Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 15, 2016, Pages E2142-E2151

  Monteith, Andrew J ^a   Kang, Sunah ^a   Scott, Eric ^a   Hillman, Kai ^a   Rajfur, Zenon ^a,b   Jacobson, Ken ^a,c   Costello, M Joseph ^a   Vilen, Barbara J ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

AIM2; Fc gamma receptors; Lysosomal acidification; Systemic lupus erythematosus; TRIM21

Indexed keywords

AIM2 PROTEIN; ALPHA INTERFERON; CELL MEMBRANE PROTEIN; CELL NUCLEUS ANTIGEN; DOUBLE STRANDED DNA; IMMUNOGLOBULIN G; TOLL LIKE RECEPTOR; TRIM21 PROTEIN; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; ANTIGEN ANTIBODY COMPLEX; DNA; DNA BINDING PROTEIN; HEMOCYANIN; MEMBRANE PROTEIN; REACTIVE OXYGEN METABOLITE; RIBONUCLEOPROTEIN; SS-A ANTIGEN; TLR7 PROTEIN, MOUSE; TLR9 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRINITROPHENYL KEYHOLE LIMPET HEMOCYANIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL DEATH; CELL MATURATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOSOL; DEGRADATION; INTERNALIZATION; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SELF CONCEPT; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; C57BL MOUSE; ESCHERICHIA COLI; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; METABOLISM; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; CELL MEMBRANE PERMEABILITY; DNA; DNA-BINDING PROTEINS; ESCHERICHIA COLI; HEMOCYANIN; IMMUNITY, INNATE; IMMUNOGLOBULIN G; INTERFERON-ALPHA; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYSOSOMES; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE, INBRED C57BL; MICE, INBRED MRL LPR; MICE, TRANSGENIC; REACTIVE OXYGEN SPECIES; RIBONUCLEOPROTEINS; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9;

EID: 84963735245     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1513943113     Document Type: Article

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