Structural basis for the disruption of the Cerebral Cavernous Malformations 2 (CCM2) interaction with Krev Interaction Trapped 1 (KRIT1) by disease-associated mutations

Journal of Biological Chemistry

Volumn 290, Issue 5, 2015, Pages 2842-2853

  Fisher, Oriana S ^a   Liu, Weizhi ^a,d   Zhang, Rong ^a   Stiegler, Amy L ^a   Ghedia, Sondhya ^b   Weber, James L ^c   Boggon, Titus J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c PreventionGenetics ^*  (United States)

^d OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PROTEINS;

COCRYSTAL STRUCTURE; GENE SEQUENCING; MISSENSE POINT MUTATIONS; MOLECULAR LEVEL INTERACTIONS; PHOSPHOTYROSINE BINDINGS; STRUCTURAL BASIS;

CRYSTAL STRUCTURE;

BINDING PROTEIN; CEREBRAL CAVERNOUS MALFORMATIONS 2 PROTEIN; KREV INTERACTION TRAPPED 1 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CCM2 PROTEIN, HUMAN; KRIT1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN; PROTEIN BINDING;

ARTICLE; CAVERNOUS HEMANGIOMA; CEREBRAL CAVERNOUS MALFORMATIONS 2 GENE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; GENE; GENE SEQUENCE; HUMAN; IN VITRO STUDY; KREV INTERACTION TRAPPED 1 GENE; MISSENSE MUTATION; MUTAGENESIS; MUTATIONAL ANALYSIS; POINT MUTATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; STRUCTURE ANALYSIS; BRAIN HEMANGIOMA; CHEMISTRY; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SIZE EXCLUSION CHROMATOGRAPHY;

CARRIER PROTEINS; CHROMATOGRAPHY, GEL; HEMANGIOMA, CAVERNOUS, CENTRAL NERVOUS SYSTEM; HUMANS; IMMUNOPRECIPITATION; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; MUTATION, MISSENSE; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS;

EID: 84921905586     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.616433     Document Type: Article

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