Sensitivity to Intranasal Oxytocin in Adult Men with Early Parental Separation

Biological Psychiatry

Volumn 61, Issue 9, 2007, Pages 1109-1111

  Meinlschmidt, Gunther ^a   Heim, Christine ^a  

^a UNIVERSITY OF TRIER   (Germany)

Author keywords

Attachment; bonding; development; oxytocin; resilience; stress

Indexed keywords

HYDROCORTISONE; OXYTOCIN; PLACEBO;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; HUMAN; MALE; NEUROENDOCRINE SYSTEM; PERSONAL EXPERIENCE; PRIORITY JOURNAL; SALIVA ANALYSIS; SOCIAL PSYCHIATRY;

ADMINISTRATION, INTRANASAL; ADULT; DOUBLE-BLIND METHOD; HUMANS; HYDROCORTISONE; MALE; OBJECT ATTACHMENT; OXYTOCIN; PARENTS; SALIVA;

EID: 34047251000     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.09.007     Document Type: Article

References (20)

1. Agid O., Kohn Y., and Lerer B. Environmental stress and psychiatric illness. Biomed Pharmacother 54 (2000) 135-141
2. Born J., Lange T., Kern W., McGregor G.P., Bickel U., and Fehm H.L. Sniffing neuropeptides: A transnasal approach to the human brain. Nat Neurosci 5 (2002) 514-516
3. Charney D.S. Psychobiological mechanisms of resilience and vulnerability: Implications for successful adaptation to extreme stress. Am J Psychiatry 161 (2004) 195-216
4. Dressendoerfer R.A., Kirschbaum C., Rohde W., Stahl F., and Strasburger C.J. Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement. J Steroid Biochem Mol Biol 43 (1992) 683-692
5. Engelmann M., Landgraf R., and Wotjak C.T. The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: An old concept revisited. Front Neuroendocrinol 25 (2004) 132-149
6. Francis D.D., Young L.J., Meaney M.J., and Insel T.R. Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: Gender differences. J Neuroendocrinol 14 (2002) 349-353
7. Fries A.B., Ziegler T.E., Kurian J.R., Jacoris S., and Pollak S.D. Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. Proc Natl Acad Sci U S A 102 (2005) 17237-17240
8. Heim C., Plotsky P.M., and Nemeroff C.B. Importance of studying the contributions of early adverse experience to neurobiological findings in depression. Neuropsychopharmacology 29 (2004) 641-648
9. Heinrichs M., Baumgartner T., Kirschbaum C., and Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 54 (2003) 1389-1398
10. Heinrichs M., Meinlschmidt G., Wippich W., Ehlert U., and Hellhammer D.H. Selective amnesic effects of oxytocin on human memory. Physiol Behav 83 (2004) 31-38
11. House J.S., Landis K.R., and Umberson D. Social relationships and health. Science 241 (1988) 540-545
12. Insel T.R., and Young L.J. The neurobiology of attachment. Nat Rev Neurosci 2 (2001) 129-136
13. Kendler K.S., Neale M.C., Kessler R.C., Heath A.C., and Eaves L.J. Childhood parental loss and adult psychopathology in women. A twin study perspective. Arch Gen Psychiatry 49 (1992) 109-116
14. Kirsch P., Esslinger C., Chen Q., Mier D., Lis S., Siddhanti S., et al. Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 25 (2005) 11489-11493
15. Kosfeld M., Heinrichs M., Zak P.J., Fischbacher U., and Fehr E. Oxytocin increases trust in humans. Nature 435 (2005) 673-676
16. Legros J.J. Inhibitory effect of oxytocin on corticotrope function in humans: Are vasopressin and oxytocin ying-yang neurohormones?. Psychoneuroendocrinology 26 (2001) 649-655
17. Luecken L.J., and Lemery K.S. Early caregiving and physiological stress responses. Clin Psychol Rev 24 (2004) 171-191
18. Meinlschmidt G., and Heim C. Decreased cortisol awakening response after early loss experience. Psychoneuroendocrinology 30 (2005) 568-576
19. Neumann I.D. Involvement of the brain oxytocin system in stress coping: Interactions with the hypothalamo-pituitary-adrenal axis. Prog Brain Res 139 (2002) 147-162
20. Pennebaker J.W., and Susman J.R. Disclosure of traumas and psychosomatic processes. Soc Sci Med 26 (1988) 327-332