Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells

Oncotarget

Volumn 7, Issue 10, 2016, Pages 11424-11433

  Benitz, Simone ^a   Regel, Ivonne ^a,c   Reinhard, Tobias ^a   Popp, Anna ^a   Schäffer, Isabell ^a   Raulefs, Susanne ^a   Kong, Bo ^a   Esposito, Irene ^c   Michalski, Christoph W ^b   Kleeff, Jörg ^a,c,d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Differentiation gene silencing; Histone mono ubiquitination; Pancreatic cancer; Polycomb repressor complex

Indexed keywords

BMI1 PROTEIN; MUSCLE RING FINGER 1 PROTEIN; POLYCOMB REPRESSOR COMPLEX 1; PTF1 L COMPLEX; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 6; UNCLASSIFIED DRUG; HISTONE; TRANSCRIPTION FACTOR PTF1;

ACINAR TO DUCTAL METAPLASIA; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EPIGENETIC REPRESSION; GENE EXPRESSION; GENE SILENCING; H2AK119UB; H3K27ME3; HISTONE UBIQUITINATION; IN VITRO STUDY; METAPLASIA; MOUSE; MURINE; NONHUMAN; PANCREAS CANCER; PROTEIN EXPRESSION; REGULATORY MECHANISM; TUMOR CELL; ANIMAL; C57BL MOUSE; CELL DEDIFFERENTIATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UBIQUITINATION;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL DEDIFFERENTIATION; CELL LINE, TUMOR; GENE SILENCING; HISTONES; IMMUNOHISTOCHEMISTRY; METAPLASIA; MICE; MICE, INBRED C57BL; PANCREATIC NEOPLASMS; POLYCOMB REPRESSIVE COMPLEX 1; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 84961990505     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6717     Document Type: Article

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