-
1
-
-
33846858227
-
Genetics of cavernous angiomas
-
Labauge, P., Denier, C., Bergametti, F. & Tournier-Lasserve, E. Genetics of cavernous angiomas. Lancet. Neurol. 6, 237-244 (2007).
-
(2007)
Lancet. Neurol.
, vol.6
, pp. 237-244
-
-
Labauge, P.1
Denier, C.2
Bergametti, F.3
Tournier-Lasserve, E.4
-
2
-
-
84855404378
-
Cerebral cavernous malformations: From genes to proteins to disease
-
Cavalcanti, D. D. et al. Cerebral cavernous malformations: from genes to proteins to disease. J. Neurosurg. 116, 122-132 (2012).
-
(2012)
J. Neurosurg.
, vol.116
, pp. 122-132
-
-
Cavalcanti, D.D.1
-
3
-
-
33749263696
-
Cerebral cavernous malformation: New molecular and clinical insights
-
Revencu, N. & Vikkula, M. Cerebral cavernous malformation: new molecular and clinical insights. J. Med. Genet. 43, 716-721 (2006).
-
(2006)
J. Med. Genet.
, vol.43
, pp. 716-721
-
-
Revencu, N.1
Vikkula, M.2
-
4
-
-
0034050739
-
Mekk3 is essential for early embryonic cardiovascular development
-
Yang, J. et al. Mekk3 is essential for early embryonic cardiovascular development. Nat. Genet. 24, 309-313 (2000).
-
(2000)
Nat. Genet.
, vol.24
, pp. 309-313
-
-
Yang, J.1
-
5
-
-
0344668554
-
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
-
Uhlik, M. T. et al. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat. Cell Biol. 5, 1104-1110 (2003).
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 1104-1110
-
-
Uhlik, M.T.1
-
6
-
-
36348946966
-
Proteomic identification of the cerebral cavernous malformation signaling complex
-
Hilder, T. L. et al. Proteomic identification of the cerebral cavernous malformation signaling complex. J. Proteome Res. 6, 4343-4355 (2007).
-
(2007)
J. Proteome Res.
, vol.6
, pp. 4343-4355
-
-
Hilder, T.L.1
-
7
-
-
35048839667
-
MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis
-
Deng, Y., Yang, J., McCarty, M. & Su, B. MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. Am. J. Physiol. Cell Physiol. 293, C1404-C1411 (2007).
-
(2007)
Am. J. Physiol. Cell Physiol.
, vol.293
, pp. C1404-C1411
-
-
Deng, Y.1
Yang, J.2
McCarty, M.3
Su, B.4
-
8
-
-
84921523373
-
The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression
-
Zhou, Z. et al. The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Dev. Cell 32, 168-180 (2015).
-
(2015)
Dev. Cell
, vol.32
, pp. 168-180
-
-
Zhou, Z.1
-
9
-
-
59649086507
-
Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: Implications for human cerebral cavernous malformations
-
Boulday, G. et al. Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations. Dis. Model. Mech. 2, 168-177 (2009).
-
(2009)
Dis. Model. Mech.
, vol.2
, pp. 168-177
-
-
Boulday, G.1
-
10
-
-
59649084619
-
The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases
-
Whitehead, K. J. et al. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat. Med. 15, 177-184 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 177-184
-
-
Whitehead, K.J.1
-
11
-
-
77951044950
-
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
-
Stockton, R. A., Shenkar, R., Awad, I. A. & Ginsberg, M. H. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J. Exp. Med. 207, 881-896 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 881-896
-
-
Stockton, R.A.1
Shenkar, R.2
Awad, I.A.3
Ginsberg, M.H.4
-
12
-
-
84921905586
-
Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations
-
Fisher, O. S. et al. Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations. J. Biol. Chem. 290, 2842-2853 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 2842-2853
-
-
Fisher, O.S.1
-
13
-
-
84872933454
-
Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus
-
Fisher, O. S. et al. Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus. FEBS Lett. 587, 272-277 (2013).
-
(2013)
FEBS. Lett.
, vol.587
, pp. 272-277
-
-
Fisher, O.S.1
-
14
-
-
36749044194
-
Insight into the binding properties of MEKK3 PB1 to MEK5 PB1 from its solution structure
-
Hu, Q. et al. Insight into the binding properties of MEKK3 PB1 to MEK5 PB1 from its solution structure. Biochemistry 46, 13478-13489 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 13478-13489
-
-
Hu, Q.1
-
15
-
-
84879690589
-
EndMT contributes to the onset and progression of cerebral cavernous malformations
-
Maddaluno, L. et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature 498, 492-496 (2013).
-
(2013)
Nature
, vol.498
, pp. 492-496
-
-
Maddaluno, L.1
-
16
-
-
79960309920
-
A mechanism of Rap1-induced stabilization of endothelial cellcell junctions
-
Liu, J. J. et al. A mechanism of Rap1-induced stabilization of endothelial cellcell junctions. Mol. Biol. Cell 22, 2509-2519 (2011).
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 2509-2519
-
-
Liu, J.J.1
-
17
-
-
84877106886
-
Cerebral cavernous malformations: From CCM genes to endothelial cell homeostasis
-
Fischer, A., Zalvide, J., Faurobert, E., Albiges-Rizo, C. & Tournier-Lasserve, E. Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis. Trends Mol. Med. 19, 302-308 (2013).
-
(2013)
Trends. Mol. Med.
, vol.19
, pp. 302-308
-
-
Fischer, A.1
Zalvide, J.2
Faurobert, E.3
Albiges-Rizo, C.4
Tournier-Lasserve, E.5
-
18
-
-
77951240109
-
Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype
-
Borikova, A. L. et al. Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype. J. Biol. Chem. 285, 11760-11764 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 11760-11764
-
-
Borikova, A.L.1
-
19
-
-
84876537947
-
Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling
-
Richardson, B. T., Dibble, C. F., Borikova, A. L. & Johnson, G. L. Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling. Biol. Chem. 394, 35-42 (2013).
-
(2013)
Biol. Chem.
, vol.394
, pp. 35-42
-
-
Richardson, B.T.1
Dibble, C.F.2
Borikova, A.L.3
Johnson, G.L.4
-
20
-
-
65449158398
-
MEKK3 is essential for lymphopenia-induced T cell proliferation and survival
-
Wang, X., Chang, X., Facchinetti, V., Zhuang, Y. & Su, B. MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. J. Immunol. 182, 3597-3608 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 3597-3608
-
-
Wang, X.1
Chang, X.2
Facchinetti, V.3
Zhuang, Y.4
Su, B.5
-
21
-
-
0035911253
-
Conditional vascular cell adhesion molecule 1 deletion in mice: Impaired lymphocyte migration to bone marrow
-
Koni, P. A. et al. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J. Exp. Med. 193, 741-754 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 741-754
-
-
Koni, P.A.1
-
22
-
-
0030990991
-
Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells
-
Zambrowicz, B. P. et al. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc. Natl Acad. Sci. USA 94, 3789-3794 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 3789-3794
-
-
Zambrowicz, B.P.1
-
23
-
-
0037090881
-
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/inactivation in the mouse
-
Hayashi, S. & McMahon, A. P. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol. 244, 305-318 (2002).
-
(2002)
Dev. Biol.
, vol.244
, pp. 305-318
-
-
Hayashi, S.1
McMahon, A.P.2
-
24
-
-
3042856262
-
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
-
Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
-
(2001)
BMC. Dev. Biol.
, vol.1
, pp. 4
-
-
Srinivas, S.1
-
25
-
-
77953029002
-
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
-
Wang, Y. et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465, 483-486 (2010).
-
(2010)
Nature
, vol.465
, pp. 483-486
-
-
Wang, Y.1
-
26
-
-
0037648580
-
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
-
Nitta, T. et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J. Cell Biol 161, 653-660 (2003).
-
(2003)
J. Cell Biol
, vol.161
, pp. 653-660
-
-
Nitta, T.1
-
27
-
-
30444457217
-
Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways
-
Zhang, D. et al. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways. EMBO J. 25, 97-107 (2006).
-
(2006)
EMBO. J.
, vol.25
, pp. 97-107
-
-
Zhang, D.1
-
28
-
-
77954926292
-
Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity
-
Li, X. et al. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. J. Biol. Chem. 285, 24099-24107 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 24099-24107
-
-
Li, X.1
-
29
-
-
0031059866
-
-
eds Carter, C. W. & Sweet, R. M. Academic Press
-
Otwinowski, Z. & Minor, W. in Methods in Enzymology Vol. 276, Part A (eds Carter, C. W. & Sweet, R. M.) 307-326 (Academic Press, 1997).
-
(1997)
Methods in Enzymology Part A
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
30
-
-
33846426122
-
Solving structures of protein complexes by molecular replacement with Phaser
-
McCoy, A. J. Solving structures of protein complexes by molecular replacement with Phaser. Acta. Crystallogr. D Biol. Crystallogr. 63, 32-41 (2007).
-
(2007)
Acta. Crystallogr. D Biol. Crystallogr
, vol.63
, pp. 32-41
-
-
McCoy, A.J.1
-
31
-
-
76449098262
-
PHENIX: A comprehensive Python-based system for macromolecular structure solution
-
Adams, P. D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta. Crystallogr. D Biol. Crystallogr. 66, 213-221 (2010).
-
(2010)
Acta. Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
-
32
-
-
77949535720
-
Features and development of Coot
-
Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. Features and development of Coot. Acta. Crystallogr. D Biol. Crystallogr. 66, 486-501 (2010).
-
(2010)
Acta. Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
33
-
-
79953763877
-
REFMAC5 for the refinement of macromolecular crystal structures
-
Murshudov, G. N. et al. REFMAC5 for the refinement of macromolecular crystal structures. Acta. Crystallogr. D Biol. Crystallogr. 67, 355-367 (2011).
-
(2011)
Acta. Crystallogr. D Biol. Crystallogr.
, vol.67
, pp. 355-367
-
-
Murshudov, G.N.1
-
34
-
-
85064960453
-
Cutting edge: Collaboration gets the most out of software
-
Morin, A. et al. Cutting edge: Collaboration gets the most out of software. Elife 2, e01456 (2013).
-
(2013)
Elife
, vol.2
, pp. e01456
-
-
Morin, A.1
-
35
-
-
33646088705
-
Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction
-
Calabria, A. R., Weidenfeller, C., Jones, A. R., de Vries, H. E. & Shusta, E. V. Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction. J. Neurochem. 97, 922-933 (2006).
-
(2006)
J. Neurochem.
, vol.97
, pp. 922-933
-
-
Calabria, A.R.1
Weidenfeller, C.2
Jones, A.R.3
De Vries, H.E.4
Shusta, E.V.5
-
36
-
-
79953765276
-
Presenting your structures: The CCP4mg molecular-graphics software
-
McNicholas, S., Potterton, E., Wilson, K. S. & Noble, M. E. Presenting your structures: The CCP4mg molecular-graphics software. Acta. Crystallogr. D Biol. Crystallogr. 67, 386-394 (2011).
-
(2011)
Acta. Crystallogr. D Biol. Crystallogr.
, vol.67
, pp. 386-394
-
-
McNicholas, S.1
Potterton, E.2
Wilson, K.S.3
Noble, M.E.4
-
38
-
-
33845979829
-
MEKK3 is essential for lipopolysaccharide-induced interleukin-6 and granulocyte-macrophage colonystimulating factor production in macrophages
-
Kim, K., Duramad, O., Qin, X. F. & Su, B. MEKK3 is essential for lipopolysaccharide-induced interleukin-6 and granulocyte-macrophage colonystimulating factor production in macrophages. Immunology 120, 242-250 (2007).
-
(2007)
Immunology
, vol.120
, pp. 242-250
-
-
Kim, K.1
Duramad, O.2
Qin, X.F.3
Su, B.4
|