Study of the cardiotoxicity of venenum bufonis in rats using an 1H NMR-based metabolomics approach

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Dong, Ge ^a   Wei, Dandan ^a   Wang, Junsong ^b   Guo, Pingping ^a   Li, Minghui ^b   Yang, Minghua ^a   Kong, Lingyi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; CREATINE KINASE; FATTY ACID; GAMMA GLUTAMYLTRANSFERASE; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VENENUM BUFONIS; VERY LOW DENSITY LIPOPROTEIN; BUFADIENOLIDE DERIVATIVE; CARDIOTOXIN; CHAN SU;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CARDIOTOXICITY; CHINESE MEDICINE; CLINICAL CHEMISTRY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTROCARDIOGRAPHY; ENERGY METABOLISM; HEART INJURY; HISTOPATHOLOGY; INFLAMMATION; ISOLATED HEART; ISOLATED LIVER; LIVER TOXICITY; MALE; METABOLITE; METABOLOMICS; NONHUMAN; OXIDATIVE STRESS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RAT MODEL; TOXICITY TESTING; ANIMAL; CARDIAC MUSCLE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; METABOLOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY;

RATTUS;

ANIMALS; BUFANOLIDES; CARDIOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; MYOCARDIUM; RATS;

EID: 84924942637     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119515     Document Type: Article

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