Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease

Neurobiology of Aging

Volumn 42, Issue , 2016, Pages 80-90

  Tiernan, Chelsea T ^a   Ginsberg, Stephen D ^b,c   Guillozet Bongaarts, Angela L ^d   Ward, Sarah M ^a   He, Bin ^e   Kanaan, Nicholas M ^a,f   Mufson, Elliott J ^e   Binder, Lester I ^a   Counts, Scott E ^a,f  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^d ALLEN INSTITUTE FOR BRAIN SCIENCE   (United States)

^e BARROW NEUROLOGICAL INSTITUTE   (United States)

^f St Mary's Mercy Medical Center   (United States)

Author keywords

Alzheimer's disease; Cholinergic basal forebrain; Mild cognitive impairment; Protein homeostasis; Tau

Indexed keywords

MESSENGER RNA; TAU PROTEIN; NERVE PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CELL; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MEYNERT BASAL NUCLEUS; MILD COGNITIVE IMPAIRMENT; NEUROFIBRILLARY TANGLE; NUCLEUS BASALIS NEURON; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN METABOLISM; PROTEIN PROCESSING; UPREGULATION; COGNITIVE DEFECT; GENETICS; HOMEOSTASIS; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BASAL NUCLEUS OF MEYNERT; CELL SURVIVAL; COGNITIVE DYSFUNCTION; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; HOMEOSTASIS; HUMANS; MALE; NERVE TISSUE PROTEINS; NEUROFIBRILLARY TANGLES; NEURONS; PHOSPHORYLATION; PROTEOLYSIS; TAU PROTEINS; UP-REGULATION;

EID: 84962179904     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2016.02.031     Document Type: Article

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