Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene

Development and Psychopathology

Volumn 23, Issue 2, 2011, Pages 439-452

  Bradley, Bekh ^a,b   Westen, Drew ^b   Mercer, Kristina B ^c   Binder, Elisabeth B ^b   Jovanovic, Tanja ^b   Crain, Daniel ^b   Wingo, Aliza ^a,b   Heim, Christine ^b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN RECEPTOR;

ADOLESCENT; ADULT; AFRICAN AMERICAN; AGED; ARTICLE; CHILD; CHILD ABUSE; EMOTION; FEMALE; GENETICS; HUMAN; LIFE EVENT; MALE; MENTAL HEALTH; MENTAL STRESS; MIDDLE AGED; POVERTY; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; URBAN POPULATION; VERY ELDERLY;

ADOLESCENT; ADULT; ADULT SURVIVORS OF CHILD ABUSE; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; CHILD; CHILD ABUSE; EMOTIONS; FEMALE; HUMANS; LIFE CHANGE EVENTS; MALE; MENTAL HEALTH; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POVERTY; QUESTIONNAIRES; RECEPTORS, OXYTOCIN; STRESS, PSYCHOLOGICAL; URBAN POPULATION;

EID: 79956113984     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579411000162     Document Type: Article

References (105)

1. Abrams, K., Rifkin, A., & Hesse, E. (2006). Examining the role of parental frightened/frightening subtypes in predicting disorganized attachment within a brief observational procedure. Development and Psychopathology, 18, 345-361.
2. Aldao, A., Nolen-Hoeksema, S., & Schweizer, S. (2010). Emotion-regulation strategies across psychopathology: A meta-analytic review. Clinical Psychology Review, 30, 217-237.
3. Alink, L., Cicchetti, D., Kim, J., & Rogosch, F. (2009). Mediating and moderating processes in the relation between maltreatment and psychopathology: Mother-child relationship quality and emotion regulation. Journal of Abnormal Child Psychology, 37, 831-843.
4. Anda,R., Felitti,V.,Bremner, J.,Walker, J.,Whitfield, C., Perry,B., et al. (2006). The enduring effects of abuse and related adverse experiences in childhood. European Archives of Psychiatry and Clinical Neuroscience, 256, 174-186.
5. Bakermans-Kranenburg, M., & van IJzendoorn, M. (2007). Research review: Genetic vulnerability or differential susceptibility in child development: The case of attachment. Journal of Child Psychology and Psychiatry, 48, 1160-1173. (Pubitemid 350256554)
6. Bakermans-Kranenburg, M., & van IJzendoorn, M. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affective Neuroscience, 3, 128-134. (Pubitemid 351827056)
7. Bakermans-Kranenburg, M., van IJzendoorn, M., Pijlman, F., Mesman, J., & Juffer, F. (2008). Experimental evidence for differential susceptibility: Dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in a randomized controlled trial. Developmental Psychology, 44, 293-300.
8. Bartz, J., Zaki, J., Bolger, N., Hollander, E., Ludwig, N., Kolevzon, A., et al. (2010). Oxytocin selectively improves empathic accuracy. Psychological Science 10, 1426-1428.
9. Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009). Vulnerability genes or plasticity genes? Molecular Psychiatry, 14, 746-754.
10. Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908.
11. Bernstein, D., Stein, J., Newcomb, M.,Walker, E., Pogge, D., Ahluvalia, T., et al. (2003). Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse & Neglect, 27, 169-190. (Pubitemid 36293325)
12. Bernstein, D. P., & Fink, L. (1998). Childhood Trauma Questionnaire manual. San Antonio, TX: Psychological Corporation.
13. Binder, E. B., Bradley, R., Liu,W., Epstein, M. P., Deveau, T. C., Mercer, K. B., et al. (2008). Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. Journal of the American Medical Association, 299, 1291-1305. (Pubitemid 351439075)
14. Blau,V., Maurer, U., Tottenham, N.,&McCandliss, B. (2007). The face-specific N170 component is modulated by emotional facial expression. Behavioral and Brain Functions, 3, 7.
15. Borelli, J., Crowley, M., David, D., Sbarra, D., Anderson, G., & Mayes, L. (2010). Attachment and emotion in school-aged children. Emotion, 10, 475-485.
16. Bradley, B., DeFife, J., Guanaccia, C., Pfifer, J., Fani, N., Ressler, K., et al. (in press). Emotion dysregulation and negative affect: Association with psychiatric symptoms. Journal of Clinical Psychiatry.
17. Bradley, R., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu,W., et al. (2008). Influence of child abuse on adult depression: Moderation by the corticotropin-releasing hormone receptor gene. Archives of General Psychiatry, 65, 190-200. (Pubitemid 351214318)
18. Bradley, R., & Westen, D. (2005). The psychodynamics of borderline personality disorder: A view from developmental psychopathology. Development and Psychopathology, 17, 927-957. (Pubitemid 43362198)
19. Calkins, S. D., & Hill, A. (2007). Caregiver influences on emerging emotion regulation: Biological and environmental transactions in early development. In J. Gross (Ed.), Handbook of emotion regulation. (pp. 229- 248): New York: Guilford Press.
20. Carlson, V., Cicchetti, D., Barnett, D., & Braunwald, K. (1989). Disorganized/ disoriented attachment relationships in maltreated infants. Developmental Psychology, 25, 525-531.
21. Cassidy, J., & Mohr, J. (2001). Unsolvable fear, trauma, and psychopathology: Theory, research, and clinical considerations related to disorganized attachment across the life span. Clinical Psychology: Science and Practice, 8, 275-298. (Pubitemid 33681912)
22. Cicchetti, D., & Barnett, D. (1991). Attachment organization in maltreated preschoolers. Development and Psychopathology, 3, 397-411.
23. Cicchetti, D.,&Cannon, T. (1999). Neurodevelopmental processes in the ontogenesis and epigenesis of psychopathology. Development and Psychopathology, 11, 375-393.
24. Cicchetti, D., & Dawson, G. (2002). Multiple levels of analysis [Editorial]. Development and Psychopathology, 14, 417-420.
25. Cicchetti, D., & Gunnar, M. (2008). Integrating biological measures into the design and evaluation of preventive interventions. Development and Psychopathology, 20, 737-743. (Pubitemid 352003596)
26. Cicchetti, D., Rogosch, F., & Toth, S. (2006). Fostering secure attachment in infants in maltreating families through preventive interventions. Development and Psychopathology, 18, 623-649. (Pubitemid 44445155)
27. Cicchetti, D., & Tucker, D. (1994). Development and self-regulatory structures of the mind. Development and Psychopathology, 6, 533-549.
28. Cloitre, M., Stovall McClough, C., Zorbas, P., & Charuvastra, A. (2008). Attachment organization, emotion regulation, and expectations of support in a clinical sample of women with childhood abuse histories. Journal of Traumatic Stress, 21, 282-289. (Pubitemid 351961995)
29. Cole, P., Michel, M., & Teti, L. (1994). The development of emotion regulation and dysregulation: A clinical perspective. Monographs of the Society for Research in Child Development, 59, 73-100.
30. Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., et al. (2009). Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 34, 1506-1514.
31. Cyr, C., Euser, E., Bakermans-Kranenburg, M., & van IJzendoorn, M. (2010). Attachment security and disorganization in maltreating and high-risk families: A series of meta-analyses. Development and Psychopathology, 22, 87-108.
32. Dalgleish, T., Taghavi, R., Neshat-Doost, H., Moradi, A., Canterbury, R., & Yule, W. (2003). Patterns of processing bias for emotional information across clinical disorders: A comparison of attention, memory, and prospective cognition in children and adolescents with depression, generalized anxiety, and posttraumatic stress disorder. Journal of Clinical Child & Adolescent Psychology, 32, 10-21. (Pubitemid 36400037)
33. De Pauw S.,&Mervielde I. (2010). Temperament, personality and developmental psychopathology: A review based on the conceptual dimensions underlying childhood traits. Child Psychiatry and Human Development, 41, 313-329.
34. Dodge, K., Greenberg, M., & Malone, P. (2008). Testing an idealized dynamic cascade model of the development of serious violence in adolescence. Child Development, 79, 1907-1927.
35. Donaldson, Z. R.,&Young, L. J. (2008). Oxytocin, vasopressin, and the neurogenetics of sociality. Science, 322, 900-904.
36. Francis, D., Champagne, F.,&Meaney, M. (2000).Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat. Journal of Neuroendocrinology, 12, 1145-1148.
37. Gillespie, C., Bradley, B., Mercer, K., Smith, A., Conneely, K., Gapen, M., et al. (2009). Trauma exposure and stress-related disorders in inner city primary care patients. General Hospital Psychiatry, 31, 505-514.
38. Gross, J. (Ed.). (2007). Handbook of emotion regulation: New York: Guilford Press.
39. Gunnar, M., Mangelsdorf, S., Larson, M., & Hertsgaard, L. (1989). Attachment, temperament, and adrenocortical activity in infancy: A study of psychoendocrine regulation. Developmental Psychology, 25, 355-363.
40. Heim, C., Young, L., Newport, D., Mletzko, T., Miller, A., & Nemeroff, C. (2008). Lower CSF oxytocin concentrations in women with a history of childhood abuse. Molecular Psychiatry, 14, 954-958.
41. Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54, 1389-1398. (Pubitemid 37522163)
42. Hertsgaard, L., Gunnar, M., Erickson, M., & Nachmias, M. (1995). Adrenocortical responses to the strange situation in infants with disorganized/ disoriented attachment relationships. Child Development, 66, 1100-1106.
43. Juffer, F., Bakermans-Kranenburg, M., & van IJzendoorn, M. (2008). Promoting positive parenting: An attachment-based intervention. Mahwah, NJ: Erlbaum.
44. Kim, H., Sherman, D., Sasaki, J., Xu, J., Chu, T., Ryu, C., et al. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of the National Academy of Sciences of the United States of America, 107, 15717-15721.
45. Kim, J., & Cicchetti, D. (2010). Longitudinal pathways linking child maltreatment, emotion regulation, peer relations, and psychopathology. Journal of Child Psychology and Psychiatry, 51, 706-716.
46. Kinnally, E., Huang, Y., Haverly, R., Burke, A., Galfalvy, H., Brent, D., et al. (2009). Parental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult women. Psychiatric Genetics, 19, 126-133.
47. Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of Neuroscience, 25, 11489-11493. (Pubitemid 43083720)
48. Krueger, R. F., Hicks, B. M., Patrick, C. J., Carlson, S. R., Lacono,W. G., & McGue, M. (2002). Etiologic connections among substance dependence, antisocial behavior, and personality: Modeling the externalizing spectrum. Journal of Abnormal Psychology, 111, 411-424. (Pubitemid 34791142)
49. Krueger, R. F., & Tackett, J. L. (2003). Personality and psychopathology: Working toward the bigger picture. Journal of Personality Disorders, 17, 109-128. (Pubitemid 36535095)
50. Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2007). Association between the oxytocin receptor (OXTR) gene and autism: Relationship to Vineland Adaptive Behavior Scales and cognition. Molecular Psychiatry, 13, 980-988.
51. Leve, L., Harold, G., Ge, X., Neiderhiser, J., Shaw, D., Scaramella, L., et al. (2009). Structured parenting of toddlers at high versus low genetic risk: Two pathways to child problems. Journal of the American Academy of Child & Adolescent Psychiatry, 48, 1102-1109.
52. Levy, K. (2005). The implications of attachment theory and research for understanding borderline personality disorder. Development and Psychopathology, 17, 959-986. (Pubitemid 43362199)
53. Lewin-Bizan, S., Bowers, E., & Lerner, R. (2010). One good thing leads to another: Cascades of positive youth development among American adolescents. Development and Psychopathology, 22, 759-770.
54. Linehan, M. M., & Heard, H. L. (1992). Dialectical behavior therapy for borderline personality disorder. In J. F. Clarkin, E. Marziali, & H. Munroe- Blum (Eds.), Borderline personality disorder: Clinical and empirical perspectives (pp. 248-267). New York: Guilford Press.
55. Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., et al. (2009). Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33, 860-866.
56. Lyons-Ruth, K., Dutra, L., Schuder, M., & Bianchi, I. (2006). From infant attachment disorganization to adult dissociation: Relational adaptations or traumatic experiences? Psychiatric Clinics of North America, 29, 63.
57. Lyons-Ruth, K., & Jacobvitz, D. (1999). Attachment disorganization: Unresolved loss, relational violence, and lapses in behavioral and attentional strategies. In J. Cassidy & P. Shaver (Eds.), Handbook of attachment: Theory, research, and clinical implications (pp. 520-554). New York: Guilford Press.
58. Lyons-Ruth, K., Melnick, S., Bronfman, E., Sherry, S., & Llanas, L. (2004). Hostile-helpless relational models and disorganized attachment patterns between parents and their young children: Review of research and implications for clinical work. In L. Atkinson & K. Zucker (Eds.), Attachment issues in psychopathology and intervention (pp. 65-94). Mahwah, NJ: Erlbaum.
59. MacMillan, H.,Wathen, C., Barlow, J., Fergusson, D., Leventhal, J., & Taussig, H. (2009). Interventions to prevent child maltreatment and associated impairment. Lancet, 373, 250-266.
60. Madigan, S., Bakermans-Kranenburg, M., van IJzendoorn, M., Moran, G., Pederson, D.,&Benoit, D. (2006). Unresolved states of mind, anomalous parental behavior, and disorganized attachment:Areviewandmeta-analysis of a transmission gap. Attachment & Human Development, 8, 89-111. (Pubitemid 44044293)
61. Main, M., & Hesse, E. (1990). Parents' unresolved traumatic experiences are related to infant disorganized status: Is frightened and/or frightening parental behavior the linking mechanism. InM. Greenberg, D. Cicchetti, & E. Cummings (Eds.), Attachment in the preschool years theory research and intervention (pp. 161-184). Chicago: University of Chicago Press.
62. Masten, A., & Cicchetti, D. (2010). Developmental cascades. Development and Psychopathology, 22, 491-495.
63. Masten, A., Roisman, G., Long, J., Burt, K., Obradovic, J., Riley, J., et al. (2005). Developmental cascades: Linking academic achievement and externalizing and internalizing symptoms over 20 years. Developmental Psychology, 41, 733-745.
64. Masten, A., & Wright, M. (2010). Resilience over the lifespan: Developmental perspectives on resistance, recovery and transformation. In J.Reich, A. Zautra, & J. Hall (Eds.), Handbook of adult resilience (pp. 213-237). New York: Guilford Press.
65. McGowan, S. (2002). Mental Representations in Stressful Situations: The calming and distressing effects of significant others. Journal of Experimental Social Psychology, 38, 152-161.
66. Mikulincer, M.,&Shaver, P. (2007). Attachment in adulthood: Structure, dynamics, and change. New York: Guilford Press.
67. Mikulincer, M., Shaver, P., & Pereg, D. (2003). Attachment theory and affect regulation: The dynamics, development, and cognitive consequences of attachment-related strategies. Motivation and Emotion, 27, 77-102. (Pubitemid 36964238)
68. Moriceau, S., Roth, T., & Sullivan, R. (2010). Rodent model of infant attachment learning and stress. Developmental Psychobiology, 52, 651-660.
69. Moriceau, S., Shionoya, K., Jakubs, K., & Sullivan, R. (2009). Early-life stress disrupts attachment learning: The role of amygdala corticosterone, locus ceruleus corticotropin releasing hormone, and olfactory bulb norepinephrine. Journal of Neuroscience, 29, 4106-4109.
70. Moulson, M.,Westerlund, A., Fox, N., Zeanah, C., & Nelson, C. (2009). The effects of early experience on face recognition: An event related potential study of institutionalized children in Romania. Child Development, 80, 1039-1056.
71. Nigg, J. (2000). On inhibition/disinhibition in developmental psychopathology: Views from cognitive and personality psychology and a working inhibition taxonomy. Psychological Bulletin, 126, 220-246.
72. O'Brien, R. (2007). A caution regarding rules of thumb for variance inflation factors. Quality and Quantity, 41, 673-690.
73. Pollak, S., Klorman, R., Thatcher, J., & Cicchetti, D. (2001). P3b reflects maltreated children's reactions to facial displays of emotion. Psychophysiology, 38, 267-274. (Pubitemid 32267769)
74. Pollak, S., Messner, M., Kistler, D., & Cohn, J. (2009). Development of perceptual expertise in emotion recognition. Cognition, 110, 242-247.
75. Raineki, C., Moriceau, S., & Sullivan, R. (2010). Developing a neurobehavioral animal model of infant attachment to an abusive caregiver. Biological Psychiatry, 67, 1137-1145.
76. Ressler, K., Bradley, B., Mercer, K., Deveau, T., Smith, A., Gillespie, C., et al. (2010). Polymorphisms in CRHR1 and the serotonin transporter loci: Gene × Gene × Environment interactions on depressive symptoms. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153, 812-824.
77. Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of the National Academy of Sciences of the United States of America, 106, 21437-21441.
78. Rogosch, F., Cicchetti, D., & Aber, J. (1995). The role of child maltreatment in early deviations in cognitive and affective processing abilities and later peer relationship problems. Development and Psychopathology, 7, 591-609.
79. Ross, H. E.,&Young, L. J. (2009). Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Frontiers in Neuroendocrinology, 30, 534-547.
80. Scantamburlo, G., Hansenne, M., Fuchs, S., Pitchot, W., Maréchal, P., Pequeux, C., et al. (2007). Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology, 32, 407-410. (Pubitemid 46617779)
81. Schieche, M., & Spangler, G. (2005). Individual differences in biobehavioral organization during problem-solving in toddlers: The influence of maternal behavior, infant-mother attachment, and behavioral inhibition on the attachment-exploration balance. Developmental Psychobiology, 46, 293-306. (Pubitemid 40776519)
82. Schuengel, C., Bakermans-Kranenburg, M., & van IJzendoorn, M. (1999). Frightening maternal behavior linking unresolved loss and disorganized infant attachment. Journal of Consulting and Clinical Psychology, 67, 54.
83. Schwartz, A. C., Bradley, R., Sexton, M., Sherry, A., & Ressler, K. J. (2005). Posttraumatic stress disorder among African Americans in an inner city mental health clinic. Psychiatric Services, 56, 212-215. (Pubitemid 40216781)
84. Shamay-Tsoory, S., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009). Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biological Psychiatry, 66, 864-870.
85. Shaver, P., & Mikulincer, M. (2007). Adult attachment strategies and the regulation of emotion. In J. Gross (Ed.), Handbook of emotion regulation (pp. 446-465). New York: Guilford Press.
86. Shedler, J., & Westen, D. (2004). Dimensions of personality pathology: An alternative to the Five Factor Model. American Journal of Psychiatry, 161, 1743-1754. (Pubitemid 39314662)
87. Shields, A., & Cicchetti, D. (1997). Emotion regulation among school-age children: The development and validation of a new criterion Q-sort scale. Developmental Psychology, 33, 906-916.
88. Shields, A., & Cicchetti, D. (1998). Reactive aggression among maltreated children: The contributions of attention and emotion dysregulation. Journal of Clinical Child & Adolescent Psychology, 27, 381-395.
89. Stolk, M., Mesman, J., van Zeijl, J., Alink, L., Bakermans-Kranenburg, M., van IJzendoorn, M., et al. (2008). Early parenting intervention aimed at maternal sensitivity and discipline: A process evaluation. Journal of Community Psychology, 36, 780-797.
90. Stovall-McClough, K., & Cloitre, M. (2006). Unresolved attachment, PTSD, and dissociation in women with childhood abuse histories. Journal of Consulting and Clinical Psychology, 74, 219-228. (Pubitemid 43807354)
91. Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., et al. (2005). Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proceeding of the National Academy of Sciences of the United States of America, 102, 16096-16101. (Pubitemid 41552873)
92. Thompson, R. (2008). Early attachment and later development: Familiar questions, new answers. In J. Cassidy & P. Shaver (Eds.), Handbook of attachment: Theory research and clinical implications (pp. 348-365). New York: Guilford Press.
93. Tottenham, N., Hare, T., Quinn, B., McCarry, T., Nurse, M., Gilhooly, T., et al. (2010). Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Developmental Science, 13, 46-61.
94. van IJzendoorn, M., Schuengel, C., & Bakermans-Kranenburg, M. (1999). Disorganized attachment in early childhood: Meta-analysis of precursors, concomitants, and sequelae. Development and Psychopathology, 11, 225-250.
95. Westen,D. (1991). Cultural, emotional, and unconscious aspects of self. In R. C. Curtis (Ed.), The relational self (pp. 181-210). New York: Guilford Press.
96. Westen, D. (1998). Affect regulation and psychopathology: Applications to depression and borderline personality disorder. In W. Flack & J. Laird (Eds.), Affect and psychopathology (pp. 394-406). New York: Oxford University Press.
97. Westen, D., Muderrisoglu, S., Fowler, C., Shedler, J., & Koren, D. (1997). Affect regulation and affective experience: Individual differences, group differences, and measurement using a Q-sort procedure. Journal of Consulting & Clinical Psychology, 65, 429-439. (Pubitemid 27246784)
98. Westen, D., Nakash, O., Thomas, C., & Bradley, B. (2006). Clinical assessment of attachment patterns and personality disorder in adolescents and adults. Journal of Consulting and Clinical Psychology, 74, 1065.
99. Westen, D.,&Shedler, J. (1999a). Revising and assessing Axis II, Part 1: Developing a clinically and empirically valid assessment method. American Journal of Psychiatry, 156, 258-272. (Pubitemid 29077118)
100. Westen, D., & Shedler, J. (1999b). Revising and assessing Axis II, Part 2: Toward an empirically based and clinically useful classification of personality disorders. American Journal of Psychiatry, 156, 273-285. (Pubitemid 29077119)
101. Winslow, J., Noble, P., Lyons, C., Sterk, S., & Insel, T. (2003). Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys. Neuropsychopharmacology, 28, 910-918.
102. Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Shuang, M., et al. (2005). Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biological Psychiatry, 58, 74-77. (Pubitemid 40909939)
103. Yates, T., Obradovi, J., & Egeland, B. (2010). Transactional relations across contextual strain, parenting quality, and early childhood regulation and adaptation in a high-risk sample. Development and Psychopathology, 22, 539-555.
104. Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L. J., Onaka, T., et al. (2009). Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. Journal of Neuroscience, 29, 2259-2271.
105. Zittel Conklin, C., & Westen, D. (2005). Borderline personality disorder as seen in clinical practice: Implications for DSM-V. American Journal of Psychiatry, 162, 867-875. (Pubitemid 40676198)