Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans

Environment International

Volumn 57-58, Issue , 2013, Pages 2-10

  Fletcher, Tony ^a   Galloway, Tamara S ^b   Melzer, David ^c   Holcroft, Paul ^b   Cipelli, Riccardo ^b   Pilling, Luke C ^c   Mondal, Debapriya ^a   Luster, Michael ^d   Harries, Lorna W ^c  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^d WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Cholesterol; Human; PFOA; PFOS; Toxicogenomics

Indexed keywords

CHOLESTEROL; METABOLISM; PHYSIOLOGY; REGRESSION ANALYSIS;

CHOLESTEROL METABOLISM; ELEVATED CONCENTRATIONS; HUMAN; LINEAR REGRESSION MODELS; PERFLUOROOCTANOIC ACID; PFOA; PFOS; TOXICOGENOMICS;

GENE EXPRESSION;

CHOLESTEROL; DRINKING WATER; MESSENGER RNA; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID;

BLOOD; CONCENTRATION (COMPOSITION); GENE EXPRESSION; GENOMICS; HEALTH IMPACT; METABOLISM; RNA; TOXICOLOGY;

ABCG1 GENE; ADULT; ARTICLE; BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONCENTRATION RESPONSE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL PARAMETERS; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; MALE; NPC1 GENE; NR1H2 GENE; POLLUTION MONITORING; PRIORITY JOURNAL; SEX DIFFERENCE; WATER CONTAMINATION;

EID: 84877024688     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2013.03.008     Document Type: Article

References (30)

1. Andersen M.E., Butenhoff J.L., Chang S.C., Farrar D.G., Kennedy G.L., Lau C., et al. Perfluoroalkyl acids and related chemistries - toxicokinetics and modes of action. Toxicol Sci 2008, 102:3-14.
2. Bartell S.M., Calafat A.M., Lyu C., Kato K., Ryan P.B., Steenland K. Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia. Environ Health Perspect 2010, 118:222-228.
3. Bultel S., Helin L., Clavey V., Chinetti-Gbaguidi G., Rigamonti E., Colin M., et al. Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages. Arterioscler Thromb Vasc Biol 2008, 28:2288-2295.
4. Butenhoff J.L., Chang S.C., Olsen G.W., Thomford P.J. Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats. Toxicology 2012, 293:1-15.
5. Debey-Pascher S., Eggle D., Schultze J.L. RNA stabilization of peripheral blood and profiling by bead chip analysis. Methods Mol Biol 2009, 496:175-210.
6. Fitz-Simon N, Fletcher T, Luster M, Steenland K, Calafat AM, Kato K, Armstrong B. Reductions in serum lipids in relation to a 4.4-year decrease in serum concentrations of perfluorooctanoic acid and perfluorooctanesulfonic acid. Epidemiology in press.
7. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
8. Frisbee S.J., Brooks A.P., Maher A., Flensborg P., Arnold S., Fletcher T., et al. The C8 health project: design, methods, and participants. Environ Health Perspect 2009, 117:1873-1882.
9. Ghosh S., Natarajan R. Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements. Biochem Biophys Res Commun 2001, 284:1065-1070.
10. Igarashi M., Osuga J., Uozaki H., Sekiya M., Nagashima S., Takahashi M., et al. The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages. Circ Res 2010, 107:1387-1395.
11. Lau C., Anitole K., Hodes C., Lai D., Pfahles-Hutchens A., Seed J. Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci 2007, 99:366-394.
12. Loveless S.E., Finlay C., Everds N.E., Frame S.R., Gillies P.J., O'Connor J.C., et al. Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO). Toxicology 2006, 220:203-217.
13. Luebker D.J., Hansen K.J., Bass N.M., Butenhoff J.L., Seacat A.M. Interactions of fluorochemicals with rat liver fatty acid-binding protein. Toxicology 2002, 176(3):175-185. (Jul 15).
14. Maher A.C., Akhtar M., Vockley J., Tarnopolsky M.A. Women have higher protein content of beta-oxidation enzymes in skeletal muscle than men. PLoS One 2010, 5:e12025.
15. Maloney E.K., Waxman D.J. Trans-activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 1999, 161:209-218.
16. Nelson J.W., Hatch E.E., Webster T.F. Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population. Environ Health Perspect 2010, 118:197-202.
17. Olsen G.W., Burris J.M., Ehresman D.J., Froehlich J.W., Seacat A.M., Butenhoff J.L., et al. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect 2007, 115:1298-1305.
18. Onishchenko N., Fischer C., Wan Ibrahim W.N., Negri S., Spulber S., Cottica D., et al. Prenatal exposure to PFOS or PFOA alters motor function in mice in a sex-related manner. Neurotox Res 2011, 19:452-461.
19. Patel C.J., Cullen M.R., Ioannidis J.P., Butte A.J. Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol 2012, 41:828-843.
20. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45.
21. Rigamonti E., Chinetti-Gbaguidi G., Staels B. Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men. Arterioscler Thromb Vasc Biol 2008, 28:1050-1059.
22. Rosen M.B., Lee J.S., Ren H., Vallanat B., Liu J., Waalkes M.P., et al. Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. Toxicol Sci 2008, 103:46-56.
23. Rosenson R.S., Brewer H.B., Davidson W.S., Fayad Z.A., Fuster V., Goldstein J., et al. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation 2012, 125:1905-1919.
24. Rylander C., Dumeaux V., Olsen K.S., Waaseth M., Sandanger T.M., Lund E. Using blood gene signatures for assessing effects of exposure to perfluoroalkyl acids (PFAAs) in humans: the NOWAC postgenome study. Int J Mol Epidemiol Genet 2011, 2:207-216.
25. Sakr C.J., Leonard R.C., Kreckmann K.H., Slade M.D., Cullen M.R. Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate. J Occup Environ Med 2007, 49:872-879.
26. Sakr C.J., Symons J.M., Kreckmann K.H., Leonard R.C. Ischaemic heart disease mortality study among workers with occupational exposure to ammonium perfluorooctanoate. Occup Environ Med 2009, 66:699-703.
27. Steenland K., Tinker S., Frisbee S., Ducatman A., Vaccarino V. Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant. Am J Epidemiol 2009, 170:1268-1278.
28. Steenland K., Fletcher T., Savitz D.A. Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA). Environ Health Perspect 2010, 118:1100-1108.
29. Trudel D., Horowitz L., Wormuth M., Scheringer M., Cousins I.T., Hungerbuhler K. Estimating consumer exposure to PFOS and PFOA. Risk Anal 2008, 28:251-269.
30. Vanden Heuvel J.P., Thompson J.T., Frame S.R., Gillies P.J. Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. Toxicol Sci 2006, 92:476-489.