-
1
-
-
57149142495
-
The impact of O2 availability on human cancer
-
Bertout, J. A., Patel, S. A. & Simon, M. C. The impact of O2 availability on human cancer. Nat. Rev. Cancer 8, 967-975 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 967-975
-
-
Bertout, J.A.1
Patel, S.A.2
Simon, M.C.3
-
2
-
-
0141869070
-
Investigating hypoxic tumor physiology through gene expression patterns
-
Denko, N. C. et al. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene 22, 5907-5914 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 5907-5914
-
-
Denko, N.C.1
-
3
-
-
0035925098
-
Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
-
Hockel, M. & Vaupel, P. Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 93, 266-276 (2001).
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
4
-
-
66449130218
-
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer
-
Nanni, S. et al. Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. J. Clin. Invest. 119, 1093-1108 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1093-1108
-
-
Nanni, S.1
-
5
-
-
0034331255
-
Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age: An Eppendorf pO(2) study
-
Movsas, B. et al. Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age: an Eppendorf pO(2) study. Cancer 89, 2018-2024 (2000).
-
(2000)
Cancer
, vol.89
, pp. 2018-2024
-
-
Movsas, B.1
-
6
-
-
0031875310
-
Microvessel density in prostate cancer: Prognostic and therapeutic utility
-
Bostwick, D. G. & Iczkowski, K. A. Microvessel density in prostate cancer: prognostic and therapeutic utility. Semin. Urol. Oncol. 16, 118-123 (1998).
-
(1998)
Semin. Urol. Oncol.
, vol.16
, pp. 118-123
-
-
Bostwick, D.G.1
Iczkowski, K.A.2
-
7
-
-
33746161915
-
Study of microvessel density and the expression of the angiogenic factors VEGF, bFGF and the receptors Flt-1 and FLK-1 in benign, premalignant and malignant prostate tissues
-
Pallares, J. et al. Study of microvessel density and the expression of the angiogenic factors VEGF, bFGF and the receptors Flt-1 and FLK-1 in benign, premalignant and malignant prostate tissues. Histol. Histopathol. 21, 857-865 (2006).
-
(2006)
Histol. Histopathol.
, vol.21
, pp. 857-865
-
-
Pallares, J.1
-
8
-
-
44149092895
-
Hypoxia in prostate cancer: A powerful shield against tumour destruction?
-
Marignol, L., Coffey, M., Lawler, M. & Hollywood, D. Hypoxia in prostate cancer: a powerful shield against tumour destruction? Cancer Treat. Rev. 34, 313-327 (2008).
-
(2008)
Cancer Treat. Rev.
, vol.34
, pp. 313-327
-
-
Marignol, L.1
Coffey, M.2
Lawler, M.3
Hollywood, D.4
-
9
-
-
35148828429
-
Hypoxia-inducible factor 1 (HIF-1) pathway
-
Semenza, G. L. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci. STKE. 2007, cm8 (2007).
-
(2007)
Sci. STKE.
, vol.2007
, pp. cm8
-
-
Semenza, G.L.1
-
10
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick, R. K. & McKnight, S. L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340 (2001).
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
11
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon, P. C., Hirota, K. & Semenza, G. L. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15, 2675-2686 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
12
-
-
18844408840
-
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: Identification of a functional hypoxia-responsive element
-
Metzen, E. et al. Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Biochem J. 387, 711-717 (2005).
-
(2005)
Biochem J.
, vol.387
, pp. 711-717
-
-
Metzen, E.1
-
13
-
-
1542344522
-
Hypoxia-inducible factor-1 and oncogenic signalling
-
Bardos, J. I. & Ashcroft, M. Hypoxia-inducible factor-1 and oncogenic signalling. Bioessays 26, 262-269 (2004).
-
(2004)
Bioessays
, vol.26
, pp. 262-269
-
-
Bardos, J.I.1
Ashcroft, M.2
-
14
-
-
28544446058
-
Mitochondrial tumour suppressors: A genetic and biochemical update
-
Gottlieb, E. & Tomlinson, I. P. Mitochondrial tumour suppressors: a genetic and biochemical update. Nat. Rev. Cancer 5, 857-866 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 857-866
-
-
Gottlieb, E.1
Tomlinson, I.P.2
-
15
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732 (2003).
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
16
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong, H. et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59, 5830-5835 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
-
17
-
-
1842426907
-
Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis
-
Zhong, H., Semenza, G. L., Simons, J. W. & De Marzo, A. M. Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detect. Prev. 28, 88-93 (2004).
-
(2004)
Cancer Detect. Prev.
, vol.28
, pp. 88-93
-
-
Zhong, H.1
Semenza, G.L.2
Simons, J.W.3
De Marzo, A.M.4
-
18
-
-
84920271526
-
The effects of nonspecific HIF1alpha inhibitors on development of castrate resistance and metastases in prostate cancer
-
Ranasinghe, W. K. et al. The effects of nonspecific HIF1alpha inhibitors on development of castrate resistance and metastases in prostate cancer. Cancer Med. 3, 245-251 (2014).
-
(2014)
Cancer Med.
, vol.3
, pp. 245-251
-
-
Ranasinghe, W.K.1
-
19
-
-
39749110083
-
Small non-coding RNAs in animal development
-
Stefani, G. & Slack, F. J. Small non-coding RNAs in animal development. Nat. Rev. Mol. Cell Biol. 9, 219-230 (2008).
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 219-230
-
-
Stefani, G.1
Slack, F.J.2
-
20
-
-
70349168446
-
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation
-
Huang, X. et al. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol. Cell 35, 856-867 (2009).
-
(2009)
Mol. Cell
, vol.35
, pp. 856-867
-
-
Huang, X.1
-
21
-
-
79959425207
-
A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like
-
Kelly, T. J., Souza, A. L., Clish, C. B. & Puigserver, P. A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol. Cell. Biol. 31, 2696-2706 (2011).
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 2696-2706
-
-
Kelly, T.J.1
Souza, A.L.2
Clish, C.B.3
Puigserver, P.4
-
22
-
-
84897051446
-
Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210
-
Wang, H. et al. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nat. Immunol. 15, 393-401 (2014).
-
(2014)
Nat. Immunol.
, vol.15
, pp. 393-401
-
-
Wang, H.1
-
23
-
-
76749131605
-
MIR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma
-
Liu, C. J. et al. miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma. Cancer Res. 70, 1635-1644 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 1635-1644
-
-
Liu, C.J.1
-
24
-
-
78049424494
-
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis
-
Ghosh, G. et al. Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis. J. Clin. Invest. 120, 4141-4154 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 4141-4154
-
-
Ghosh, G.1
-
25
-
-
84874639351
-
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis
-
Chen, Z. et al. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J. Clin. Invest. 123, 1057-1067 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1057-1067
-
-
Chen, Z.1
-
26
-
-
74049163692
-
Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma
-
Schaefer, A. et al. Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. Int. J. Cancer 126, 1166-1176 (2010).
-
(2010)
Int. J. Cancer
, vol.126
, pp. 1166-1176
-
-
Schaefer, A.1
-
27
-
-
84455170150
-
MIR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells
-
Mihelich, B. L. et al. miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. J. Biol. Chem. 286, 44503-44511 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 44503-44511
-
-
Mihelich, B.L.1
-
28
-
-
84873850704
-
MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer
-
Hirata, H. et al. MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. PLoS One 8, e55502 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e55502
-
-
Hirata, H.1
-
29
-
-
84880466847
-
Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1)
-
Liu, R., Li, J., Teng, Z., Zhang, Z. & Xu, Y. Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1). PLoS One 8, e68982 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e68982
-
-
Liu, R.1
Li, J.2
Teng, Z.3
Zhang, Z.4
Xu, Y.5
-
30
-
-
84878016403
-
MIR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells
-
Qu, Y. et al. MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells. Int. J. Cancer 133, 544-555 (2013).
-
(2013)
Int. J. Cancer
, vol.133
, pp. 544-555
-
-
Qu, Y.1
-
31
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxiainducible factor
-
Appelhoff, R. J. et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxiainducible factor. J. Biol. Chem. 279, 38458-38465 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
-
32
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara, N. & Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr. Rev. 18, 4-25 (1997).
-
(1997)
Endocr. Rev.
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
33
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel, W. et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14, 391-396 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 391-396
-
-
Zundel, W.1
-
34
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong, H. et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60, 1541-1545 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
-
35
-
-
10744222860
-
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
-
Wang, S. et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4, 209-221 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 209-221
-
-
Wang, S.1
-
36
-
-
60549112361
-
Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor
-
Segura, M. F. et al. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc. Natl. Acad. Sci. USA. 106, 1814-1819 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA.
, vol.106
, pp. 1814-1819
-
-
Segura, M.F.1
-
37
-
-
84870623242
-
Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer
-
Hirata, H. et al. Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer. PLoS One 7, e51056 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e51056
-
-
Hirata, H.1
-
38
-
-
84895929429
-
Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis
-
Lei, R. et al. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene 33, 1287-1296 (2014).
-
(2014)
Oncogene
, vol.33
, pp. 1287-1296
-
-
Lei, R.1
-
39
-
-
84930435906
-
Thyroid hormone regulates muscle fiber type conversion via miR-133a1
-
Zhang, D. et al. Thyroid hormone regulates muscle fiber type conversion via miR-133a1. J. Cell Biol. 207, 753-766 (2014).
-
(2014)
J. Cell Biol.
, vol.207
, pp. 753-766
-
-
Zhang, D.1
-
40
-
-
84863361375
-
MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1
-
Shi, Z. M. et al. MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. PLoS One 7, e32709 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e32709
-
-
Shi, Z.M.1
-
41
-
-
84881401763
-
TRAF6 upregulates expression of HIF-1alpha and promotes tumor angiogenesis
-
Sun, H. et al. TRAF6 upregulates expression of HIF-1alpha and promotes tumor angiogenesis. Cancer Res. 73, 4950-4959 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 4950-4959
-
-
Sun, H.1
|