-
1
-
-
0036789917
-
Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3
-
Kubasiak, L. A., Hernandez, O. M., Bishopric, N. H. & Webster, K. A. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proceedings of the National Academy of Sciences of the United States of America 99, 12825-12830, doi: 10. 1073/pnas. 202474099 (2002).
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 12825-12830
-
-
Kubasiak, L.A.1
Hernandez, O.M.2
Bishopric, N.H.3
Webster, K.A.4
-
2
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
Bellot, G. et al. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Molecular and cellular biology 29, 2570-2581, doi: 10. 1128/MCB. 00166-09 (2009).
-
(2009)
Molecular and Cellular Biology
, vol.29
, pp. 2570-2581
-
-
Bellot, G.1
-
3
-
-
62849105988
-
The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death
-
Burton, T. R. & Gibson, S. B. The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death. Cell death and differentiation 16, 515-523, doi: 10. 1038/cdd. 2008. 185 (2009).
-
(2009)
Cell Death and Differentiation
, vol.16
, pp. 515-523
-
-
Burton, T.R.1
Gibson, S.B.2
-
4
-
-
33845511362
-
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy
-
Hamacher-Brady, A. et al. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell death and differentiation 14, 146-157, doi: 10. 1038/sj. cdd. 4401936 (2007).
-
(2007)
Cell Death and Differentiation
, vol.14
, pp. 146-157
-
-
Hamacher-Brady, A.1
-
5
-
-
84859151396
-
Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death
-
Ma, X., Godar, R. J., Liu, H. & Diwan, A. Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Autophagy 8, 297-309, doi: 10. 4161/auto. 18658 (2012).
-
(2012)
Autophagy
, vol.8
, pp. 297-309
-
-
Ma, X.1
Godar, R.J.2
Liu, H.3
Diwan, A.4
-
6
-
-
34948816749
-
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice
-
Diwan, A. et al. Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest 117, 2825-2833, doi: 10. 1172/JCI32490 (2007).
-
(2007)
J Clin Invest
, vol.117
, pp. 2825-2833
-
-
Diwan, A.1
-
7
-
-
84937680856
-
Ischemic heart disease worldwide, 1990 to 2013: Estimates from the global burden of disease study 2013
-
Shepard, D. et al. Ischemic Heart Disease Worldwide, 1990 to 2013: Estimates From the Global Burden of Disease Study 2013. Circ Cardiovasc Qual Outcomes 8, 455-456, doi: 10. 1161/CIRCOUTCOMES. 115. 002007 (2015).
-
(2015)
Circ Cardiovasc Qual Outcomes
, vol.8
, pp. 455-456
-
-
Shepard, D.1
-
8
-
-
84899781662
-
MIR-210 suppresses BNIP3 to protect against the apoptosis of neural progenitor cells
-
Wang, F. et al. miR-210 suppresses BNIP3 to protect against the apoptosis of neural progenitor cells. Stem Cell Res 11, 657-667, doi: 10. 1016/j. scr. 2013. 04. 005 (2013).
-
(2013)
Stem Cell Res
, vol.11
, pp. 657-667
-
-
Wang, F.1
-
9
-
-
84866515571
-
MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (H(2)O(2))-induced apoptosis through targeting the mitochondria apoptotic pathway
-
Li, R. et al. MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (H(2)O(2))-induced apoptosis through targeting the mitochondria apoptotic pathway. Plos One 7, e44907, doi: 10. 1371/journal. pone. 0044907 (2012).
-
(2012)
Plos One
, vol.7
, pp. e44907
-
-
Li, R.1
-
10
-
-
77950818716
-
MicroRNA145 targets BNIP3 and suppresses prostate cancer progression
-
Chen, X. et al. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. Cancer Res 70, 2728-2738, doi: 10. 1158/0008-5472. CAN-09-3718 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 2728-2738
-
-
Chen, X.1
-
11
-
-
84908059702
-
MicroRNA-145: A potent tumour suppressor that regulates multiple cellular pathways
-
Cui, S. Y., Wang, R. & Chen, L. B. MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways. J Cell Mol Med 18, 1913-1926, doi: 10. 1111/jcmm. 12358 (2014).
-
(2014)
J Cell Mol Med
, vol.18
, pp. 1913-1926
-
-
Cui, S.Y.1
Wang, R.2
Chen, L.B.3
-
12
-
-
78650624101
-
RNA interference in the clinic: Challenges and future directions
-
Pecot, C. V., Calin, G. A., Coleman, R. L., Lopez-Berestein, G. & Sood, A. K. RNA interference in the clinic: challenges and future directions. Nat Rev Cancer 11, 59-67, doi: 10. 1038/nrc2966 (2011).
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 59-67
-
-
Pecot, C.V.1
Calin, G.A.2
Coleman, R.L.3
Lopez-Berestein, G.4
Sood, A.K.5
-
13
-
-
84898669488
-
Heart regeneration: Opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents
-
Plowright, A. T., Engkvist, O., Gill, A., Knerr, L. & Wang, Q. D. Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents. Angew Chem Int Ed Engl 53, 4056-4075, doi: 10. 1002/anie. 201307034 (2014).
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 4056-4075
-
-
Plowright, A.T.1
Engkvist, O.2
Gill, A.3
Knerr, L.4
Wang, Q.D.5
-
14
-
-
84880466847
-
Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1)
-
Liu, R., Li, J., Teng, Z., Zhang, Z. & Xu, Y. Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1). Plos One 8, e68982, doi: 10. 1371/journal. pone. 0068982 (2013).
-
(2013)
Plos One
, vol.8
, pp. e68982
-
-
Liu, R.1
Li, J.2
Teng, Z.3
Zhang, Z.4
Xu, Y.5
-
15
-
-
84877698814
-
MicroRNA-182 promotes cell growth, invasion, and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas
-
Wang, Y. Q., Guo, R. D., Guo, R. M., Sheng, W. & Yin, L. R. MicroRNA-182 promotes cell growth, invasion, and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas. J Cell Biochem 114, 1464-1473, doi: 10. 1002/jcb. 24488 (2013).
-
(2013)
J Cell Biochem
, vol.114
, pp. 1464-1473
-
-
Wang, Y.Q.1
Guo, R.D.2
Guo, R.M.3
Sheng, W.4
Yin, L.R.5
-
16
-
-
84900448989
-
MicroRNA-182 targets special AT-rich sequence-binding protein 2 to promote colorectal cancer proliferation and metastasis
-
Yang, M. H. et al. microRNA-182 targets special AT-rich sequence-binding protein 2 to promote colorectal cancer proliferation and metastasis. J Transl Med 12, 109, doi: 10. 1186/1479-5876-12-109 (2014).
-
(2014)
J Transl Med
, vol.12
, pp. 109
-
-
Yang, M.H.1
-
17
-
-
84907495479
-
MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes
-
Sachdeva, M. et al. MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. J Clin Invest 124, 4305-4319, doi: 10. 1172/JCI77116 (2014).
-
(2014)
J Clin Invest
, vol.124
, pp. 4305-4319
-
-
Sachdeva, M.1
-
18
-
-
84920436503
-
Roles of MIR-182 in sensory organ development and cancer
-
Wei, Q., Lei, R. & Hu, G. Roles of miR-182 in sensory organ development and cancer. Thorac Cancer 6, 2-9, doi: 10. 1111/1759-7714. 12164 (2015).
-
(2015)
Thorac Cancer
, vol.6
, pp. 2-9
-
-
Wei, Q.1
Lei, R.2
Hu, G.3
-
19
-
-
84864115273
-
MIR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1
-
Kim, K. M. et al. miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1. J Bone Miner Res 27, 1669-1679, doi: 10. 1002/jbmr. 1604 (2012).
-
(2012)
J Bone Miner Res
, vol.27
, pp. 1669-1679
-
-
Kim, K.M.1
-
20
-
-
84977443604
-
MicroRNA-182 modulates high glucose-induced cardiomyocyte hypertrophy via targeting Rac1
-
Meng, Z. et al. [MicroRNA-182 modulates high glucose-induced cardiomyocyte hypertrophy via targeting Rac1]. Zhonghua Xin Xue Guan Bing Za Zhi 43, 619-624 (2015).
-
(2015)
Zhonghua Xin Xue Guan Bing Za Zhi
, vol.43
, pp. 619-624
-
-
Meng, Z.1
-
21
-
-
34250805982
-
MicroRNA targeting specificity in mammals: Determinants beyond seed pairing
-
Grimson, A. et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 27, 91-105, doi: 10. 1016/j. molcel. 2007. 06. 017 (2007).
-
(2007)
Mol Cell
, vol.27
, pp. 91-105
-
-
Grimson, A.1
-
22
-
-
84891818318
-
MiRBase: Annotating high confidence microRNAs using deep sequencing data
-
Kozomara, A. & Griffiths-Jones, S. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res 42, D68-73, doi: 10. 1093/nar/gkt1181 (2014).
-
(2014)
Nucleic Acids Res
, vol.42
, pp. D68-73
-
-
Kozomara, A.1
Griffiths-Jones, S.2
-
23
-
-
77953123212
-
The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms
-
Landes, T. et al. The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms. EMBO Rep 11, 459-465, doi: 10. 1038/embor. 2010. 50 (2010).
-
(2010)
EMBO Rep
, vol.11
, pp. 459-465
-
-
Landes, T.1
-
24
-
-
84869219338
-
MIR-34-A microRNA replacement therapy is headed to the clinic
-
Bader, A. G. miR-34-a microRNA replacement therapy is headed to the clinic. Frontiers in genetics 3, 120, doi: 10. 3389/ fgene. 2012. 00120 (2012).
-
(2012)
Frontiers in Genetics
, vol.3
, pp. 120
-
-
Bader, A.G.1
-
25
-
-
79960963683
-
MicroRNA replacement therapy for MIR-145 and MIR-33a is efficacious in a model of colon carcinoma
-
Ibrahim, A. F. et al. MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. Cancer Res 71, 5214-5224, doi: 10. 1158/0008-5472. CAN-10-4645 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 5214-5224
-
-
Ibrahim, A.F.1
-
26
-
-
77449141681
-
Small molecule modifiers of the microRNA and RNA interference pathway
-
Deiters, A. Small molecule modifiers of the microRNA and RNA interference pathway. AAPS J 12, 51-60, doi: 10. 1208/s12248-009-9159-3 (2010).
-
(2010)
AAPS J
, vol.12
, pp. 51-60
-
-
Deiters, A.1
-
27
-
-
77953312157
-
Small molecule modifiers of microRNA MIR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma
-
Young, D. D., Connelly, C. M., Grohmann, C. & Deiters, A. Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma. J Am Chem Soc 132, 7976-7981, doi: 10. 1021/ja910275u (2010).
-
(2010)
J Am Chem Soc
, vol.132
, pp. 7976-7981
-
-
Young, D.D.1
Connelly, C.M.2
Grohmann, C.3
Deiters, A.4
-
28
-
-
54749089002
-
Small-molecule inhibitors of microrna MIR-21 function
-
Gumireddy, K. et al. Small-molecule inhibitors of microrna miR-21 function. Angew Chem Int Ed Engl 47, 7482-7484, doi: 10. 1002/ anie. 200801555 (2008).
-
(2008)
Angew Chem Int Ed Engl
, vol.47
, pp. 7482-7484
-
-
Gumireddy, K.1
-
29
-
-
84909645350
-
A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma
-
Xiao, Z. et al. A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma. Cancer Res 74, 6236-6247, doi: 10. 1158/0008-5472. CAN-14-0855 (2014).
-
(2014)
Cancer Res
, vol.74
, pp. 6236-6247
-
-
Xiao, Z.1
-
30
-
-
77955287613
-
Identification of small molecules that suppress microRNA function and reverse tumorigenesis
-
Watashi, K., Yeung, M. L., Starost, M. F., Hosmane, R. S. & Jeang, K. T. Identification of small molecules that suppress microRNA function and reverse tumorigenesis. J Biol Chem 285, 24707-24716, doi: 10. 1074/jbc. M109. 062976 (2010).
-
(2010)
J Biol Chem
, vol.285
, pp. 24707-24716
-
-
Watashi, K.1
Yeung, M.L.2
Starost, M.F.3
Hosmane, R.S.4
Jeang, K.T.5
-
31
-
-
84897024057
-
Sequence-based design of bioactive small molecules that target precursor microRNAs
-
Velagapudi, S. P., Gallo, S. M. & Disney, M. D. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nat Chem Biol 10, 291-297, doi: 10. 1038/nchembio. 1452 (2014).
-
(2014)
Nat Chem Biol
, vol.10
, pp. 291-297
-
-
Velagapudi, S.P.1
Gallo, S.M.2
Disney, M.D.3
-
32
-
-
76049083966
-
Reactive oxygen species, cellular redox systems, and apoptosis
-
Circu, M. L. & Aw, T. Y. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48, 749-762, doi: 10. 1016/j. freeradbiomed. 2009. 12. 022 (2010).
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 749-762
-
-
Circu, M.L.1
Aw, T.Y.2
-
33
-
-
84862967638
-
Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905)
-
Duffey, M. O. et al. Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905). J Med Chem 55, 197-208, doi: 10. 1021/jm2011172 (2012).
-
(2012)
J Med Chem
, vol.55
, pp. 197-208
-
-
Duffey, M.O.1
-
34
-
-
0033614949
-
Paullones, a series of cyclin-dependent kinase inhibitors: Synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity
-
Schultz, C. et al. Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J Med Chem 42, 2909-2919, doi: 10. 1021/jm9900570 (1999).
-
(1999)
J Med Chem
, vol.42
, pp. 2909-2919
-
-
Schultz, C.1
-
35
-
-
4344619713
-
Pharmacological inhibitors of glycogen synthase kinase 3
-
Meijer, L., Flajolet, M. & Greengard, P. Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci 25, 471-480, doi: 10. 1016/j. tips. 2004. 07. 006 (2004).
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 471-480
-
-
Meijer, L.1
Flajolet, M.2
Greengard, P.3
-
36
-
-
0037155691
-
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
-
Liu, C. et al. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847 (2002).
-
(2002)
Cell
, vol.108
, pp. 837-847
-
-
Liu, C.1
-
37
-
-
84873734483
-
Up-regulation of MIR-182 by beta-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK
-
Chiang, C. H., Hou, M. F. & Hung, W. C. Up-regulation of miR-182 by beta-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK. Biochim Biophys Acta 1830, 3067-3076, doi: 10. 1016/j. bbagen. 2013. 01. 009 (2013).
-
(2013)
Biochim Biophys Acta
, vol.1830
, pp. 3067-3076
-
-
Chiang, C.H.1
Hou, M.F.2
Hung, W.C.3
-
38
-
-
41649098360
-
A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities
-
Handeli, S. & Simon, J. A. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol Cancer Ther 7, 521-529, doi: 10. 1158/1535-7163. MCT-07-2063 (2008).
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 521-529
-
-
Handeli, S.1
Simon, J.A.2
-
39
-
-
84937892977
-
Hypoxia-inducible MIR-182 enhances HIF1alpha signaling via targeting PHD2 and FIH1 in prostate cancer
-
Li, Y. et al. Hypoxia-inducible miR-182 enhances HIF1alpha signaling via targeting PHD2 and FIH1 in prostate cancer. Sci Rep 5, 12495, doi: 10. 1038/srep12495 (2015).
-
(2015)
Sci Rep
, vol.5
, pp. 12495
-
-
Li, Y.1
-
40
-
-
11844263980
-
Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia
-
Schnitzer, S. E., Schmid, T., Zhou, J., Eisenbrand, G. & Brune, B. Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia. FEBS Lett 579, 529-533, doi: 10. 1016/j. febslet. 2004. 12. 023 (2005).
-
(2005)
FEBS Lett
, vol.579
, pp. 529-533
-
-
Schnitzer, S.E.1
Schmid, T.2
Zhou, J.3
Eisenbrand, G.4
Brune, B.5
-
41
-
-
77958149675
-
The microRNA MIR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes
-
Stittrich, A. B. et al. The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol 11, 1057-1062, doi: 10. 1038/ni. 1945 (2010).
-
(2010)
Nat Immunol
, vol.11
, pp. 1057-1062
-
-
Stittrich, A.B.1
-
42
-
-
84859715525
-
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease
-
Sheikh, F. et al. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest 122, 1209-1221, doi: 10. 1172/JCI61134 (2012).
-
(2012)
J Clin Invest
, vol.122
, pp. 1209-1221
-
-
Sheikh, F.1
-
43
-
-
84899477189
-
Getting the skinny on thick filament regulation in cardiac muscle biology and disease
-
Sheikh, F., Lyon, R. C. & Chen, J. Getting the skinny on thick filament regulation in cardiac muscle biology and disease. Trends Cardiovasc Med 24, 133-141, doi: 10. 1016/j. tcm. 2013. 07. 004 (2014).
-
(2014)
Trends Cardiovasc Med
, vol.24
, pp. 133-141
-
-
Sheikh, F.1
Lyon, R.C.2
Chen, J.3
-
44
-
-
84861582126
-
Connexin43 phosphorylation and cytoprotection in the heart
-
Jeyaraman, M. M. & Srisakuldee, W., Nickel, B. E. & Kardami, E. Connexin43 phosphorylation and cytoprotection in the heart. Biochimica et biophysica acta 1818, 2009-2013, doi: 10. 1016/j. bbamem. 2011. 06. 023 (2012).
-
(2012)
Biochimica et Biophysica Acta
, vol.1818
, pp. 2009-2013
-
-
Jeyaraman, M.M.1
Srisakuldee, W.2
Nickel, B.E.3
Kardami, E.4
-
45
-
-
82755162967
-
MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2
-
Liu, X. et al. MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2. J Biol Chem 286, 42371-42380, doi: 10. 1074/jbc. M111. 261065 (2011).
-
(2011)
J Biol Chem
, vol.286
, pp. 42371-42380
-
-
Liu, X.1
|