Mechanisms for the hepatoprotective action of kolaviron: Studies on hepatic enzymes, microsomal lipids and lipid peroxidation in carbontetrachloride-treated rats

Pharmacological Research

Volumn 42, Issue 1, 2000, Pages 75-80

  Olatunde Farombi, E ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Antioxidant; CCl4; Hepatic enzymes; Kolaviron; Lipid peroxidation; Microsomal lipids

Indexed keywords

AMINOPHENAZONE; CARBON TETRACHLORIDE; ETHOXYRESORUFIN DEETHYLASE; GARCINIA KOLA EXTRACT; GLUCOSE 6 PHOSPHATASE; GLUTATHIONE TRANSFERASE; KOLAVIRON; LIPID PEROXIDE; LIVER ENZYME; MALONALDEHYDE; METHYLTRANSFERASE; UNSPECIFIC MONOOXYGENASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACTION; LIPID PEROXIDATION; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL; RAT;

EID: 0033847108     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1999.0648     Document Type: Article

References (41)

1. Free radical mechanisms in tissue injury
2. Tryptophan reaction with free radicals arisen from carbon tetrachloride in a model system. A mass spectrometric study
3. Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola
4. Biflavanoids
5. Systematic significance of xanthones, benzophenones and biflavonoids in Garcinia
6. Antihepatotoxic, constituents of Garcina kola seeds
7. Evaluation of the antihepatotoxic activity of the biflavanoids of Garcinia kola seeds
8. Protective effects of Garcinia kola seed extract against paracetamol-induced hepatotoxicity in rats
9. Prevention of thioacetamide-induced hepatoxicity by biflavanones of Garcinia kola
10. Inhibition of drug metabolism by flavonoid extract (kolaviron) of Garcinia kola seeds in the rat
11. Spectral studies of drug interaction with hepatic microsomal cytochrome
12. Enzymatic dealkylation of aminopyrine and other alkylamines
13. The colorimetric estimation of formaldehyde by means of the Hantzech reaction
14. Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats
15. The solubilization and partial purification of glucuronyl transferase from rabbit liver microsomes
16. Alteration in tissue levels of UDP-glucose dehydrogenase, UDP-glucuronic acid pyrophosphatase and glucuronyl transferase induced by substances influencing the production of ascorbic acid
17. Glutathione-S-transferase
18. A simplified procedure for the assay of 5'nucleotidase
19. The pathological occurrence of glucose-6-phosphatase in serum in liver diseases
20. A simple method for the isolation and purification of total lipids from animal tissue
21. The colorimetric determination of phosphorus
22. Phosphorus assay in column chromatography
23. Determination of cholesterol using O-phthaldehyde
24. Microsomal lipid peroxidation
25. Protein measurement with Folin phenol reagent
26. Antihepatotoxic biochemical effects of kolaviron, a biflavonoid of Garcinia kola seeds
27. Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice
28. Effect of Eugenol on drug-metabolizing enzymes of carbon tetrachloride-intoxicated rat liver
29. Metabolic activation of haloalkanes and tests in vitro for mutagenicity
30. Formation of chloroform from carbontetrachloride in liver microsomes, lipid peroxidation and destruction of cytochrome P-450
31. Lipid peroxidation and the degradation of cytochrome P-450 heme
32. Resolution of the cytochrome P-450 containing co-hydroxylation system of liver microsomes into three components
33. Changes in some rat hepatic microsomal components induced by prolonged administration of chloroquine
34. Dietary influences on membrane function: Importance in protection against damage and disease
35. Lipid peroxidation of rat liver microsomes
36. Oxygen radical-induced inhibition of alkaline phosphatase activity in reconstituted membranes
37. Regulation of uridine diphosphate glucuronosyltransferase expression by phenolic antioxidants
38. Modulation of glutathione S-transferases and glutathionc peroxidase by the anticarcinogen butylated hydroxyanisole in murine extrahepatic organs