Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 14, 2016, Pages E2001-E2010

  Julien, Olivier ^a   Zhuang, Min ^a,c   Wiita, Arun P ^a,b   O'Donoghue, Anthony J ^a,d   Knudsen, Giselle M ^a   Craik, Charles S ^a   Wells, James A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SHANGHAITECH UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Apoptosis; Caspase; N terminomics; Proteolysis; Proteomics

Indexed keywords

CASPASE; CASPASE 2; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; PROTEIN;

APOPTOSIS; ARTICLE; CATALYTIC EFFICIENCY; CELL LYSATE; CONTROLLED STUDY; ENZYME SPECIFICITY; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; MASS SPECTROMETRY; METABOLISM; PROCEDURES;

CASPASES; MASS SPECTROMETRY; PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84962415185     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1524900113     Document Type: Article

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