A review of dihydroartemisinin as another gift from traditional Chinese medicine not only for malaria control but also for schistosomiasis control

Parasitology Research

Volumn 113, Issue 5, 2014, Pages 1769-1773

  Zhang, Xu Guang ^a   Li, Gui Xin ^a   Zhao, Shu Shun ^a   Xu, Fu Liang ^a   Wang, Yun Hai ^a   Wang, Wei ^b,c  

^a WEIFANG MEDICAL UNIVERSITY   (China)

^b JIANGSU INSTITUTE OF PARASITIC DISEASES   (China)

^c BEIJING HOSPITAL   (China)

Author keywords

Artemisinin; Dihydroartemisinin; Malaria; Schistosomiasis; Traditional Chinese medicine

Indexed keywords

AMODIAQUINE PLUS ARTESUNATE; ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; ARTESUNATE PLUS MEFLOQUINE; DIHYDROARTEMISININ; PRAZIQUANTEL; PYRIMETHAMINE PLUS SULFADOXINE;

ARTICLE; CHINESE MEDICINE; DOSE RESPONSE; ECHINOCOCCUS; GIARDIA LAMBLIA; IN VIVO STUDY; LEISHMANIA; MALARIA CONTROL; MALARIA FALCIPARUM; MULTIPLE CANCER; PLASMODIUM FALCIPARUM; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; SCHISTOSOMA JAPONICUM; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHISTOSOMULUM; SINGLE DRUG DOSE; TOXOPLASMA GONDII; TRICHOMONAS VAGINALIS;

ANIMALS; ANTIMALARIALS; ARTEMISININS; DRUGS, CHINESE HERBAL; FEMALE; MALARIA, FALCIPARUM; MICE; PRAZIQUANTEL; SCHISTOSOMIASIS JAPONICA; SCHISTOSOMICIDES;

EID: 84901325010     PISSN: 09320113     EISSN: 14321955     Source Type: Journal    
DOI: 10.1007/s00436-014-3822-z     Document Type: Article

References (57)

1. Adjuik M, Babiker A, Garner P, Olliaro P, Taylor W, White N; International Artemisinin Study Group (2004) Artesunate combinations for treatment of malaria: meta-analysis. Lancet 363:9-17 (Pubitemid 38076919)
2. Ansari MT, Saify ZS, Sultana N, Ahmad I, Saeed-Ul-Hassan S, Tariq I, Khanum M (2013) Malaria and artemisinin derivatives: an updated review. Mini Rev Med Chem 1:1879-1902
3. Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G (2009) Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis 49:1629-1637
4. Aung W, Sogawa C, Furukawa T, Saga T (2011) Anticancer effect of dihydroartemisinin (DHA) in a pancreatic tumormodel evaluated by conventional methods and optical imaging. Anticancer Res 31:1549-1558
5. Ba Q, Zhou N, Duan J, Chen T, Hao M, Yang X, Li J, Yin J, Chu R, Wang H (2012) Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. PLoS One 7:e42703
6. Chen DJ, Fu LF, Shao PP, Wu FZ, Fan CZ, Shu H, Ren CX, Sheng XL (1980) Experimental studies on antischistosomal activity of qinghaosu. Chin Med J 60:422-425
7. Chen H, Sun B, Pan S, Jiang H, Sun X (2009) Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo. Anticancer Drugs 20:131-140
8. Douglas NM, Anstey NM, Angus BJ, Nosten F, Price RN (2010) Artemisinin combination therapy for vivax malaria. Lancet Infect Dis 10:405-416
9. Duffy PE, Mutabingwa TK (2006) Artemisinin combination therapies. Lancet 367:2037-2039
10. Gargano N, Ubben D, Tommasini S, Bacchieri A, Corsi M, Bhattacharyya PC, Rao BH, Dubashi N, Dev V, Ghosh SK, Kumar A, Srivastava B, Valecha N (2012) Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India. Malar J 11:233
11. Giha HA (2010) Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope. Parasitol Res 106:549-552
12. Hua HY, Liang YS, Zhang Y, Wei JF, Guo HX (2010) The sensitivity of artesunate against Schistosoma japonicum decreased after 10 years of use in China. Parasitol Res 107:873-878
13. Ji Y, Zhang YC, Pei LB, Shi LL, Yan JL, Ma XH (2011) Anti-tumor effects of dihydroartemisinin on human osteosarcoma. Mol Cell Biochem 351:99-108
14. Jordan P, Webbe G, Sturrock RF (1993) Human schistosomiasis. CAB International, Wallingford
15. Ke OY, Krug EC, Marr JJ, Berens RL (1990) Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives. Antimicrob Agents Chemother 34:1961-1965 (Pubitemid 20290297)
16. Keiser J, Utzinger J (2012) Antimalarials in the treatment of schistosomiasis. Curr Pharm Des 18:3531-3538
17. Klayman DL (1985) Qinghaosu (artemisinin). An antimalarial drug from China. Science 228:1049-1055
18. Leang R, Barrette A, Bouth DM, Menard D, Abdur R, Duong S, Ringwald P (2013) Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010. Antimicrob Agents Chemother 57:818-826
19. Li GQ, Guo XB, Fu LC, Jian HX, Wang XH (1994) Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Trans R Soc Trop Med Hyg 88:S5-S6
20. Li S, Wu L, Liu Z, Hu L, Xu P, Xuan Y, Liu Y, Liu X, Fan J (1996) Studies on prophylactic effect of artesunate on schistosomiasis japonica. Chin Med J (Engl) 109:848-853 (Pubitemid 26420766)
21. Li YS, Chen HG, He HB, Hou XY, Ellis M, McManus DP (2005) A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China. Acta Trop 96:184-190 (Pubitemid 41463749)
22. Li HJ, Wang W, Qu GL, Tao YH, Xing YT, Li YZ, Wei JY, Dai JR, Liang YS (2011a) In-vivo activity of dihydroartemisinin against Schistosoma japonicum. Ann Trop Med Parasitol 105:181-185
23. Li HJ, Wang W, Tao YH, Qu GL, Xing YT, Li YZ, Wei JY, Dai JR, Liang YS (2011b) Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice. Ann Trop Med Parasitol 105:329-333
24. Li HJ, Wang W, Li YZ, Qu GL, Xing YT, Tao YH, Wei JY, Dai JR, Liang YS (2011c) Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum. Parasitol Res 109:515-519
25. Li HJ, Liang YS, Dai JR, Wang W, Qu GL, Li YZ, Xing YT, Tao YH, Qian K, Jia Y, Yang ZK, Wei JY (2011d) Studies on resistance of Schistosoma to praziquantel XIV Experimental comparison of susceptibility to praziquantel between PZQ-resistant isolates and PZQ-susceptible isolates of Schistosoma japonicum in stages of adult worms, miracidia and cercariae. Chin J Schisto Control 23:611-619
26. Li HJ, Wang W, Qu GL, Li YZ, Tao YH, Xing YT, Wang XT, Dai Y, Wei JY, Dai JR, Coles GC, Liang YS (2012) Effect of the in vivo activity of dihydroartemisinin against Schistosoma mansoni infection in mice. Parasitol Res 110:1727-1732
27. Li HJ, Wang W, Li YZ, Qu GL, Xing YT, Qian K, Jia Y, Yang ZK, Qian YL, Dai JR, Liang YS (2013) In vivo activity of dihydroartemisinin against Schistosoma mansoni schistosomula in mice. Southeast Asian J Trop Med Public Health 44:379-387
28. Li HJ, Xu FL, Wang YH, Yi ZJ, Wang W (2014) Dihydroartemisinin: a new story of an old drug against Schistosoma mansoni infection. Parasitol Res 113:239-241
29. Liang YS, Li HJ, Dai JR, Wang W, Qu GL, Tao YH, Xing YT, Li YZ, Qian K, Wei JY (2011) Studies on resistance of Schistosoma to praziquantel XIII Resistance of Schistosoma japonicum to praziquantel is experimentally induced in laboratory. Chin J Schisto Control 23:605-610
30. Liu R, Dong HF, Guo Y, Zhao QP, Jiang MS (2011) Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis. Parasit Vectors 4:201
31. Liu R, Dong HF, Jiang MS (2012a) The sensitivity of artesunate against Schistosoma japonicum decreased after 10 years of use in China? Parasitol Res 110:1563-1564
32. Liu R, Dong HF, Jiang MS (2012b) Artemisinin: the gifts from traditional Chinese medicine not only for malaria control but also for schistosomiasis control. Parasitol Res 110:2071-2074
33. Liu Y, Wang W, Xu J, Li L, Dong Q, Shi Q, Zuo G, Zhou L, Weng Y, Tang M, He T, Luo J (2013) Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/β-catenin signaling. Oncol Rep 30:1723-1730
34. Lu DM, Hu XS, Ma Y, Wang YJ, Chen JP (1999) In vitro activity of dihydroartemisinin against Leishmania donovani promastigotes. Chin J Parasit Dis Control 12:23-25
35. Meshnick SR (2002) Artemisinin: mechanisms of action, resistance and toxicity. Int J Parasitol 32:1655-1660
36. Miller LH, Su X (2011) Artemisinin: discovery from the Chinese herbal garden. Cell 146:855-858
37. Naing C, Mak JW, Aung K, Wong JY (2013) Efficacy and safety of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in endemic countries: meta-analysis of randomised controlled studies. Trans R Soc Trop Med Hyg 107:65-73
38. Pérez del Villar L, Burguillo FJ, López-Abán J, Muro A (2012) Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis. PLoS One 7:e45867
39. Seto EY, Wong BK, Lu D, Zhong B (2011) Human schistosomiasis resistance to praziquantel in China: should we be worried? Am J Trop Med Hyg 85:74-82
40. Spicher M, Roethlisberger C, Lany C, Stadelmann B, Keiser J, Ortega-Mora LM, Gottstein B, Hemphill A (2008) In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives. Antimicrob Agents Chemother 52:3447-3450
41. Sun H, Meng X, Han J, Zhang Z, Wang B, Bai X, Zhang X (2013) Anti-cancer activity of DHA on gastric cancer-an in vitro and in vivo study. Tumour Biol 34:3791-3800
42. Tian XF, Lu SQ, Liu YM, Wang FY, Huang S (2005) Effect of dihydroartemisinin on ultrastructure of Giardia lamblia in vitro. Chin J Parasitol Parasit Dis 23:292-295
43. Tian XF, Shen HE, Li J, Chen Y, Yang ZH, Lu SQ (2010) The effects of dihydroartemisinin on Giardia lamblia morphology and cell cycle in vitro. Parasitol Res 107:369-375
44. Tran TH, Dolecek C, Pham PM, Nguyen TD, Nguyen TT, Le HT, Dong TH, Tran TT, Stepniewska K, White NJ, Farrar J (2004) Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomized clinical trial. Lancet 363:18-22 (Pubitemid 38076920)
45. Tu YY (2011) The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nature Med 17:1217-1220
46. Wang W, Dai JR, Li HJ, Shen XH, Liang YS (2010) Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China. Parasitology 137:1905-1912
47. Wang W, Wang L, Liang YS (2012a) Susceptibility or resistance of praziquantel in human schistosomiasis: a review. Parasitol Res 111:1871-1877
48. Wang W, Dai JR, Li HJ, Shen XH, Liang YS (2012b) The sensitivity of Schistosoma japonicum to praziquantel: a field evaluation in areas with low endemicity of China. Am J Trop Med Hyg 86:834-836
49. Wang W, Li HJ, Qu GL, Xing YT, Yang ZK, Dai JR, Liang YS (2014) Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum? Parasitol Res 113:223-228
50. WHO (2010) Guidelines for the treatment of malaria, Second editionth edn. World Health Organization, Geneva, Available at http://whqlibdoc.who.int/ publications/2010/9789241547925-eng.pdf. Accessed on 14 October 2013
51. Wu W, Huang Y (2013) Application of praziquantel in schistosomiasis japonica control strategies in China. Parasitol Res 112:909-915
52. Wu LJ, Xu PS, Yang MJ, Fan JT, Li SW(1998) Study on the interaction of artesunate and praziquantel in the treatment of schistosomiasis. Chin J Schisto Control 10:65-68
53. Wu B, Hu K, Li S, Zhu J, Gu L, Shen H, Hambly BD, Bao S, Di W (2012) Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer. Oncol Rep 7:101-108
54. Xu JB, Gao XZ (2004) Effect of dihydroartemisinin on the ultrastructure of Trichomonas vaginalis trophozoites in vitro. Chin J Parasit Dis Control 17:12-14
55. Ye B, Chen YT, Liu HW (2000) The effect of dihydroartemisinin on Pneumocystis carinii observed by electron microscopy. Chin J Zoonosis 16:21-23
56. You JQ, Mei JY, Xiao SH (1994) Combined treatment of praziquantel and artemether in murine schistosomiasis. Chin J Parasit Dis Control 7:50-51
57. Zhang CZ, Zhang H, Yun J, Chen GG, Lai PB (2012) Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo. Biochem Pharmacol 83:1278-1289