Loss of PINK1 function affects development and results in neurodegeneration in zebrafish

Journal of Neuroscience

Volumn 28, Issue 33, 2008, Pages 8199-8207

  Anichtchik, Oleg ^a,b   Diekmann, Heike ^a   Fleming, Angeleen ^a   Roach, Alan ^a   Goldsmith, Paul ^a,b,c   Rubinsztein, David C ^c,d  

^a Addenbrooke's Hospital ^*

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

Mitochondria; Neurodegeneration; Parkinson's disease; PINK1; ROS; Zebrafish

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; CASPASE 3; LITHIUM CHLORIDE; MEMBRANE PROTEIN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN INDUCED PUTATIVE KINASE 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; PROTEIN KINASE; PTEN INDUCED PUTATIVE KINASE; PTEN-INDUCED PUTATIVE KINASE; ZEBRAFISH PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL DEATH; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LOSS OF FUNCTION MUTATION; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; ZEBRA FISH; ANIMAL; COMPARATIVE STUDY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; NERVE CELL; NERVE FIBER; PATHOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT;

ANIMALS; AXONS; CELL DEATH; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; NERVE DEGENERATION; NEURONS; PHENOTYPE; PROTEIN KINASES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 51149105923     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0979-08.2008     Document Type: Article

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