Efficacy of digoxin specific Fab fragments (Digibind®) in the treatment of toad venom poisoning

Toxicon

Volumn 37, Issue 6, 1999, Pages 931-942

  Brubacher, J R ^a   Lachmanen, D ^b   Ravikumar, P R ^b   Hoffman, R S ^c  

^a VANCOUVER HOSPITAL AND HEALTH SCIENCES CENTRE   (Canada)

^b NEW YORK CITY DEPARTMENT OF HEALTH AND MENTAL HYGIENE   (United States)

^c NEW YORK CITY POISON CONTROL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIBIAN VENOM; BUFADIENOLIDE; BUFALIN; BUFOTENINE; CINOBUFAGIN; CINOBUFOTALIN; DIGOXIN ANTIBODY F(AB) FRAGMENT; INOTROPIC AGENT; UNCLASSIFIED DRUG; VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAN SU; CHINESE MEDICINE; CONTROLLED STUDY; DEATH; DRUG EFFICACY; ENVENOMATION; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LETHAL DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SUBCUTANEOUS DRUG ADMINISTRATION; TRADITIONAL MEDICINE;

AMPHIBIAN VENOMS; ANIMALS; APHRODISIACS; BUFANOLIDES; BUFONIDAE; BUFOTENIN; CARDENOLIDES; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; IMMUNOGLOBULIN FAB FRAGMENTS; MEDICINE, CHINESE TRADITIONAL; MICE; POISONING; SEIZURES; SURVIVAL RATE;

EID: 0032917163     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(98)00224-4     Document Type: Article

References (28)

1. Anonymous Family eats toad: 1 dies of poisoning: Child is victim of strange food. Honolulu Star Bull. 18:1935;1.
2. Bagrov A.Y., Roukoyatkina N.I., Fedorova O.V.et al. Digitalis-like and vasoconstrictor effects of endogenous digoxin-like factors from the venom of Bufo marinus toad. Eur. J. Pharmacol. 234:1993;165-172.
3. Bania T., Hoffman R.S., Howland M.A. Accidental Indian Hemp (Apocyneacea cannabinum) cardiac glycoside toxicity. Vet. Hum. Toxicol. 35:1993;328. abstract.
4. Brubacher J.R., Ravikumar P.R., Bania T., Heller M.B., Hoffman R.S. Treatment of toad venom poisoning with digoxin-specific Fab fragments. Chest. 110:1996;1282-1288.
5. Chen K.K., Kovarikova A. Pharmacology and toxicology of toad venom. J. Pharmaceut. Sci. 56:1967;1535-1541.
6. Chern M.S., Ray C.Y., Wu D. Biologic intoxication due to digitalis-like substance after ingestion of cooked toad soup. Am. J. Cardiol. 67:1991;443-444.
7. De Smet P.A., Rivier L. Intoxicating snuffs of the Venezuelan Piaroa Indians. J. Psychoact. Drugs. 17:1985;93-103.
8. Fabing H.D., Hawkins J.R. Intravenous bufotenine injection in the human being. Science. 123:1956;886-887.
9. Fushimi R., Koh T., Iyam S.et al. Digoxin-like immunoreactivity in Chinese medicine. Therapeut. Drug Monitor. 12:1990;242-245.
10. Hastreiter A.R., Van Der Horst R.L., Chow-Tung E. Digitalis toxicity in infants and children. Pediatr. Cardiol. 5:1984;131-148.
11. 2 antibody fragments. Am. Heart J. 98:1979;767-771.
12. Hitt M., Ettinger D.D. Toad toxicity. N. Engl. J. Med. 314:1986;1517.
13. Hoch, J.H., 1961. A Survey of Cardiac Glycosides and Genins. University of South Carolina Press.
14. Huang, C., 1993. Chan Su. In: Huang, K.C. (Ed.), The Pharmacology of Chinese Herbs. CRC Press, pp. 114-117.
15. Lewis, R.L., Sweet, D.V. (Eds.), 1985. Registry of toxic effects of chemical substrates, vol. I, 1983-84 Suppl. US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, 1985, p. 776.
16. Licht L.E. Death following possible ingestion of toad eggs. Toxicon. 5:1967;141-142.
17. Lyttle T. Misuse and legend in the 'toad licking' phenomenon. Int. J. Addict. 28:1993;521-538.
18. Morishita S., Shoji M., Oguni Y., Ito C., Higuchi M., Sakanashi M. Pharmacological actions of 'Kyushin', a drug containing toad venom: Cardiotonic and arrhythmogenic effects, and excitatory effect on respiration. Am. J. Chin. Med. 20:1992;245-256.
19. Ojiri Y., Noguchi K., Sakanashi M. Effects of a senso (toad venom) containing drug on systemic hemodynamics, cardiac function and myocardial oxygen consumption in anesthetized dogs. Am. J. Chin. Med. 19:1991;17-31.
20. Ojiri Y., Chibana T., Noguchi K.et al. Cardiovascular effect of a senso (toad venom) - containing drug in anesthetized dogs (2): influence of propranolol. Am. J. Chin. Med. 20:1992;147-155.
21. Osterloh J., Herold S., Pond S. Oleander interference in the digoxin radioimmunoassay in a fatal ingestion. JAMA. 247:1982;1596-1597.
22. Palumbo N.E., Perri S., Read B.S. Experimental induction and treatment of toad venom poisoning in the dog. J. Am. Vet. Med. Assoc. 167:1975;1000-1005.
23. Rich S.A., Libera J.M., Locke R.J. Treatment of foxglove poisoning with digoxin-specific FAB fragments. Ann. Emerg. Med. 22:1993;1904-1907.
24. Sabouraud A., Urtizberea M., Cano N.et al. Specific anti-digoxin Fab fragments: An available antidote for proscillarin and scilliroside poisoning? Hum. Exper. Toxicol. 9:1990;191-193.
25. Safadi R., Levy I., Amitai Y.et al. Beneficial effect of digoxin-specific Fab antibody fragments in oleander intoxication. Arch. Int. Med. 155:1995;2121-2125.
26. Shumaik G.M., Wu A.W., Ping A.C.et al. Oleander poisoning: Treatment with digoxin-specific FAB antibody fragments. Ann. Emerg. Med. 17:1988;732-735.
27. Yei C.C., Deng J.F. Toad or toad cake intoxication in Taiwan: Report of four cases. J. Formos. Med. Assoc. 92(Suppl 3):1993;S135-S139.
28. Yoshida S., Kamano Y., Sakai T. Studies on the surface anesthetic activity of bufadienolides isolated from Ch'an Su. Chem. Pharm. Bull. 24:1976;1714-1717.