Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

Nature

Volumn 532, Issue 7597, 2016, Pages 122-126

  Zhou, Zinan ^a   Tang, Alan T ^a   Wong, Weng Yew ^b   Bamezai, Sharika ^a   Goddard, Lauren M ^a   Shenkar, Robert ^c   Zhou, Su ^a   Yang, Jisheng ^a   Wright, Alexander C ^d   Foley, Matthew ^e   Arthur, J Simon C ^f   Whitehead, Kevin J ^g   Awad, Issam A ^c   Li, Dean Y ^g,h   Zheng, Xiangjian ^g,i   Kahn, Mark L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CENTENARY INSTITUTE   (Australia)

^c UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF SYDNEY   (Australia)

^f UNIVERSITY OF DUNDEE   (United Kingdom)

^g UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^h SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

ⁱ University of Sydney   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 2; KRUPPEL LIKE FACTOR 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3; ADAM PROTEIN; CARRIER PROTEIN; CCM2 PROTEIN, HUMAN; KLF2 PROTEIN, HUMAN; KLF2 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; MAP3K3 PROTEIN, HUMAN; MAP3K3 PROTEIN, MOUSE; PROTEIN BINDING; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

BLOOD; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CELLS AND CELL COMPONENTS; GENE EXPRESSION; MUTATION; NEUROLOGY; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAVERNOUS HEMANGIOMA; CONTRAST ENHANCEMENT; CONTROLLED STUDY; ENDOCARDIUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GERMLINE MUTATION; HAPLOINSUFFICIENCY; IMMUNOBLOTTING; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; ANIMAL; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; FEMALE; GENETICS; HEMANGIOMA, CAVERNOUS, CENTRAL NERVOUS SYSTEM; HUMAN; MALE; METABOLISM; NEWBORN; PATHOLOGY;

MUS; VERTEBRATA;

ADAM PROTEINS; ANIMALS; ANIMALS, NEWBORN; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; HEMANGIOMA, CAVERNOUS, CENTRAL NERVOUS SYSTEM; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MAP KINASE KINASE KINASE 3; MAP KINASE SIGNALING SYSTEM; MICE; PROTEIN BINDING; RHO GTP-BINDING PROTEINS;

EID: 84963532773     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17178     Document Type: Article

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