An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-5

  Handel, Adam E ^a,b   Williamson, Alexander J ^b   Disanto, Giulio ^a,b   Handunnetthi, Lahiru ^a,b   Giovannoni, Gavin ^c   Ramagopalan, Sreeram V ^a,b,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DISEASE ASSOCIATION; DISEASE COURSE; GENETIC VARIABILITY; HIGH RISK PATIENT; HUMAN; INFECTIOUS MONONUCLEOSIS; MEDICAL LITERATURE; MEDLINE; METHODOLOGY; MULTIPLE SCLEROSIS; RISK ASSESSMENT; SEX RATIO; COHORT ANALYSIS; FEMALE; MALE; META ANALYSIS; RISK FACTOR; VIROLOGY;

HUMAN HERPESVIRUS 4;

COHORT STUDIES; FEMALE; HUMANS; INFECTIOUS MONONUCLEOSIS; MALE; MULTIPLE SCLEROSIS; RISK FACTORS;

EID: 77958600548     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012496     Document Type: Article

References (41)

1. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG (2000) Multiple sclerosis. N Engl J Med 343: 938-952.
2. Handel AE, Giovannoni G, Ebers GC, Ramagopalan SV (2010) Environmental factors and their timing in adult-onset multiple sclerosis. Nat Rev Neurol 6: 156-166.
3. Handel AE, Handunnetthi L, Giovannoni G, Ebers GC, Ramagopalan SV (2010) Genetic and environmental factors and the distribution of multiple sclerosis in Europe. Eur J Neurol.
4. Simon KC, van der Mei IA, Munger KL, Ponsonby A, Dickinson J, et al. (2010) Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1*1501 on multiple sclerosis risk. Neurology 74: 1365-1371.
5. Ramagopalan SV, Maugeri NJ, Handunnetthi L, Lincoln MR, Orton SM, et al. (2009) Expression of the multiple sclerosis-associated MHC class II Allele HLADRB1* 1501 is regulated by vitamin D. PLoS Genet 5: e1000369.
6. Salvetti M, Giovannoni G, Aloisi F (2009) Epstein-Barr virus and multiple sclerosis. Curr Opin Neurol 22: 201-206.
7. Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernan MA, et al. (2001) Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA 286: 3083-3088.
8. Goodin DS (2009) The causal cascade to multiple sclerosis: a model for MS pathogenesis. PLoS ONE 4: e4565.
9. Lunemann JD, Tintore M, Messmer B, Strowig T, Rovira A, et al. (2010) Elevated Epstein-Barr virus-encoded nuclear antigen-1 immune responses predict conversion to multiple sclerosis. Ann Neurol 67: 159-169.
10. Farrell RA, Antony D, Wall GR, Clark DA, Fisniku L, et al. (2009) Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 73: 32-38.
11. Warner HB, Carp RI (1981) Multiple sclerosis and Epstein-Barr virus. Lancet 2: 1290.
12. Ascherio A, Munger KL (2007) Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann Neurol 61: 288-299.
13. Thacker EL, Mirzaei F, Ascherio A (2006) Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann Neurol 59: 499-503.
14. De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, et al. (2009) Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol 8: 1111-1119.
15. Operskalski EA, Visscher BR, Malmgren RM, Detels R (1989) A case-control study of multiple sclerosis. Neurology 39: 825-829.
16. Souberbielle BE, Martin-Mondiere C, O'Brien ME, Carydakis C, Cesaro P, et al. (1990) A case-control epidemiological study of MS in the Paris area with particular reference to past disease history and profession. Acta Neurol Scand 82: 303-310.
17. Hopkins RS, Indian RW, Pinnow E, Conomy J (1991) Multiple sclerosis in Galion, Ohio: prevalence and results of a case-control study. Neuroepidemiology 10: 192-199.
18. Martyn CN, Cruddas M, Compston DA (1993) Symptomatic Epstein-Barr virus infection and multiple sclerosis. J Neurol Neurosurg Psychiatry 56: 167-168.
19. Casetta I, Granieri E, Malagu S, Tola MR, Paolino E, et al. (1994) Environmental risk factors and multiple sclerosis: a community-based, casecontrol study in the province of Ferrara, Italy. Neuroepidemiology 13: 120-128.
20. Gusev E, Boiko A, Lauer K, Riise T, Deomina T (1996) Environmental risk factors in MS: a case-control study in Moscow. Acta Neurol Scand 94: 386-394.
21. Marrie RA, Wolfson C, Sturkenboom MC, Gout O, Heinzlef O, et al. (2000) Multiple sclerosis and antecedent infections: a case-control study. Neurology 54: 2307-2310.
22. Hernan MA, Zhang SM, Lipworth L, Olek MJ, Ascherio A (2001) Multiple sclerosis and age at infection with common viruses. Epidemiology 12: 301-306.
23. Zorzon M, Zivadinov R, Nasuelli D, Dolfini P, Bosco A, et al. (2003) Risk factors of multiple sclerosis: a case-control study. Neurol Sci 24: 242-247.
24. Haahr S, Plesner AM, Vestergaard BF, Hollsberg P (2004) A role of late Epstein- Barr virus infection in multiple sclerosis. Acta Neurol Scand 109: 270-275.
25. Ponsonby AL, van der Mei I, Dwyer T, Blizzard L, Taylor B, et al. (2005) Exposure to infant siblings during early life and risk of multiple sclerosis. JAMA 293: 463-469.
26. Zaadstra BM, Chorus AM, van Buuren S, Kalsbeek H, van Noort JM (2008) Selective association of multiple sclerosis with infectious mononucleosis. Mult Scler 14: 307-313.
27. Ramagopalan SV, Valdar W, Dyment DA, DeLuca GC, Yee IM, et al. (2009) Association of infectious mononucleosis with multiple sclerosis. a populationbased study. Neuroepidemiology 32: 257-262.
28. Ahlgren C, Toren K, Oden A, Andersen O (2009) A population-based casecontrol study on viral infections and vaccinations and subsequent multiple sclerosis risk. Eur J Epidemiol 24: 541-552.
29. Lindberg C, Andersen O, Vahlne A, Dalton M, Runmarker B (1991) Epidemiological investigation of the association between infectious mononucleosis and multiple sclerosis. Neuroepidemiology 10: 62-65.
30. Haahr S, Koch-Henriksen N, Moller-Larsen A, Eriksen LS, Andersen HM (1995) Increased risk of multiple sclerosis after late Epstein-Barr virus infection: a historical prospective study. Mult Scler 1: 73-77.
31. Goldacre MJ, Wotton CJ, Seagroatt V, Yeates D (2004) Multiple sclerosis after infectious mononucleosis: record linkage study. J Epidemiol Community Health 58: 1032-1035.
32. Nielsen TR, Rostgaard K, Nielsen NM, Koch-Henriksen N, Haahr S, et al. (2007) Multiple sclerosis after infectious mononucleosis. Arch Neurol 64: 72-75.
33. Conn HO (1997) Interpretation of data from multiple trials: a critical review. J Intern Med 241: 177-183.
34. Handel AE, Giovannoni G, Ebers GC, Ramagopalan SV (2010) Environmental factors and their timing in adult-onset multiple sclerosis. Nat Rev Neurol.
35. Crawford DH, Macsween KF, Higgins CD, Thomas R, McAulay K, et al. (2006) A cohort study among university students: identification of risk factors for Epstein-Barr virus seroconversion and infectious mononucleosis. Clin Infect Dis 43: 276-282.
36. Lunemann JD, Kamradt T, Martin R, Munz C (2007) Epstein-barr virus: environmental trigger of multiple sclerosis? J Virol 81: 6777-6784.
37. Sotgiu S, Piana A, Pugliatti M, Sotgiu A, Deiana GA, et al. (2001) Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls. Mult Scler 7: 371-374.
38. Fainardi E, Castellazzi M, Tamborino C, Seraceni S, Tola MR, et al. (2009) Chlamydia pneumoniae-specific intrathecal oligoclonal antibody response is predominantly detected in a subset of multiple sclerosis patients with progressive forms. J Neurovirol 15: 425-433.
39. Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, et al. (2009) Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 132: 3318-3328.
40. Hammond SR, English DR, McLeod JG (2000) The age-range of risk of developing multiple sclerosis: evidence from a migrant population in Australia. Brain 123(Pt 5): 968-974.
41. Gaudet JP, Hashimoto L, Sadovnick AD, Ebers GC (1995) A study of birth order and multiple sclerosis in multiplex families. Neuroepidemiology 14: 188-192.