A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty

Journal of Surgical Research

Volumn 184, Issue 2, 2013, Pages 880-887

  Tan, Jixiang ^a   Chen, Hong ^b   Liu, Qin ^a   Chen, Cheng ^b   Huang, Wei ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Arthroplasty; Meta analysis; Total knee; Tranexamic acid

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

ARTICLE; BLOOD TRANSFUSION; BLOOD VOLUME; CLINICAL PROTOCOL; DRUG EFFICACY; DRUG SAFETY; HEART DISEASE; HEMATOMA; HUMAN; LUNG INFECTION; META ANALYSIS; OPERATIVE BLOOD LOSS; PEROPERATIVE COMPLICATION; POSTOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY FAILURE; SURGICAL PATIENT; TOTAL KNEE REPLACEMENT; VENOUS THROMBOEMBOLISM;

ARTHROPLASTY; META-ANALYSIS; TOTAL KNEE; TRANEXAMIC ACID;

ADMINISTRATION, INTRAVENOUS; ADULT; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; FEMALE; HUMANS; MALE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; TRANEXAMIC ACID; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM;

EID: 84883875521     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.03.099     Document Type: Article

References (44)

1. J.J. Callaghan, M.R. O'Rourke, and S.S. Liu Blood management: issues and options J Arthroplasty 20 2005 51
2. E.M. Keating, J.B. Meding, P.M. Faris, and M.A. Ritter Predictors of transfusion risk in elective knee surgery Clin Orthop Relat Res 357 1998 50
3. A.G. Mylod Jr., M.P. France, D.E. Muser, and J.R. Parsons Perioperative blood loss associated with total kneearthroplasty: a comparison of procedures performed with and without cementing J Bone Joint Surg Am 72 1990 1010
4. B.E. Bierbaum, J.J. Calaghan, J.O. Galante, H.E. Rubash, R.E. Tooms, and R.B. Welch An analysis of blood management in patients having a total hip or knee arthroplasty J Bone Joint Surg Am 81 1999 2
5. M. Janssens, J. Joris, J.L. David, R. Lemaire, and M. Lamy High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery Anesthesiology 80 1994 23
6. B. Risberg The response of the fibrinolytic system in trauma Acta Chir Scand Suppl 522 1985 245
7. P. Aglietti, A. Baldini, L.M. Vena, R. Abbate, S. Fedi, and M. Falciani Effect of tourniquet use on activation of coagulation in total knee arthroplasty Clin Orthop Relat Res 371 2000 169
8. E.K. Kruithof, G. Nicolosa, and F. Bachmann Plasminogen activator inhibitor 1: development of a radioimmunoassay and observations on its plasma concentration during venous occlusion and after platelet aggregation Blood 70 1987 1645
9. J. Petaja, P. Myllynen, G. Myllyla, and E. Vahtera Fibrinolysis after application of a pneumatic tourniquet Acta Chir Scand 153 1987 647
10. N.R. Fahmy, and D.G. Patel Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet J Bone Joint Surg Am 63 1981 461
11. D.A. Henry, A.J. Moxey, and P.A. Carless Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion Cochrane Database Syst Rev 2001 CD001886
12. H. Sasanuma, H. Sekiya, K. Takatoku, H. Takada, N. Sugimoto, and Y. Hoshino Efficient strategy for controlling postoperative hemorrhage in total knee arthroplasty Knee Surg Sports Traumatol Arthrosc 19 2011 921
13. M. Hynes, P. Calder, and G. Scott The use of tranexamic acid to reduce blood loss during total knee arthroplasty Knee 10 2003 375
14. M. Lozano, M. Basora, and L. Peidro Effectiveness and safety of tranexamic acid administration during total knee arthroplasty Vox Sang 95 2008 39
15. F.E. Ralley, D. Berta, V. Binns, J. Howard, and D.D. Naudie One intraoperative dose of tranexamic Acid for patients having primary hip or knee arthroplasty Clin Orthop Relat Res 468 2010 1905
16. J.M. Engel, T. Hohaus, R. Ruwoldt, T. Menges, I. Jürgensen, and G. Hempelmann Regional hemostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin Anesth Analg 92 2001 775
17. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. Version 4.2.5, 2005. [Online]
18. Handoll H, Elstub L, Elliott J, et al. Cochrane Bone, Joint and Muscle Trauma Group. About the Cochrane collaboration (Cochrane Review Groups (CRGS)) 2008; Issue 4. Art. No: MUSKINJ. Available from: http://bjmtg.cochrane.org/ sites/bjmtg.cochrane.org/files/uploads/Quality%20assessment%20tool.pdf.
19. R.N. Maniar, G. Kumar, T. Singhi, R.M. Nayak, and P.R. Maniar Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients Clin Orthop Relat Res 470 2012 2605
20. K. Charoencholvanich, and P. Siriwattanasakul Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial Clin Orthop Relat Res 469 2011 2874
21. P.C. Lin, C.H. Hsu, W.S. Chen, and J.W. Wang Does tranexamic acid save blood in minimally invasive total knee arthroplasty Clin Orthop Relat Res 469 2011 1995
22. P.N. Kakar, N. Gupta, P. Govil, and V. Shah Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial Indian J Anaesth 53 2009 667
23. J.C. Alvarez, F.X. Santiveri, I. Ramos, E. Vela, L. Puig, and F. Escolano Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied Transfusion 48 2008 519
24. F. Zhang, Z. Gao, and J. Yu Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21 2007 1302
25. M.A. Camarasa, G. Olle, and M. Serra-Prat Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial Br J Anaesth 96 2006 576
26. N.M. Orpen, C. Little, G. Walker, and E.J. Crawfurd Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients Knee 13 2006 106
27. E. Zohar, M. Ellis, N. Ifrach, A. Stern, O. Sapir, and B. Fredman The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement Anesth Analg 99 2004 1679
28. L. Good, E. Peterson, and B. Lisander Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement Br J Anaesth 90 2003 596
29. M. Veien, J.V. Sørensen, F. Madsen, and P. Juelsgaard Tranexamic acid given intraoperatively reduces blood loss after total knee replacement Acta Anaesthesiol Scand 46 2002 1206
30. N. Tanaka, H. Sakahashi, E. Sato, K. Hirose, T. Ishima, and S. Ishii Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee J Bone Joint Surg Br 83 2001 702
31. M.H. Ellis, B. Fredman, E. Zohar, N. Ifrach, and R. Jedeikin The effect of tourniquet application, tranexamic acid, and desmopressin on the procoagulant and fibrinolytic systems during total knee replacement J Clin Anesth 13 2001 509
32. K. Ido, M. Neo, and Y. Asada Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties Arch Orthop Trauma Surg 120 2000 518
33. A.J. Jansen, S. Andreica, M. Claeys, J. D'Haese, F. Camu, and K. Jochmans Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty Br J Anaesth 83 1999 596
34. S.T. Hiippala, L.J. Strid, and M.I. Wennerstrand Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty Anesth Analg 84 1997 839
35. G. Benoni, and H. Fredin Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients J Bone Joint Surg Br 78 1996 434
36. S. Hiippala, L. Strid, and M. Wennerstrand Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty Br J Anaesth 74 1995 534
37. L. Klenerman, R. Chakrabarti, I. Mackie, M. Brozovic, and Y. Stirling Changes in haemostatic system after application of a tourniquet Lancet 1 1977 970
38. C.J. Dunn, and K.L. Goa Tranexamic acid: a review of its use in surgery and other indications Drugs 57 1999 1005
39. J.D. Eubanks Antifibrinolytics in major orthopaedic surgery J Am Acad Orthop Surg 18 2010 132
40. J. Cid, and M. Lozano Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials Transfusion 45 2005 1302
41. P. Zufferey, F. Merquiol, and S. Laporte Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology 105 2006 1034
42. Y.K. Kagoma, M.A. Crowther, J. Douketis, M. Bhandari, J. Eikelboom, and W. Lim Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials Thromb Res 123 2009 687
43. Z.G. Yang, W.P. Chen, and L.D. Wu Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis J Bone Joint Surg Am 94 2012 1153
44. I.M. Nilsson Clinical pharmacology of aminocaproic and tranexamic acids J Clin Pathol Suppl 14 1980 41