Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway

Laboratory Investigation

Volumn 92, Issue 12, 2012, Pages 1738-1748

  Xu, Hong ^a   Zhou, Yang ^a,b   Lu, Chao ^a   Ping, Jian ^a,b   Xu, Lie Ming ^a,b,c  

^a SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Shanghai Municipal Education Commission   (China)

Author keywords

contraction; endothelin 1; hepatic stellate cells; RhoA ROCK signaling pathway; salvianolic acid B

Indexed keywords

BAPTA AM; CALCIUM; CHELATING AGENT; COLLAGEN GEL; DIMETHYLNITROSAMINE; ENDOTHELIN 1; F ACTIN; ISOTHIOCYANIC ACID; MYOSIN LIGHT CHAIN 2; PHALLOIDIN; PROTEIN KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ROCK PROTEIN; SALVIANOLIC ACID B; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; GEL ELECTROPHORESIS; LIVER CIRRHOSIS; MALE; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; STRESS FIBER;

ACTINS; ANIMALS; BENZOFURANS; CARDIAC MYOSINS; CELLS, CULTURED; DIMETHYLNITROSAMINE; ENDOTHELIN-1; HEPATIC STELLATE CELLS; HISTOCYTOCHEMISTRY; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MYOSIN LIGHT CHAINS; PHOSPHORYLATION; PORTAL PRESSURE; PROTEIN PHOSPHATASE 1; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; STRESS FIBERS;

EID: 84870464039     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.113     Document Type: Article

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