Tranexamic acid in hip fracture surgery: A randomized controlled trial

British Journal of Anaesthesia

Volumn 104, Issue 1, 2010, Pages 23-30

  Zufferey, P J ^a   Miquet, M ^a   Quenet, S ^a   Martin, P ^a   Adam, P ^b   Albaladejo, P ^c   Mismetti, P ^a   Molliex, S ^a  

^a UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^b SERVICE DE NEUROLOGIE   (France)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

Blood; Complications, thrombosis; Pharmacology, blood loss; Surgery, orthopaedic; Transfusion

Indexed keywords

HEMOGLOBIN; PLACEBO; TRANEXAMIC ACID;

ADULT; AGED; ARTICLE; BACTERIAL INFECTION; BLEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ERYTHROCYTE TRANSFUSION; FEMALE; HEART INFARCTION; HIP ARTHROPLASTY; HIP FRACTURE; HUMAN; KNEE ARTHROPLASTY; MAJOR CLINICAL STUDY; MALE; OSTEOSYNTHESIS; POSTOPERATIVE INFECTION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SKIN INCISION; ST SEGMENT ELEVATION; TREATMENT OUTCOME; VEIN THROMBOSIS;

EID: 72749110502     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep314     Document Type: Article

References (30)

1. Foss NB, Kehlet H. Hidden blood loss after surgery for hip fracture. J Bone Joint Surg Br 2006; 88: 1053-1059
2. Lawrence VA, Silverstein JH, Cornell JE, Pederson T, Noveck H, Carson JL. Higher Hb level is associated with better early functional recovery after hip fracture repair. Transfusion 2003; 43: 1717-1722
3. Eriksson BI, Bauer KA, Lassen MR, Turpie AG, Steering Committee of the Pentasaccharide in Hip-Fracture Surgery Study. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N Engl J Med 2001; 345: 1298-1304
4. Klein HG, Spahn DR, Carson JL. Red blood cell transfusion in clinical practice. Lancet 2007; 370: 415-426
5. Carson JL, Altman DG, Duff A, et al. Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair. Transfusion 1999; 39: 694-700
6. Mannucci PM, Levi M. Prevention and treatment of major blood loss. N Engl J Med 2007; 356: 2301-2311
7. Zufferey P, Merquiol F, Laporte S, et al. Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology 2006; 105: 1034-1046
8. Panteghini M, Pagani F, Yeo KT, et al. Committee on Standardization of Markers of Cardiac Damage of the IFCC. Evaluation of imprecision for cardiac troponin assays at low-range concentrations. Clin Chem 2004; 50: 327-332
9. Devereaux PJ, Goldman L, Yusuf S, Gilbert K, Leslie K, Guyatt GH. Surveillance and prevention of major perioperative ischemic cardiac events in patients undergoing noncardiac surgery: a review. CMAJ 2005; 173: 779-788
10. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16: 128-140
11. Good L, Peterson E, Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 2003; 90: 596-599
12. Altman DG. Confidence intervals for the number needed to treat. Br Med J 1998; 317: 1309-1312
13. Orpen NM, Little C, Walker G, Crawfurd EJ. Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients. Knee 2006; 13: 106-110
14. Camarasa MA, Ollé G, Serra-Prat M, et al. Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 2006; 96: 576-582
15. Molloy DO, Archbold HA, Ogonda L, McConway J, Wilson RK, Beverland DE. Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br 2007; 89: 306-309
16. Alvarez JC, Santiveri FX, Ramos I, Vela E, Puig L, Escolano F. Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion 2008; 48: 519-525
17. Claeys MA, Vermeersch N, Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery. Acta Chir Belg 2007; 107: 397-401
18. Sadeghi M, Mehr-Aein A. Does a single bolus dose of tranexamic acid reduce blood loss and transfusion requirements during hip fracture surgery? A prospective randomized double blind study in patients. Acta Medica Iranica 2007; 45: 437-442
19. Niskanen RO, Korkala OL. Tranexamic acid reduces blood loss in cemented hip arthroplasty: a randomized, double-blind study of patients with osteoarthritis. Acta Orthop 2005; 76: 829-832
20. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S. Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg Br 2001; 83: 702-705
21. Benoni G, Lethagen S, Nilsson P, Fredin H. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty. Acta Orthop Scand 2000; 71: 250-254
22. Benoni G, Fredin H, Knebel R, Nilsson P. Blood conservation with tranexamic acid in total hip arthroplasty: a randomized, double-blind study in 40 primary operations. Acta Orthop Scand 2001; 72: 442-448
23. Weiskopf RB. If you prick us, do we not bleed? Anesthesiology 2006; 105: 873-876
24. Montori VM, Permanyer-Miralda G, Ferreira-González I, et al. Validity of composite end points in clinical trials. Br Med J 2005; 330: 594-596
25. Kamel HK. The frequency and factors linked to a urinary tract infection coding in patients undergoing hip fracture surgery. J Am Med Dir Assoc 2005; 6: 316-320
26. Rosencher N, Vielpeau C, Emmerich J, Fagnani F, Samama CM, the ESCORTE group. Venous thromboembolism and mortality after hip fracture surgery: the ESCORTE study. J Thromb Haemost 2005; 3: 2006-2014
27. Eriksson BI, Lassen MR, PENTasaccharide in HIp-FRActure Surgery Plus Investigators. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: a multicenter, randomized, placebo-controlled, double-blind study. Arch Intern Med 2003; 163: 1337-1342
28. Ausset S, Minville V, Marquis C, Benhamou D, Rigal S. Elevated serum cardiac troponin I in older patients with hip fracture: incidence and prognostic significance. Arch Orthop Trauma Surg 2008; 128: 761-762
29. Dawson-Bowling S, Chettiar K, Cottam H, et al. Troponin T as a predictive marker of morbidity in patients with fractured neck of femur. Injury 2008; 39: 775-780
30. Shiga T, Wajima Z, Ohe Y. Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Can J Anaesth 2008; 55: 146-154