Hydrolysis of organophosphate compounds by mutant butyrylcholinesterase: A story of two histidines

Proteins: Structure, Function and Bioinformatics

Volumn 79, Issue 2, 2011, Pages 352-364

  Amitay, Moshe ^a   Shurki, Avital ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Butyrylcholinesterase; Computer simulations; Dephosphorylation; Enzyme catalysis; General acid base catalysis; Organophosphate esters; Reaction mechanism; RNAse A; Toxicology

Indexed keywords

BASE; CHOLINESTERASE; ECOTHIOPATE; HIS117; HISTIDINE; HYDROLASE; HYDROXIDE; ORGANOPHOSPHATE; PHOSPHATE; RIBONUCLEASE A; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DEPHOSPHORYLATION; ENERGY TRANSFER; ENZYME ACTIVITY; HYDROLYSIS; MUTATIONAL ANALYSIS; NUCLEOPHILICITY; PH MEASUREMENT; PRIORITY JOURNAL; PROTON TRANSPORT;

EID: 84962433300     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22864     Document Type: Article

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