메뉴 건너뛰기




Volumn 74, Issue 6, 2013, Pages 1575-1586

Tranexamic acid in trauma: How should we use it?

Author keywords

[No Author keywords available]

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 131; AMINOCAPROIC ACID; APROTININ; PLACEBO; TRANEXAMIC ACID;

EID: 84880095773     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e318292cc54     Document Type: Review
Times cited : (174)

References (83)
  • 2
    • 35848943443 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: Mechanism, identification and effect
    • Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13: 680-685.
    • (2007) Curr Opin Crit Care , vol.13 , pp. 680-685
    • Brohi, K.1    Cohen, M.J.2    Davenport, R.A.3
  • 4
    • 34247568437 scopus 로고    scopus 로고
    • Acute traumatic coagulopathy: Initiated by hypoperfusion: Modulated through the protein C pathway?
    • Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007;245:812-818.
    • (2007) Ann Surg , vol.245 , pp. 812-818
    • Brohi, K.1    Cohen, M.J.2    Ganter, M.T.3    Matthay, M.A.4    MacKersie, R.C.5    Pittet, J.F.6
  • 5
    • 43449134118 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis
    • discussion 1217
    • Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64:1211-1217; discussion 1217.
    • (2008) J Trauma , vol.64 , pp. 1211-1217
    • Brohi, K.1    Cohen, M.J.2    Ganter, M.T.3    Schultz, M.J.4    Levi, M.5    MacKersie, R.C.6    Pittet, J.F.7
  • 7
    • 44649109632 scopus 로고    scopus 로고
    • Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients
    • Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, David JS. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008;100:792-797.
    • (2008) Br J Anaesth , vol.100 , pp. 792-797
    • Levrat, A.1    Gros, A.2    Rugeri, L.3    Inaba, K.4    Floccard, B.5    Negrier, C.6    David, J.S.7
  • 8
    • 70350459505 scopus 로고    scopus 로고
    • Hyperfibrinolysis after major trauma: Differential diagnosis of lysis patterns and prognostic value of thrombelastometry
    • Schochl H, Frietsch T, Pavelka M, Jambor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 2009;67:125-131.
    • (2009) J Trauma , vol.67 , pp. 125-131
    • Schochl, H.1    Frietsch, T.2    Pavelka, M.3    Jambor, C.4
  • 9
    • 80051737043 scopus 로고    scopus 로고
    • Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: Results of the 'diagnosis and treatment of trauma-induced coagulopathy (DIA-TRE-TIC) study'
    • Tauber H, Innerhofer P, Breitkopf R, Westermann I, Beer R, El Attal R, Strasak A, Mittermayr M. Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: results of the 'Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study'. Br J Anaesth. 2011;107:378-387.
    • (2011) Br J Anaesth , vol.107 , pp. 378-387
    • Tauber, H.1    Innerhofer, P.2    Breitkopf, R.3    Westermann, I.4    Beer, R.5    El, A.R.6    Strasak, A.7    Mittermayr, M.8
  • 10
    • 84864369467 scopus 로고    scopus 로고
    • Towards hemostatic resuscitation: The changing understanding of acute traumatic biology, massive bleeding, and damagecontrol resuscitation
    • Cohen MJ. Towards hemostatic resuscitation: the changing understanding of acute traumatic biology, massive bleeding, and damagecontrol resuscitation. Surg Clin North Am. 2012;92:877-891, viii.
    • (2012) Surg Clin North Am , vol.92 , Issue.8 , pp. 877-891
    • Cohen, M.J.1
  • 11
    • 79960720528 scopus 로고    scopus 로고
    • Fibrinogen availability and coagulation function after hemorrhage and resuscitation in pigs
    • Martini WZ. Fibrinogen availability and coagulation function after hemorrhage and resuscitation in pigs. Mol Med. 2011;17:757-761.
    • (2011) Mol Med , vol.17 , pp. 757-761
    • Martini, W.Z.1
  • 14
    • 84855826297 scopus 로고    scopus 로고
    • Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients
    • Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012;255: 379-385.
    • (2012) Ann Surg , vol.255 , pp. 379-385
    • Cohen, M.J.1    Call, M.2    Nelson, M.3    Calfee, C.S.4    Esmon, C.T.5    Brohi, K.6    Pittet, J.F.7
  • 16
    • 84874796718 scopus 로고    scopus 로고
    • Pathogenesis of acute traumatic coagulopathy
    • Davenport R. Pathogenesis of acute traumatic coagulopathy. Transfusion. 2013;53(Suppl 1):23S-27S.
    • (2013) Transfusion , vol.53 , Issue.SUPPL. 1
    • Davenport, R.1
  • 18
    • 38949185037 scopus 로고    scopus 로고
    • Early coagulopathy after traumatic brain injury: The role of hypoperfusion and the protein C pathway
    • discussion 61-62
    • Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma. 2007;63:1254-1261; discussion 61-62.
    • (2007) J Trauma , vol.63 , pp. 1254-1261
    • Cohen, M.J.1    Brohi, K.2    Ganter, M.T.3    Manley, G.T.4    Mackersie, R.C.5    Pittet, J.F.6
  • 19
    • 0141819138 scopus 로고    scopus 로고
    • The protein C pathway
    • Esmon CT. The protein C pathway. Chest. 2003;124(Suppl):26S-32S.
    • (2003) Chest , vol.124 , Issue.SUPPL.
    • Esmon, C.T.1
  • 21
    • 84868515379 scopus 로고    scopus 로고
    • Detection of tPAinduced hyperfibrinolysis in whole bloods by Rapid TEG, KaolinTEG, and functional fibrinogenTEG in healthy individuals
    • Genet GF, Ostrowski SR, Sorensen AM, Johansson P. Detection of tPAinduced hyperfibrinolysis in whole bloods by Rapid TEG, KaolinTEG, and functional fibrinogenTEG in healthy individuals. Clin Appl Thromb Hemost. 2012;18:638-644.
    • (2012) Clin Appl Thromb Hemost , vol.18 , pp. 638-644
    • Genet, G.F.1    Ostrowski, S.R.2    Sorensen, A.M.3    Johansson, P.4
  • 23
    • 31644436226 scopus 로고    scopus 로고
    • Elastic modular-based thrombelastographic quantification of plasma clot fibrinolysis with progressive plasminogen activation
    • Nielsen VG, Cohen BM, Cohen E. Elastic modular-based thrombelastographic quantification of plasma clot fibrinolysis with progressive plasminogen activation. Blood Coag Fibrinolysis. 2006;17:75-81.
    • (2006) Blood Coag Fibrinolysis , vol.17 , pp. 75-81
    • Nielsen, V.G.1    Cohen, B.M.2    Cohen, E.3
  • 24
    • 70350459505 scopus 로고    scopus 로고
    • Hyperfibrinolysis after traumaVdifferential diagnosis of lysis patterns and prognostic value of thrombelastography
    • Schochl H, Frietsch T, Pavelka M, Jambor C. Hyperfibrinolysis after traumaVdifferential diagnosis of lysis patterns and prognostic value of thrombelastography. J Trauma. 2009;67:125-131.
    • (2009) J Trauma , vol.67 , pp. 125-131
    • Schochl, H.1    Frietsch, T.2    Pavelka, M.3    Jambor, C.4
  • 26
    • 19044363528 scopus 로고    scopus 로고
    • The effect of platelet count on clot retraction and tissue plasminogen activator-induced fibrinolysis on thrombelastography
    • Kotora N, Tanaka KA, Szlam F, Levy JH. The effect of platelet count on clot retraction and tissue plasminogen activator-induced fibrinolysis on thrombelastography. Anesth Analg. 2005;100:1781-1785.
    • (2005) Anesth Analg , vol.100 , pp. 1781-1785
    • Kotora, N.1    Tanaka, K.A.2    Szlam, F.3    Levy, J.H.4
  • 27
    • 79953280012 scopus 로고    scopus 로고
    • Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion
    • Afshari A, Wikkelso A, Brok J, Moller AM, Wetterslev J. Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev. 2011;CD007871.
    • (2011) Cochrane Database Syst Rev
    • Afshari, A.1    Wikkelso, A.2    Brok, J.3    Moller, A.M.4    Wetterslev, J.5
  • 29
    • 77950681467 scopus 로고    scopus 로고
    • Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)- guided administration of fibrinogen concentrate and prothrombin complex concentrate
    • Schöchl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)- guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care. 2010;14:R55.
    • (2010) Crit Care , vol.14
    • Schöchl, H.1    Nienaber, U.2    Hofer, G.3    Voelckel, W.4    Jambor, C.5    Scharbert, G.6    Kozek-Langenecker, S.7    Solomon, C.8
  • 33
    • 84865482138 scopus 로고    scopus 로고
    • Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: Experience with 1974 consecutive trauma patients
    • Holcomb JB, Minei KM, Scerbo ML, Radwan ZA, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Khan S, et al. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients. Ann Surg. 2012;256:476Y486.
    • (2012) Ann Surg. , vol.256
    • Holcomb, J.B.1    Minei, K.M.2    Scerbo, M.L.3    Radwan, Z.A.4    Wade, C.E.5    Kozar, R.A.6    Gill, B.S.7    Albarado, R.8    McNutt, M.K.9    Khan, S.10
  • 35
    • 84858778521 scopus 로고    scopus 로고
    • Tranexamic acid: A review of its use in the treatment of hyperfibrinolysis
    • McCormack PL. Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs. 2012;72:585-617.
    • (2012) Drugs , vol.72 , pp. 585-617
    • McCormack, P.L.1
  • 36
    • 68349132607 scopus 로고    scopus 로고
    • Cyklokapron (tranexamic acid) injection [package insert]. New York, NY. Accessed November 10, 2012
    • Cyklokapron (tranexamic acid) injection [package insert]. Pfizer Inc., New York, NY. 2008. Available at: www.pfizer.com/products/rx/prescription.jsp. Accessed November 10, 2012.
    • (2008) Pfizer Inc.
  • 37
    • 84880118114 scopus 로고    scopus 로고
    • tranexamic acid) tablets [package insert]. Accessed November 10, 2012
    • Lysteda (tranexamic acid) tablets [package insert]. Xanodyne Pharmaceuticals, Newport, Kentucky. 2009; Available at: www.lysteda.com. Accessed November 10, 2012.
    • (2009) Xanodyne Pharmaceuticals, Newport, Kentucky
  • 38
    • 84860238434 scopus 로고    scopus 로고
    • Efficacy of tranexamic acid in the treatment of idiopathic and non-functional heavy menstrual bleeding: A systematic review
    • Naoulou B, Tsai MC. Efficacy of tranexamic acid in the treatment of idiopathic and non-functional heavy menstrual bleeding: a systematic review. Acta Obstet Gynecol Scand. 2012;91:529-537.
    • (2012) Acta Obstet Gynecol Scand , vol.91 , pp. 529-537
    • Naoulou, B.1    Tsai, M.C.2
  • 39
    • 77954717667 scopus 로고    scopus 로고
    • Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial
    • CRASH-2 trial collaborators
    • CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376:23.
    • (2010) Lancet , vol.376 , pp. 23
    • Shakur, H.1    Roberts, I.2    Bautista, R.3    Caballero, J.4    Coats, T.5    Dewan, Y.6    El-Sayed, H.7    Gogichaishvili, T.8    Gupta, S.9
  • 40
    • 84880124783 scopus 로고    scopus 로고
    • Accessed November 10
    • CRASH 2. The Use of Tranexamic Acid. Available at: http://crash2.lshtm. ac.uk/Accessed November 10, 2012.
    • (2012) The Use of Tranexamic Acid
  • 41
    • 84876482386 scopus 로고    scopus 로고
    • The use of tranexamic acid for trauma patients?
    • Weber BJ, Kjelland CB. The use of tranexamic acid for trauma patients? CJEM. 2012;14:53-56.
    • (2012) CJEM , vol.14 , pp. 53-56
    • Weber, B.J.1    Kjelland, C.B.2
  • 42
    • 84857508828 scopus 로고    scopus 로고
    • Avoidable mortality from giving tranexamic acid to bleeding trauma patients: An estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial
    • Ker K, Kiriya J, Perel P, Edwards P, Shakur H, Roberts I. Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. BMC Emerg Med. 2012;12:3.
    • (2012) BMC Emerg Med , vol.12 , pp. 3
    • Ker, K.1    Kiriya, J.2    Perel, P.3    Edwards, P.4    Shakur, H.5    Roberts, I.6
  • 44
    • 84880090701 scopus 로고    scopus 로고
    • Proposal for the Inclusion of tranexamic acid (Anti-FibrinolyticYLysine Analogue)
    • Accessed November 10, 2012
    • Proposal for the Inclusion of Tranexamic Acid (Anti-FibrinolyticYLysine Analogue) in the WHO Model List of Essential Medicines. Available http://www.who.int/selection-medicines/committees/expert/17/application/ TRANEXAMIC-ACID.pdf Accessed November 10, 2012.
    • The WHO Model List of Essential Medicines
  • 45
    • 79952269248 scopus 로고    scopus 로고
    • CRASH-2 Trial collaborators, Antifibrinolytic drugs for acute traumatic injury
    • Review
    • Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators, Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2012;12:CD004896. Review.
    • (2012) Cochrane Database Syst Rev. , vol.12
    • Roberts, I.1    Shakur, H.2    Ker, K.3    Coats, T.4
  • 48
    • 84861503406 scopus 로고    scopus 로고
    • Effect of tranexamic acid on surgical bleeding: Systematic review and cumulative meta-analysis
    • Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ. 2012;344:e3054.
    • (2012) BMJ , vol.344
    • Ker, K.1    Edwards, P.2    Perel, P.3    Shakur, H.4    Roberts, I.5
  • 49
    • 79953163189 scopus 로고    scopus 로고
    • The importance of early treatment with tranexamic acid in bleeding trauma patients: An exploratory analysis of the CRASH-2 randomised controlled trial
    • CRASH-2 collaborators
    • CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011; 377:1096-1101.
    • (2011) Lancet , vol.377 , pp. 1096-1101
    • Roberts, I.1    Shakur, H.2    Afolabi, A.3    Brohi, K.4    Coats, T.5    Dewan, Y.6    Gando, S.7    Guyatt, G.8    Hunt, B.J.9
  • 50
    • 84859136754 scopus 로고    scopus 로고
    • CRASH-2 (clinical randomisation of an antifibrinolytic in significant haemorrhage) intracranial bleeding study: The effect of tranexamic acid in traumatic brain injury - A nested randomised, placebo-controlled trial
    • Perel P, Salman RA, Kawahara T, Morris Z, Prieto-Merino D, Roberts I, Sandercock P, Shakur H, Wardlaw J. CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injuryVa nested randomised, placebo-controlled trial. Health Technol Assess. 2012;16: iii-xii, 1-54.
    • (2012) Health Technol Assess , vol.16 , Issue.3-12 , pp. 1-54
    • Perel, P.1    Salman, R.A.2    Kawahara, T.3    Morris, Z.4    Prieto-Merino, D.5    Roberts, I.6    Sandercock, P.7    Shakur, H.8    Wardlaw, J.9
  • 51
    • 79960688357 scopus 로고    scopus 로고
    • Effect of tranexamic acid in traumatic brain injury: A nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study)
    • CRASH-2 Collaborators, Intracranial Bleeding Study
    • CRASH-2 Collaborators, Intracranial Bleeding Study. Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). BMJ. 2011;343:d3795.
    • (2011) BMJ , vol.343
  • 52
    • 84857430357 scopus 로고    scopus 로고
    • Military application of tranexamic acid in trauma emergency resuscitation (matters) study
    • Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg. 2012;147:113-119.
    • (2012) Arch Surg. , vol.147 , pp. 113-119
    • Morrison, J.J.1    Dubose, J.J.2    Rasmussen, T.E.3    Midwinter, M.J.4
  • 53
    • 84857437100 scopus 로고    scopus 로고
    • Antifibrinolytics in trauma patients: Does it MATTER? comment on military application of tranexamic acid in trauma emergency resuscitation (matters) study
    • Inaba K. Antifibrinolytics in trauma patients: does it MATTER? Comment on "Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study". Invited critique. Arch Surg. 2012;147:119.
    • (2012) Invited Critique. Arch Surg , vol.147 , pp. 119
    • Inaba, K.1
  • 54
    • 84880112207 scopus 로고    scopus 로고
    • Association of cryoprecipitate and tranexamic acid improved survival following wartime injury: Findings from theMATTERs II study
    • Morrison JJ, Ross JD, Dubose JJ, Jansen JO, Midwinter MJ, Rasmussen TE. Association of cryoprecipitate and tranexamic acid improved survival following wartime injury: findings from theMATTERs II study. Arch Surg. 2012.
    • (2012) Arch Surg.
    • Morrison, J.J.1    Ross, J.D.2    Dubose, J.J.3    Jansen, J.O.4    Midwinter, M.J.5    Rasmussen, T.E.6
  • 55
    • 84880126756 scopus 로고    scopus 로고
    • Available at:, Accessed November 10, 2012
    • Available at: http://www.usaisr.amedd.army.mil/assets/cpgs/Damage- Control-Resuscitation-10-Aug-2011%20.pdf Accessed November 10, 2012.
  • 57
    • 84867651181 scopus 로고    scopus 로고
    • The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: Systematic review and meta-analysis of observational studies and randomized trials
    • Ross J, Salman RA. The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials. Curr Drug Saf. 2012;7:44-54.
    • (2012) Curr Drug Saf , vol.7 , pp. 44-54
    • Ross, J.1    Salman, R.A.2
  • 58
    • 34250692681 scopus 로고    scopus 로고
    • Fibrinolysis, inflammation, and regulation of the plasminogen activating system
    • Medcalf RL. Fibrinolysis, inflammation, and regulation of the plasminogen activating system. J Thromb Haemost. 2007;5(Suppl 1):132-142.
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 1 , pp. 132-142
    • Medcalf, R.L.1
  • 59
    • 2442534668 scopus 로고    scopus 로고
    • Novel aspects and new roles for the serine protease plasmin
    • Syrovets T, Simmet T. Novel aspects and new roles for the serine protease plasmin. Cell Mol Life Sci. 2004;61:873-885.
    • (2004) Cell Mol Life Sci. , vol.61 , pp. 873-885
    • Syrovets, T.1    Simmet, T.2
  • 60
    • 38549180575 scopus 로고    scopus 로고
    • Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: A case control study followed by a randomized double-blind controlled trial
    • Jimenez JJ, Iribarren JL, Lorente L, Rodriguez JM, Hernandez D, Nassar I, Perez R, Brouard M, Milena A, Martinez R, Mora ML. Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial. Crit Care. 2007;11:R117.
    • (2007) Crit Care , vol.11
    • Jimenez, J.J.1    Iribarren, J.L.2    Lorente, L.3    Rodriguez, J.M.4    Hernandez, D.5    Nassar, I.6    Perez, R.7    Brouard, M.8    Milena, A.9    Martinez, R.10    Mora, M.L.11
  • 61
    • 80053999848 scopus 로고    scopus 로고
    • Safety and effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: A randomized double-blind, dose-dependent, phase IV clinical trial
    • Jiménez JJ, Iribarren JL, Brouard M, Hernández D, Palmero S, Jiménez A, Lorente L, Machado P, Borreguero JM, Raya JM, et al. Safety and effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: a randomized double-blind, dose-dependent, phase IV clinical trial. J Cardiothorac Surg. 2011;6:138.
    • (2011) J Cardiothorac Surg. , vol.6 , pp. 138
    • Jiménez, J.J.1    Iribarren, J.L.2    Brouard, M.3    Hernández, D.4    Palmero, S.5    Jiménez, A.6    Lorente, L.7    Machado, P.8    Borreguero, J.M.9    Raya, J.M.10
  • 62
    • 84863202667 scopus 로고    scopus 로고
    • Tranexamic acid: Less bleeding and less thrombosis
    • Godier A, Roberts I, Hunt B. Tranexamic acid: less bleeding and less thrombosis. Crit Care. 2012;16:135.
    • (2012) Crit Care , vol.16 , pp. 135
    • Godier, A.1    Roberts, I.2    Hunt, B.3
  • 63
    • 79955763845 scopus 로고    scopus 로고
    • CRASH 2 trial collaborators, Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial
    • Guerriero C, Cairns J, Perel P, Shakur H, Roberts I; CRASH 2 trial collaborators. Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. PLoS One. 2011;6:e18987.
    • (2011) PLoS One , vol.6
    • Guerriero, C.1    Cairns, J.2    Perel, P.3    Shakur, H.4    Roberts, I.5
  • 64
    • 77954745372 scopus 로고    scopus 로고
    • Antifibrinolytic therapy: New data and new concepts
    • Levy JH. Antifibrinolytic therapy: new data and new concepts. Lancet. 2010;376:3-4.
    • (2010) Lancet , vol.376 , pp. 3-4
    • Levy, J.H.1
  • 66
    • 84862496057 scopus 로고    scopus 로고
    • CRASH-3Vtranexamic acid for the treatment of significant traumatic brain injury: Study protocol for an international randomized, double-blind, placebo-controlled trial
    • Dewan Y, Komolafe EO, Mejía-Mantilla JH, Perel P, Roberts I, Shakur H. CRASH-3Vtranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial. Trials. 2012;13:87.
    • (2012) Trials , vol.13 , pp. 87
    • Dewan, Y.1    Komolafe, E.O.2    Mejía-Mantilla, J.H.3    Perel, P.4    Roberts, I.5    Shakur, H.6
  • 68
    • 84880121685 scopus 로고    scopus 로고
    • ClinicalTrials.gov ID NCT00872469; Protocol Number ISRCTN76912190
    • ClinicalTrials.gov ID NCT00872469; Protocol Number ISRCTN76912190.
  • 69
    • 84880118406 scopus 로고    scopus 로고
    • Tranexamic acid for the treatment of postpartum haemorrhage: An international randomized, double-blind, placebo-controlled trial
    • Accessed November 10
    • Tranexamic acid for the treatment of postpartum haemorrhage: an international randomized, double-blind, placebo-controlled trial. London School of Hygiene and Tropical Medicine. Available at: http://www.thewomantrial.lshtm. ac.uk/. Accessed November 10, 2012.
    • (2012) London School of Hygiene and Tropical Medicine
  • 70
    • 84880110654 scopus 로고    scopus 로고
    • Available at, Accessed November 10
    • The Lancet. CRASH-2 goes viral. Available at: http://www.lancet.com/ journals/lancet/article/PIIS0140673611617601/fulltext. Accessed November 10, 2012.
    • (2012) CRASH-2 Goes Viral
  • 71
    • 84880123585 scopus 로고    scopus 로고
    • Available at:, Accessed November 10
    • Available at: http://www.traumafoundation.org/restricted/tinymce/ jscripts/tiny-mce/plugins/filemanager/files/ask-traumacare/ ATC%20Tranexamic%20Acid%20with%20attachments.pdf. Accessed November 10, 2012.
    • (2012)
  • 72
    • 84867279403 scopus 로고    scopus 로고
    • On behalf of the CRASH-2 collaborators, Effect of tranexamic acid onmortality in patientswith traumatic bleeding: Prespecified analysis of data from randomised controlled trial
    • Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt BJ, Lecky F, Brohi K, Willett K; on behalf of the CRASH-2 collaborators, Effect of tranexamic acid onmortality in patientswith traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ. 2012;345:e5839.
    • (2012) BMJ , vol.345
    • Roberts, I.1    Perel, P.2    Prieto-Merino, D.3    Shakur, H.4    Coats, T.5    Hunt, B.J.6    Lecky, F.7    Brohi, K.8    Willett, K.9
  • 75
    • 76249100902 scopus 로고    scopus 로고
    • High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients
    • Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg. 2010;110:350-353.
    • (2010) Anesth Analg , vol.110 , pp. 350-353
    • Murkin, J.M.1    Falter, F.2    Granton, J.3    Young, B.4    Burt, C.5    Chu, M.6
  • 77
    • 78751659459 scopus 로고    scopus 로고
    • Predictors and outcomes of seizures after cardiac surgery: A multivariable analysis of 2, 578 patients
    • Goldstone AB, Bronster DJ, Chikwe J. Predictors and outcomes of seizures after cardiac surgery: a multivariable analysis of 2, 578 patients. Ann Thorac Surg. 2011;91:514-518.
    • (2011) Ann Thorac Surg. , vol.91 , pp. 514-518
    • Goldstone, A.B.1    Bronster, D.J.2    Chikwe, J.3
  • 78
    • 84856953707 scopus 로고    scopus 로고
    • Seizures following cardiac surgery: The impact of tranexamic acid and other risk factors
    • Manji RA, Menkis AH, Jacobsohn E. Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Can J Anaesth. 2012; 59:6-13.
    • (2012) Can J Anaesth , vol.59 , pp. 6-13
    • Manji, R.A.1    Menkis, A.H.2    Jacobsohn, E.3
  • 79
    • 84055192250 scopus 로고    scopus 로고
    • Highdose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass
    • Kalavrouziotis D, Voisine P, Mohammadi S, Dionne S, Dagenais F. Highdose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass. Ann Thorac Surg. 2012;93:148-154.
    • (2012) Ann Thorac Surg. , vol.93 , pp. 148-154
    • Kalavrouziotis, D.1    Voisine, P.2    Mohammadi, S.3    Dionne, S.4    Dagenais, F.5
  • 83
    • 84880109509 scopus 로고    scopus 로고
    • US Food and Drug Administration. Cyklokapron (tranexamic acid) injection, Accessed November 10
    • US Food and Drug Administration. Cyklokapron (tranexamic acid) injection. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm241709. htm. Accessed November 10, 2012.
    • (2012)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.