Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors

Journal of Pathology

Volumn 230, Issue 4, 2013, Pages 365-376

  Liu, Yang ^a   Saiyan, Saiyan ^a   Men, Tong Yi ^b   Gao, Hui Ying ^a   Wen, Chuan ^a   Liu, Yong ^a   Zhou, Xu ^c   Wu, Chu Tse ^a   Wang, Li Sheng ^a   Cui, Chun Ping ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b SHANDONG UNIVERSITY   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

fibrosis development; hepatic stellate cell; hepatocyte; hepatopoietin Cn; liver injury; sphingosine kinase 1 sphingosine 1 phosphate S1P receptors pathway

Indexed keywords

4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; ALCOHOL; CARBON TETRACHLORIDE; HEPATOPOIETIN; HEPATOPOIETIN CN; MITOGEN ACTIVATED PROTEIN KINASE 1; N,N DIMETHYLSPHINGOSINE; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1; SURAMIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; LIVER FIBROSIS; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN FUNCTION; STELLATE CELL;

FIBROSIS DEVELOPMENT; HEPATIC STELLATE CELL; HEPATOCYTE; HEPATOPOIETIN CN; LIVER INJURY; SPHINGOSINE KINASE 1/SPHINGOSINE 1-PHOSPHATE/S1P RECEPTORS PATHWAY;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ETHANOL; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HEPATOCYTE GROWTH FACTOR; HUMANS; LIVER; LIVER CIRRHOSIS, ALCOHOLIC; LYSOPHOSPHOLIPIDS; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NUCLEAR PROTEINS; OXIDATIVE STRESS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, LYSOSPHINGOLIPID; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPHINGOSINE; TIME FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880086208     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4194     Document Type: Article

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