Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP3 inflammasome pathway

IUBMB Life

Volumn 67, Issue 4, 2015, Pages 312-321

  Wu, Xiafei ^a   Zhang, Feng ^a   Xiong, Xin ^a   Lu, Chunfeng ^a   Lian, Naqi ^a   Lu, Yin ^a   Zheng, Shizhong ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

hepatic stellate cells; inflammation; liver fibrosis; NLRP3 inflammasome; tetramethylpyrazine

Indexed keywords

CARBON TETRACHLORIDE; COLLAGEN; CRYOPYRIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIVER ENZYME; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TETRAMETHYLPYRAZINE; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CARRIER PROTEIN; NOD-LIKE RECEPTOR 3, RAT; PLATELET DERIVED GROWTH FACTOR; PYRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROGENESIS; HEPATITIS; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IN VITRO STUDY; LIVER FIBROSIS; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DRUG EFFECTS; INFLAMMATION; LIVER CELL; LIVER CIRRHOSIS; METABOLISM; SPRAGUE DAWLEY RAT;

LIGUSTICUM CHUANXIONG; RATTUS;

ANIMALS; CARRIER PROTEINS; CASPASE 1; CYTOKINES; HEPATOCYTES; INFLAMMASOMES; INFLAMMATION; INFLAMMATION MEDIATORS; LIVER CIRRHOSIS; MALE; PLATELET-DERIVED GROWTH FACTOR; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84930200776     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1348     Document Type: Article

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