Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 32, 2015, Pages 10014-10019

  Fletcher, Adam J ^a   Mallery, Donna L ^a   Watkinson, Ruth E ^a   Dickson, Claire F ^a   James, Leo C ^a   Luban, Jeremy ^b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

NF kB; Poh1; TRIM21; Ube2N Ube2V2; Ube2W

Indexed keywords

48 LINKED UBIQUITIN; CYTOKINE; CYTOSOL RECEPTOR; DEUBIQUITINASE; DEUBIQUITINASE POH1; ENZYME; HETERODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; K63 LINKED UBIQUITIN; MONOUBIQUITIN; POLYUBIQUITIN; PROTEASOME; TRIPARTITE MOTIF PROTEIN 21; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; LYSINE; PSMD14 PROTEIN, HUMAN; RIBONUCLEOPROTEIN; SS-A ANTIGEN; TRANSACTIVATOR PROTEIN; UBE2N PROTEIN, HUMAN; UBE2W PROTEIN, HUMAN; UBIQUITIN CONJUGATING ENZYME;

ARTICLE; CONJUGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEUBIQUITINATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME MECHANISM; FEMALE; HUMAN; HUMAN CELL; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; VIRUS NEUTRALIZATION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; ENZYME SPECIFICITY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE; SERODIAGNOSIS;

ANIMALS; CELL LINE; CYTOKINES; HUMANS; LYSINE; MICE; MODELS, BIOLOGICAL; NEUTRALIZATION TESTS; NF-KAPPA B; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; RIBONUCLEOPROTEINS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION;

EID: 84938932273     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507534112     Document Type: Article

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