Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism

Molecular and Cellular Biochemistry

Volumn 414, Issue 1-2, 2016, Pages 23-36

  Onasanwo, Samuel A ^a   Velagapudi, Ravikanth ^b   El Bakoush, Abdelmeneim ^b   Olajide, Olumayokun A ^b  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b UNIVERSITY OF HUDDERSFIELD   (United Kingdom)

Author keywords

Kolaviron; Microglia; Neuroinflammation; Neuroprotective; Nrf2 signalling pathway

Indexed keywords

CYCLOOXYGENASE 2; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; KOLAVIRON; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; FLAVONOID; NFE2L2 PROTEIN, MOUSE; NITRIC OXIDE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BINDING ASSAY; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; ENZYME INHIBITION; GENE SILENCING; HIPPOCAMPAL NEURONAL CULTURE; IMMUNOBLOTTING; MICROGLIAL CELL CULTURE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; GENETICS; INFLAMMATION; METABOLISM; MICROGLIA; PATHOLOGY; SECRETION (PROCESS);

ANIMALS; CELL LINE; COCULTURE TECHNIQUES; CYCLOOXYGENASE 2; DINOPROSTONE; FLAVONOIDS; GENE SILENCING; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84962173279     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-016-2655-8     Document Type: Article

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