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Volumn 7, Issue FEB, 2016, Pages

Mesenchymal stem cell-derived extracellular vesicles promote angiogenesis: Potencial clinical application

Author keywords

Angiogenesis; Extracellular vesicles; Mesenchymal stem cell

Indexed keywords

ADIPOCYTE; ADULT; ANGIOGENESIS; CARTILAGE CELL; CELL DIFFERENTIATION; EXOSOME; MESENCHYMAL STEM CELL; MULTIPOTENT STEM CELL; OSTEOCYTE; SOLUBILITY; TISSUE REGENERATION;

EID: 84962683835     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2016.00024     Document Type: Short Survey
Times cited : (198)

References (95)
  • 1
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams, R. H., and Alitalo, K. (2007). Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8, 464-478. doi: 10.1038/nrm2183.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 2
    • 84912019913 scopus 로고    scopus 로고
    • Endothelium trans differentiated from Wharton's jelly mesenchymal cells promote tissue regeneration: potential role of soluble pro-angiogenic factors
    • Aguilera, V., Briceño, L., Contreras, H., Lamperti, L., Sepúlveda, E., Díaz-Perez, F., et al. (2014). Endothelium trans differentiated from Wharton's jelly mesenchymal cells promote tissue regeneration: potential role of soluble pro-angiogenic factors. PLoS ONE 9:e111025. doi: 10.1371/journal.pone.0111025.
    • (2014) PLoS ONE , vol.9
    • Aguilera, V.1    Briceño, L.2    Contreras, H.3    Lamperti, L.4    Sepúlveda, E.5    Díaz-Perez, F.6
  • 3
    • 84862736306 scopus 로고    scopus 로고
    • Metastasis: Exosomes drive premetastatic niche formation
    • Alderton, G. K. (2012). Metastasis: Exosomes drive premetastatic niche formation. Nat. Rev. Cancer 12, 447-447. doi: 10.1038/nrc3304.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 447-447
    • Alderton, G.K.1
  • 4
    • 33847753491 scopus 로고    scopus 로고
    • Term amniotic membrane is a high throughput source for multipotent mesenchymal stem cells with the ability to differentiate into endothelial cells in vitro
    • Alviano, F., Fossati, V., Marchionni, C., Arpinati, M., Bonsi, L., Franchina, M., et al. (2007). Term amniotic membrane is a high throughput source for multipotent mesenchymal stem cells with the ability to differentiate into endothelial cells in vitro. BMC Dev. Biol. 7:11. doi: 10.1186/1471-213X-7-11.
    • (2007) BMC Dev. Biol , vol.7 , pp. 11
    • Alviano, F.1    Fossati, V.2    Marchionni, C.3    Arpinati, M.4    Bonsi, L.5    Franchina, M.6
  • 5
    • 84938697816 scopus 로고    scopus 로고
    • Human bone marrow-and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species
    • Baglio, S. R., Rooijers, K., Koppers-Lalic, D., Verweij, F. J., Lanzón, M. P., Zini, N., et al. (2015). Human bone marrow-and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res. Ther. 6, 1-20. doi: 10.1186/s13287-015-0116-z.
    • (2015) Stem Cell Res. Ther , vol.6 , pp. 1-20
    • Baglio, S.R.1    Rooijers, K.2    Koppers-Lalic, D.3    Verweij, F.J.4    Lanzón, M.P.5    Zini, N.6
  • 6
    • 33947218520 scopus 로고    scopus 로고
    • Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation
    • Battula, V. L., Bareiss, P. M., Treml, S., Conrad, S., Albert, I., Hojak, S., et al. (2007). Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation 75, 279-291. doi: 10.1111/j.1432-0436.2006.00139.x.
    • (2007) Differentiation , vol.75 , pp. 279-291
    • Battula, V.L.1    Bareiss, P.M.2    Treml, S.3    Conrad, S.4    Albert, I.5    Hojak, S.6
  • 7
    • 84875221828 scopus 로고    scopus 로고
    • Flow control in our vessels: vascular valves make sure there is no way back
    • Bazigou, E., and Makinen, T. (2013). Flow control in our vessels: vascular valves make sure there is no way back. Cell. Mol. Life Sci. 70, 1055-1066. doi: 10.1007/s00018-012-1110-6.
    • (2013) Cell. Mol. Life Sci , vol.70 , pp. 1055-1066
    • Bazigou, E.1    Makinen, T.2
  • 8
    • 84858185865 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury
    • Bruno, S., Grange, C., Collino, F., Deregibus, M. C., Cantaluppi, V., Biancone, L., et al. (2012). Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS ONE 7:e33115. doi: 10.1371/journal.pone.0033115.
    • (2012) PLoS ONE , vol.7
    • Bruno, S.1    Grange, C.2    Collino, F.3    Deregibus, M.C.4    Cantaluppi, V.5    Biancone, L.6
  • 9
    • 77958098024 scopus 로고    scopus 로고
    • Exosomes/microvesicles as a mechanism of cell-to-cell communication
    • Camussi, G., Deregibus, M. C., Bruno, S., Cantaluppi, V., and Biancone, L. (2010). Exosomes/microvesicles as a mechanism of cell-to-cell communication. Kidney Int. 78, 838-848. doi: 10.1038/ki.2010.278.
    • (2010) Kidney Int , vol.78 , pp. 838-848
    • Camussi, G.1    Deregibus, M.C.2    Bruno, S.3    Cantaluppi, V.4    Biancone, L.5
  • 10
    • 84865520827 scopus 로고    scopus 로고
    • Microvesicles derived from endothelial progenitor cells enhance neoangiogenesis of human pancreatic islets
    • Cantaluppi, V., Biancone, L., Figliolini, F., Beltramo, S., Medica, D., Deregibus, M. C., et al. (2012). Microvesicles derived from endothelial progenitor cells enhance neoangiogenesis of human pancreatic islets. Cell Transplant. 21, 1305-1320. doi: 10.3727/096368911X627534.
    • (2012) Cell Transplant , vol.21 , pp. 1305-1320
    • Cantaluppi, V.1    Biancone, L.2    Figliolini, F.3    Beltramo, S.4    Medica, D.5    Deregibus, M.C.6
  • 11
    • 77952238570 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats
    • Cao, H., Qian, H., Xu, W., Zhu, W., Zhang, X., Chen, Y., et al. (2010). Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats. Biotechnol. Lett. 32, 725-732. doi: 10.1007/s10529-010-0207-y.
    • (2010) Biotechnol. Lett , vol.32 , pp. 725-732
    • Cao, H.1    Qian, H.2    Xu, W.3    Zhu, W.4    Zhang, X.5    Chen, Y.6
  • 12
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan, A. I. (1991). Mesenchymal stem cells. J. Orthop. Res. 9, 641-650. doi: 10.1002/jor.1100090504.
    • (1991) J. Orthop. Res , vol.9 , pp. 641-650
    • Caplan, A.I.1
  • 13
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • Caplan, A. I., and Dennis, J. E. (2006). Mesenchymal stem cells as trophic mediators. J. Cell. Biochem. 98, 1076-1084. doi: 10.1002/jcb.20886.
    • (2006) J. Cell. Biochem , vol.98 , pp. 1076-1084
    • Caplan, A.I.1    Dennis, J.E.2
  • 14
    • 84945966687 scopus 로고    scopus 로고
    • Paracrine in vivo inhibitory effects of adipose tissue-derived mesenchymal stromal cells in the early stages of the acute inflammatory response
    • Carceller, M. C., Guillén, M. I., Ferrándiz, M. L., and Alcaraz, M. J. (2015). Paracrine in vivo inhibitory effects of adipose tissue-derived mesenchymal stromal cells in the early stages of the acute inflammatory response. Cytotherapy 17, 1230-1239. doi: 10.1016/j.jcyt.2015.06.001.
    • (2015) Cytotherapy , vol.17 , pp. 1230-1239
    • Carceller, M.C.1    Guillén, M.I.2    Ferrándiz, M.L.3    Alcaraz, M.J.4
  • 15
    • 84875368334 scopus 로고    scopus 로고
    • Angiogenic cytokines in renovascular disease: do they have potential for therapeutic use?
    • Chade, A. R., and Stewart, N. (2013). Angiogenic cytokines in renovascular disease: do they have potential for therapeutic use? J. Am. Soc. Hypertens. 7, 180-190. doi: 10.1016/j.jash.2013.01.004.
    • (2013) J. Am. Soc. Hypertens , vol.7 , pp. 180-190
    • Chade, A.R.1    Stewart, N.2
  • 16
    • 75649119273 scopus 로고    scopus 로고
    • Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs
    • Chen, T. S., Lai, R. C., Lee, M. M., Choo, A. B. H., Lee, C. N., and Lim, S. K. (2010). Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs. Nucleic Acids Res. 38, 215-224. doi: 10.1093/nar/gkp857.
    • (2010) Nucleic Acids Res , vol.38 , pp. 215-224
    • Chen, T.S.1    Lai, R.C.2    Lee, M.M.3    Choo, A.B.H.4    Lee, C.N.5    Lim, S.K.6
  • 17
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
    • Colombo, M., Raposo, G., and Théry, C. (2014). Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255-289. doi: 10.1146/annurev-cellbio-101512-122326.
    • (2014) Annu. Rev. Cell Dev. Biol , vol.30 , pp. 255-289
    • Colombo, M.1    Raposo, G.2    Théry, C.3
  • 18
    • 33646119401 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation
    • Copelan, E. A. (2006). Hematopoietic stem-cell transplantation. New Engl. J. Med. 354, 1813-1826. doi: 10.1056/NEJMra052638.
    • (2006) New Engl. J. Med , vol.354 , pp. 1813-1826
    • Copelan, E.A.1
  • 19
    • 30744432619 scopus 로고    scopus 로고
    • Endothelial cells and VEGF in vascular development
    • Coultas, L., Chawengsaksophak, K., and Rossant, J. (2005). Endothelial cells and VEGF in vascular development. Nature 438, 937-945. doi: 10.1038/nature04479.
    • (2005) Nature , vol.438 , pp. 937-945
    • Coultas, L.1    Chawengsaksophak, K.2    Rossant, J.3
  • 20
    • 84879992781 scopus 로고    scopus 로고
    • Porcine adipose tissue-derived mesenchymal stem cells retain their proliferative characteristics, senescence, karyotype and plasticity after long-term cryopreservation
    • Dariolli, R., Bassaneze, V., Nakamuta, J. S., Omae, S. V., Campos, L. C. G., and Krieger, J. E. (2013). Porcine adipose tissue-derived mesenchymal stem cells retain their proliferative characteristics, senescence, karyotype and plasticity after long-term cryopreservation. PLoS ONE 8:e67939. doi: 10.1371/journal.pone.0067939.
    • (2013) PLoS ONE , vol.8
    • Dariolli, R.1    Bassaneze, V.2    Nakamuta, J.S.3    Omae, S.V.4    Campos, L.C.G.5    Krieger, J.E.6
  • 21
    • 70849103924 scopus 로고    scopus 로고
    • Mechanisms involved in the therapeutic properties of mesenchymal stem cells
    • Da Silva Meirelles, L., Fontes, A. M., Covas, D. T., and Caplan, A. I. (2009). Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev. 20, 419-427. doi: 10.1016/j.cytogfr.2009.10.002.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 419-427
    • Da Silva Meirelles, L.1    Fontes, A.M.2    Covas, D.T.3    Caplan, A.I.4
  • 22
    • 34948834742 scopus 로고    scopus 로고
    • Endothelial progenitor cell-derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA
    • Deregibus, M. C., Cantaluppi, V., Calogero, R., Iacono, M. L., Tetta, C., Biancone, L., et al. (2007). Endothelial progenitor cell-derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood 110, 2440-2448. doi: 10.1182/blood-2007-03-078709.
    • (2007) Blood , vol.110 , pp. 2440-2448
    • Deregibus, M.C.1    Cantaluppi, V.2    Calogero, R.3    Iacono, M.L.4    Tetta, C.5    Biancone, L.6
  • 23
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement
    • Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F., Krause, D., et al. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 8, 315-317. doi: 10.1080/14653240600855905.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6
  • 24
    • 84872144085 scopus 로고    scopus 로고
    • Mechanisms of mesenchymal stromal cell immunomodulation
    • English, K. (2013). Mechanisms of mesenchymal stromal cell immunomodulation. Immunol. Cell Biol. 91, 19-26. doi: 10.1038/icb.2012.56.
    • (2013) Immunol. Cell Biol , vol.91 , pp. 19-26
    • English, K.1
  • 25
    • 0016269155 scopus 로고
    • Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues: cloning in vitro and retransplantation in vivo
    • Friedenstein, A. J., Chailakhyan, R. K., Latsinik, N. V., Panasyuk, A. F., and Keiliss-Borok, I. V. (1974). Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues: cloning in vitro and retransplantation in vivo. Transplantation 17, 331-340. doi: 10.1097/00007890-197404000-00001.
    • (1974) Transplantation , vol.17 , pp. 331-340
    • Friedenstein, A.J.1    Chailakhyan, R.K.2    Latsinik, N.V.3    Panasyuk, A.F.4    Keiliss-Borok, I.V.5
  • 26
    • 84905453740 scopus 로고    scopus 로고
    • The gap between the physiological and therapeutic roles of mesenchymal stem cells
    • Galderisi, U., and Giordano, A. (2014). The gap between the physiological and therapeutic roles of mesenchymal stem cells. Med. Res. Rev. 34, 1100-1126. doi: 10.1002/med.21322.
    • (2014) Med. Res. Rev , vol.34 , pp. 1100-1126
    • Galderisi, U.1    Giordano, A.2
  • 27
    • 84867101024 scopus 로고    scopus 로고
    • Active Wnt proteins are secreted on exosomes
    • Gross, J. C., Chaudhary, V., Bartscherer, K., and Boutros, M. (2012). Active Wnt proteins are secreted on exosomes. Nat. Cell Biol. 14, 1036-1045. doi: 10.1038/ncb2574.
    • (2012) Nat. Cell Biol , vol.14 , pp. 1036-1045
    • Gross, J.C.1    Chaudhary, V.2    Bartscherer, K.3    Boutros, M.4
  • 28
    • 84862981326 scopus 로고    scopus 로고
    • Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model
    • He, J., Wang, Y., Sun, S., Yu, M., Wang, C., Pei, X., et al. (2012). Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model. Nephrology 17, 493-500. doi: 10.1111/j.1440-1797.2012.01589.x.
    • (2012) Nephrology , vol.17 , pp. 493-500
    • He, J.1    Wang, Y.2    Sun, S.3    Yu, M.4    Wang, C.5    Pei, X.6
  • 31
    • 84921926547 scopus 로고    scopus 로고
    • Exosomes in mesenchymal stem cells, a new therapeutic strategy for cardiovascular diseases?
    • Huang, L., Ma, W., Ma, Y., Feng, D., Chen, H., and Cai, B. (2015). Exosomes in mesenchymal stem cells, a new therapeutic strategy for cardiovascular diseases? Int. J. Biol. Sci. 11, 238-245. doi: 10.7150/ijbs.10725.
    • (2015) Int. J. Biol. Sci , vol.11 , pp. 238-245
    • Huang, L.1    Ma, W.2    Ma, Y.3    Feng, D.4    Chen, H.5    Cai, B.6
  • 32
    • 84859258692 scopus 로고    scopus 로고
    • Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal
    • Hunkapiller, J., Shen, Y., Diaz, A., Cagney, G., McCleary, D., Ramalho-Santos, M., et al. (2012). Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet. 8:e1002576. doi: 10.1371/journal.pgen.1002576.
    • (2012) PLoS Genet , vol.8
    • Hunkapiller, J.1    Shen, Y.2    Diaz, A.3    Cagney, G.4    McCleary, D.5    Ramalho-Santos, M.6
  • 33
    • 84879603171 scopus 로고    scopus 로고
    • Exosomes in tumor microenvironment influence cancer progression and metastasis
    • Kahlert, C., and Kalluri, R. (2013). Exosomes in tumor microenvironment influence cancer progression and metastasis. J. Mol. Med. 91, 431-437. doi: 10.1007/s00109-013-1020-6.
    • (2013) J. Mol. Med , vol.91 , pp. 431-437
    • Kahlert, C.1    Kalluri, R.2
  • 34
    • 84929649938 scopus 로고    scopus 로고
    • Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via akt signaling pathway following myocardial infarction
    • Kang, K., Ma, R., Cai, W., Huang, W., Paul, C., Liang, J., et al. (2015). Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via akt signaling pathway following myocardial infarction. Stem Cells Int. 2015:659890. doi: 10.1155/2015/659890.
    • (2015) Stem Cells Int , vol.2015
    • Kang, K.1    Ma, R.2    Cai, W.3    Huang, W.4    Paul, C.5    Liang, J.6
  • 35
    • 84899624274 scopus 로고    scopus 로고
    • Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes
    • Kastelowitz, N., and Yin, H. (2014). Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes. Chembiochem 15, 923-928. doi: 10.1002/cbic.201400043.
    • (2014) Chembiochem , vol.15 , pp. 923-928
    • Kastelowitz, N.1    Yin, H.2
  • 36
    • 84878009661 scopus 로고    scopus 로고
    • Preconditioning diabetic mesenchymal stem cells with myogenic medium increases their ability to repair diabetic heart
    • Khan, M., Ali, F., Mohsin, S., Akhtar, S., Mehmood, A., Choudhery, M. S., et al. (2013). Preconditioning diabetic mesenchymal stem cells with myogenic medium increases their ability to repair diabetic heart. Stem Cell Res. Ther. 4, 58-71. doi: 10.1186/scrt207.
    • (2013) Stem Cell Res. Ther , vol.4 , pp. 58-71
    • Khan, M.1    Ali, F.2    Mohsin, S.3    Akhtar, S.4    Mehmood, A.5    Choudhery, M.S.6
  • 37
    • 84897966003 scopus 로고    scopus 로고
    • Paracrine mechanisms of proliferative, anti-apoptotic and anti-inflammatory effects of mesenchymal stromal cells in models of acute organ injury
    • Khubutiya, M. S., Vagabov, A. V., Temnov, A. A., and Sklifas, A. N. (2014). Paracrine mechanisms of proliferative, anti-apoptotic and anti-inflammatory effects of mesenchymal stromal cells in models of acute organ injury. Cytotherapy 16, 579-585. doi: 10.1016/j.jcyt.2013.07.017.
    • (2014) Cytotherapy , vol.16 , pp. 579-585
    • Khubutiya, M.S.1    Vagabov, A.V.2    Temnov, A.A.3    Sklifas, A.N.4
  • 38
    • 84863060761 scopus 로고    scopus 로고
    • Proteomic analysis of microvesicles derived from human mesenchymal stem cells
    • Kim, H.-S., Choi, D.-Y., Yun, S. J., Choi, S.-M., Kang, J. W., Jung, J. W., et al. (2011). Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J. Proteome Res. 11, 839-849. doi: 10.1021/pr200682z.
    • (2011) J. Proteome Res , vol.11 , pp. 839-849
    • Kim, H.-S.1    Choi, D.-Y.2    Yun, S.J.3    Choi, S.-M.4    Kang, J.W.5    Jung, J.W.6
  • 39
    • 1642373909 scopus 로고    scopus 로고
    • Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    • Kinnaird, T., Stabile, E., Burnett, M., Lee, C., Barr, S., Fuchs, S., et al. (2004a). Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ. Res. 94, 678-685. doi: 10.1161/01.RES.0000118601.37875.AC.
    • (2004) Circ. Res , vol.94 , pp. 678-685
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.3    Lee, C.4    Barr, S.5    Fuchs, S.6
  • 40
    • 1842486565 scopus 로고    scopus 로고
    • Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    • Kinnaird, T., Stabile, E., Burnett, M., Shou, M., Lee, C., Barr, S., et al. (2004b). Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109, 1543-1549. doi: 10.1161/01.CIR.0000124062.31102.57.
    • (2004) Circulation , vol.109 , pp. 1543-1549
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.3    Shou, M.4    Lee, C.5    Barr, S.6
  • 41
    • 84881548270 scopus 로고    scopus 로고
    • Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development
    • Kitagawa, M., Hojo, M., Imayoshi, I., Goto, M., Ando, M., Ohtsuka, T., et al. (2013). Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development. Mech. Dev. 130, 458-466. doi: 10.1016/j.mod.2013.07.001.
    • (2013) Mech. Dev , vol.130 , pp. 458-466
    • Kitagawa, M.1    Hojo, M.2    Imayoshi, I.3    Goto, M.4    Ando, M.5    Ohtsuka, T.6
  • 42
    • 77952293014 scopus 로고    scopus 로고
    • Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    • Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., et al. (2010). Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 4, 214-222. doi: 10.1016/j.scr.2009.12.003.
    • (2010) Stem Cell Res , vol.4 , pp. 214-222
    • Lai, R.C.1    Arslan, F.2    Lee, M.M.3    Sze, N.S.K.4    Choo, A.5    Chen, T.S.6
  • 43
    • 84866524463 scopus 로고    scopus 로고
    • Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome
    • Lai, R. C., Tan, S. S., Teh, B. J., Sze, S. K., Arslan, F., De Kleijn, D. P., et al. (2012). Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome. Int. J. Proteomics 2012:971907. doi: 10.1155/2012/971907.
    • (2012) Int. J. Proteomics , vol.2012
    • Lai, R.C.1    Tan, S.S.2    Teh, B.J.3    Sze, S.K.4    Arslan, F.5    De Kleijn, D.P.6
  • 44
    • 84929275438 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosomes
    • Lai, R. C., Yeo, R. W., and Limm, S. K. (2015). Mesenchymal stem cell exosomes. Semin. Cell Dev. Biol. 40, 82-88. doi: 10.1016/j.semcdb.2015.03.001.
    • (2015) Semin. Cell Dev. Biol , vol.40 , pp. 82-88
    • Lai, R.C.1    Yeo, R.W.2    Limm, S.K.3
  • 45
    • 42749092828 scopus 로고    scopus 로고
    • Itinerant exosomes: emerging roles in cell and tissue polarity
    • Lakkaraju, A., and Rodriguez-Boulan, E. (2008). Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol. 18, 199-209. doi: 10.1016/j.tcb.2008.03.002.
    • (2008) Trends Cell Biol , vol.18 , pp. 199-209
    • Lakkaraju, A.1    Rodriguez-Boulan, E.2
  • 46
    • 84891373674 scopus 로고    scopus 로고
    • Towards clinical application of mesenchymal stem cells for treatment of neurological diseases of the central nervous system
    • Laroni, A., Novi, G., de Rosbo, N. K., and Uccelli, A. (2013). Towards clinical application of mesenchymal stem cells for treatment of neurological diseases of the central nervous system. J. Neuroimmune Pharmacol. 8, 1062-1076. doi: 10.1007/s11481-013-9456-6.
    • (2013) J. Neuroimmune Pharmacol , vol.8 , pp. 1062-1076
    • Laroni, A.1    Novi, G.2    de Rosbo, N.K.3    Uccelli, A.4
  • 47
    • 84870239895 scopus 로고    scopus 로고
    • Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension
    • Lee, C., Mitsialis, S. A., Aslam, M., Vitali, S. H., Vergadi, E., Konstantinou, G., et al. (2012). Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 126, 2601-2611. doi: 10.1161/CIRCULATIONAHA.112.114173.
    • (2012) Circulation , vol.126 , pp. 2601-2611
    • Lee, C.1    Mitsialis, S.A.2    Aslam, M.3    Vitali, S.H.4    Vergadi, E.5    Konstantinou, G.6
  • 48
    • 84894211631 scopus 로고    scopus 로고
    • Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells
    • Lee, J.-K., Park, S.-R., Jung, B.-K., Jeon, Y.-K., Lee, Y.-S., Kim, M.-K., et al. (2013). Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS ONE 8:e84256. doi: 10.1371/journal.pone.0084256.
    • (2013) PLoS ONE , vol.8
    • Lee, J.-K.1    Park, S.-R.2    Jung, B.-K.3    Jeon, Y.-K.4    Lee, Y.-S.5    Kim, M.-K.6
  • 49
    • 84953371563 scopus 로고    scopus 로고
    • Paracrine effect of inflammatory cytokine-activated bone marrow mesenchymal stem cells and its role in osteoblast function
    • Li, C., Li, G., Liu, M., Zhou, T., and Zhou, H. (2015). Paracrine effect of inflammatory cytokine-activated bone marrow mesenchymal stem cells and its role in osteoblast function. J. Biosci. Bioeng. 121, 213-219. doi: 10.1016/j.jbiosc.2015.05.017.
    • (2015) J. Biosci. Bioeng , vol.121 , pp. 213-219
    • Li, C.1    Li, G.2    Liu, M.3    Zhou, T.4    Zhou, H.5
  • 50
    • 84871980628 scopus 로고    scopus 로고
    • Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy
    • Li, Q., and Lozano, G. (2013). Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy. Clin. Cancer Res. 19, 34-41. doi: 10.1158/1078-0432.CCR-12-0053.
    • (2013) Clin. Cancer Res , vol.19 , pp. 34-41
    • Li, Q.1    Lozano, G.2
  • 51
    • 84876241933 scopus 로고    scopus 로고
    • Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis
    • Li, T., Yan, Y., Wang, B., Qian, H., Zhang, X., Shen, L., et al. (2012). Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev. 22, 845-854. doi: 10.1089/scd.2012.0395.
    • (2012) Stem Cells Dev , vol.22 , pp. 845-854
    • Li, T.1    Yan, Y.2    Wang, B.3    Qian, H.4    Zhang, X.5    Shen, L.6
  • 52
    • 84906964309 scopus 로고    scopus 로고
    • Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives
    • Liang, X., Ding, Y., Zhang, Y., Tse, H. F., and Lian, Q. (2014). Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives. Cell Transplant. 23, 1045-1059. doi: 10.3727/096368913X667709.
    • (2014) Cell Transplant , vol.23 , pp. 1045-1059
    • Liang, X.1    Ding, Y.2    Zhang, Y.3    Tse, H.F.4    Lian, Q.5
  • 53
    • 84899585740 scopus 로고    scopus 로고
    • Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential
    • Lopatina, T., Bruno, S., Tetta, C., Kalinina, N., Porta, M., and Camussi, G. (2014). Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential. Cell Commun. Signal. 12, 26. doi: 10.1186/1478-811X-12-26.
    • (2014) Cell Commun. Signal , vol.12 , pp. 26
    • Lopatina, T.1    Bruno, S.2    Tetta, C.3    Kalinina, N.4    Porta, M.5    Camussi, G.6
  • 54
    • 84859499653 scopus 로고    scopus 로고
    • Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells
    • Lu, R., Qu, Y., Ge, J., Zhang, L., Su, Z., Pflugfelder, S. C., et al. (2012). Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells. Stem Cells 30, 753-761. doi: 10.1002/stem.1032.
    • (2012) Stem Cells , vol.30 , pp. 753-761
    • Lu, R.1    Qu, Y.2    Ge, J.3    Zhang, L.4    Su, Z.5    Pflugfelder, S.C.6
  • 55
    • 78751641526 scopus 로고    scopus 로고
    • Growth and differentiation properties of mesenchymal stromal cell populations derived from whole human umbilical cord
    • Majore, I., Moretti, P., Stahl, F., Hass, R., and Kasper, C. (2011). Growth and differentiation properties of mesenchymal stromal cell populations derived from whole human umbilical cord. Stem Cell Rev. 7, 17-31. doi: 10.1007/s12015-010-9165-y.
    • (2011) Stem Cell Rev , vol.7 , pp. 17-31
    • Majore, I.1    Moretti, P.2    Stahl, F.3    Hass, R.4    Kasper, C.5
  • 57
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: extracellular organelles important in intercellular communication
    • Mathivanan, S., Ji, H., and Simpson, R. J. (2010). Exosomes: extracellular organelles important in intercellular communication. J. Proteomics 73, 1907-1920. doi: 10.1016/j.jprot.2010.06.006.
    • (2010) J. Proteomics , vol.73 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 58
    • 84859788618 scopus 로고    scopus 로고
    • Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies
    • Mimeault, M., and Batra, S. K. (2012). Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies. Adv. Exp. Med. Biol. 741, 171-186. doi: 10.1007/978-1-4614-2098-9_12.
    • (2012) Adv. Exp. Med. Biol , vol.741 , pp. 171-186
    • Mimeault, M.1    Batra, S.K.2
  • 59
    • 77953247307 scopus 로고    scopus 로고
    • Culture and characterization of mesenchymal stem cells from human gingival tissue
    • Mitrano, T. I., Grob, M. S., Carrion, F., Nova-Lamperti, E., Luz, P. A., Fierro, F. S., et al. (2010). Culture and characterization of mesenchymal stem cells from human gingival tissue. J. Periodontol. 81, 917-925. doi: 10.1902/jop.2010.090566.
    • (2010) J. Periodontol , vol.81 , pp. 917-925
    • Mitrano, T.I.1    Grob, M.S.2    Carrion, F.3    Nova-Lamperti, E.4    Luz, P.A.5    Fierro, F.S.6
  • 60
    • 84947488952 scopus 로고    scopus 로고
    • Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering
    • Molina, E. R., Smith, B. T., Shah, S. R., Shin, H., and Mikos, A. G. (2015). Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering. J. Control Release 219, 107-118. doi: 10.1016/j.jconrel.2015.08.038.
    • (2015) J. Control Release , vol.219 , pp. 107-118
    • Molina, E.R.1    Smith, B.T.2    Shah, S.R.3    Shin, H.4    Mikos, A.G.5
  • 61
    • 0032979424 scopus 로고    scopus 로고
    • Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy
    • Morishita, R., Nakamura, S., Hayashi, S.-I., Taniyama, Y., Moriguchi, A., Nagano, T., et al. (1999). Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy. Hypertension 33, 1379-1384. doi: 10.1161/01.HYP.33.6.1379.
    • (1999) Hypertension , vol.33 , pp. 1379-1384
    • Morishita, R.1    Nakamura, S.2    Hayashi, S.-I.3    Taniyama, Y.4    Moriguchi, A.5    Nagano, T.6
  • 62
    • 84901010166 scopus 로고    scopus 로고
    • miR-191: an emerging player in disease biology
    • Nagpal, N., and Kulshreshtha, R. (2014). miR-191: an emerging player in disease biology. Front. Genet. 5:99. doi: 10.3389/fgene.2014.00099.
    • (2014) Front. Genet , vol.5 , pp. 99
    • Nagpal, N.1    Kulshreshtha, R.2
  • 63
    • 84936766922 scopus 로고    scopus 로고
    • Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
    • Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., et al. (2015). Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Lett. 589, 1257-1265. doi: 10.1016/j.febslet.2015.03.031.
    • (2015) FEBS Lett , vol.589 , pp. 1257-1265
    • Nakamura, Y.1    Miyaki, S.2    Ishitobi, H.3    Matsuyama, S.4    Nakasa, T.5    Kamei, N.6
  • 65
    • 40949143606 scopus 로고    scopus 로고
    • Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells
    • Parolini, O., Alviano, F., Bagnara, G. P., Bilic, G., Bühring, H. J., Evangelista, M., et al. (2008). Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells. Stem Cells 26, 300-311. doi: 10.1634/stemcells.2007-0594.
    • (2008) Stem Cells , vol.26 , pp. 300-311
    • Parolini, O.1    Alviano, F.2    Bagnara, G.P.3    Bilic, G.4    Bühring, H.J.5    Evangelista, M.6
  • 66
    • 84903702539 scopus 로고    scopus 로고
    • Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer
    • Pate, K. T., Stringari, C., Sprowl-Tanio, S., Wang, K., TeSlaa, T., Hoverter, N. P., et al. (2014). Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 33, 1454-1473. doi: 10.15252/embj.201488598.
    • (2014) EMBO J , vol.33 , pp. 1454-1473
    • Pate, K.T.1    Stringari, C.2    Sprowl-Tanio, S.3    Wang, K.4    TeSlaa, T.5    Hoverter, N.P.6
  • 67
    • 84876231145 scopus 로고    scopus 로고
    • Mesenchymal stem cell population isolated from the subepithelial layer of umbilical cord tissue
    • Patel, A. N., Vargas, V., Revello, P., and Bull, D. A. (2013). Mesenchymal stem cell population isolated from the subepithelial layer of umbilical cord tissue. Cell Transplant. 22, 513-519. doi: 10.3727/096368912X655064.
    • (2013) Cell Transplant , vol.22 , pp. 513-519
    • Patel, A.N.1    Vargas, V.2    Revello, P.3    Bull, D.A.4
  • 68
    • 84947059499 scopus 로고    scopus 로고
    • Adipose-and bone marrow-derived mesenchymal stem cells prolong graft survival in vascularized composite allotransplantation
    • Plock, J. A., Schnider, J. T., Zhang, W., Schweizer, R., Tsuji, W., Kostereva, N., et al. (2015). Adipose-and bone marrow-derived mesenchymal stem cells prolong graft survival in vascularized composite allotransplantation. Transplantation 99, 1765-1773. doi: 10.1097/TP.0000000000000731.
    • (2015) Transplantation , vol.99 , pp. 1765-1773
    • Plock, J.A.1    Schnider, J.T.2    Zhang, W.3    Schweizer, R.4    Tsuji, W.5    Kostereva, N.6
  • 69
    • 84929050359 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
    • Rani, S., Ryan, A. E., Griffin, M. D., and Ritter, T. (2015). Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications. Mol. Ther. 23, 812-823. doi: 10.1038/mt.2015.44.
    • (2015) Mol. Ther , vol.23 , pp. 812-823
    • Rani, S.1    Ryan, A.E.2    Griffin, M.D.3    Ritter, T.4
  • 70
    • 84877108215 scopus 로고    scopus 로고
    • Wnt signaling in the vasculature
    • Reis, M., and Liebner, S. (2013). Wnt signaling in the vasculature. Exp. Cell Res. 319, 1317-1323. doi: 10.1016/j.yexcr.2012.12.023.
    • (2013) Exp. Cell Res , vol.319 , pp. 1317-1323
    • Reis, M.1    Liebner, S.2
  • 71
    • 84892676248 scopus 로고    scopus 로고
    • Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes
    • Salomon, C., Kobayashi, M., Ashman, K., Sobrevia, L., Mitchell, M. D., and Rice, G. E. (2013). Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes. PLoS ONE. 8:e79636. doi: 10.1371/journal.pone.0079636.
    • (2013) PLoS ONE , vol.8
    • Salomon, C.1    Kobayashi, M.2    Ashman, K.3    Sobrevia, L.4    Mitchell, M.D.5    Rice, G.E.6
  • 72
  • 73
    • 33845961014 scopus 로고    scopus 로고
    • Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies
    • Shih, T., and Lindley, C. (2006). Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clin. Ther. 28, 1779-1802. doi: 10.1016/j.clinthera.2006.11.015.
    • (2006) Clin. Ther , vol.28 , pp. 1779-1802
    • Shih, T.1    Lindley, C.2
  • 74
    • 79751504754 scopus 로고    scopus 로고
    • Mesenchymal stem cells: mechanisms of inflammation
    • Singer, N. G., and Caplan, A. I. (2011). Mesenchymal stem cells: mechanisms of inflammation. Annu. Rev. Pathol. 6, 457-478. doi: 10.1146/annurev-pathol-011110-130230.
    • (2011) Annu. Rev. Pathol , vol.6 , pp. 457-478
    • Singer, N.G.1    Caplan, A.I.2
  • 75
    • 0032771824 scopus 로고    scopus 로고
    • The inhibitory effects of transforming growth factor beta1 on breast cancer cell proliferation are mediated through regulation of aberrant nuclear factor-kappaB/Rel expression
    • Sovak, M. A., Arsura, M., Zanieski, G., Kavanagh, K. T., and Sonenshein, G. E. (1999). The inhibitory effects of transforming growth factor beta1 on breast cancer cell proliferation are mediated through regulation of aberrant nuclear factor-kappaB/Rel expression. Cell Growth Differ. 10, 537-544.
    • (1999) Cell Growth Differ , vol.10 , pp. 537-544
    • Sovak, M.A.1    Arsura, M.2    Zanieski, G.3    Kavanagh, K.T.4    Sonenshein, G.E.5
  • 76
    • 84905237972 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models
    • Tan, C. Y., Lai, R. C., Wong, W., Dan, Y. Y., Lim, S. K., and Ho, H. K. (2014). Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models. Stem Cell Res. Ther. 5, 76. doi: 10.1186/scrt465.
    • (2014) Stem Cell Res. Ther , vol.5 , pp. 76
    • Tan, C.Y.1    Lai, R.C.2    Wong, W.3    Dan, Y.Y.4    Lim, S.K.5    Ho, H.K.6
  • 77
    • 44349134076 scopus 로고    scopus 로고
    • Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium
    • Timmers, L., Lim, S. K., Arslan, F., Armstrong, J. S., Hoefer, I. E., Doevendans, P. A., et al. (2008). Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Stem Cell Res. 1, 129-137. doi: 10.1016/j.scr.2008.02.002.
    • (2008) Stem Cell Res , vol.1 , pp. 129-137
    • Timmers, L.1    Lim, S.K.2    Arslan, F.3    Armstrong, J.S.4    Hoefer, I.E.5    Doevendans, P.A.6
  • 78
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., and Lötvall, J. O. (2007). Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9, 654-659. doi: 10.1038/ncb1596.
    • (2007) Nat. Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 79
    • 84860858416 scopus 로고    scopus 로고
    • Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
    • Vlassov, A. V., Magdaleno, S., Setterquist, R., and Conrad, R. (2012). Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta 1820, 940-948. doi: 10.1016/j.bbagen.2012.03.017.
    • (2012) Biochim. Biophys. Acta , vol.1820 , pp. 940-948
    • Vlassov, A.V.1    Magdaleno, S.2    Setterquist, R.3    Conrad, R.4
  • 80
    • 77954724494 scopus 로고    scopus 로고
    • Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells
    • Vrijsen, K., Sluijter, J., Schuchardt, M., Van Balkom, B., Noort, W., Chamuleau, S., et al. (2010). Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells. J. Cell. Mol. Med. 14, 1064-1070. doi: 10.1111/j.1582-4934.2010.01081.x.
    • (2010) J. Cell. Mol. Med , vol.14 , pp. 1064-1070
    • Vrijsen, K.1    Sluijter, J.2    Schuchardt, M.3    Van Balkom, B.4    Noort, W.5    Chamuleau, S.6
  • 81
    • 84937949535 scopus 로고    scopus 로고
    • Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability
    • Walter, M., Kohli, N., Major, T., Fuller, H., Wright, K., Kuiper, J., et al. (2015). Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. J. Stem Cells Regen. Med. 11, 18-24.
    • (2015) J. Stem Cells Regen. Med , vol.11 , pp. 18-24
    • Walter, M.1    Kohli, N.2    Major, T.3    Fuller, H.4    Wright, K.5    Kuiper, J.6
  • 82
    • 84895779700 scopus 로고    scopus 로고
    • Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer
    • Wang, M., Zhao, C., Shi, H., Zhang, B., Zhang, L., Zhang, X., et al. (2014). Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer. Br. J. Cancer 110, 1199-1210. doi: 10.1038/bjc.2014.14.
    • (2014) Br. J. Cancer , vol.110 , pp. 1199-1210
    • Wang, M.1    Zhao, C.2    Shi, H.3    Zhang, B.4    Zhang, L.5    Zhang, X.6
  • 83
    • 84890559123 scopus 로고    scopus 로고
    • Role of mesenchymal stem cells in bone regeneration and fracture repair: a review
    • Wang, X., Wang, Y., Gou, W., Lu, Q., Peng, J., and Lu, S. (2013). Role of mesenchymal stem cells in bone regeneration and fracture repair: a review. Int. Orthop. 37, 2491-2498. doi: 10.1007/s00264-013-2059-2.
    • (2013) Int. Orthop , vol.37 , pp. 2491-2498
    • Wang, X.1    Wang, Y.2    Gou, W.3    Lu, Q.4    Peng, J.5    Lu, S.6
  • 84
    • 77953861412 scopus 로고    scopus 로고
    • The POU domain transcription factor POU3F1 is an important intrinsic regulator of GDNF-induced survival and self-renewal of mouse spermatogonial stem cells
    • Wu, X., Oatley, J. M., Oatley, M. J., Kaucher, A. V., Avarbock, M. R., and Brinster, R. L. (2010). The POU domain transcription factor POU3F1 is an important intrinsic regulator of GDNF-induced survival and self-renewal of mouse spermatogonial stem cells. Biol. Reprod. 82, 1103-1111. doi: 10.1095/biolreprod.109.083097.
    • (2010) Biol. Reprod , vol.82 , pp. 1103-1111
    • Wu, X.1    Oatley, J.M.2    Oatley, M.J.3    Kaucher, A.V.4    Avarbock, M.R.5    Brinster, R.L.6
  • 85
    • 84862867271 scopus 로고    scopus 로고
    • Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth
    • Xin, H., Li, Y., Buller, B., Katakowski, M., Zhang, Y., Wang, X., et al. (2012). Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 30, 1556-1564. doi: 10.1002/stem.1129.
    • (2012) Stem Cells , vol.30 , pp. 1556-1564
    • Xin, H.1    Li, Y.2    Buller, B.3    Katakowski, M.4    Zhang, Y.5    Wang, X.6
  • 86
    • 59849123877 scopus 로고    scopus 로고
    • Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo
    • Yan, Y., Xu, W., Qian, H., Si, Y., Zhu, W., Cao, H., et al. (2009). Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int. 29, 356-365. doi: 10.1111/j.1478-3231.2008.01855.x.
    • (2009) Liver Int , vol.29 , pp. 356-365
    • Yan, Y.1    Xu, W.2    Qian, H.3    Si, Y.4    Zhu, W.5    Cao, H.6
  • 87
    • 79960984966 scopus 로고    scopus 로고
    • Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model
    • Yang, C., Kim, S.-H., Bianco, N. R., and Robbins, P. D. (2011). Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model. PLoS ONE 6:e22517. doi: 10.1371/journal.pone.0022517.
    • (2011) PLoS ONE , vol.6
    • Yang, C.1    Kim, S.-H.2    Bianco, N.R.3    Robbins, P.D.4
  • 88
    • 84949058412 scopus 로고    scopus 로고
    • Extracellular vesicles derived from bone marrow mesenchymal stem cells protect against experimental colitis via attenuating colon inflammation, oxidative stress and apoptosis
    • Yang, J., Liu, X. X., Fan, H., Tang, Q., Shou, Z. X., Zuo, D. M., et al. (2015). Extracellular vesicles derived from bone marrow mesenchymal stem cells protect against experimental colitis via attenuating colon inflammation, oxidative stress and apoptosis. PLoS ONE 10:e0140551. doi: 10.1371/journal.pone.0140551.
    • (2015) PLoS ONE , vol.10
    • Yang, J.1    Liu, X.X.2    Fan, H.3    Tang, Q.4    Shou, Z.X.5    Zuo, D.M.6
  • 89
    • 84863924849 scopus 로고    scopus 로고
    • Discovery and characterization of novel microRNAs during endothelial differentiation of human embryonic stem cells
    • Yoo, J. K., Kim, J., Choi, S. J., Noh, H. M., Kwon, Y. D., Yoo, H., et al. (2011). Discovery and characterization of novel microRNAs during endothelial differentiation of human embryonic stem cells. Stem Cells Dev. 21, 2049-2057. doi: 10.1089/scd.2011.0500.
    • (2011) Stem Cells Dev , vol.21 , pp. 2049-2057
    • Yoo, J.K.1    Kim, J.2    Choi, S.J.3    Noh, H.M.4    Kwon, Y.D.5    Yoo, H.6
  • 90
    • 84939253225 scopus 로고    scopus 로고
    • Exosomes in development, metastasis and drug resistance of breast cancer
    • Yu, D. D., Wu, Y., Shen, H. Y., Lv, M. M., Chen, W. X., Zhang, X. H., et al. (2015). Exosomes in development, metastasis and drug resistance of breast cancer. Cancer Sci. 106, 959-964. doi: 10.1111/cas.12715.
    • (2015) Cancer Sci , vol.106 , pp. 959-964
    • Yu, D.D.1    Wu, Y.2    Shen, H.Y.3    Lv, M.M.4    Chen, W.X.5    Zhang, X.H.6
  • 92
    • 84930424126 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/beta-catenin pathway
    • Zhang, B., Wu, X., Zhang, X., Sun, Y., Yan, Y., Shi, H., et al. (2015). Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/beta-catenin pathway. Stem Cells Transl. Med. 4, 513-522. doi: 10.5966/sctm.2014-0267.
    • (2015) Stem Cells Transl. Med , vol.4 , pp. 513-522
    • Zhang, B.1    Wu, X.2    Zhang, X.3    Sun, Y.4    Yan, Y.5    Shi, H.6
  • 93
    • 84876875077 scopus 로고    scopus 로고
    • Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro
    • Zhou, Y., Xu, H., Xu, W., Wang, B., Wu, H., Tao, Y., et al. (2013). Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro. Stem Cell Res. Ther. 4:34. doi: 10.1186/scrt194.
    • (2013) Stem Cell Res. Ther , vol.4 , pp. 34
    • Zhou, Y.1    Xu, H.2    Xu, W.3    Wang, B.4    Wu, H.5    Tao, Y.6
  • 94
    • 81955167406 scopus 로고    scopus 로고
    • Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
    • Zhu, W., Huang, L., Li, Y., Zhang, X., Gu, J., Yan, Y., et al. (2012). Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Lett. 315, 28-37. doi: 10.1016/j.canlet.2011.10.002.
    • (2012) Cancer Lett , vol.315 , pp. 28-37
    • Zhu, W.1    Huang, L.2    Li, Y.3    Zhang, X.4    Gu, J.5    Yan, Y.6
  • 95
    • 84982291499 scopus 로고    scopus 로고
    • Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
    • Zomer, H. D., Vidane, A. S., Gonçalves, N. N., and Ambrósio, C. E. (2015). Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives. Stem Cells Cloning 8, 125. doi: 10.2147/SCCAA.S88036.
    • (2015) Stem Cells Cloning , vol.8 , pp. 125
    • Zomer, H.D.1    Vidane, A.S.2    Gonçalves, N.N.3    Ambrósio, C.E.4


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