Investigation of pharmaceuticals in processed animal by-products by liquid chromatography coupled to high-resolution mass spectrometry

Chemosphere

Volumn 154, Issue , 2016, Pages 231-239

  Nácher Mestre, Jaime ^a,b   Ibáñez, María ^a   Serrano, Roque ^a   Boix, Clara ^a   Bijlsma, Lubertus ^a   Lunestad, Bjørn Tore ^c   Hannisdal, Rita ^c   Alm, Martin ^d   Hernández, Félix ^a   Berntssen, Marc H G ^c  

^a UNIVERSITAT JAUME I   (Spain)

^b CSIC Instituto de Acuicultura de Torre de la Sal IATS   (Spain)

^c INSTITUTE OF MARINE RESEARCH   (Norway)

^d European Fat Processors and Renderers Association (EFPRA)   (Belgium)

Author keywords

Aquaculture; Dyes; Liquid chromatography; Pharmaceuticals; Processed animal products; Quadrupole time of flight; Salmon; Screening; Undesirables

Indexed keywords

ANIMALS; AQUACULTURE; DRUG PRODUCTS; DYES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; RISK ASSESSMENT; SCREENING;

ANIMAL PRODUCTS; HIGH RESOLUTION MASS SPECTROMETRY; QUADRUPOLE-TIME OF FLIGHTS; SALMON; SALMON FARMING INDUSTRY; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES; UNDESIRABLES; WIDE-SCOPE SCREENINGS;

QUALITY CONTROL;

DYE;

ANALYTICAL METHOD; ANIMAL; AQUACULTURE; ARTIFICIAL DIET; DRUG; DYE; EUROPEAN UNION; FOOD SAFETY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; SALMONID; SUSTAINABILITY;

AGRICULTURAL WORKER; ANIMAL PRODUCT; ARTICLE; CONTROLLED STUDY; FOOD SAFETY; METABOLITE; NONHUMAN; QUALITY CONTROL; SALMONINE; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALYSIS; ANIMAL; ANIMAL FOOD; FISHERY; FOOD CONTAMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROCEDURES;

ANIMALIA;

ANIMAL FEED; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; FISHERIES; FOOD CONTAMINATION; FOOD SAFETY; MASS SPECTROMETRY; SALMON;

EID: 84962338951     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2016.03.091     Document Type: Article

References (49)

1. Bade R., Bijlsma L., Miller T.H., Barron L.P., Sancho J.V., Hernández F. Suspect screening of large numbers of emerging contaminants in environmental waters using artificial neural networks for chromatographic retention time prediction and high resolution mass spectrometry data analysis. Sci. Tot. Environ. 2015, 538:934-941.
2. Berntssen M.H.G., Valdersnes S., Lunestad B.T., Hatlen B., Alm M., Waagbo R., Buttle L. Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish. Aquac. Nutr. 2014, 20:712-721.
3. Blazquez J., Couce A., Rodriguez-Beltran J., Rodriguez-Rojas A. Antimicrobials as promoters of genetic variation. Curr. Opin. Microbiol. 2012, 15:561-569.
4. Bohn T., Pellet T., Boscher A., Hoffmann L. Developing a microbiological growth inhibition screening assay for the detection of 27 veterinary drugs from 13 different classes in animal feedingstuffs. Food Addit. Contam. Part A Chem. 2013, 30:1870-1887.
5. Boix C., Ibáñez M., Sancho J.V., León N., Yusá V., Hernández F. Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry: potential application to quantitative analysis. Food Chem. 2014, 160:313-320.
6. Bransden M.P., Carter C.G., Nowak B.F. Effects of dietary protein source on growth, immune function, blood chemistry and disease resistance of Atlantic salmon (Salmo salar L.) parr. Anim. Sci. 2001, 73:105-113.
7. Burr G.S., Wolters W.R., Barrows F.T., Hardy R.W. Replacing fishmeal with blends of alternative proteins on growth performance of rainbow trout (Oncorhynchus mykiss), and early or late stage juvenile Atlantic salmon (Salmo salar). Aquaculture 2012, 334:110-116.
8. Chapman H.D. Milestones in avian coccidiosis research: a review. Poult. Sci. 2014, 93:501-511.
9. EC Council Directive 96/23/EC of 29 April 1996 on measures to monitor substances and residues thereof of in live animals and animal products and repealing Directives 85/358/EEC and 86/469/EEC and Decisions 89/187/EEC and 91/664/EEC. Off. J. Eur. Commun. 1996, L125:10.
10. EC Regulation (EC) N° 999/2001 of the European Parliament and of the Council of 22 May 2001 laying down rules for the prevention, control and eradication of certain transmissible spongiform encephalopathies. Off. J. Eur. Union 2001, L147:1-38.
11. EC Commission Decision (EC) N° 2002/657 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off. J. Eur. Commun. 2002, L221:8-36.
12. EC Commission regulation 1234/2003 of 10 July 2003 amending Annexes I, IV and XI to Regulation (EC) N° 999/2001 of the European Parliament and of the Council and Regulation (EC) N° 1326/2001 as regards transmissible spongiform encephalopathies and animal feeding. Off. J. Eur. Union 2003, L173:6-13.
13. EC Regulation (EC) N°1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition. Off. J. Eur. Union 2003.
14. EC Commission regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Off. J. Eur. Union 2009, L15:1-72.
15. EC Commission Directive 2009/8/EC of 10 February 2009 amending Annex I to Directive 2002/32/EC of the European Parliament and of the Council as regards maximum levels of unavoidable carry-over of coccidiostats or histomonostats in nontarget feed. Off. J. Eur. Union 2009, L40:19.
16. ° 1069/2009 of the European Parliament and of the Council of 21 October 2009 laying down health rules as regards animal by-products and derived products not intended for human consumption and repealing Regulation (EC) N° 1774/2002 (Animal by-products Regulation). Off. J. Eur. Union 2009.
17. EC Commission regulation (EU) N° 56/2013 of 16 January 2013 amending Annexes I and IV to Regulation (EC) N° 999/2001 of the European Parliament and of the Council laying down rules for the prevention, control and eradication of certain transmissible spongiform encephalopathies. Off. J. Eur. Union 2013, 21:3-16.
18. EC SANCO/12571/2013. Guidance document on Analytical Quality Control and Validation Procedures for Pesticide Residues Analysis in Food and Feed 2013.
19. EFSA Scientific opinion on the revision of the quantitative risk assessment (QRA) of the BSE risk posed by processed animal proteins (PAPs). EFSA Panel on Biological Hazards (BIOHAZ). EFSA J. 2011, 9:1947.
20. EMA Trends in the Sales of Veterinary Antimicrobial Agents in Nine European Countries Reporting Period: 2005-2009 2011, (EMA/238630/2011). http://www.ema.europa.eu/docs/en_GB/document_library/Report/2011/2009/WC500112309.pdf.
21. FAO The State of World Fisheries and Aquaculture 2014 2014, FAO Fisheries and Aquaculture Department Food and Agriculture Organization of the United Nations, Rome. http://www.fao.org/3/a-i3720e.pdf.
22. FDA FVM Executive Council 2015. Foods and Veterinary Medicine Science and Research Steering Committee. Guidelines for the Validation of Chemical Methods for the FDA FVM Program 2015, US Food & Drug Administration, Office of Food and Veterinary Medicine. second ed.
23. Friesen E.N., Ikonomou M.G., Higgs D.A., Ang K.P., Dubetz C. Use of terrestrial based lipids in aquaculture feeds and the effects on flesh organohalogen and fatty acid concentrations in farmed Atlantic salmon. Environ. Sci. Technol. 2008, 42:3519-3523.
24. Gillings M.R. Evolutionary consequences of antibiotic use for the resistome, mobilome, and microbial pangenome. Front. Microbiol. 2013, 4:1-19.
25. Gracia-Lor E., Sancho J.V., Hernández F. Simultaneous determination of acidic, neutral and basic pharmaceuticals in urban wastewater by ultra high-pressure liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2010, 1217:622-632.
26. Grave K., Hansen M.K., Kruse H., Bangen M., Kristoffersen A.B. Prescription of antimicrobial drugs in Norwegian aquaculture with an emphasis on "new" fish species. Prev. Vet. Med. 2008, 83:156-169.
27. Hernández F., Ibáñez M., Botero-Coy A.M., Bade R., Bustos-López M.C., Rincón J., Moncayo A., Bijlsma L. LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogotá, Colombia. Anal. Bioanal. Chem. 2015, 407:6405-6416.
28. Ibáñez M., Portolés T., Rúbies T., Muñoz E., Muñoz G., Pineda L., Serrahima E., Sancho J.V., Centrich F., Hernández F. The power of hyphenated chromatography/time-of-flight mass spectrometry in public health laboratories. J. Agric. Food Chem. 2012, 60:5311-5323.
29. Love D.C., Halden R.U., Davis M.F., Nachman K.E. Feather meal: a previously unrecognized route for reentry into the food supply of multiple pharmaceuticals and personal care products (PPCPs). Environ. Sci. Technol. 2012, 46:3795-3802.
30. Mani S., Bharagava R.N. Exposure to crystal violet, its toxic, genotoxic and carcinogenic effects on environment and its degradation and detoxification for environmental safety. Rev. Environ. Contam. T. 2016, 237:71-104.
31. Masiá A., Campo J., Blasco C., Picó Y. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry to identify contaminants in water: an insight on environmental forensics. J. Chromatogr. A 2014, 1345:86-97.
32. Nácher-Mestre J., Ibáñez M., Serrano R., Pérez-Sánchez J., Hernández F. Qualitative screening of undesirable compounds from feeds to fish by liquid chromatography coupled to mass spectrometry. J. Agric. Food Chem. 2013, 61:2077-2087.
33. Paterson J.R., Baxter G., Dreyer J.S., Halket J.M., Flynn R., Lawrence J.R. Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid. J. Agric. Food. Chem. 2008, 56:11648-11652.
34. Poppi D.A., Quinton V.M., Hua K., Bureau D.P. Development of a test diet for assessing the bioavailability of arginine in feather meal fed to rainbow trout (Oncorhynchus mykiss). Aquaculture 2011, 314:100-109.
35. Rahnema S., Borton R. Determination of the effects of fish vs plant and feather meal-based diets on the growth and health of rainbow trout. J. Appl. Anim. Res. 2007, 32:113-117.
36. Reig M., Toldra F. Veterinary Drugs and Growth Promoters Residues in Meat and Processed Meats 2009, 233. Springer, Spring Street, New York, Ny 10013, United States.
37. Rosenlund G., Obach A., Sandberg M.G., Standal H., Tveit K. Effect of alternative lipid sources on long-term growth performance and quality of Atlantic salmon (Salmo salar L.). Aquac. Res. 2001, 32:323-328.
38. Ruff M.D. Important parasites in poultry production systems. Vet. Parasitol. 1999, 84:337-347.
39. Scotter M.J., Roberts D.P.T., Wilson L.A., Howard F.A.C., Davis J., Mansell N. Free salicylic acid and acetyl salicylic acid content of foods using gas chromatography-mass spectrometry. Food Chem. 2007, 105:273-279.
40. Serratosa J., Blass A., Rigau B., Mongrell B., Rigau T., Tortades M., Tolosa E., Aguilar C., Ribo O., Balague J. Residues from veterinary medicinal products, growth promoters and performance enhancers in food-producing animals: a European Union perspective. J. Rev. Sci. Tech. Off. Int. Epizoot. 2006, 25:637-653.
41. Tacon A.G.J., Metian M. Global overview on the use of fish meal and fish oil in industrially compounded aquafeeds: trends and future prospects. Aquaculture 2008, 285:146-158.
42. Toldra F., Aristoy M.C., Mora L., Reig M. Nutritional pork meat compounds as affected by ham dry-curing. Meat Sci. 2012, 92:290-296.
43. Torrissen O., Olsen R.E., Toresen R., Hemre G.I., Tacon A.G.J., Asche F., Hardy R.W., Lall S. Atlantic Salmon (Salmo salar): the "Super-Chicken" of the sea?. Rev. Fish. Sci. 2011, 19:257-278.
44. Turnipseed S.B., Lohne J.J., Storey J.M., Andersen W.C., Young S.L., Carr J.R., Madson M.R. Challenges in implementing a screening method for veterinary drugs in milk using liquid chromatography quadrupole time-of-flight mass spectrometry. J. Agric. Food Chem. 2014, 62:3660-3674.
45. Venema D.P., Hollman P.C.H., Janssen K.P.L.T.M., Katan M.B. Determination of acetylsalicylic acid and salicylic acid in foods, using HPLC with fluorescence detection. J. Agric. Food Chem. 1996, 44:1762-1767.
46. Waagbo R., Berntssen M.H.G., Danielsen T., Helberg H., Kleppa A.L., Lea T.B., Rosenlund G., Tvenning L., Susort S., Vikesa V., Breck O. Feeding Atlantic salmon diets with plant ingredients during the seawater phase - a full-scale net production of marine protein with focus on biological performance, welfare, product quality and safety. Aquac. Nutr. 2013, 19:598-618.
47. WADA, 2010.World Anti-Doping Agency International Standard for Laboratories. Identification Criteria for Qualitative Assays TD2010IDCR 2010.
48. Wilson C.M., Friesen E.N., Higgs D.A., Farrell A.P. The effect of dietary lipid and protein source on the swimming performance, recovery ability and oxygen consumption of Atlantic salmon (Salmo salar). Aquaculture 2007, 273:687-699.
49. Yanik T., Dabrowski K., Bai S.C. Replacing fish meal in rainbow trout (Oncorhynchus mykiss) diets. Isr. J. Aquacult-Bamid. 2003, 55:179-186.