Venenum Bufonis induces rat neuroinflammation by activiating NF-κB pathway and attenuation of BDNF

Journal of Ethnopharmacology

Volumn 186, Issue , 2016, Pages 103-110

  Bi, Qi Rui ^a,b   Hou, Jin Jun ^b   Qi, Peng ^b   Ma, Chun Hua ^a   Shen, Yao ^b   Feng, Rui Hong ^b   Yan, Bing Peng ^a,b   Wang, Jian Wei ^a,b   Shi, Xiao Jian ^a,b   Zheng, Yuan Yuan ^b   Wu, Wan Ying ^b   Guo, Dean ^a,b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Brain derived neurotrophic factor (BDNF); Inflammation; Neurotoxicity; NF B pathway; Venenum Bufonis

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CARBOXYMETHYLCELLULOSE; DOPAMINE; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; SEROTONIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VENENUM BUFONIS; VENOM; BUFADIENOLIDE DERIVATIVE; CHAN SU; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; ATTENUATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FEMALE; IN VIVO STUDY; MALE; NERVOUS SYSTEM INFLAMMATION; NERVOUS SYSTEM INJURY; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; METABOLISM; SPRAGUE DAWLEY RAT; WISTAR RAT;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; BUFANOLIDES; CYTOKINES; GENE EXPRESSION REGULATION; INFLAMMATION; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 84962886159     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.03.049     Document Type: Article

References (41)

1. M.A. Abdel-Rahman, S.H. Ahmed, and Z.I. Nabil In vitro cardiotoxicity and mechanism of action of the Egyptian green toad Bufo viridis skin secretions Toxicol. in Vitro 24 2010 480 485
2. J.R. Brubacher, D. Lachmanen, P.R. Ravikumar, and R.S. Hoffman Efficacy of digoxin specific Fab fragments (Digibind) in the treatment of toad venom poisoning Toxicon 37 1999 931 942
3. R.J. Bick, B.J. Poindexter, R.R. Sweney, and A. Dasgupta Effects of Chan Su, a traditional Chinese medicine, on the calcium transients of isolated cardiomyocytes: Cardiotoxicity due to more than Na, K-ATPase blocking Life Sci. 72 2002 699 709
4. J.Y. Ban, and Y.H. Seong Blockade of 5-HT (3) receptor with MDL 72222 and Y 25130 reduces beta-amyloid protein (25 - 35)-induced neurotoxicity in cultured rat cortical neurons Eur. J. Pharmacol. 520 2005 12 21
5. R. Bovolenta, S. Zucchini, B. Paradiso, D. Rodi, F. Merigo, G.N. Mora, F. Osculati, E. Berto, P. Marconi, A. Marzola, P.F. Fabene, and M. Simonato Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures J. Neuroinflamm. 7 2010 81 87
6. W.S. Choi, C.A. Machida, and O.K. Ronnekleiv Distribution of dopamine D1, D2 and D5 receptor mRNAs in the monkey brain: ribonuclease protection assay analysis Mol. Brain Res. 31 1995 86 94
7. J.C. Conover, and G.D. Yancopoulos Neurotrophin regulation of the developing nervous system: analyses of knockout mice Rev. Neurosci. 8 1997 13 27
8. H.T. Chi, D.Z. Hung, W.H. Hu, and et al. Prognostic implications of hyperkalemia in toad toxin intoxication Hum. Exp. Toxicol. 17 1998 343 346
9. Z. Cai, X. Zhang, G. Wang, H. Wang, Z. Liu, and et al. BDNF attenuates IL-1β-induced F-actin remodeling by inhibiting NF-κB signaling in hippocampal neurons Neuroendocrinol. Lett. 35 2014 13 19
10. A.M. Davies Neurotrophins: neurotrophic modulation of neurite growth Curr. Biol. 10 2000 198 200
11. G. Dong, D.D. Wei, J.S. Wang, P.P. Guo, M.H. Li, M.H. Yang, L.Y. Kong, and et al. Study of the cardiotoxicity of Venenum Bufonis in rats using an 1H NMR-based metabolomics approach PLoS One 10 2015 e0119515
12. J. Feng, X. Cai, J. Zhao, and Z. Yan Serotonin receptors modulate GABA A receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons J. Neurosci. 21 2001 6502 6511
13. S. Hao, Y.M. Bao, R.G. Zhao, H.S. Wang, J. Bi, L.J. An, and et al. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons Neurosci. Lett. 501 2011 112 116
14. S. Hao, Y.M. Bao, L.J. An, W. Cheng, R.G. Zhao, J. Bi, and et al. Effects of resibufogenin and cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons Toxicol. in Vitro 25 2011 1644 1653
15. H.M. Huang, Y.G. Yang, C. LV, W.L. Chang, C.C. Peng, S.P. Wang, and et al. Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice J. Ethnopharmacol. 161 2015 175 185
16. K.R. Kessler, G. Wunderlich, H. Hefter, and R.J. Seitz Secondary progressive chronic manganism associated with markedly decreased striatal D2 receptor density Mov. Disord. 18 2003 217 218
17. E.M. Kawamoto, L.S. Lima, C.D. Munhoz, L.M. Yshii, P.F. Kinoshita, F.G. Amaral, R.R.F. Pestana, A.M.M. Orellana, J. Cipolla-Neto, L.R.G. Britto, M.C.W. Avellar, L.V. Rossoni, and C. Scavone Influence of N-methyl-d-aspartate receptors on ouabain activation of nuclear factor-κB in the rat hippocampus J. Neurosci. Res. 90 2012 213 228
18. P.F. Kinoshita, L.M. Yshii, A.R. Vasconcelos, A.M.M. Orellana, L. Lima, A.P. Davel, L.V. Rossoni, E.M. Kawamoto, and C. Scavone Signaling function of Na,K-ATPase induced by ouabain against LPS as an inflammation model in hippocampus J. Neuroinflamm. 11 2014 218 230
19. C.S. Lin, M.C. Lin, K.S. Chen, and et al. A digoxin-like immunoreactive substance and atrioventricular block induced by a Chinese medicine kyushin Jpn. Circ. J. 53 1989 1077 1080
20. Y. Liang, A.H. Liu, S. Qin, J.H. Sun, M. Yang, P. Li, and D.A. Guo Simultaneous determination and pharmacokinetics of five bufadienolides in rat plasma after oral administration of ChanSu extract by SPE-HPLC method J. Pharm. Biomed. Anal. 46 2008 442 448
21. L. Lima, E.M. Kawamoto, C.D. Munhoz, P.F. Kinoshita, A.M.M. Orellana, R. Curi, L.V. Rossoni, M.C.W. Avellar, and C. Scavone Ouabain activates NFkB through an NMDA signaling pathway in cultured cerebellar cells Neuropharmacology 73 2013 327 336
22. S. Morishita, M. Shoji, Y. Oguni, C. Ito, M. Higuchi, and et al. Pharmacological actions of "kyushin, a drug containing toad venom: cardiotonic and arrhythmogenic effects, and excitatory effect on respiration Am. J. Chin. Med. 20 1992 245 256
23. M.R. Micheli, R. Bova, M.A. Laurenzi, M. Bazzucchi, and G. Grassi Zucconi Modulation of BDNF and TrkB expression in rat hippocampus in response to acute neurotoxicity by diethyldithiocarbamate Neurosci. Lett. 410 2006 66 70
24. H.Y. Ma, J.P. Kou, J.R. Wang, and B.Y. Yu Evaluation of the anti-inflammatory and analgesic activities of Liu-Shen-Wan and its individual fractions J. Ethnopharmacol. 112 2007 108 114
25. Y.L. Miao, J.M. Ren, L. Jiang, J.B. Liu, B. Jiang, and X.L. Zhang α-lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet Int. J. Mol. Med. 32 2013 1179 1186
26. H.M. Mahdy, M.R. Mohamed, M.A. Emam, A.M. Karim, A.B. Abdel-Naim, and et al. Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms Neurochem. Res. 39 2014 321 332
27. National Commission of Chinese Pharmacopoeia Pharmacopoeia of the People's Republic of China 2010 Chemical Industry Press Beijing
28. M.N. Oyesiku, C.O. Evans, S. Houston, R.S. Darrell, J.S. Smith, and et al. Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain Brain Res. 833 1999 161 172
29. A. Patapoutian, and L.F. Reichardt TrkB receptors: mediators of neurotrophin action Curr. Opin. Neurobiol. 11 2001 272 280
30. N.J. Rothwell, and G.N. Luheshi Interleukin 1 in the brain: biology, pathology, and therapeutic target Trends Neurosci. 23 2000 618 625
31. S. Rostelato-Ferreira, C. Belo, G.B. Leite, S. Hyslop, and L. Rodrigues-Simioni Presynaptic neuromuscular action of a methanol extract from the venom of Rhinella schneideri toad J. Venom. Anim. Toxins Incl. Trop. Dis. 20 2014 30 34
32. H. Thoenen Neurotrophins and activity-dependent plasticity Prog. Brain Res. 128 2000 183 191
33. Y. Wang, Y. Wu, L. Li, J. Zheng, R. Liu, J. Zhou, and et al. Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells J. Neuroinflamm. 8 2011 95
34. Z.J. Wang, LQ. Sun, and T. Heinbockel Resibufogenin and cinobufagin activate central neurons through an ouabain-like action PLoS One 9 2014 e113272
35. P.H. Wei, Q.S. Liu, D. Li, Q. Zheng, J.F. Zhou, and J.J. Li Acute nicotine treatment attenuates lipopolysaccharide-induced cognitive dysfunction by increasing BDNF expression and inhibiting neuroinflammation in the rat hippocampus Neurosci. Lett. 604 2015 161 166
36. W. Xu, H. Luo, Y.P. Zhang, L. Shan, H.Y. Li, M. Yang, and et al. Simultaneous determination of five main active bufadienolides of ChanSu in rat plasma by liquid chromatography tandem mass spectrometry J. Chromatogr. B 859 2007 157 163
37. X.L. Xia, H.Z. Jin, S.K. Yan, and W.D. Zhang Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection J. Pharm. Biomed. Anal. 53 2010 646 654
38. Q. Yan, R.D. Rosenfeld, C.R. Matheson, N. Hawkins, O.T. Lopez, L. Bennet, and A.A. Welcher Expression of brain-derived neurotrophic factor (BDNF) protein in the adult rat central nervous system Neurosci. 78 1997 431 448
39. M. Ye, H. Gao, H.Z. Guo, J. Han, and D.A. Guo Simultaneous determination of cytotoxic bufadienolides in the Chinese medicine ChanSu by high-performance liquid chromatography coupled with photodiode array and mass spectrometry detections J. Chromatogr. B 838 2006 86 95
40. Zhong Yao Da Ci Dian (Chinese medical Great dictionary), 1979. Shanghai People Press, Shanghai, pp. 2714-2717.
41. Zhong Hua Ben Cao (Chinese Materia Medica), 1999, Shanghai Science and Technology Press, Shanghai. vol. 9, pp. 362-367