Application of Tranexamic Acid in Trauma and Orthopedic Surgery

Orthopedic Clinics of North America

Volumn 47, Issue 1, 2016, Pages 137-143

  Jennings, John D ^a   Solarz, Mark K ^a,b   Haydel, Christopher ^a,b  

^a TEMPLE UNIVERSITY HOSPITAL   (United States)

^b NONE   (United States)

Author keywords

Antifibrinolytics; Hemorrhage; Orthopedics; Tranexamic acid; Transfusion; Trauma

Indexed keywords

PLACEBO; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

BLOOD TRANSFUSION; BLUNT TRAUMA; BONE INJURY; COST CONTROL; DEEP VEIN THROMBOSIS; DRUG APPROVAL; DRUG BLOOD LEVEL; DRUG COST; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; EVIDENCE BASED MEDICINE; FOOD AND DRUG ADMINISTRATION; HUMAN; JOINT PROSTHESIS; LUNG EMBOLISM; META ANALYSIS (TOPIC); OFF LABEL DRUG USE; OPERATIVE BLOOD LOSS; OPTIMAL DRUG DOSE; ORTHOPEDIC SURGERY; OUTCOME ASSESSMENT; PENETRATING TRAUMA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SPINE SURGERY; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT; TREATMENT DURATION; HIP ARTHROPLASTY; KNEE ARTHROPLASTY; WOUNDS AND INJURIES;

ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; HUMANS; ORTHOPEDIC PROCEDURES; TRANEXAMIC ACID; WOUNDS AND INJURIES;

EID: 84961784011     PISSN: 00305898     EISSN: 15581373     Source Type: Journal    
DOI: 10.1016/j.ocl.2015.08.014     Document Type: Review

References (50)

1. Napolitano L.M., Cohen M.J., Cotton B.A., et al. Tranexamic acid in trauma: how should we use it?. J Trauma Acute Care Surg 2013, 74(6):1575-1586.
2. Perel P., Clayton T., Altman D.G., et al. Red blood cell transfusion and mortality in trauma patients: risk-stratified analysis of an observational study. PLoS Med 2014, 11(6):e1001664.
3. McCormack P.L. Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 2012, 72(5):585-617.
4. Jimenez J.J., Iribarren J.L., Lorente L., et al. Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial. Crit Care 2007, 11(6):R117.
5. Wei Z., Liu M. The effectiveness and safety of tranexamic acid in total hip or knee arthroplasty: a meta-analysis of 2720 cases. Transfus Med 2015, 25(3):151-162.
6. Danninger T., Memtsoudis S.G. Tranexamic acid and orthopedic surgery-the search for the holy grail of blood conservation. Ann Transl Med 2015, 3(6):77.
7. Poeran J., Rasul R., Suzuki S., et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ 2014, 349:g4829.
8. Digas G., Koutsogiannis I., Meletiadis G., et al. Intra-articular injection of tranexamic acid reduce blood loss in cemented total knee arthroplasty. Eur J Orthop Surg Traumatol 2015, 25(5):1-8.
9. Cheriyan T., Maier S.P., Bianco K., et al. Efficacy of tranexamic acid on surgical bleeding in spine surgery: a meta-analysis. Spine J 2015, 15(4):752-761.
10. Li Z.J., Fu X., Xing D., et al. Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials. Eur Spine J 2013, 22(9):1950-1957.
11. Vijay B.S., Bedi V., Mitra S., et al. Role of tranexamic acid in reducing postoperative blood loss and transfusion requirement in patients undergoing hip and femoral surgeries. Saudi J Anaesth 2013, 7(1):29-32.
12. Zufferey P.J., Miquet M., Quenet S., et al. Tranexamic acid in hip fracture surgery: a randomized controlled trial. Br J Anaesth 2010, 104(1):23-30.
13. Hunt B.J. The current place of tranexamic acid in the management of bleeding. Anaesthesia 2015, 70(Suppl 1):50-53. e18.
14. Tengborn L., Blombäck M., Berntorp E. Tranexamic acid: an old drug still going strong and making a revival. Thromb Res 2015, 135(2):231-242.
15. Dunn C.J., Goa K.L. Tranexamic acid: a review of its use in surgery and other indications. Drugs 1999, 57(6):1005-1032.
16. Benoni G., Lethagen S., Fredin H. The effect of tranexamic acid on local and plasma fibrinolysis during total knee arthroplasty. Thromb Res 1997, 85(3):195-206.
17. Dahuja A., Dahuja G., Jaswal V., et al. A prospective study on role of tranexamic acid in reducing postoperative blood loss in total knee arthroplasty and its effect on coagulation profile. J Arthroplasty 2014, 29(4):733-735.
18. Wang C.G., Sun Z.H., Liu J., et al. Safety and efficacy of intra-articular tranexamic acid injection without drainage on blood loss in total knee arthroplasty: a randomized clinical trial. Int J Surg 2015, 20:1-7.
19. Gao F., Sun W., Guo W., et al. Topical application of tranexamic acid plus diluted epinephrine reduces postoperative hidden blood loss in total hip arthroplasty. J Arthroplasty 2015, [Epub ahead of print].
20. Panteli M., Papakostidis C., Dahabreh Z., et al. Topical tranexamic acid in total knee replacement: a systematic review and meta-analysis. Knee 2013, 20(5):300-309.
21. Aguilera X., Martínez-Zapata M.J., Hinarejos P., et al. Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty: a multicenter, randomized, controlled trial. Arch Orthop Trauma Surg 2015, 135(7):1017-1025.
22. Roberts I., Shakur H., Coats T., et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess 2013, 17(10):1-79.
23. Johansson T., Pettersson L.G., Lisander B. Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients. Acta Orthop 2005, 76(3):314-319.
24. Oremus K. Tranexamic acid for the reduction of blood loss in total knee arthroplasty. Ann Transl Med 2015, 3(Suppl 1):S40.
25. Yang Z.G., Chen W.P., Wu L.D. Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg Am 2012, 94(13):1153-1159.
26. Tan J., Chen H., Liu Q., et al. A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res 2013, 184(2):880-887.
27. Morrison J.J., Dubose J.J., Rasmussen T.E., et al. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg 2012, 147(2):113-119.
28. Shakur H., Roberts I., Bautista R., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010, 376(9734):23-32.
29. Morrison J.J., Ross J.D., Dubose J.J., et al. Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II study. JAMA Surg 2013, 148(3):218-225.
30. Guerriero C., Cairns J., Perel P., et al. Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. PLoS One 2011, 6(5):e18987. CRASH 2 Trial Collaborators.
31. Jawa R., Singer A., McCormack J., et al. Use of tranexamic acid in civilian US trauma centers: results of a national survey 2015, Academic Surgical Congress, Las Vegas (Nevada).
32. Valle E.J., Allen C.J., Van Haren R.M., et al. Do all trauma patients benefit from tranexamic acid?. J Trauma Acute Care Surg 2014, 76(6):1373-1378.
33. Sukeik M., Alshryda S., Haddad F.S., et al. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br 2011, 93(1):39-46.
34. Lemaire R. Strategies for blood management in orthopaedic and trauma surgery. J Bone Joint Surg Br 2008, 90(9):1128-1136.
35. Garneti N., Field J. Bone bleeding during total hip arthroplasty after administration of tranexamic acid. J Arthroplasty 2004, 19(4):488-492.
36. Whiting D.R., Duncan C.M., Sierra R.J., et al. Tranexamic acid benefits total joint arthroplasty patients regardless of preoperative hemoglobin value. J Arthroplasty 2015, [Epub ahead of print].
37. Wang C., Xu G.J., Han Z., et al. Topical application of tranexamic acid in primary total hip arthroplasty: a systemic review and meta-analysis. Int J Surg 2015, 15:134-139.
38. Benoni G., Carlsson A., Petersson C., et al. Does tranexamic acid reduce blood loss in knee arthroplasty?. Am J Knee Surg 1995, 8(3):88-92.
39. Hiippala S., Strid L., Wennerstrand M., et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 1995, 74(5):534-537.
40. Kundu R., Das A., Basunia S.R., et al. Does a single loading dose of tranexamic acid reduce perioperative blood loss and transfusion requirements after total knee replacement surgery? A randomized, controlled trial. J Nat Sci Biol Med 2015, 6(1):94-99.
41. Ishii Y., Noguchi H., Sato J., et al. Effect of a single injection of tranexamic acid on blood loss after primary hybrid TKA. Knee 2015, 22(3):197-200.
42. Sabatini L., Atzori F. Topical intra-articular and intravenous tranexamic acid to reduce blood loss in total knee arthroplasty. Ann Transl Med 2015, 3(Suppl 1):S18.
43. Farrokhi M.R., Kazemi A.P., Eftekharian H.R., et al. Efficacy of prophylactic low dose of tranexamic acid in spinal fixation surgery: a randomized clinical trial. J Neurosurg Anesthesiol 2011, 23(4):290-296.
44. Raksakietisak M., Sathitkarnmanee B., Srisaen P., et al. Two doses of tranexamic acid reduce blood transfusion in complex spine surgery: a prospective randomized study. Spine (Phila Pa 1976) 2015, [Epub ahead of print].
45. Yang B., Li H., Wang D., et al. Systematic review and meta-analysis of perioperative intravenous tranexamic acid use in spinal surgery. PLoS One 2013, 8(2):e55436.
46. Xie J., Lenke L.G., Li T., et al. Preliminary investigation of high-dose tranexamic acid for controlling intraoperative blood loss in patients undergoing spine correction surgery. Spine J 2015, 15(4):647-654.
47. Lee C., Freeman R., Edmondson M., et al. The efficacy of tranexamic acid in hip hemiarthroplasty surgery: an observational cohort study. Injury 2015, [Epub ahead of print].
48. Kadar A., Chechik O., Steinberg E., et al. Predicting the need for blood transfusion in patients with hip fractures. Int Orthop 2013, 37(4):693-700.
49. Sadeghi M., Mehr-Aein A. Does a single bolus dose of tranexamic acid reduce blood loss and transfusion requirements during hip fracture surgery? A prospective randomized double blind study in 67 patients. Acta Med Iran 2007, 45(6):437-442.
50. Emara W.M., Moez K.K., Elkhouly A.H. Topical versus intravenous tranexamic acid as a blood conservation intervention for reduction of post-operative bleeding in hemiarthroplasty. Anesth Essays Res 2014, 8(1):48-53.