Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells

FEBS Letters

Volumn 588, Issue 9, 2014, Pages 1562-1570

  Ma, Lei ^a   Deng, Xubin ^a   Wu, Minhua ^b   Zhang, Gong ^c   Huang, Jianqing ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

^c SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

Author keywords

Cdc42; Epstein Barr virus; Latent membrane protein 1; miR 204; Nasopharyngeal carcinoma; Stat 3

Indexed keywords

ANTINEOPLASTIC AGENT; LATENT MEMBRANE PROTEIN 1; MICRORNA 204; PROTEIN CDC42; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER PROGNOSIS; CARCINOMA CELL; CELL INVASION; CONTROLLED STUDY; DOWN REGULATION; EPSTEIN BARR VIRUS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; METASTASIS INHIBITION; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING;

HUMAN HERPESVIRUS 4;

CDC42; EPSTEIN-BARR VIRUS; LATENT MEMBRANE PROTEIN 1; MIR-204; NASOPHARYNGEAL CARCINOMA; STAT-3;

ANIMALS; BASE SEQUENCE; BINDING SITES; CDC42 GTP-BINDING PROTEIN; CELL LINE, TUMOR; DISEASE PROGRESSION; DOWN-REGULATION; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HERPESVIRUS 4, HUMAN; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; PROGNOSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR BURDEN; VIRAL MATRIX PROTEINS;

EID: 84899659338     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.02.039     Document Type: Article

References (28)

1. J.P. Spano, P. Busson, D. Atlan, J. Bourhis, J.P. Pignon, C. Esteban, and J.P. Armand Nasopharyngeal carcinomas: an update Eur. J. Cancer 39 2003 2121 2135
2. Y.K. Ong, D.M. Heng, B. Chung, S.S. Leong, J. Wee, K.W. Fong, T. Tan, and E.H. Tan Design of a prognostic index score for metastatic nasopharyngeal carcinoma Eur. J. Cancer 39 2003 1535 1541
3. K.W. Lo, K.F. To, and D.P. Huang Focus on nasopharyngeal carcinoma Cancer Cell 5 2004 423 428
4. R. Pathmanathan, U. Prasad, G. Chandrika, R. Sadler, K. Flynn, and N. Raab-Traub Undifferentiated, nonkeratinizing, and squamous cell carcinoma of the nasopharynx. Variants of Epstein-Barr virus-infected neoplasia Am. J. Pathol. 146 1995 1355 1367
5. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
6. B. Zhang, X. Pan, G.P. Cobb, and T.A. Anderson MicroRNAs as oncogenes and tumor suppressors Dev. Biol. 302 2007 1 12
7. H.C. Chen, G.H. Chen, Y.H. Chen, W.L. Liao, C.Y. Liu, K.P. Chang, Y.S. Chang, and S.J. Chen MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma Br. J. Cancer 100 2009 1002 1011
8. H. Zhang, M. Qi, S. Li, T. Qi, H. Mei, K. Huang, L. Zheng, and Q. Tong MicroRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells Mol. Cancer Ther. 11 2012 1454 1466
9. A. Courboulin, R. Paulin, N.J. Giguere, N. Saksouk, T. Perreault, J. Meloche, E.R. Paquet, S. Biardel, S. Provencher, J. Cote, M.J. Simard, and S. Bonnet Role for miR-204 in human pulmonary arterial hypertension J. Exp. Med. 208 2011 535 548
10. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
11. L. Ma, J. Young, H. Prabhala, E. Pan, P. Mestdagh, D. Muth, J. Teruya-Feldstein, F. Reinhardt, T.T. Onder, S. Valastyan, F. Westermann, F. Speleman, J. Vandesompele, and R.A. Weinberg MiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis Nat. Cell Biol. 12 2010 247 256
12. C.P. Kung, and N. Raab-Traub Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor through effects on Bcl-3 and STAT3 J. Virol. 82 2008 5486 5493
13. Z. Wang, F. Luo, L. Li, L. Yang, D. Hu, X. Ma, Z. Lu, L. Sun, and Y. Cao STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 and ERK signaling Eur. J. Cancer 46 2010 2996 3006
14. H.P. Liu, C.C. Chen, C.C. Wu, Y.C. Huang, S.C. Liu, Y. Liang, K.P. Chang, and Y.S. Chang Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells PLoS Pathog. 8 2012 e1002690
15. Y.M. Yeh, Y.T. Pan, and T.C. Wang Cdc42/Rac1 participates in the control of telomerase activity in human nasopharyngeal cancer cells Cancer Lett. 218 2005 207 213
16. K.E. Abou-Elhamd, T.N. Habib, A.E. Moussa, and B.S. Badawy The role of genetic susceptibility in head and neck squamous cell carcinoma Eur. Arch. Otorhinolaryngol. 265 2008 217 222
17. V.L. Bauer, H. Braselmann, M. Henke, D. Mattern, A. Walch, K. Unger, M. Baudis, S. Lassmann, R. Huber, J. Wienberg, M. Werner, and H.F. Zitzelsberger Chromosomal changes characterize head and neck cancer with poor prognosis J. Mol. Med. 86 2008 1353 1365
18. Y. Lee, X. Yang, Y. Huang, H. Fan, Q. Zhang, Y. Wu, J. Li, R. Hasina, C. Cheng, M.W. Lingen, M.B. Gerstein, R.R. Weichselbaum, H.R. Xing, and Y.A. Lussier Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis PLoS Comput. Biol. 6 2010 e1000730
19. R. Fahraeus et al. Expression of Epstein-Barr virus-encoded proteins in nasopharyngeal carcinoma Int. J. Cancer 42 1988 329 338
20. L.S. Young, C.W. Dawson, D. Clark, H. Rupani, P. Busson, T. Tursz, A. Johnson, and A.B. Rickinson Epstein-Barr virus gene expression in nasopharyngeal carcinoma J. Gen. Virol. 69 Pt 5 1988 1051 1065
21. S.Y. Lin, N.M. Tsang, S.C. Kao, Y.L. Hsieh, Y.P. Chen, C.S. Tsai, T.T. Kuo, S.P. Hao, I.H. Chen, and J.H. Hong Presence of Epstein-Barr virus latent membrane protein 1 gene in the nasopharyngeal swabs from patients with nasopharyngeal carcinoma Head Neck 23 2001 194 200
22. R. Pathmanathan, U. Prasad, R. Sadler, K. Flynn, and N. Raab-Traub Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma N. Engl. J. Med. 333 1995 693 698
23. S.W. Tsao, G. Tramoutanis, C.W. Dawson, A.K. Lo, and D.P. Huang The significance of LMP1 expression in nasopharyngeal carcinoma Semin. Cancer Biol. 12 2002 473 487
24. C.W. Dawson, R.J. Port, and L.S. Young The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC) Semin. Cancer Biol. 22 2012 144 153
25. S. Gondhowiardjo Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) and tumor proliferation rate as predictive factors of nasopharyngeal cancer (NPC) radiation response Gan To Kagaku Ryoho 27 Suppl 2 2000 323 331
26. Y. Ho, S.W. Tsao, M. Zeng, and V.W. Lui STAT3 as a therapeutic target for Epstein-Barr virus (EBV): associated nasopharyngeal carcinoma Cancer Lett. 330 2013 141 149
27. J. Hu, A. Mukhopadhyay, P. Truesdell, H. Chander, U.K. Mukhopadhyay, A.S. Mak, and A.W. Craig Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis J. Cell Sci. 124 2011 1739 1751
28. C.M. Tsang, E.P. Lau, K. Di, P.Y. Cheung, P.M. Hau, Y.P. Ching, Y.C. Wong, A.L. Cheung, T.S. Wan, Y. Tong, S.W. Tsao, and Y. Feng Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells Int. J. Mol. Med. 24 2009 131 138