Acute nicotine treatment attenuates lipopolysaccharide-induced cognitive dysfunction by increasing BDNF expression and inhibiting neuroinflammation in the rat hippocampus

Neuroscience Letters

Volumn 604, Issue , 2015, Pages 161-166

  Wei, Penghui ^a   Liu, Qingshen ^b   Li, Dong ^a   Zheng, Qiang ^a   Zhou, Jinfeng ^a   Li, Jianjun ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Acute nicotine treatment; Brain derived neurotrophic factor (BDNF); Cognitive dysfunction; Lipopolysaccharide (LPS); Neuroinflammation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NICOTINE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; LIPOPOLYSACCHARIDE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOKINE RELEASE; DORSAL HIPPOCAMPUS; DRUG EFFECT; DRUG MECHANISM; HIPPOCAMPUS; MALE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; COGNITION DISORDERS; DRUG EFFECTS; INFLAMMATION; MAZE TEST; METABOLISM; PSYCHOLOGY; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASPASE 3; COGNITION DISORDERS; HIPPOCAMPUS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MAZE LEARNING; NEUROPROTECTIVE AGENTS; NICOTINE; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84939223380     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.08.008     Document Type: Article

References (27)

1. Schnydrig S., Korner L., Landweer S., Ernst B., Walker G., Otten U., Kunz D. Peripheral lipopolysaccharide administration transiently affects expression of brain-derived neurotrophic factor, corticotropin and proopiomelanocortin in mouse brain. Neurosci. Lett. 2007, 429:69-73.
2. Dantzer R. Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur. J. Pharmacol. 2004, 500:399-411.
3. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
4. Shaw K.N., Commins S., O'Mara S.M. Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus. Behav. Brain Res. 2001, 124.
5. Sparkman N.L., Buchanan J.B., Heyen J.R.R., Chen J., Beverly J.L., Johnson R.W. Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J. Neurosci. 2006, 26:10709-10716.
6. Russo I., Barlati S., Bosetti F. Effects of neuroinflammation on the regenerative capacity of brain stem cells. J. Neurochem. 2011, 116:947-956.
7. Hritcu L., Gorgan L.D. Intranigral lipopolysaccharide induced anxiety and depression by altered BDNF mRNA expression in rat hippocampus. Prog. Neuropsychopharmacol. Biol. Psychiatry 2014, 51:126-132.
8. Wang H., Liao H., Ochani M., Justiniani M., Lin X., Yang L., Al-Abed Y., Metz C., Miller E.J., Tracey K.J., Ulloa L. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 2004, 10:1216-1221.
9. Mabley J., Gordon S., Pacher P. Nicotine exerts an anti-inflammatory effect in a murine model of acute lung injury. Inflammation 2010, 34:231-237.
10. Park J., Kang J.-W., Lee S.-M. Activation of the cholinergic anti-inflammatory pathway by nicotine attenuates hepatic ischemia/reperfusion injury via heme oxygenase-1 induction. Eur. J. Pharmacol. 2013, 707:61-70.
11. Levin E.D., McClernon F.J., Rezvani A.H. Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization. Psychopharmacology (Berl.) 2005, 184:523-539.
12. Murray C., Sanderson D.J., Barkus C., Deacon R.M.J., Rawlins J.N.P., Bannerman D.M., Cunningham C. Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol. Aging 2012, 33:603-616. e603.
13. de Jonge W.J., van der Zanden E.P., The F.O., Bijlsma M.F., van Westerloo D.J., Bennink R.J., Berthoud H.-R., Uematsu S., Akira S., van den Wijngaard R.M., Boeckxstaens G.E. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat. Immunol. 2005, 6:844-851.
14. Wang H., Liao H., Ochani M., Justiniani M., Lin X., Yang L., Al-Abed Y., Wang H., Metz C., Miller E.J., Tracey K.J., Ulloa L. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 2004, 10:1216-1221.
15. McCormick C., Kirsten T.B., Galvão M.C., Reis-Silva T.M., Queiroz-Hazarbassanov N., Bernardi M.M. Zinc prevents sickness behavior induced by lipopolysaccharides after a stress challenge in rats. PLoS One 2015, 10:e0120263.
16. Fidalgo A.R., Cibelli M., White J.P.M., Nagy I., Maze M., Ma D. Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Neurosci. Lett. 2011, 498:63-66.
17. Vorhees C.V., Williams M.T. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat. Protoc. 2006, 1:848-858.
18. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-δδCT method. Methods 2001, 25:402-408.
19. Chen J., Buchanan J.B., Sparkman N.L., Godbout J.P., Freund G.G., Johnson R.W. Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav. Immun. 2008, 22:301-311.
20. Michelle Block L., Skelly D.T., Hennessy E., Dansereau M.-A., Cunningham C. A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1B, TNF-α and IL-6 challenges in C57BL/6 mice. PLoS One 2013, 8:e69123.
21. Frank M.G., Baratta M.V., Sprunger D.B., Watkins L.R., Maier S.F. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav. Immun. 2007, 21:47-59.
22. Cunningham C. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 2005, 25:9275-9284.
23. Harry G.J., Lefebvre d'Hellencourt C., McPherson C.A., Funk J.A., Aoyama M., Wine R.N. Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons. J. Neurochem. 2008, 106:281-298.
24. Nolan Y., Vereker E., Lynch A.M., Lynch M.A. Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus. Exp. Neurol. 2003, 184:794-804.
25. Andresen J.H., Løberg E.M., Wright M., Goverud I.L., Stray-Pedersen B., Saugstad O.D. Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets. J. Perinat. Med. 2009, 37.
26. Duman R.S., Malberg J., Nakagawa S., D'Sa C. Neuronal plasticity and survival in mood disorders. Biol. Psychiatry 2000, 48:732-739.
27. Shoval G., Weizman A. The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia. Eur. Neuropsychopharmacol. 2005, 15:319-329.