메뉴 건너뛰기




Volumn 11, Issue 6, 2007, Pages

Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: A case control study followed by a randomized double-blind controlled trial

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; D DIMER; INTERLEUKIN 6; NORADRENALIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTAMINE; SODIUM CHLORIDE; TRANEXAMIC ACID; TUMOR NECROSIS FACTOR RECEPTOR; ANTIFIBRINOLYTIC AGENT; AUTACOID;

EID: 38549180575     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc6173     Document Type: Article
Times cited : (177)

References (26)
  • 1
    • 0036305603 scopus 로고    scopus 로고
    • The systemic inflammatory response to cardiac surgery: Implications for the anesthesiologist
    • 10.1097/00000542-200207000-00030 12131125
    • Laffey JG Boylan JF Cheng DC The systemic inflammatory response to cardiac surgery: Implications for the anesthesiologist Anesthesiology 2002, 97:215-252. 10.1097/00000542-200207000-00030 12131125
    • (2002) Anesthesiology , vol.97 , pp. 215-252
    • Laffey, J.G.1    Boylan, J.F.2    Cheng, D.C.3
  • 2
    • 38549115523 scopus 로고    scopus 로고
    • Hyperdynamic circulation following cardiopulmonary bypass predisposes to postoperative bleeding
    • (2 March 2001)
    • Taneja R Yared JP Hammel J O'Connor MS Insler S Starr NJ Hyperdynamic circulation following cardiopulmonary bypass predisposes to postoperative bleeding Critical Care 2001, 5(Suppl 1):P110. (2 March 2001)
    • (2001) Critical Care , vol.5 , Issue.SUPPL. 1
    • Taneja, R.1    Yared, J.P.2    Hammel, J.3    O'Connor, M.S.4    Insler, S.5    Starr, N.J.6
  • 3
    • 0028923431 scopus 로고
    • Angiotensin-converting enzyme inhibitors increase vasoconstrictor requirements after cardiopulmonary bypass
    • 10.1097/00000539-199503000-00007
    • Tuman KJ McCarthy RJ O'Connor CJ Holm WE Ivankovich AD Angiotensin-converting enzyme inhibitors increase vasoconstrictor requirements after cardiopulmonary bypass Anesth Analg 1995, 80:473-479. 10.1097/00000539-199503000-00007 7864410
    • (1995) Anesth Analg , vol.80 , pp. 473-479
    • Tuman, K.J.1    McCarthy, R.J.2    O'Connor, C.J.3    Holm, W.E.4    Ivankovich, A.D.5
  • 5
    • 0345356441 scopus 로고    scopus 로고
    • Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: A randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin
    • 10.1016/S0022-5223(03)00946-2 14666025
    • Greilich PE Brouse CF Whitten CW Chi L Dimaio JM Jessen ME Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: A randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin J Thorac Cardiovasc Surg 2003, 126:1498-1503. 10.1016/ S0022-5223(03)00946-2 14666025
    • (2003) J Thorac Cardiovasc Surg , vol.126 , pp. 1498-1503
    • Greilich, P.E.1    Brouse, C.F.2    Whitten, C.W.3    Chi, L.4    Dimaio, J.M.5    Jessen, M.E.6
  • 6
    • 0343134542 scopus 로고    scopus 로고
    • A retrospective survey of fibrinolysis as an indicator of poor outcome after cardiopulmonary bypass and a possible early sign of systemic inflammation syndrome
    • 10.1046/j.1365-2346.2000.00643.x 10758466
    • Cvachovec K Horacek M Vislocky I A retrospective survey of fibrinolysis as an indicator of poor outcome after cardiopulmonary bypass and a possible early sign of systemic inflammation syndrome Eur J Anaesthesiol 2000, 17:173-176. 10.1046/j.1365-2346.2000.00643.x 10758466
    • (2000) Eur J Anaesthesiol , vol.17 , pp. 173-176
    • Cvachovec, K.1    Horacek, M.2    Vislocky, I.3
  • 8
    • 0032973241 scopus 로고    scopus 로고
    • Low systemic vascular resistance state in patients undergoing cardiopulmonary bypass
    • 10.1097/00003246-199906000-00033 10397216
    • Kristof AS Magder S Low systemic vascular resistance state in patients undergoing cardiopulmonary bypass Crit Care Med 1999, 27:1121-1127. 10.1097/00003246-199906000-00033 10397216
    • (1999) Crit Care Med , vol.27 , pp. 1121-1127
    • Kristof, A.S.1    Magder, S.2
  • 9
    • 0033043915 scopus 로고    scopus 로고
    • Low systemic vascular resistance after cardiopulmonary bypass: Are we any closer to understanding the enigma?
    • 10.1097/00003246-199906000-00008 10397196
    • Johnson MR Low systemic vascular resistance after cardiopulmonary bypass: Are we any closer to understanding the enigma? Crit Care Med 1999, 27:1048-1050. 10.1097/00003246-199906000-00008 10397196
    • (1999) Crit Care Med , vol.27 , pp. 1048-1050
    • Johnson, M.R.1
  • 10
    • 0031035860 scopus 로고    scopus 로고
    • Dear SIRS, I'm sorry to say that I don't like you
    • 10.1097/00003246-199702000-00029 9034279
    • Vincent JL Dear SIRS, I'm sorry to say that I don't like you Crit Care Med 1997, 25:372-374. 10.1097/00003246-199702000-00029 9034279
    • (1997) Crit Care Med , vol.25 , pp. 372-374
    • Vincent, J.L.1
  • 12
    • 0037387583 scopus 로고    scopus 로고
    • Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery
    • 10.1097/01.CCM.0000059646.89546.98 12682474
    • Kilger E Weis F Briegel J Frey L Goetz AE Reuter D Nagy A Schuetz A Lamm P Knoll A Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Crit Care Med 2003, 31:1068-1074. 10.1097/01.CCM.0000059646.89546.98 12682474
    • (2003) Crit Care Med , vol.31 , pp. 1068-1074
    • Kilger, E.1    Weis, F.2    Briegel, J.3    Frey, L.4    Goetz, A.E.5    Reuter, D.6    Nagy, A.7    Schuetz, A.8    Lamm, P.9    Knoll, A.10
  • 13
    • 0031778437 scopus 로고    scopus 로고
    • Interleukin-6 levels in serum and lung lavage fluid of children undergoing open heart surgery correlate with postoperative morbidity
    • 10.1007/s001340050600 9660265
    • Hauser GJ Ben-Ari J Colvin MP Dalton HJ Hertzog JH Bearb M Hopkins RA Walker SM Interleukin-6 levels in serum and lung lavage fluid of children undergoing open heart surgery correlate with postoperative morbidity Intensive Care Med 1998, 24:481-486. 10.1007/s001340050600 9660265
    • (1998) Intensive Care Med , vol.24 , pp. 481-486
    • Hauser, G.J.1    Ben-Ari, J.2    Colvin, M.P.3    Dalton, H.J.4    Hertzog, J.H.5    Bearb, M.6    Hopkins, R.A.7    Walker, S.M.8
  • 14
    • 0035163406 scopus 로고    scopus 로고
    • Mechanisms and attenuation of hemostatic activation during extracorporeal circulation
    • 10.1016/S0003-4975(01)03211-8 11722116
    • Despotis GJ Avidan MS Hogue CW Jr Mechanisms and attenuation of hemostatic activation during extracorporeal circulation Ann Thorac Surg 2001, 72:S1821-S1831. 10.1016/S0003-4975(01)03211-8 11722116
    • (2001) Ann Thorac Surg , vol.72
    • Despotis, G.J.1    Avidan, M.S.2    Hogue Jr., C.W.3
  • 15
    • 33646269014 scopus 로고    scopus 로고
    • [Inflammatory response and haematological disorders in cardiac surgery: Toward a more physiological cardiopulmonary bypass]
    • 10.1016/j.annfar.2005.12.002 16488106
    • Baufreton C Corbeau JJ Pinaud F [Inflammatory response and haematological disorders in cardiac surgery: Toward a more physiological cardiopulmonary bypass] Ann Fr Anesth Reanim 2006, 25:510-520. 10.1016/ j.annfar.2005.12.002 16488106
    • (2006) Ann Fr Anesth Reanim , vol.25 , pp. 510-520
    • Baufreton, C.1    Corbeau, J.J.2    Pinaud, F.3
  • 16
    • 38549122231 scopus 로고    scopus 로고
    • Vasoplegic syndrome after cardiopulmonary bypass surgery associated factors and clinical outcomes: A nested case-control study
    • (22 March 2007) 10.1186/cc5414
    • Iribarren J Jimenez J Brouard M Lorenzo J Perez R Lorente L Nuñez C Henry C Martinez R Mora ML Vasoplegic syndrome after cardiopulmonary bypass surgery associated factors and clinical outcomes: A nested case-control study Crit Care 2007, 11(Suppl 2):P254. (22 March 2007) 10.1186/cc5414
    • (2007) Crit Care , vol.11 , Issue.SUPPL. 2
    • Iribarren, J.1    Jimenez, J.2    Brouard, M.3    Lorenzo, J.4    Perez, R.5    Lorente, L.6    Nuñez, C.7    Henry, C.8    Martinez, R.9    Mora, M.L.10
  • 17
    • 0035877968 scopus 로고    scopus 로고
    • Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation
    • 10.1182/blood.V97.12.3941 11389038
    • Syrovets T Jendrach M Rohwedder A Schule A Simmet T Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation Blood 2001, 97:3941-3950. 10.1182/blood.V97.12.3941 11389038
    • (2001) Blood , vol.97 , pp. 3941-3950
    • Syrovets, T.1    Jendrach, M.2    Rohwedder, A.3    Schule, A.4    Simmet, T.5
  • 18
    • 0028363702 scopus 로고
    • Fibrin degradation product D-dimer induces the synthesis and release of biologically active IL-1 beta, IL-6 and plasminogen activator inhibitors from monocytes in vitro
    • 8199021
    • Robson SC Shephard EG Kirsch RE Fibrin degradation product D-dimer induces the synthesis and release of biologically active IL-1 beta, IL-6 and plasminogen activator inhibitors from monocytes in vitro Br J Haematol 1994, 86:322-326. 8199021
    • (1994) Br J Haematol , vol.86 , pp. 322-326
    • Robson, S.C.1    Shephard, E.G.2    Kirsch, R.E.3
  • 19
    • 0033005358 scopus 로고    scopus 로고
    • Tranexamic acid: A review of its use in surgery and other indications
    • 10.2165/00003495-199957060-00017 10400410
    • Dunn CJ Goa KL Tranexamic acid: A review of its use in surgery and other indications Drugs 1999, 57:1005-1032. 10.2165/00003495-199957060-00017 10400410
    • (1999) Drugs , vol.57 , pp. 1005-1032
    • Dunn, C.J.1    Goa, K.L.2
  • 20
    • 33644680067 scopus 로고    scopus 로고
    • A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery
    • 10.1111/j.1537-2995.2006.00724.x 16533273
    • Karkouti K Beattie WS Dattilo KM McCluskey SA Ghannam M Hamdy A Wijeysundera DN Fedorko L Yau TM A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery Transfusion 2006, 46:327-338. 10.1111/ j.1537-2995.2006.00724.x 16533273
    • (2006) Transfusion , vol.46 , pp. 327-338
    • Karkouti, K.1    Beattie, W.S.2    Dattilo, K.M.3    McCluskey, S.A.4    Ghannam, M.5    Hamdy, A.6    Wijeysundera, D.N.7    Fedorko, L.8    Yau, T.M.9
  • 21
    • 14844348838 scopus 로고    scopus 로고
    • Reducing allogeneic transfusion in cardiac surgery: A randomized double-blind placebo-controlled trial of antifibrinolytic therapies used in addition to intra-operative cell salvage
    • 10.1093/bja/aei044 15591329
    • Diprose P Herbertson MJ O'Shaughnessy D Deakin CD Gill RS Reducing allogeneic transfusion in cardiac surgery: A randomized double-blind placebo-controlled trial of antifibrinolytic therapies used in addition to intra-operative cell salvage Br J Anaesth 2005, 94:271-278. 10.1093/ bja/aei044 15591329
    • (2005) Br J Anaesth , vol.94 , pp. 271-278
    • Diprose, P.1    Herbertson, M.J.2    O'Shaughnessy, D.3    Deakin, C.D.4    Gill, R.S.5
  • 22
    • 0036021886 scopus 로고    scopus 로고
    • Differential effects of aprotinin and tranexamic acid on endotoxin desensitization of blood cells induced by circulation through an isolated extracorporeal circuit
    • 10.1053/jcan.2002.125145 12154423
    • Asehnoune K Dehoux M Lecon-Malas V Toueg ML Gonieaux MH Omnes L Desmonts JM Durand G Philip I Differential effects of aprotinin and tranexamic acid on endotoxin desensitization of blood cells induced by circulation through an isolated extracorporeal circuit J Cardiothorac Vasc Anesth 2002, 16:447-451. 10.1053/jcan.2002.125145 12154423
    • (2002) J Cardiothorac Vasc Anesth , vol.16 , pp. 447-451
    • Asehnoune, K.1    Dehoux, M.2    Lecon-Malas, V.3    Toueg, M.L.4    Gonieaux, M.H.5    Omnes, L.6    Desmonts, J.M.7    Durand, G.8    Philip, I.9
  • 24
    • 0036345710 scopus 로고    scopus 로고
    • Soluble tumor necrosis factor receptor p55 predicts cytokinemia and systemic inflammatory response after cardiopulmonary bypass
    • 10.1097/00003246-200208000-00006 12163781
    • el-Barbary M Khabar KS Soluble tumor necrosis factor receptor p55 predicts cytokinemia and systemic inflammatory response after cardiopulmonary bypass Crit Care Med 2002, 30:1712-1716. 10.1097/ 00003246-200208000-00006 12163781
    • (2002) Crit Care Med , vol.30 , pp. 1712-1716
    • el-Barbary, M.1    Khabar, K.S.2
  • 25
    • 3042811398 scopus 로고    scopus 로고
    • Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between on-pump and off-pump techniques
    • 10.1016/j.jtcvs.2003.10.034 15224025
    • Casati V Della Valle P Benussi S Franco A Gerli C Baili P Alfieri O D'Angelo A Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between on-pump and off-pump techniques J Thorac Cardiovasc Surg 2004, 128:83-91. 10.1016/j.jtcvs.2003.10.034 15224025
    • (2004) J Thorac Cardiovasc Surg , vol.128 , pp. 83-91
    • Casati, V.1    Della Valle, P.2    Benussi, S.3    Franco, A.4    Gerli, C.5    Baili, P.6    Alfieri, O.7    D'Angelo, A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.