A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4726-4734

  Okorji, Uchechukwu P ^a   Olajide, Olumayokun A ^a  

^a UNIVERSITY OF HUDDERSFIELD   (United Kingdom)

Author keywords

Artesunate; COX 2; Microglia; mPGES 1; NF B; p38 MAPK

Indexed keywords

ARTEMISININ DERIVATIVE; ARTESUNATE; CYCLOOXYGENASE 2; GAMMA INTERFERON; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG STRUCTURE; ENZYME IMMUNOASSAY; ENZYME INHIBITION; GENE EXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ARTESUNATE;

ANIMALS; ARTEMISININS; CELL SURVIVAL; CELLS, CULTURED; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MOLECULAR STRUCTURE; NF-KAPPA B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906935243     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.007     Document Type: Article

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