Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice

Journal of Ethnopharmacology

Volumn 161, Issue , 2015, Pages 175-185

  Huang, Huimei ^a,b   Yang, Yongge ^c   Lv, Chao ^b   Chang, Wanlin ^b   Peng, Chengcheng ^d   Wang, Shuping ^a   Ge, Guangbo ^e   Han, Lin ^a   Zhang, Weidong ^a,b,c   Liu, Runhui ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Department of Clinical Pharmacology Beijing Military Command General Hospital   (China)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

^e DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Bufadienolides; LCESI MS MS; Pharmacokinetic; Shexiang BaoxinPill; Tissue distribution

Indexed keywords

ACETIC ACID ETHYL ESTER; ARENOBUFAGIN; BUFADIENOLIDE DERIVATIVE; BUFALIN; BUFOGENIN; BUFOTALIN; CARDIOVASCULAR AGENT; CHINESE DRUG; GAMABUFOTALIN; SHEXIANG BAOXIN; UNCLASSIFIED DRUG; HERBACEOUS AGENT; TABLET;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STABILITY; DRUG TISSUE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; ELIMINATION HALF-LIFE; ELUTION; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; KIDNEY PARENCHYMA; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; LIVER; LUNG PARENCHYMA; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; SENSITIVITY AND SPECIFICITY; SMALL INTESTINE; SPLEEN; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION; ANIMAL; BLOOD; CHEMISTRY; INSTITUTE FOR CANCER RESEARCH MOUSE; KIDNEY; LUNG; METABOLISM; ORAL DRUG ADMINISTRATION; TABLET;

ANIMALIA; MUS; RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BUFANOLIDES; DRUG STABILITY; DRUGS, CHINESE HERBAL; INTESTINE, SMALL; KIDNEY; LIVER; LUNG; MALE; MICE, INBRED ICR; TABLETS; TISSUE DISTRIBUTION;

EID: 84920416400     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.07.056     Document Type: Article

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