Design and synthesis of aminostilbene-arylpropenones as tubulin polymerization inhibitors

ChemMedChem

Volumn 9, Issue 11, 2014, Pages 2565-2579

  Kamal, Ahmed ^a,b   Kumar, G Bharath ^a   Polepalli, Sowjanya ^a   Shaik, Anver Basha ^a   Reddy, Vangala Santhosh ^a   Reddy, M Kashi ^a   Reddy, Ch Ratna ^a   Mahesh, Rasala ^a   Kapure, Jeevak Sopanrao ^b   Jain, Nishant ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

antiproliferation; cell cycle arrest; dot blot analyses; molecular docking; polymerization

Indexed keywords

(Z) 1 (1H INDOL 3 YL) 3 [(2 METHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO]PROP 2 EN 1 ONE; (Z) 1 (2 BROMO 3,4,5 TRIMETHOXYPHENYL) 3 [(2 HYDROXY 3 METHOXY 6 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; (Z) 1 (2 BROMO 3,4,5 TRIMETHOXYPHENYL) 3 [(2 METHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO]PROP 2 EN 1 ONE; (Z) 1 (2 BROMO 3,4,5 TRIMETHOXYPHENYL) 3 [(2,3 DIMETHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO[PROP 2 EN 1 ONE; (Z) 1 (3 AMINO 4 METHOXYPHENYL) 3 [(2 HYDROXY 3 METHOXY 6 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO]PROP 2 EN 1 ONE; (Z) 1 (3 HYDROXY 4 METHOXYPHENYL) 3 [(2 METHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO]PROP 2 EN 1 ONE; (Z) 1 (3 ZMINO 4 METHOXYPHENYL) 3 [(2,3 DIMETHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO]PROP 2 EN 1 ONE; (Z) 1 (4 AMINO 3 METHOXYPHENYL) 3 [(2 METHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO]PROP 2 EN 1 ONE; (Z) 1 (4 METHOXY 3 NITROPHENYL) 3 [(2 METHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO]PROP 2 EN 1 ONE; (Z) 1 [3 (TERT BUTYLDIMETHYLSILYLOXY) 4 METHOXYPHENYL] 3 [(2 HYDROXY 3 METHOXY 6 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; (Z) 3 [(2 HYDROXY 3 METHOXY 6 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 EN 1 ONE; (Z) 3 [(2 HYDROXY 3 METHOXY 6 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; (Z) 3 [(2 HYDROXY 3 METHOXY 6 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (4 METHOXY 3 NITROPHENYL)PROP 2 EN 1 ONE; (Z) 3 [(2 HYDROXY 3 METHOXY 6 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 [4 (TRIFLUOROMETHOXY)PHENYL]PROP 2 EN 1 ONE; (Z) 3 [(2 METHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO) 1 (4 (TRIFLUOROMETHOXY)PHENYL]PROP 2 EN 1 ONE; (Z) 3 [(2 METHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (1 METHYL 1H INDOL 3 YL)PROP 2 EN 1 ONE; (Z) 3 [(2 METHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; (Z) 3 [(2,3 DIMETHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (1 METHYL 1H INDOL 3 YL)PROP 2 EN 1 ONE; (Z) 3 [(2,3 DIMETHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (1H INDOL 3 YL)PROP 2 EN 1 ONE; (Z) 3 [(2,3 DIMETHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 EN 1 ONE; (Z) 3 [(2,3 DIMETHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; (Z) 3 [(2,3 DIMETHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 (4 METHOXY 3 NITRO PHENYL)PROP 2 EN 1 ONE; (Z) 3 [(2,3 DIMETHOXY 5 ((Z) 3,4,5 TRIMETHOXYSTYRYL)PHENYL)AMINO] 1 [4 (TRIFLUOROMETHOXY)PHENYL]PROP 2 EN 1 ONE; AMINOSTILBENE DERIVATIVE; ARYLPROPENONE DERIVATIVE; COLCHICINE; CYCLIN B1; STILBENE; TUBULIN; TUBULIN MODULATOR; UNCLASSIFIED DRUG; ALKENE; ANTINEOPLASTIC AGENT; PROPYLENE; STILBENE DERIVATIVE;

A549 CELL LINE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING SITE; CELL CYCLE ASSAY; CELL CYCLE M PHASE; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; GROWTH INHIBITION; HCT116 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IC50; INVESTIGATIVE PROCEDURES; MCF 7 CELL LINE; MICHAEL ADDITION; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; NATIONAL HEALTH ORGANIZATION; PRIORITY JOURNAL; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; G2 PHASE CELL CYCLE CHECKPOINT; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; TUMOR CELL LINE;

ALKENES; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B1; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; STILBENES; TUBULIN; TUBULIN MODULATORS;

EID: 84925341399     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201402256     Document Type: Article

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