The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma

Tumor Biology

Volumn 37, Issue 9, 2016, Pages 11733-11741

  Lu, Yaoyong ^a   Li, Tao ^a   Wei, Ganbao ^a   Liu, Liangbo ^a   Chen, Qinsheng ^a   Xu, Lufei ^a   Zhang, Kunqiang ^a   Zeng, Dehao ^a   Liao, Rongwei ^a  

^a The People Hospital of Gaozhou   (China)

Author keywords

Epithelial to mesenchymal transition; miR 204; NEAT1; Radioresistance; ZEB1

Indexed keywords

CASPASE 3; COMPLEMENTARY DNA; LONG UNTRANSLATED RNA; MICRORNA; MICRORNA 204; OLIGONUCLEOTIDE; PROTEIN BCL 2; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR ZEB1; UNCLASSIFIED DRUG; MIRN204 MICRORNA, HUMAN; NEAT1 LONG NON-CODING RNA, HUMAN; ZEB1 PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CANCER GROWTH; CLONOGENIC ASSAY; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; AGED; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PATHOLOGY; PHYSIOLOGY; RADIATION TOLERANCE; TUMOR CELL LINE;

ADULT; AGED; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; MALE; MICRORNAS; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; RADIATION TOLERANCE; RNA, LONG NONCODING; ZINC FINGER E-BOX-BINDING HOMEOBOX 1;

EID: 84961615175     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-4773-4     Document Type: Article

References (27)

1. Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005;365:2041–54.
2. Lee AW, Poon YF, Foo W, Law SC, Cheung FK, Chan DK, et al. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure. Int J Radiat Oncol Biol Phys. 1992;23:261–70.
3. Teoh JW, Yunus RM, Hassan F, Ghazali N, Abidin ZA. Nasopharyngeal carcinoma in dermatomyositis patients: a 10-year retrospective review in hospital selayang, malaysia. Rep Pract Oncol Radiotherapy: J Greatpoland Cancer Center Poznan Polish Soc Radiat Oncol. 2014;19:332–6.
4. Chang L, Graham PH, Hao J, Ni J, Bucci J, Cozzi PJ, et al. Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/MTOR pathway in prostate cancer radioresistance. Cell Death Dis. 2013;4:e875.
5. Johnsson P, Morris KV. Expanding the functional role of long noncoding RNAs. Cell Res. 2014;24:1284–5.
6. Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009;23:1494–504.
7. Chen LL, Zhao JC. Functional analysis of long noncoding RNAs in development and disease. Adv Exp Med Biol. 2014;825:129–58.
8. Chakravarty D, Sboner A, Nair SS, Giannopoulou E, Li R, Hennig S, et al. The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat Commun. 2014;5:5383.
9. Kang J, Kim E, Kim W, Seong KM, Youn H, Kim JW, et al. Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (emt) by mir-34a-mediated suppression of notch-1 expression in non-small cell lung cancer cell lines. J Biol Chem. 2013;288:27343–57.
10. Jalali S, Bhartiya D, Lalwani MK, Sivasubbu S, Scaria V. Systematic transcriptome wide analysis of lncRNA-miRNA interactions. PLoS One. 2013;8:e53823.
11. Chiyomaru T, Fukuhara S, Saini S, Majid S, Deng G, Shahryari V, et al. Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. J Biol Chem. 2014;289:12550–65.
12. Nakagawa S, Shimada M, Yanaka K, Mito M, Arai T, Takahashi E, et al. The lncRNA NEAT1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice. Development. 2014;141:4618–27.
13. Deng X, Ma L, Wu M, Zhang G, Jin C, Guo Y, et al. Mir-124 radiosensitizes human glioma cells by targeting cdk4. J Neuro-Oncol. 2013;114:263–74.
14. Karreth FA, Pandolfi PP. Cerna cross-talk in cancer: when ce-bling rivalries go awry. Cancer Discov. 2013;3:1113–21.
15. Ma L, Deng X, Wu M, Zhang G, Huang J. Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells. FEBS Lett. 2014;588:1562–70.
16. Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell. 2005;123:631–40.
17. Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Smythies J, et al. Tumor hypoxia induces nuclear paraspeckle formation through hif-2alpha dependent transcriptional activation of neat1 leading to cancer cell survival. Oncogene. 2015;34:4546.
18. Li Y, Li Y, Chen W, He F, Tan Z, Zheng J, et al. Neat expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer. Oncotarget. 2015;6:27641–50.
19. Su H, Jin X, Zhang X, Zhao L, Lin B, Li L, et al. Fh535 increases the radiosensitivity and reverses epithelial-to-mesenchymal transition of radioresistant esophageal cancer cell line kyse-150r. J Transl Med. 2015;13:104.
20. Zhang Z, Zhu Z, Watabe K, Zhang X, Bai C, Xu M, et al. Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ. 2013;20:1558–68.
21. Liu XH, Sun M, Nie FQ, Ge YB, Zhang EB, Yin DD, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer. 2014;13:92.
22. Zeng J, Wei M, Shi R, Cai C, Liu X, Li T et al. Mir-204-5p/six1 feedback loop promotes epithelial-mesenchymal transition in breast cancer. Tumour Biol: J Int Soc Oncodev Biol Med 2015.
23. Zhang L, Wang X, Chen P. Mir-204 down regulates sirt1 and reverts sirt1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells. BMC Cancer. 2013;13:290.
24. Su H, Jin X, Shen L, Fang Y, Fei Z, Zhang X et al. Inhibition of cyclin d1 enhances sensitivity to radiotherapy and reverses epithelial to mesenchymal transition for esophageal cancer cells. Tumour Biol: J Int Soc Oncodev Biol Med 2015.
25. de Jong MC, Ten Hoeve JJ, Grenman R, Wessels LF, Kerkhoven R, Te Riele H, et al. Pretreatment microRNA expression impacting on epithelial-to-mesenchymal transition predicts intrinsic radiosensitivity in head and neck cancer cell lines and patients. Clin Cancer Res: Off J Am Assoc Cancer Res. 2015;21:5630–8.
26. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, et al. Atm-mediated stabilization of zeb1 promotes DNA damage response and radioresistance through chk1. Nat Cell Biol. 2014;16:864–75.
27. Preca BT, Bajdak K, Mock K, Sundararajan V, Pfannstiel J, Maurer J, et al. A self-enforcing CD44S/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells. Int J Cancer J int du Cancer. 2015;137:2566–77.