Do all trauma patients benefit from tranexamic acid?

Journal of Trauma and Acute Care Surgery

Volumn 76, Issue 6, 2014, Pages 1373-1378

  Valle, Evan J ^a   Allen, Casey J ^a   Van Haren, Robert M ^a   Jouria, Jassin M ^a   Li, Hua ^a   Livingstone, Alan S ^a   Namias, Nicholas ^a   Schulman, Carl I ^a   Proctor, Kenneth G ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Hemostasis; resuscitation; transfusion

Indexed keywords

TRANEXAMIC ACID;

AGE DISTRIBUTION; AGED; BLOOD TRANSFUSION; CONFERENCE PAPER; CONTROLLED STUDY; DEATH; EMERGENCY HEALTH SERVICE; EMERGENCY SURGERY; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; INJURY; INJURY SCALE; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; TRAUMATIC BRAIN INJURY;

ADULT; ANTIFIBRINOLYTIC AGENTS; BRAIN INJURIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HEMODYNAMICS; HUMANS; INCIDENCE; INJECTIONS, INTRAVENOUS; INJURY SEVERITY SCORE; INTRACRANIAL HEMORRHAGE, TRAUMATIC; MALE; PROGNOSIS; PROSPECTIVE STUDIES; RESUSCITATION; RISK FACTORS; SURVIVAL RATE; TRANEXAMIC ACID; TRAUMA CENTERS; UNITED STATES;

EID: 84901999597     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000242     Document Type: Conference Paper

References (18)

1. CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376(9734):23-32.
2. Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military Application of TranexamicAcid in TraumaEmergency Resuscitation (MATTERs) study. Arch Surg. 2012;147(2):113-119.
3. CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377(9771):1096-1101.
4. Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt BJ, Lecky F, Brohi K,Willett K; CRASH-2 Collaborators. Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. Br Med J. 2012;345:e5839.
5. Pusateri AE, Weiskopf RB, Bebarta V, Butler F, Cestero RF, Chaudry IH, Deal V, Dorlac WC, Gerhardt RT, Given MB, et al.; US DoD Hemorrhage and Resuscitation Research and Development Steering Committee. Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Shock. 2013;39(2):121-126.
6. Napolitano LM, Cohen MJ, Cotta BA, Schreiber MA, Moore EE. Tranexamic acid in trauma: how should we use it J Trauma Acute Care Surg. 2013;74(6):1575-1586.
7. Morrison JJ, Ross JD. Is viscoelastic evidence of hyperfibrinolysis the ideal indicator for tranexamic acid administration in trauma J Trauma Acute Care Surg. 2013;75(4):743.
8. Stuart EA. Matching methods for causal inference: a review and a look forward. Stat Sci. 2010;25(1):1-21.
9. Schochl H, Voelckel W, Grassetto A, Schlimp CJ. Practical application of point-of-care coagulation testing to guide treatment decisions in trauma. J Trauma Acute Care Surg. 2013;74(6):1587-1598.
10. Schlimp CJ, Schochl H. The role of fibrinogen in trauma-induced coagulopathy. Hamostaseologie. 2013;34(1):29-39.
11. Faraoni D, Van Der Linden P. A systematic review of antifibrinolytics and massive injury. Minerva Anestesiol. 2013. Nov 28 [epub ahead of print].
12. Schochl H, Schlimp CJ, Voelckel W. Potential value of pharmacological protocols in trauma. Curr Opin Anaesthesiol. 2013;26(2):221-229.
13. Chapman MP, Moore EE, Ramos CR, Ghasabyan A, Harr JN, Chin TL, Stringham JR, Sauaia A, Silliman CC, Banerjee A. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg. 2013;75(6):961-967; discussion 967.
14. Wafaisade A, Wutzler S, Lefering R, Tjardes T, Banerjee M, Paffrath T, Bouillon B, Maegele M, Trauma Registry of DGU. Drivers of acute coagulopathy after severe trauma: a multivariate analysis of 1987 patients. Emerg Med J. 2010(27):934-939.
15. Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65(4):748-754.
16. Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, Biffli WL, Burlew CC, Johnson JL, Sauaia A. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg. 2010:252(3):434-442.
17. Vu EN, Sclamp RS, Wand RT, Kleine-Deters GA, Vu MP, Tallon JM. Prehospital use of tranexamic acid for hemorrhagic shock in primary and secondary air medical evacuation. Air Med J. 2013;32(5):289-292.
18. Tranexamic Acid Injection 100 mg/ml NDC 67457-197-10 10 mL single dose vial, packages of 10 [package insert]. Rockford, IL: Mylan Institutional, LLC.