Paracrine effect of inflammatory cytokine-activated bone marrow mesenchymal stem cells and its role in osteoblast function

Journal of Bioscience and Bioengineering

Volumn 121, Issue 2, 2016, Pages 213-219

  Li, Cheng ^a,b   Li, Guoqiang ^a,b   Liu, Meng ^b   Zhou, Tiantian ^b   Zhou, Haibin ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

Bone marrow mesenchymal stem cells; Bone regeneration; Inflammatory cytokine; Osteogenesis; Paracrine

Indexed keywords

BONE; FLOWCHARTING; POLYMERASE CHAIN REACTION; STEM CELLS; TISSUE REGENERATION;

BONE MARROW MESENCHYMAL STEM CELLS; BONE REGENERATION; CYTOKINES; OSTEOGENESIS; PARACRINE;

CELL CULTURE;

ALIZARIN; CALCIUM; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; AUTACOID; CONDITIONED MEDIUM; TUMOR NECROSIS FACTOR;

ARTICLE; BONE DEVELOPMENT; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE MINERALIZATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INFLAMMATION; OSTEOBLAST; PARACRINE SIGNALING; POLYMERASE CHAIN REACTION; BONE MARROW CELL; BONE REGENERATION; CELL DIFFERENTIATION; CELL LINE; CELL MOTION; CONDITIONED MEDIUM; CYTOLOGY; DRUG EFFECTS; MESENCHYMAL STROMA CELL; METABOLISM; PHARMACOLOGY; SECRETION (PROCESS);

BONE MARROW CELLS; BONE REGENERATION; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CULTURE MEDIA, CONDITIONED; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; PARACRINE COMMUNICATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84953371563     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2015.05.017     Document Type: Article

References (42)

1. Wakitani S., Saito T., Caplan A.I. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995, 18:1417-1426.
2. Woodbury D., Schwarz E.J., Prockop D.J., Black I.B. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 2000, 61:364-370.
3. Reyes M., Lund T., Lenvik T., Aguiar D., Koodie L., Verfaillie C.M. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 2001, 98:2615-2625.
4. Horwitz E.M., Le Blanc K., Dominici M., Mueller I., Slaper-Cortenbach I., Marini F.C., Deans R.J., Krause D.S., Keating A. Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy 2005, 7:393-395.
5. Kinnaird T., Stabile E., Burnett M.S., Lee C.W., Barr S., Fuchs S., Epstein S.E. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circulation Res. 2004, 94:678-685.
6. Zhang M., Mal N., Kiedrowski M., Chacko M., Askari A.T., Popovic Z.B., Koc O.N., Penn M.S. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J. 2007, 21:3197-3207.
7. Sasaki M., Abe R., Fujita Y., Ando S., Inokuma D., Shimizu H. Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J. Immunol. 2008, 180:2581-2587.
8. Matsumoto T., Cooper G.M., Gharaibeh B., Meszaros L.B., Li G., Usas A., Fu F.H., Huard J. Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1. Arthritis Rheum. 2009, 60:1390-1405.
9. Murphy J.M., Fink D.J., Hunziker E.B., Barry F.P. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 2003, 48:3464-3474.
10. Kim H.J., Lee J.H., Kim S.H. Therapeutic effects of human mesenchymal stem cells on traumatic brain injury in rats: secretion of neurotrophic factors and inhibition of apoptosis. J. Neurotrauma 2010, 27:131-138.
11. Wei X., Du Z., Zhao L., Feng D., Wei G., He Y., Tan J., Lee W.H., Hampel H., Dodel R., other 4 authors IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells 2009, 27:478-488.
12. Rosova I., Dao M., Capoccia B., Link D., Nolta J.A. Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells 2008, 26:2173-2182.
13. Ren G., Zhang L., Zhao X., Xu G., Zhang Y., Roberts A.I., Zhao R.C., Shi Y. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008, 2:141-150.
14. Shi Y., Hu G., Su J., Li W., Chen Q., Shou P., Xu C., Chen X., Huang Y., Zhu Z., other 4 authors Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010, 20:510-518.
15. English K. Mechanisms of mesenchymal stromal cell immunomodulation. Immunol. Cell Biol. 2013, 91:19-26.
16. Polchert D., Sobinsky J., Douglas G., Kidd M., Moadsiri A., Reina E., Genrich K., Mehrotra S., Setty S., Smith B., Bartholomew A. IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease. Eur. J. Immunol. 2008, 38:1745-1755.
17. Augello A., Tasso R., Negrini S.M., Amateis A., Indiveri F., Cancedda R., Pennesi G. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur. J. Immunol. 2005, 35:1482-1490.
18. Lu Z., Wang G., Dunstan C.R., Zreiqat H. Short-term exposure to tumor necrosis factor-alpha enables human osteoblasts to direct adipose tissue-derived mesenchymal stem cells into osteogenic differentiation. Stem Cells Dev. 2012, 21:2420-2429.
19. Hess K., Ushmorov A., Fiedler J., Brenner R.E., Wirth T. TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway. Bone 2009, 45:367-376.
20. Horwitz E.M., Prockop D.J., Fitzpatrick L.A., Koo W.W., Gordon P.L., Neel M., Sussman M., Orchard P., Marx J.C., Pyeritz R.E., Brenner M.K. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat. Med. 1999, 5:309-313.
21. Bang O.Y., Lee J.S., Lee P.H., Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann. Neurol. 2005, 57:874-882.
22. Ringden O., Uzunel M., Rasmusson I., Remberger M., Sundberg B., Lonnies H., Marschall H.U., Dlugosz A., Szakos A., Hassan Z., other 4 authors Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006, 81:1390-1397.
23. Burlacu A., Grigorescu G., Rosca A.M., Preda M.B., Simionescu M. Factors secreted by mesenchymal stem cells and endothelial progenitor cells have complementary effects on angiogenesis in vitro. Stem Cells Dev. 2013, 22:643-653.
24. Caplan A.I., Dennis J.E. Mesenchymal stem cells as trophic mediators. J. Cell. Biochem. 2006, 98:1076-1084.
25. Chen L., Tredget E.E., Wu P.Y., Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PloS One 2008, 3:e1886.
26. Di Nicola M., Carlo-Stella C., Magni M., Milanesi M., Longoni P.D., Matteucci P., Grisanti S., Gianni A.M. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002, 99:3838-3843.
27. Krampera M., Glennie S., Dyson J., Scott D., Laylor R., Simpson E., Dazzi F. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003, 101:3722-3729.
28. Nauta A.J., Kruisselbrink A.B., Lurvink E., Willemze R., Fibbe W.E. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J. Immunol. 2006, 177:2080-2087.
29. Uccelli A., Moretta L., Pistoia V. Immunoregulatory function of mesenchymal stem cells. Eur. J. Immunol. 2006, 36:2566-2573.
30. Liu Y., Han Z.P., Zhang S.S., Jing Y.Y., Bu X.X., Wang C.Y., Sun K., Jiang G.C., Zhao X., Li R., other 4 authors Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer. J. Biol. Chem. 2011, 286:25007-25015.
31. Linero I., Chaparro O. Paracrine effect of mesenchymal stem cells derived from human adipose tissue in bone regeneration. PloS One 2014, 9:e107001.
32. Tsai S.W., Liou H.M., Lin C.J., Kuo K.L., Hung Y.S., Weng R.C., Hsu F.Y. MG63 osteoblast-like cells exhibit different behavior when grown on electrospun collagen matrix versus electrospun gelatin matrix. PloS One 2012, 7:e31200.
33. van den Beucken J.J., Walboomers X.F., Boerman O.C., Vos M.R., Sommerdijk N.A., Hayakawa T., Fukushima T., Okahata Y., Nolte R.J., Jansen J.A. Functionalization of multilayered DNA-coatings with bone morphogenetic protein 2. J. Control. Release 2006, 113:63-72.
34. Frank O., Heim M., Jakob M., Barbero A., Schafer D., Bendik I., Dick W., Heberer M., Martin I. Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro. J. Cell. Biochem. 2002, 85:737-746.
35. Tsai S.W., Hsu F.Y., Chen P.L. Beads of collagen-nanohydroxyapatite composites prepared by a biomimetic process and the effects of their surface texture on cellular behavior in MG63 osteoblast-like cells. Acta Biomater. 2008, 4:1332-1341.
36. Midy V., Plouet J. Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts. Biochem. Biophys. Res. Commun. 1994, 199:380-386.
37. Zhao L., Jiang S., Hantash B.M. Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells. Tissue Eng. Part A 2010, 16:725-733.
38. Chen G., Deng C., Li Y.P. TGF-beta and BMP signaling in osteoblast differentiation and bone formation. Int. J. Biological Sci. 2012, 8:272-288.
39. Hoch A.I., Binder B.Y., Genetos D.C., Leach J.K. Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PloS One 2012, 7:e35579.
40. Chen K., Perez-Stable C., D'Ippolito G., Schiller P.C., Roos B.A., Howard G.A. Human bone marrow-derived stem cell proliferation is inhibited by hepatocyte growth factor via increasing the cell cycle inhibitors p53, p21 and p27. Bone 2011, 49:1194-1204.
41. Liu Y., Wang T., Yan J., Jiagbogu N., Heideman D.A., Canfield A.E., Alexander M.Y. HGF/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro. Atherosclerosis 2011, 219:440-447.
42. Scheller J., Chalaris A., Schmidt-Arras D., Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim. Biophys. Acta 2011, 1813:878-888.