Triptolide modulates TREM-1 signal pathway to inhibit the inflammatory response in rheumatoid arthritis

International Journal of Molecular Sciences

Volumn 17, Issue 4, 2016, Pages 1-14

  Fan, Danping ^a   He, Xiaojuan ^a,b   Bian, Yanqin ^c   Guo, Qingqing ^a,d   Zheng, Kang ^a   Zhao, Yukun ^a,c   Lu, Cheng ^a   Liu, Baoqin ^e   Xu, Xuegong ^e   Zhang, Ge ^b   Lu, Aiping ^a,b,c  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d SOUTHWEST JIAOTONG UNIVERSITY   (China)

^e Henan Province Traditional Chinese Medicine Hospital   (China)

Author keywords

Bioinformatics analysis; Rheumatoid arthritis; TREM 1 signal pathway; Triptolide

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; SMALL INTERFERING RNA; STAT3 PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CYTOKINE; DITERPENE; EPOXIDE; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; PHENANTHRENE DERIVATIVE; TREM1 PROTEIN, HUMAN; TREM1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANKLE; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DISEASE SEVERITY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TRIPTERYGIUM WILFORDII; WESTERN BLOTTING; ANIMAL; ARTHRITIS, RHEUMATOID; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; MALE; SPRAGUE DAWLEY RAT; TRIPTERYGIUM; TUMOR CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARTHRITIS, RHEUMATOID; CELL LINE, TUMOR; CYTOKINES; DITERPENES; EPOXY COMPOUNDS; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; PHENANTHRENES; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TRIPTERYGIUM;

EID: 84962367639     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17040498     Document Type: Article

References (42)

1. Onozaki, K. Etiological and biological aspects of cigarette smoking in rheumatoid arthritis. Inflamm. Allergy Drug Targets 2009, 8, 364-368. [CrossRef] [PubMed]
2. Zwerina, J.; Redlich, K.; Schett, G.; Smolen, J.S. Pathogenesis of rheumatoid arthritis: Targeting cytokines. Ann. N. Y. Acad. Sci. 2005, 1051, 716-729. [CrossRef] [PubMed]
3. Burmester, G.R.; Stuhlmuller, B.; Keyszer, G.; Kinne, R.W. Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum. 1997, 40, 5-18. [CrossRef] [PubMed]
4. Szekanecz, Z.; Strieter, R.M.; Kunkel, S.L.; Koch, A.E. Chemokines in rheumatoid arthritis. Springer Semin. Immunopathol. 1998, 20, 115-132. [CrossRef] [PubMed]
5. Kim, W.U.; Kwok, S.K.; Hong, K.H.; Yoo, S.A.; Kong, J.S.; Choe, J.; Cho, C.S. Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis. Arthritis Res. Ther. 2007, 9. [CrossRef] [PubMed]
6. Sivalingam, S.P.; Thumboo, J.; Vasoo, S.; Thio, S.T.; Tse, C.; Fong, K.Y. In vivo pro-and anti-inflammatory cytokines in normal and patients with rheumatoid arthritis. Ann. Acad. Med. Singap. 2007, 36, 96-99. [PubMed]
7. Koch, A.E. Angiogenesis as a target in rheumatoid arthritis. Ann. Rheum. Dis. 2003, 62 (Suppl. 2), ii60-ii67. [CrossRef] [PubMed]
8. Goh, K.I.; Cusick, M.E.; Valle, D.; Childs, B.; Vidal, M.; Barabasi, A.L. The human disease network. Proc. Natl. Acad. Sci. USA 2007, 104, 8685-8690. [CrossRef] [PubMed]
9. Xiao, C.; Zhou, J.; He, Y.; Jia, H.; Zhao, L.; Zhao, N.; Lu, A. Effects of Triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-κB: A study on induced arthritis in rats. Chin. Med. 2009, 4. [CrossRef] [PubMed]
10. Tengchaisri, T.; Chawengkirttikul, R.; Rachaphaew, N.; Reutrakul, V.; Sangsuwan, R.; Sirisinha, S. Antitumor activity of Triptolide against cholangiocarcinoma growth in vitro and in hamsters. Cancer Lett. 1998, 133, 169-175. [CrossRef]
11. Wu, Y.; Cui, J.; Bao, X.; Chan, S.; Young, D.O.; Liu, D.; Shen, P. Triptolide attenuates oxidative stress, NF-κB activation and multiple cytokine gene expression in murine peritoneal macrophage. Int. J. Mol. Med. 2006, 17, 141-150. [CrossRef] [PubMed]
12. Tao, X.; Cush, J.J.; Garret, M.; Lipsky, P.E. A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii Hook F in rheumatoid arthritis. J. Rheumatol. 2001, 28, 2160-2167. [PubMed]
13. Calvano, S.E.; Xiao, W.; Richards, D.R.; Felciano, R.M.; Baker, H.V.; Cho, R.J.; Chen, R.O.; Brownstein, B.H.; Cobb, J.P.; Tschoeke, S.K.; et al. A network-based analysis of systemic inflammation in humans. Nature 2005, 437, 1032-1037. [CrossRef] [PubMed]
14. Tao, X.; Davis, L.S.; Lipsky, P.E. Effect of an extract of the Chinese herbal remedy Tripterygium wilfordii Hook F on human immune responsiveness. Arthritis Rheum. 1991, 34, 1274-1281. [CrossRef] [PubMed]
15. Gu, W.Z.; Brandwein, S.R.; Banerjee, S. Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook F. J. Rheumatol. 1992, 19, 682-688. [PubMed]
16. Kupchan, S.M.; Court, W.A.; Dailey, R.G., Jr.; Gilmore, C.J.; Bryan, R.F. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J. Am. Chem. Soc. 1972, 94, 7194-7195. [CrossRef] [PubMed]
17. Asano, K.; Matsuishi, J.; Yu, Y.; Kasahara, T.; Hisamitsu, T. Suppressive effects of Tripterygium wilfordii Hook F., a traditional Chinese medicine, on collagen arthritis in mice. Immunopharmacology 1998, 39, 117-126. [CrossRef]
18. Wang, B.; Ma, L.; Tao, X.; Lipsky, P.E. Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription. Arthritis Rheum. 2004, 50, 2995-3303. [CrossRef] [PubMed]
19. Shao, X.T.; Feng, L.; Yao, H.P.; Sun, W.J.; Zhang, L.H. Effect of Triptolide on TNFα-induced activation of NF-κB and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts. Zhejiang Da Xue Xue Bao. Yi Xue Ban = J. Zhejiang Univ. Med. Sci. 2004, 33, 160-165.
20. Zhang, N.; Xu, Y.J.; Zhang, Z.X. Regulatory function of nuclear factor κ B on lymphocyte proliferation and apoptosis in bronchial asthmatic rats and effect of Triptolide on the regulation. Zhongguo Zhong Xi Yi Jie He Za Zhi Chin. 2004, 24, 435-438.
21. Geng, Y.; Fang, M.;Wang, J.; Yu, H.; Hu, Z.; Yew, D.T.; Chen,W. Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-κB and MAP kinases in lipopolysaccharide-treated PC12 cells. Phytother. Res. PTR 2012, 26, 337-343. [CrossRef] [PubMed]
22. Premkumar, V.; Dey, M.; Dorn, R.; Raskin, I. MyD88-dependent and independent pathways of Toll-like receptors are engaged in biological activity of Triptolide in ligand-stimulated macrophages. BMC Chem. Biol. 2010, 10. [CrossRef] [PubMed]
23. Ornatowska, M.; Azim, A.C.; Wang, X.; Christman, J.W.; Xiao, L.; Joo, M.; Sadikot, R.T. Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 293, L1377-L1384. [CrossRef] [PubMed]
24. Rückert, R.; Brandt, K.; Ernst, M.; Marienfeld, K.; Csernok, E.; Metzler, C.; Budagian, V.; Bulanova, E.; Paus, R.; Bulfone-Paus, S. Interleukin-15 stimulates macrophages to activate CD4+ T cells: A role in the pathogenesis of rheumatoid arthritis? Immunology 2009, 126, 63-73. [CrossRef] [PubMed]
25. Zhao, R.; Chen, N.N.; Zhou, X.W.; Miao, P.; Hu, C.Y.; Qian, L.; Yu, Q.W.; Zhang, J.Y.; Nie, H.; Chen, X.; et al. Exogenous IFN-β regulates the RANKL-c-Fos-IFN-β signaling pathway in the collagen antibody-induced arthritis model. J. Transl. Med. 2014, 12. [CrossRef] [PubMed]
26. Arts, R.J.; Joosten, L.A.; van der Meer, J.W.; Netea, M.G. TREM-1: Intracellular signaling pathways and interaction with pattern recognition receptors. J. Leukoc. Biol. 2013, 93, 209-215. [CrossRef] [PubMed]
27. Tessarz, A.S.; Cerwenka, A. The TREM-1/DAP12 pathway. Immunol. Lett. 2008, 116, 111-116. [CrossRef] [PubMed]
28. Bleharski, J.R.; Kiessler, V.; Buonsanti, C.; Sieling, P.A.; Stenger, S.; Colonna, M.; Modlin, R.L. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J. Immunol. 2003, 170, 3812-3818. [CrossRef] [PubMed]
29. Bouchon, A.; Dietrich, J.; Colonna, M. Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J. Immunol. 2000, 164, 4991-4995. [CrossRef] [PubMed]
30. Schenk, M.; Bouchon, A.; Seibold, F.; Mueller, C. TREM-1-Expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Investig. 2007, 117, 3097-3106. [CrossRef] [PubMed]
31. Choi, S.T.; Kang, E.J.; Ha, Y.J.; Song, J.S. Levels of plasma-soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) are correlated with disease activity in rheumatoid arthritis. J. Rheumatol. 2012, 39, 933-938. [CrossRef] [PubMed]
32. Fortin, C.F.; Lesur, O.; Fulop, T., Jr. Effects of TREM-1 activation in human neutrophils: Activation of signaling pathways, recruitment into lipid rafts and association with TLR4. Int. Immunol. 2007, 19, 41-50. [CrossRef] [PubMed]
33. Kuai, J.; Gregory, B.; Hill, A.; Pittman, D.D.; Feldman, J.L.; Brown, T.; Carito, B.; O'Toole, M.; Ramsey, R.; Adolfsson, O.; et al. TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology 2009, 48, 1352-1358. [CrossRef] [PubMed]
34. Collins, C.E.; La, D.T.; Yang, H.T.; Massin, F.; Gibot, S.; Faure, G.; Stohl, W. Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis. Ann. Rheum. Dis. 2009, 68, 1768-1774. [CrossRef] [PubMed]
35. Darnell, J.E., Jr. STATs and gene regulation. Science 1997, 277, 1630-1635. [CrossRef] [PubMed]
36. Fahmy, R.G.; Waldman, A.; Zhang, G.; Mitchell, A.; Tedla, N.; Cai, H.; Geczy, C.R.; Chesterman, C.N.; Perry, M.; Khachigian, L.M. Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun. Nat. Biotechnol. 2006, 24, 856-863. [CrossRef] [PubMed]
37. Kano, A.;Wolfgang, M.J.; Gao, Q.; Jacoby, J.; Chai, G.X.; Hansen,W.; Iwamoto, Y.; Pober, J.S.; Flavell, R.A.; Fu, X.Y. Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J. Exp. Med. 2003, 198, 1517-1525. [CrossRef] [PubMed]
38. Takeda, K.; Clausen, B.E.; Kaisho, T.; Tsujimura, T.; Terada, N.; Forster, I.; Akira, S. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of STAT3 in macrophages and neutrophils. Immunity 1999, 10, 39-49. [CrossRef]
39. Holmdahl, R.; Rubin, K.; Klareskog, L.; Dencker, L.; Gustafson, G.; Larsson, E. Appearance of different lymphoid cells in synovial tissue and in peripheral blood during the course of collagen II-induced arthritis in rats. Scand. J. Immunol. 1985, 21, 197-204. [CrossRef] [PubMed]
40. Holmdahl, R.; Jansson, L.; Andersson, M.; Larsson, E. Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis. Immunology 1988, 65, 305-310. [PubMed]
41. Brenner, M.; Meng, H.C.; Yarlett, N.C.; Griffiths, M.M.; Remmers, E.F.;Wilder, R.L.; Gulko, P.S. The non-major histocompatibility complex quantitative trait locus CIA10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage. Arthritis Rheum. 2005, 52, 322-332. [CrossRef] [PubMed]
42. Bendele, A.; McAbee, T.; Sennello, G.; Frazier, J.; Chlipala, E.; McCabe, D. Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: Comparison of efficacy in animal models with human clinical data. Arthritis Rheum. 1999, 42, 498-506. [CrossRef]