Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun

Nature Biotechnology

Volumn 24, Issue 7, 2006, Pages 856-863

  Fahmy, Roger G ^a   Waldman, Alla ^a   Zhang, Guishui ^a   Mitchell, Ainslie ^a   Tedla, Nicodemus ^a   Cai, Hong ^a   Geczy, Carolyn R ^a   Chesterman, Colin N ^a   Perry, Michael ^a   Khachigian, Levon M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; BONE; CATALYSTS; CELLS; INFILTRATION; MOLECULES; PROTEINS; SWELLING;

ENDOTOXIN; LEUKOCYTES; RHEUMATOID ARTHRITIS; VASCULAR PERMEABILITY;

DNA;

ANTIINFLAMMATORY AGENT; CD31 ANTIGEN; CYTOKINE; DZ 13; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTOXIN; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN C FOS; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR ENDOTHELIAL CADHERIN;

AMINO ACID SEQUENCE; ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BONE EROSION; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRAVASATION; FEMALE; INFLAMMATION; INFLAMMATORY CELL; LEUKOCYTE; LEUKOCYTE ROLLING; MONOCYTE; MOUSE; NEUTROPHIL CHEMOTAXIS; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TARGETING; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, RHEUMATOID; CAPILLARY PERMEABILITY; CELL LINE; COCULTURE TECHNIQUES; DNA, CATALYTIC; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; MONOCYTES; PROTO-ONCOGENE PROTEINS C-JUN; RATS;

MURINAE;

EID: 33746153397     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1225     Document Type: Article

References (33)

1. Davies, N.M. Review article: non-steroidal anti-inflammatory drug-induced gastrointestinal permeability. Aliment. Pharmacol. Ther. 12, 303-320 (1998).
2. Botting, R. Antipyretic therapy. Front. Biosci. 9, 956-966 (2004).
3. Howard, P.A. & Delafontaine, P. Nonsteroidal anti-Inflammatory drugs and cardiovascular risk. J. Am. Coll. Cardiol. 43, 519-525 (2004).
4. Schuff, K.G. Issues in the diagnosis of Cushing's syndrome for the primary care physician. Prim. Care 30, 791-799 (2003).
5. Cirino, G., Fiorucci, S. & Sessa, W.C. Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends Pharmacol. Sci. 24, 91-95 (2003).
6. Carmeliet, P. Angiogenesis in health and disease. Nat. Med. 9, 653-660 (2003).
7. Murohara, T. et al. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 97, 99-107 (1998).
8. Gamble, J.R. et al. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circ. Res. 87, 603-607 (2000).
9. Ito, Y. et al. Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4. Cancer Res. 63, 6651-6657 (2003).
10. Chen, J. et al. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat. Med. 11, 1188-1196 (2005).
11. Santiago, F.S. et al. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth factor injury. Nat. Med. 5, 1264-1269 (1999).
12. Lowe, H.C., Chesterman, C.N. & Khachigian, L.M. Catalytic antisense DNA molecules targeting Egr-1 inhibit neointima formation following permanent ligation of rat common cartoid arteries. Thromb. Haemost. 87, 134-140 (2002).
13. Khachigian, L.M., Fahmy, R.G., Zhang, G., Bobryshev, Y.V. & Kaniaros, A. c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury: inhibition by a novel DNAzyme targeting c-Jun. J. Biol. Chem. 277, 22985-22991 (2002).
14. Lowe, H.C. et al. Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis. Circ. Res. 89, 670-677 (2001).
15. Zhang, G. et al. Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. J. Natl. Cancer Inst. 96, 683-696 (2004).
16. Smith, L.E. et al. Oxygen-induced retinopathy in the mouse. Invest. Ophthalmol. Vis. Sci. 35, 101-111 (1994).
17. Engelhardt, B. & Wolburg, H. Transendothelial migration of leukocytes: through the front door or around the side of the house? Eur. J. Immunol. 34, 2955-2963 (2004).
18. Min, W. & Pober, J.S. TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c- Jun/ATF2 pathways. J. Immunol. 159, 3508-3518 (1997).
19. Ahmad, M., Theofanidis, P. & Medford, R.M. Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha. J. Biol. Chem. 273, 4616-4621 (1998).
20. Wang, N. et al. Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 19, 2078-2084 (1999).
21. Staines, N.A. & Wooley, P.H. Collagen arthritis-what can it teach us? Br. J. Rheumatol. 33, 798-807 (1994).
22. van Buul, J.D. & Hordijk, P.L. Signaling in leukocyte transendothelial migration. Arterioscler. Thromb. Vasc. Biol. 24, 824-833 (2004).
23. Santoro, S.W. & Joyce, G.F. A general purpose RNA-cleaving DNA enzyme. Proc. Natl. Acad. Sci. USA 94, 4262-4266 (1997).
24. Eyetech Study Group. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 22, 143-152 (2002).
25. Gragoudas, E.S., Adamis, A.P., Cunningham, E.T., Jr., Feinsod, M. & Guyer, D.R. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med. 351, 2805-2816 (2004).
26. Ferrara, N. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin. Oncol. 29, 10-14 (2002).
27. Parry, T.J. et al. Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res. 27, 2569-2577 (1999).
28. Pavco, P.A. et al. Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin. Cancer Res. 6, 2094-2103 (2000).
29. Bitko, V., Musiyenko, A., Shulyayeva, O. & Barik, S. Inhibition of respiratory viruses by nasally administered siRNA. Nat. Med. 11, 50-55 (2004).
30. Fahmy, R.G. & Khachigian, L.M. Locked nucleic acid-modified DNA enzymes targeting early growth response-1 inhibit vascular smooth muscle cell growth. Nucleic Acids Res. 32, 2281-2285 (2004).
31. Breaker, R.R. Natural and engineered nucleic acids as tools to explore biology. Nature 432, 838-845 (2004).
32. Kagari, T., Doi, H. & Shimozato, T. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J. Immunol. 169, 1459-1466 (2002).
33. Bolon, B., Morony, S., Cheng, Y., Hu, Y.L. & Feige, U. Osteoclast numbers in Lewis rats with adjuvant-induced arthritis: identification of preferred sites and parameters for rapid quantitative analysis. Vet. Pathol. 41, 30-36 (2004).