Dihydroartemisinin restricts hepatic stellate cell contraction via an FXR-S1PR2-dependent mechanism

IUBMB Life

Volumn 68, Issue 5, 2016, Pages 376-387

  Xu, Wenxuan ^a   Lu, Chunfeng ^a   Zhang, Feng ^a   Shao, Jiangjuan ^a   Zheng, Shizhong ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

contraction; dihydroartemisinin; FXR; hepatic stellate cell; portal hypertension; S1PR2

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALCIUM ION; DIHYDROARTEMISININ; FARNESOID X RECEPTOR; FIBRONECTIN; MESSENGER RNA; MYOSIN LIGHT CHAIN; PROCOLLAGEN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; UNCLASSIFIED DRUG; ARTEMISININ DERIVATIVE; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR;

ACTIN FILAMENT; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LIVER FIBROSIS; PORTAL HYPERTENSION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING; CELL LINE; DRUG EFFECTS; HEPATIC STELLATE CELL; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; SIGNAL TRANSDUCTION;

ARTEMISININS; CELL LINE; DRUG EVALUATION, PRECLINICAL; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION;

EID: 84962642398     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1492     Document Type: Article

References (47)

1. Hernandez-Gea, V., and, Friedman, S. L., (2011) Pathogenesis of liver fibrosis. Annu. Rev. Pathol. 6, 425-456.
2. Iwakiri, Y., Grisham, M., and, Shah, V., (2008) Vascular biology and pathobiology of the liver: report of a single-topic symposium. Hepatology 47, 1754-1763.
3. Thabut, D., and, Shah, V., (2010) Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension? J. Hepatol. 53, 976-980.
4. Fiorucci, S., Antonelli, E., Rizzo, G., Renga, B., Mencarelli, A., et al., (2004) The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology 127, 1497-1512.
5. Liu, Y., Saiyan, S., Men, T. Y., Gao, H. Y., Wen, C., et al., (2013) Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. J. Pathol. 230, 365-376.
6. Li, J., Kuruba, R., Wilson, A., Gao, X., Zhang, Y., et al., (2010) Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand. PLoS One 5, e13955.
7. Verbeke, L., Farre, R., Trebicka, J., Komuta, M., Roskams, T., et al., (2014) Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats. Hepatology 59, 2286-2298.
8. Ikeda, H., Nagashima, K., Yanase, M., Tomiya, T., Arai, M., et al., (2004) Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation. Biochem. Biophys. Res. Commun. 320, 754-759.
9. Kageyama, Y., Ikeda, H., Watanabe, N., Nagamine, M., Kusumoto, Y., et al., (2012) Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents. Hepatology 56, 1427-1438.
10. Zhang, X. G., Li, G. X., Zhao, S. S., Xu, F. L., Wang, Y. H., et al., (2014) A review of dihydroartemisinin as another gift from traditional Chinese medicine not only for malaria control but also for schistosomiasis control. Parasitol. Res. 113, 1769-1773.
11. Yang, D., Yuan, W., Lv, C., Li, N., Liu, T., et al., (2015) Dihydroartemisinin suppresses inflammation and fibrosis in bleomycine-induced pulmonary fibrosis in rats. Int. J. Clin. Exp. Pathol. 8, 1270-1281.
12. Lu, C., Jiang, Y., Zhang, F., Shao, J., Wu, L., et al., (2015) Tetramethylpyrazine prevents ethanol-induced hepatocyte injury via activation of nuclear factor erythroid 2-related factor 2. Life Sci. 141, 119-127.
13. Sohail, M. A., Hashmi, A. Z., Hakim, W., Watanabe, A., Zipprich, A., et al., (2009) Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatology 49, 185-194.
14. Lu, C., Zhang, F., Xu, W., Wu, X., Lian, N., et al., (2015) Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. IUBMB Life 67, 645-658.
15. Wu, X., Zhang, F., Xiong, X., Lu, C., Lian, N., et al., (2015) Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP3 inflammasome pathway. IUBMB Life 67, 312-321.
16. Thalheimer, U., Bosch, J., and, Burroughs, A. K., (2007) How to prevent varices from bleeding: shades of grey-the case for nonselective β blockers. Gastroenterology 133, 2029-2036.
17. Fernandez, M., (2015) Molecular pathophysiology of portal hypertension. Hepatology 61, 1406-1415.
18. Fallowfield, J. A., Hayden, A. L., Snowdon, V. K., Aucott, R. L., Stutchfield, B. M., et al., (2014) Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo. Hepatology 59, 1492-1504.
19. Vanwijngaerden, Y. M., Wauters, J., Langouche, L., Vander Perre, S., Liddle, C., et al., (2011) Critical illness evokes elevated circulating bile acids related to altered hepatic transporter and nuclear receptor expression. Hepatology 54, 1741-1752.
20. Xiong, X., Wang, X., Lu, Y., Wang, E., Zhang, Z., et al., (2014) Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice. J. Hepatol. 60, 847-854.
21. Meng, Z., Wang, X., Gan, Y., Zhang, Y., Zhou, H., et al., (2012) Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J. Hepatol. 57, 1004-1012.
22. Fausther, M., and, Dranoff, J. A., (2011) New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout mice. J. Hepatol. 55, 939-940.
23. Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., et al., (2006) Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 312, 233-236.
24. Jin, L., Wang, R., Zhu, Y., Zheng, W., Han, Y., et al., (2015) Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. Sci. Rep. 5, 17288.
25. Lefebvre, P., and, Staels, B., (2014) Failing FXR expression in the liver links aging to hepatic steatosis. J. Hepatol. 60, 689-690.
26. Liu, N., Meng, Z., Lou, G., Zhou, W., Wang, X., et al., (2012) Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression. Mol. Endocrinol. 26, 775-785.
27. Verbeke, L., Farre, R., Verbinnen, B., Covens, K., Vanuytsel, T., et al., (2015) The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats. Am. J. Pathol. 185, 409-419.
28. Ilagan, R., Guthrie, K., Quinlan, S., Rapoport, H. S., Jones, S., et al., (2010) Linear measurement of cell contraction in a capillary collagen gel system. Biotechniques 48, 153-155.
29. Liu, Y., Ko, J. A., Yanai, R., Kimura, K., Chikama, T., et al., (2008) Induction by latanoprost of collagen gel contraction mediated by human tenon fibroblasts: role of intracellular signaling molecules. Invest. Ophthalmol. Vis. Sci. 49, 1429-1436.
30. Liu, Z., van Grunsven, L. A., Van Rossen, E., Schroyen, B., Timmermans, J. P., et al., (2010) Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells. Br. J. Pharmacol. 159, 304-315.
31. Xu, H., Zhou, Y., Lu, C., Ping, J., and, Xu, L. M., (2012) Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway. Lab. Invest. 92, 1738-1748.
32. Kharbanda, K. K., Rogers, D. D., II, Wyatt, T. A., Sorrell, M. F., and, Tuma, D. J., (2004) Transforming growth factor-β induces contraction of activated hepatic stellate cells. J. Hepatol. 41, 60-66.
33. Hocking, D. C., Sottile, J., and, Langenbach, K. J., (2000) Stimulation of integrin-mediated cell contractility by fibronectin polymerization. J. Biol. Chem. 275, 10673-10682.
34. Ikeda, H., Watanabe, N., Ishii, I., Shimosawa, T., Kume, Y., et al., (2009) Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J. Lipid Res. 50, 556-564.
35. Li, C., Zheng, S., You, H., Liu, X., Lin, M., et al., (2011) Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. J. Hepatol. 54, 1205-1213.
36. Liu, X., Yue, S., Li, C., Yang, L., You, H., et al., (2011) Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation. J. Cell. Physiol. 226, 2370-2377.
37. Wang, X. Q., Mao, L. J., Fang, Q. H., Kobayashi, T., Kim, H. J., et al., (2014) Sphingosylphosphorylcholine induces α-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P2 receptor and Rho/Rho-kinase pathway. Prostaglandins Other Lipid Mediat. 108, 23-30.
38. Zhou, H., and, Hylemon, P. B., (2014) Bile acids are nutrient signaling hormones. Steroids 86, 62-68.
39. Kwong, E., Li, Y., Hylemon, P. B., and, Zhou, H., (2015) Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism. Acta Pharm. Sin. B 5, 151-157.
40. Copple, B. L., and, Li, T., (2015) Pharmacology of bile acid receptors: evolution of bile acids from simple detergents to complex signaling molecules. Pharmacol. Res. 104, 9-21.
41. Singh, N., Yadav, M., Singh, A. K., Kumar, H., Dwivedi, S. K., et al., (2014) Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors. Mol. Endocrinol. 28, 659-673.
42. 2+ and rho signaling pathways: two paths to hepatic stellate cell contraction. Hepatology 33, 1007-1008.
43. 2+-sensitization pathways. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G1010-G1021.
44. 2+-dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G556-G564.
45. 2+ sensitization in rabbit smooth muscle. J. Physiol. 546, 879-889.
46. Velasco, G., Armstrong, C., Morrice, N., Frame, S., and, Cohen, P., (2002) Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin. FEBS Lett. 527, 101-104.
47. Qiao, Y. N., He, W. Q., Chen, C. P., Zhang, C. H., Zhao, W., et al., (2014) Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. J. Biol. Chem. 289, 22512-22523.