eji.200838318 (2008
-
(2008)
Eur J Immunol
, vol.38
, pp. 2412-2418
-
-
Ben-Shoshan, J.1
Maysel-Auslender, S.2
Mor, A.3
Keren, G.4
George, J.5
-
31
-
-
80052277906
-
Control of th17/treg balance by hypoxia-inducible factor 1
-
Dang E. V., et al. Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1. Cell 146, 772-784, doi: 10.1016/j.cell.2011.07.033 (2011
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
-
32
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17, and Treg cells
-
Shi L. Z., et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17, and Treg cells. J Exp Med 208, 1367-1376, doi: 10.1084/jem.20110278 (2011
-
(2011)
J Exp Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
-
33
-
-
84867381718
-
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance, and function during inflammatory hypoxia of the mucosa
-
Clambey E. T., et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance, and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci USA 109, E2784-2793, doi: 10.1073/pnas.1202366109 (2012
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E2784-2793
-
-
Clambey, E.T.1
-
34
-
-
84871861969
-
PDK1 regulation of mTOR, and hypoxia-inducible factor 1 integrate metabolism, and migration of CD8+ T cells
-
Finlay D. K., et al. PDK1 regulation of mTOR, and hypoxia-inducible factor 1 integrate metabolism, and migration of CD8+ T cells. J Exp Med 209, 2441-2453, doi: 10.1084/jem.20112607 (2011
-
(2011)
J Exp Med
, vol.209
, pp. 2441-2453
-
-
Finlay, D.K.1
-
35
-
-
84857125452
-
Glut1-mediated glucose transport regulates HIV infection
-
Loisel-Meyer S., et al. Glut1-mediated glucose transport regulates HIV infection. Proc Natl Acad Sci USA 109, 2549-2554, doi: 10.1073/pnas.1121427109 (2012
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 2549-2554
-
-
Loisel-Meyer, S.1
-
36
-
-
0026801196
-
Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes
-
Murakami T., et al. Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes. J Biol Chem 267, 9300-9306 (1992
-
(1992)
J Biol Chem
, vol.267
, pp. 9300-9306
-
-
Murakami, T.1
-
37
-
-
0028805375
-
Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences
-
Ebert B. L., Firth J. D., & Ratcliffe P. J. Hypoxia, and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 270, 29083-29089 (1995
-
(1995)
J Biol Chem
, vol.270
, pp. 29083-29089
-
-
Ebert, B.L.1
Firth, J.D.2
Ratcliffe, P.J.3
-
38
-
-
0035575975
-
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development, and effector functions
-
Caldwell C. C., et al. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development, and effector functions. J Immunol 167, 6140-6149 (2001
-
(2001)
J Immunol
, vol.167
, pp. 6140-6149
-
-
Caldwell, C.C.1
-
39
-
-
0026769932
-
Distribution of lymphocyte subsets, and natural killer cells in the human body
-
Westermann J., & Pabst R. Distribution of lymphocyte subsets, and natural killer cells in the human body. Clin Investig 70, 539-544 (1992
-
(1992)
Clin Investig
, vol.70
, pp. 539-544
-
-
Westermann, J.1
Pabst, R.2
-
40
-
-
0038765482
-
Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers, and T-cell turnover in different organs of rhesus monkeys
-
Sopper S., et al. Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers, and T-cell turnover in different organs of rhesus monkeys. Blood 10, 10 (2002
-
(2002)
Blood
, vol.10
, pp. 10
-
-
Sopper, S.1
-
41
-
-
77952280516
-
Anergic T cells are metabolically anergic
-
Zheng Y., Delgoffe G. M., Meyer C. F., Chan W., & Powell J. D. Anergic T cells are metabolically anergic. J Immunol 183, 6095-6101, doi: 10.4049/jimmunol.0803510 (2009
-
(2009)
J Immunol
, vol.183
, pp. 6095-6101
-
-
Zheng, Y.1
Delgoffe, G.M.2
Meyer, C.F.3
Chan, W.4
Powell, J.D.5
-
42
-
-
84905510173
-
Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability, and resistance to metabolic inhibition in CD8 versus CD4 T cells
-
Cao Y., Rathmell J. C., & Macintyre A. N. Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability, and resistance to metabolic inhibition in CD8 versus CD4 T cells. PLoS One 9, e104104, doi: 10.1371/journal.pone.0104104 (2014
-
(2014)
Plos One
, vol.9
, pp. e104104
-
-
Cao, Y.1
Rathmell, J.C.2
Macintyre, A.N.3
-
43
-
-
84920481006
-
Metabolic programming, and PDHK1 control CD4+ T cell subsets, and inflammation
-
Gerriets V. A., et al. Metabolic programming, and PDHK1 control CD4+ T cell subsets, and inflammation. J Clin Invest 125, 194-207, doi: 10.1172/JCI76012 (2015
-
(2015)
J Clin Invest
, vol.125
, pp. 194-207
-
-
Gerriets, V.A.1
-
44
-
-
12944262229
-
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
-
Macheda M. L., Rogers S., & Best J. D. Molecular, and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 202, 654-662 (2005
-
(2005)
J Cell Physiol
, vol.202
, pp. 654-662
-
-
Macheda, M.L.1
Rogers, S.2
Best, J.D.3
-
45
-
-
0345447592
-
The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV
-
Manel N., et al. The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 115, 449-459 (2003
-
(2003)
Cell
, vol.115
, pp. 449-459
-
-
Manel, N.1
-
46
-
-
17744366201
-
HTLV-1, and -2 envelope SU subdomains, and critical determinants in receptor binding
-
Kim F. J., et al. HTLV-1, and -2 envelope SU subdomains, and critical determinants in receptor binding. Retrovirology 1, 41, doi: 10.1186/1742-4690-1-41 (2004
-
(2004)
Retrovirology
, vol.1
, pp. 41
-
-
Kim, F.J.1
|