Inflammatory and Epigenetic Pathways for Perinatal Depression

Biological Research for Nursing

Volumn 18, Issue 3, 2016, Pages 331-343

  Garfield, Lindsey ^a   Mathews, Herbert L ^b   Janusek, Linda Witek ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

childhood adversity; epigenetics; inflammation; oxytocin; perinatal depression

Indexed keywords

OXYTOCIN;

ADULT; DNA METHYLATION; FEMALE; HUMAN; INFLAMMATION; METABOLISM; PREGNANCY; PREGNANCY COMPLICATION; PUERPERAL DEPRESSION; PUERPERIUM;

ADULT; DEPRESSION, POSTPARTUM; DNA METHYLATION; FEMALE; HUMANS; INFLAMMATION; OXYTOCIN; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 84963649714     PISSN: 10998004     EISSN: 15524175     Source Type: Journal    
DOI: 10.1177/1099800415614892     Document Type: Article

References (141)

1. S.AlberiJ.J.DreifussM.Raggenbass (1997). The oxytocin-induced inward current in vagal neurons of the rat is mediated by G protein activation but not by an increase in the intracellular calcium concentration. European Journal of Neuroscience, 9, 2605–2612.
2. J.A.Alegria-TorresA.BaccarelliV.Bollati (2011). Epigenetics and lifestyle. Epigenomics, 3, 267–277.
3. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
4. J.A.AmicoJ.S.UlbrechtA.G.Robinson (1987). Clearance studies of oxytocin in humans using radioimmunoassay measurements fo the hormone in plasma and urine. Journal of Clinical Endocrinology and Metabolism, 64, 340–345.
5. G.AndersonM.Maes (2013). Postpartum depression: Psychoneuroimmunological underpinnings and treatment. Journal of Neuropsychiatric Disease and Treatment, 9, 277–287.
6. R.AzarD.Mercer (2013). Mild depressive symptoms are associated with elevated C-reactive protein and proinflammatory cytokine levels during early to midgestation: A prospective pilot study. Journal of Women’s Health, 22, 385–389.
7. P.BatesonD.BarkerT.Clutton-BrockD.DebB.D’UdineR.A.Foley…S.E.Sultan (2004). Developmental plasticity and human health. Nature, 430, 419–421.
8. C.T.Beck (1992). The lived experience of postpartum depression: A phenomenological study. Nursing Research, 41, 166–170.
9. E.R.BlackmoreS.W.GrothD.G.ChenM.A.GilchristT.G.O’ConnorJ.A.Moynihan (2014). Depressive symptoms and proinflammatory cytokines across the perinatal period in African American women. Journal of Psychosomatic Obstetrics and Gynaecology, 35, 8–15.
10. N.BorgholM.SudermanW.McArdleA.RacineM.HallettM.Pembrey…M.Szyf (2012). Associations with early-life socio-economic position in adult DNA methylation. International Journal of Epidemiology, 41, 62–74.
11. B.BradleyD.WestenK.B.MercerE.B.BinderT.JovanovicD.Crain…C.Heim (2011). Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene. Development and Psychopathology, 23, 439–452.
12. L.L.CarpenterC.E.GawugaA.R.TyrkaJ.K.LeeG.M.AndersonL.H.Price (2010). Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology, 35, 2617–2623.
13. L.L.CarpenterT.T.ShattuckA.R.TyrkaT.D.GeraciotiL.H.Price (2011). Effect of childhood physical abuse on cortisol stress response. Psychopharmacology, 214, 367–375.
14. L.L.CarpenterA.R.TyrkaN.S.RossL.KhouryG.M.AndersonL.H.Price (2009). Effect of childhood emotional abuse and age on cortisol responsivity in adulthood. Biological Psychiatry, 66, 69–75.
15. C.P.CarrC.M.MartinsA.M.StingelV.B.LemgruberM.F.Juruena (2013). The role of early life stress in adult psychiatric disorders: A systematic review according to childhood trauma subtypes. Journal of Nervous and Mental Disease, 201, 1007–1020.
16. J.E.CarrollS.CohenA.L.Marsland (2011). Early childhood socioeconomic status is associated with circulating interleukin-6 among mid-life adults. Brain, Behavior, & Immunity, 25, 1468–1474.
17. A.E.Cassidy-BushrowR.M.PetersD.A.JohnsonT.N.Templin (2012). Association of depressive symptoms with inflammatory biomarkers among pregnant African-American women. Journal of Reproductive Immunology, 94, 202–209.
18. J.R.ChallisC.J.LockwoodL.MyattJ.E.NormanJ.F.StraussIIIF.Petraglia (2009). Inflammation and pregnancy. Reproductive Sciences, 16, 206–215.
19. F.A.Champagne (2008). Epigenetic mechanisms and the transgenerational effects of maternal care. Frontiers in Neuroendocrinology, 29, 386–397.
20. F.A.ChampagneD.D.FrancisA.MarM.J.Meaney (2003). Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiology & Behavior, 79, 359–371.
21. E.ChenG.E.MillerM.S.KoborS.W.Cole (2011). Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Molecular Psychiatry, 16, 729–737.
22. L.P.ChenM.H.MuradM.L.ParasK.M.ColbensonA.L.SattlerE.N.Goranson…A.Zirakzadeh (2010). Sexual abuse and lifetime diagnosis of psychiatric disorders: Systematic review and meta-analysis. Mayo Clinic Proceedings, 85, 618–629.
23. L.M.Christian (2014). Effects of stress and depression on inflammatory immune parameters in pregnancy. American Journal of Obstetrics & Gyncology, 211, 275–277.
24. L.M.ChristianA.FrancoR.GlaserJ.D.Iams (2009). Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women. Brain, Behavior, & Immunity, 23, 750–754.
25. L.M.ChristianR.GlaserK.PorterJ.D.Iams (2013). Stress-induced inflammatory responses in women: Effects of race and pregnancy. Psychosomatic Medicine, 75, 658–669.
26. L.M.ChristianK.Porter (2014). Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: Effects of maternal body mass index. Cytokine, 70, 134–140.
27. E.K.ChungK.F.McCollumI.T.EloH.J.LeeJ.F.Culhane (2004). Maternal depressive symptoms and infant health practices among low-income women. Pediatrics, 113, 523–529.
28. M.ClodiG.VilaR.GeyereggerM.RiedlT.M.StulnigJ.Struck…A.Luger (2008). Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men. American Journal of Physiology, Endocrinology, and Metabolism, 295, E686–E691.
29. S.CohenD.Janicki-DevertsE.ChenK.A.Matthews (2010). Childhood socioeconomic status and adult health. Annals of the New York Academy of Sciences, 1186, 37–55.
30. S.CohenD.Janicki-DevertsG.E.Miller (2007). Psychological stress and disease. Journal of the American Medical Association, 298, 1685–1687.
31. E.J.CorwinY.GuoK.PajerN.LoweD.McCarthyS.Schmiege…B.Stafford (2013). Immune dysregulation and glucocorticoid resistance in minority and low income pregnant women. Psychoneuroendocrinology, 38, 1786–1796.
32. E.J.CorwinK.Pajer (2008). The psychoneuroimmunology of postpartum depression. Journal of Women’s Health, 17, 1529–1534.
33. M.E.Coussons-ReadM.L.OkunC.D.Nettles (2007). Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy. Brain, Behavior, & Immunity, 21, 343–350.
34. M.E.Coussons-ReadM.L.OkunM.P.SchmittS.Giese (2005). Prenatal stress alters cytokine levels in a manner that may endanger human pregnancy. Psychosomatic Medicine, 67, 625–631.
35. C.B.CunradiR.CaetanoJ.Schafer (2002). Socioeconomic predictors of intimate partner violence among White, Black, and Hispanic couples in the United States. Journal of Family Violence, 17, 377–389.
36. J.P.CurleyS.DavidsonP.BatesonF.A.Champagne (2009). Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice. Frontiers in Behavioral Neuroscience, 3, 25.
37. J.M.CyranowskiT.L.HofkensE.FrankH.SeltmanH.M.CaiJ.A.Amico (2008). Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosomatic Medicine, 70, 967–975.
38. A.DaneseB.S.McEwen (2012). Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology & Behavior, 106, 29–39.
39. A.DaneseT.E.MoffittC.M.ParianteA.AmblerR.PoultonA.Caspi (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry, 65, 409–415.
40. A.DaneseC.M.ParianteA.CaspiA.TaylorR.Poulton (2007). Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings of the National Academy of Sciences, 104, 1319–1324.
41. R.DantzerJ.C.O’ConnorG.G.FreundR.W.JohnsonK.W.Kelley (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews Neuroscience, 9, 46–56.
42. R.DantzerJ.C.O’ConnorM.A.LawsonK.W.Kelley (2011). Inflammation-associated depression: From serotonin to kynurenine. Psychoneuroendocrinology, 36, 426–436.
43. D.B.DavalosC.A.YadonH.C.Tregellas (2012). Untreated prenatal maternal depression and the potential risks to offspring: A review. Archives of Womens Mental Health, 15, 1–14.
44. J.DayanC.CreveuilM.DreyfusM.HerlicoviezJ.M.BaleyteV.O’Keane (2010). Developmental model of depression applied to prenatal depression: Role of present and past life events, past emotional disorders and pregnancy stress. PLoS One, 5, e12942.
45. C.de WeerthJ.K.Buitelaar (2005). Physiological stress reactivity in human pregnancy—A review. Neuroscience and Biobehavioral Reviews, 29, 295–312.
46. N.DekelY.GnainskyI.GranotG.Mor (2010). Inflammation and implantation. American Journal of Reproductive Immunology, 63, 17–21.
47. F.DusunceliS.O.IseriF.ErcanN.GedikC.YegenB.C.Yegen (2008). Oxytocin alleviates hepatic ischemia-reperfusion injury in rats. Peptides, 29, 1216–1222.
48. B.M.ElzingaK.RoelofsM.S.TollenaarP.BakvisJ.van PeltP.Spinhoven (2008). Diminished cortisol responses to psychosocial stress associated with lifetime adverse events: A study among healthy young subjects. Psychoneuroendocrinology, 33, 227–237.
49. R.Feldman (2012). Oxytocin and social affiliation in humans. Hormones and Behavior, 61, 380–391.
50. R.FeldmanA.GranatC.ParienteH.KanetyJ.KuintE.Gilboa-Schechtman (2009). Maternal depression and anxiety across the postpartum year and infant social engagement, fear regulation, and stress reactivity. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 919–927.
51. R.FeldmanA.VengroberR.P.Ebstein (2014). Affiliation buffers stress: Cumulative genetic risk in oxytocin-vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children. Translational Psychiatry, 4, e370.
52. R.FeldmanA.WellerO.Zagoory-SharonA.Levine (2007). Evidence for a neuroendocrinological foundation of human affiliation: Plasma oxytocin levels across pregnancy and the postpartum period predict mother–infant bonding. Psychological Science, 18, 965–970.
53. R.FeldmanO.Zagoory-SharonO.WeismanI.SchneidermanI.GordonR.Maoz…R.P.Ebstein (2012). Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biological Psychiatry, 72, 175–181.
54. J.C.FelgerF.E.Lotrich (2013). Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications. Neuroscience, 246, 199–229.
55. T.M.Field (1984). Early interactions between infants and their postpartum depressed mothers. Infant Behavior and Development, 7, 517–522.
56. D.D.FrancisF.C.ChampagneM.J.Meaney (2000). Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat. Journal of Neuroendocrinology, 12, 1145–1148.
57. D.D.FrancisL.J.YoungM.J.MeaneyT.R.Insel (2002). Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: Gender differences. Journal of Neuroendocrinology, 14, 349–353.
58. L.GarfieldC.GiurgescuC.S.CarterD.Holditch-DavisB.L.McFarlinD.Schwertz…R.White-Traut (2014). Depressive symptoms in the second trimester relate to low oxytocin levels in African-American women: A pilot study. Archives of Women’s Mental Health, 18, 123–129.
59. A.R.GavinE.ThompsonT.RueY.Guo (2012). Maternal early life risk factors for offspring birth weight: Findings from the add health study. Prevention Science, 13, 162–172.
60. N.I.GavinB.N.GaynesK.N.LohrS.Meltzer-BrodyG.GartlehnerT.Swinson (2005). Perinatal depression: A systematic review of prevalence and incidence. Obstetrics & Gynecology, 106, 1071–1083.
61. L.M.GlynnE.P.DavisC.A.Sandman (2013). New insights into the role of perinatal HPA-axis dysregulation in postpartum depression. Neuropeptides, 47, 363–370.
62. A.Gonzalez (2013). The impact of childhood maltreatment on biological systems: Implications for clinical interventions. Paediatrics & Child Health, 18, 415–418.
63. A.GonzalezJ.M.JenkinsM.SteinerA.S.Fleming (2009). The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women. Psychoneuroendocrinology, 34, 76–86.
64. S.HaeriA.M.BakerR.Ruano (2013). Do pregnant women with depression have a pro-inflammatory profile?Journal of Obstetrics and Gynaecology Research, 39, 948–952.
65. C.HammenN.A.HazelP.A.BrennanJ.Najman (2012). Intergenerational transmission and continuity of stress and depression: Depressed women and their offspring in 20 years of follow-up. Psychological Medicine, 42, 931–942.
66. C.HeimM.ShugartW.E.CraigheadC.B.Nemeroff (2010). Neurobiological and psychiatric consequences of child abuse and neglect. Developmental Psychobiology, 52, 671–690.
67. C.HeimL.J.YoungD.J.NewportT.MletzkoA.H.MillerC.B.Nemeroff (2009). Lower CSF oxytocin concentrations in women with a history of childhood abuse. Molecular Psychiatry, 14, 954–958.
68. M.HeinrichsG.Domes (2008). Neuropeptides and social behaviour: Effects of oxytocin and vasopressin in humans. Progress in Brain Research, 170, 337–350.
69. V.K.HoganD.RowleyT.BennettK.D.Taylor (2012). Life course, social determinants, and health inequities: Toward a national plan for achieving health equity for African American infants—A concept paper. Maternal and Child Health Journal, 16, 1143–1150.
70. C.HolzmanJ.EysterL.B.TiedjeL.A.RomanE.SeagullM.H.Rahbar (2006). A life course perspective on depressive symptoms in mid-pregnancy. Maternal and Child Health Journal, 10, 127–138.
71. A.M.HomeidaR.G.Cooke (1983). Suppression of pulsatile release of oxytocin during early pregnancy in the goat. Prostaglandins, 26, 103–109.
72. O.P.HornungC.M.Heim (2014). Gene–environment interactions and intermediate phenotypes: Early trauma and depression. Frontiers in Endocrinology (Lausanne), 5, 14.
73. M.B.HowrenD.M.LamkinJ.Suls (2009). Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis. Psychosomatic Medicine, 71, 171–186.
74. S.O.IseriF.DusunceliC.ErzikB.UsluS.ArbakB.C.Yegen (2010). Oxytocin or social housing alleviates local burn injury in rats. Journal of Surgical Research, 162, 122–131.
75. S.O.IseriG.SenerB.SaglamN.GedikF.ErcanB.C.Yegen (2005). Oxytocin protects against sepsis-induced multiple organ damage: Role of neutrophils. Journal of Surgical Research, 126, 73–81.
76. M.R.JarchoG.M.SlavichH.Tylova-SteinO.M.WolkowitzH.M.Burke (2013). Dysregulated diurnal cortisol pattern is associated with glucocorticoid resistance in women with major depressive disorder. Biological Psychology, 93, 150–158.
77. S.N.JolleyS.ElmoreK.E.BarnardD.B.Carr (2007). Dysregulation of the hypothalamic–pituitary–adrenal axis in postpartum depression. Biological Research for Nursing, 8, 210–222.
78. E.R.KatzZ.N.StoweD.J.NewportM.E.KelleyT.W.PaceJ.F.CubellsE.B.Binder (2012). Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: Association with depressive symptoms during pregnancy. Psychological Medicine, 42, 943–956.
79. J.K.Kiecolt-GlaserJ.P.GouinN.P.WengW.B.MalarkeyD.Q.BeversdorfR.Glaser (2011). Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosomatic Medicine, 73, 16–22.
80. T.Kouzarides (2007). Chromatin modifications and their function. Cell, 128, 693–705.
81. S.R.Kunz-EbrechtV.Mohamed-AliP.J.FeldmanC.KirschbaumA.Steptoe (2003). Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines. Brain, Behavior, & Immunity, 17, 373–383.
82. A.LevineO.Zagoory-SharonR.FeldmanA.Weller (2007). Oxytocin during pregnancy and early postpartum: Individual patterns and maternal–fetal attachment. Peptides, 28, 1162–1169.
83. L.C.LiR.Dahiya (2002). MethPrimer: Designing primers for methylation PCRs. Bioinformatics, 18, 1427–1431.
84. K.C.LightK.M.GrewenJ.A.AmicoM.BocciaK.A.BrownleyJ.M.Johns (2004). Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy. Addictive Behaviors, 29, 1541–1564.
85. Y.LiuS.K.MurphyA.P.MurthaB.F.FuemmelerJ.SchildkrautZ.Huang…C.Hoyo (2012). Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics, 7, 735–746.
86. M.LukasR.BredewoldI.D.NeumannA.H.Veenema (2010). Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology, 58, 78–87.
87. M.A.MagiakouG.MastorakosD.RabinB.DubbertP.W.GoldG.P.Chrousos (1996). Hypothalamic corticotropin-releasing hormone suppression during the postpartum period: Implications for the increase in psychiatric manifestations at this time. Journal of Clinical Endocrinology and Metabolism, 81, 1912–1917.
88. J.A.MartinB.E.HamiltonM.Osterman (2014). Births in the United States, 2013. National Center for Health Statistics Data Brief, 175, 1–8.
89. J.A.MartinB.E.HamiltonP.D.SuttonS.J.VenturaF.MenackerS.KirmeyerM.Munson (2007). Births: Final data for 2005. National Vital Statistics Reports, 56, 1–103.
90. H.L.MathewsL.W.Janusek (2011). Epigenetics and psychoneuroimmunology: Mechanisms and models. Brain, Behavior, & Immunity, 25, 25–39.
91. D.McGuinnessL.M.McGlynnP.C.JohnsonA.MacIntyreG.D.BattyH.Burns…P.G.Shiels (2012). Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology, 41, 151–160.
92. K.A.McLaughlinK.J.ConronK.C.KoenenS.E.Gilman (2010). Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: A test of the stress sensitization hypothesis in a population-based sample of adults. Psychological Medicine, 40, 1647–1658.
93. K.T.McLearnC.S.MinkovitzD.M.StrobinoE.MarksW.Hou (2006). Maternal depressive symptoms at 2 to 4 months postpartum and early parenting practices. Archives of Pediatrics & Adolescent Medicine, 160, 279–284.
94. J.W.MeekinsM.J.LuckasR.PijnenborgI.R.McFadyen (1997). Histological study of decidual spiral arteries and the presence of maternal erythrocytes in the intervillous space during the first trimester of normal human pregnancy. Placenta, 18, 459–464.
95. G.MeinlschmidtC.Heim (2007). Sensitivity to intranasal oxytocin in adult men with early parental separation. Biological Psychiatry, 61, 1109–1111.
96. A.H.MillerV.MaleticC.L.Raison (2009). Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biological Psychiatry, 65, 732–741.
97. G.MillerE.Chen (2007). Unfavorable socioeconomic conditions in early life presage expression of proinflammatory phenotype in adolescence. Psychosomatic Medicine, 69, 402–409.
98. G.E.MillerE.Chen (2010). Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychological Science, 21, 848–856.
99. G.E.MillerE.ChenA.K.FokH.WalkerA.LimE.F.Nicholls…M.S.Kobor (2009). Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proceedings of the National Academy of Sciences, 106, 14716–14721.
100. G.E.MillerE.ChenK.J.Parker (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137, 959–997.
101. G.E.MillerS.W.Cole (2012). Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. Biological Psychiatry, 72, 34–40.
102. C.S.MinkovitzD.StrobinoD.ScharfsteinW.HouT.MillerK.MistryK.Swartz (2005). Maternal depressive symptoms and children’s receipt of health care in the first 3 years of life. Pediatrics, 115, 306–314.
103. C.MonkJ.SpicerF.A.Champagne (2012). Linking prenatal maternal adversity to developmental outcomes in infants: The role of epigenetic pathways. Development and Psychopathology, 24, 1361–1376.
104. G.MorI.CardenasV.AbrahamsS.Guller (2011). Inflammation and pregnancy: The role of the immune system at the implantation site. Annals of the New York Academy of Sciences, 1221, 80–87.
105. D.A.NationA.SzetoA.J.MendezL.G.BrooksJ.ZaiasE.E.Herderick…P.M.McCabe (2010). Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE/mice. Psychosomatic Medicine, 72, 376–382.
106. O.Y.NaumovaM.LeeR.KoposovM.SzyfM.DozierE.L.Grigorenko (2012). Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents. Development and Psychopathology, 24, 143–155.
107. T.F.OberlanderR.GrunauL.MayesW.RiggsD.RurakM.Papsdorf…J.Weinberg (2008). Hypothalamic–pituitary–adrenal (HPA) axis function in 3-month old infants with prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposure. Early Human Development, 84, 689–697.
108. M.W.O’Hara (2009). Postpartum depression: What we know. Journal of Clinical Psychology, 65, 1258–1269.
109. M.O’HigginsI.S.RobertsV.GloverA.Taylor (2013). Mother-child bonding at 1 year: Associations with symptoms of postnatal depression and bonding in the first few weeks. Archives of Women’s Mental Health, 16, 381–389.
110. V.O’KeaneS.LightmanM.MarshS.PawlbyA.S.PapadopoulosA.Taylor…K.Patrick (2011). Increased pituitary-adrenal activation and shortened gestation in a sample of depressed pregnant women: A pilot study. Journal of Affective Disorders, 130, 300–305.
111. J.Opacka-JuffryC.Mohiyeddini (2012). Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men. Stress, 15, 1–10.
112. L.M.OsborneC.Monk (2013). Perinatal depression—The fourth inflammatory morbidity of pregnancy?Theory and literature review. Psychoneuroendocrinology, 38, 1929–1952.
113. G.Oxenkrug (2013). Serotonin-kynurenine hypothesis of depression: Historical overview and recent developments. Current Drug Targets, 14, 514–521.
114. T.W.PaceT.C.MletzkoO.AlagbeD.L.MusselmanC.B.NemeroffA.H.MillerC.M.Heim (2006). Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. American Journal of Psychiatry, 163, 1630–1633.
115. B.D.PearceS.E.GarvinJ.GroveE.A.BonneyD.J.DudleyD.E.SchendelP.Thorsen (2008). Serum macrophage migration inhibitory factor in the prediction of preterm delivery. American Journal of Obstetrics & Gyncology, 199, e41–e46.
116. M.PeterssonU.WibergT.LundebergK.Uvnas-Moberg (2001). Oxytocin decreases carrageenan induced inflammation in rats. Peptides, 22, 1479–1484.
117. D.T.PlantE.D.BarkerC.S.WatersS.PawlbyC.M.Pariante (2013). Intergenerational transmission of maltreatment and psychopathology: The role of antenatal depression. Psychological Medicine, 43, 519–528.
118. J.PoehlmannB.H.Fiese (2001). The interaction of maternal and infant vulnerabilities on developing attachment relationships. Development and Psychopathology, 13, 1–11.
119. C.L.RaisonA.H.Miller (2013). Do cytokines really sing the blues?Cerebrum, 2013, 10.
120. W.Reik (2007). Stability and flexibility of epigenetic gene regulation in mammalian development. Nature, 447, 425–432.
121. R.L.RepettiS.E.TaylorT.E.Seeman (2002). Risky families: Family social environments and the mental and physical health of offspring. Psychological Bulletin, 128, 330–366.
122. J.W.Rich-EdwardsT.James-ToddA.MohllajeeK.KleinmanA.BurkeM.W.GillmanR.J.Wright (2011). Lifetime maternal experiences of abuse and risk of pre-natal depression in two demographically distinct populations in Boston. International Journal of Epidemiology, 40, 375–384.
123. K.M.RossG.McDonald-JonesG.E.Miller (2013). Oxytocin does not attenuate the ex vivo production of inflammatory cytokines by lipopolysaccharide-activated monocytes and macrophages from healthy male and female donors. Neuroimmunomodulation, 20, 285–293.
124. G.ScantamburloM.HansenneS.FuchsW.PitchotP.MarechalC.Pequeux…J.J.Legros (2007). Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology, 32, 407–410.
125. C.D.ScherD.R.FordeJ.R.McQuaidM.B.Stein (2004). Prevalence and demographic correlates of childhood maltreatment in an adult community sample. Child Abuse & Neglect, 28, 167–180.
126. R.H.SegmanN.ShefiT.Goltser-DubnerN.FriedmanN.KaminskiA.Y.Shalev (2005). Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Molecular Psychiatry, 10, 500–513, 425.
127. M.M.SheltonD.L.SchminkeyM.W.Groer (2015). Relationships among prenatal depression, plasma cortisol, and inflammatory cytokines. Biological Research in Nursing, 17, 295–302.
128. C.E.ShenkJ.G.NollF.W.PutnamP.K.Trickett (2010). A prospective examination of the role of childhood sexual abuse and physiological asymmetry in the development of psychopathology. Child Abuse & Neglect, 34, 752–761.
129. J.P.ShonkoffW.T.BoyceB.S.McEwen (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: Building a new framework for health promotion and disease prevention. Journal of the American Medical Association, 301, 2252–2259.
130. M.SkrundzM.BoltenI.NastD.H.HellhammerG.Meinlschmidt (2011). Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. Neuropsychopharmacology, 36, 1886–1893.
131. A.SzetoD.A.NationA.J.MendezJ.Dominguez-BendalaL.G.BrooksN.SchneidermanP.M.McCabe (2008). Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. American Journal of Physiological Endocrinology and Metabolism, 295, E1495–E1501.
132. M.Szyf (2011). The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life. Epigenetics, 6, 971–978.
133. A.R.TyrkaL.H.PriceC.MarsitO.C.WaltersL.L.Carpenter (2012). Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: Preliminary findings in healthy adults. PLoS One, 7, e30148.
134. M.UddinK.C.KoenenA.E.AielloD.E.WildmanR.de los SantosS.Galea (2011). Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample. Psychological Medicine, 41, 997–1007.
135. K.Uvnas-MobergI.ArnD.Magnusson (2005). The psychobiology of emotion: The role of the oxytocinergic system. International Journal of Behavioral Medicine, 12, 59–65.
136. A.B.Wismer FriesT.E.ZieglerJ.R.KurianS.JacorisS.D.Pollak (2005). Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. Proceedings of the National Academy of Sciences, 102, 17237–17240.
137. Y.YamaguchiK.YamadaT.SuzukiY.P.WuK.KitaS.Takahashi…N.Suzuki (2004). Induction of uPA release in human peripheral blood lymphocytes by [deamino-Cysl,D-Arg8]-vasopressin (dDAVP). American Journal of Physiology, Endocrinology, and Metabolism, 287, E970–E976.
138. J.B.YoungerM.J.KendellR.H.Pickler (1997). Mastery of stress in mothers of preterm infants. Journal of the Society of Pediatric Nurses, 2, 29–37.
139. F.F.ZhangA.MorabiaJ.CarrollK.GonzalezK.FuldaM.Kaur…R.Cardarelli (2011). Dietary patterns are associated with levels of global genomic DNA methylation in a cancer-free population. Journal of Nutrition, 141, 1165–1171.
140. T.Y.ZhangM.J.Meaney (2010). Epigenetics and the environmental regulation of the genome and its function. Annual Review of Psychology, 61, 439–466, C431–C433.
141. Y.ZhangH.H.NgH.Erdjument-BromageP.TempstA.BirdD.Reinberg (1999). Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes & Development, 13, 1924–1935.