Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Karch, Celeste M ^a   Ezerskiy, Lubov A ^a   Bertelsen, Sarah ^b   Goate, Alison M ^a,b   Albert, Marilyn S ^c   Albin, Roger L ^d,e   Apostolova, Liana G ^f   Arnold, Steven E ^g   Baldwin, Clinton T ^h   Barber, Robert ⁱ   Barmada, Michael M ^j   Barnes, Lisa L ^k   Beach, Thomas G ^l   Beecham, Gary W ^m   Beekly, Duane ⁿ   Bennett, David A ^k,o   Bigio, Eileen H ^p   Bird, Thomas D ⁿ   Blacker, Deborah ^q,r   Boeve, Bradley F ^s   Bowen, James D ^t   Boxer, Adam ^u   Burke, James R ^v   Buxbaum, Joseph D ^b   Cairns, Nigel J ^w   Cantwell, Laura B ^g   Cao, Chuanhai ^x   Carlson, Chris S ^y   Carney, Regina M ^z   Carrasquillo, Minerva M ^aa   Carroll, Steven L ^ab   Chui, Helena C ^ac   Clark, David G ^ad   Corneveaux, Jason ^ae   Crane, Paul K ⁿ   Cribbs, David H ^af   Crocco, Elizabeth A ^m   Cruchaga, Carlos ^a   De Jager, Philip L ^r,ag   DeCarli, Charles ^ah   DeKosky, Steven T ^ai   Demirci, F Yesim ^j   Dick, Malcolm ^aj   Dickson, Dennis W ^aa   Duara, Ranjan ^ak   Ertekin Taner, Nilufer ^aa,al   Evans, Denis ^am   Faber, Kelley M ^an   Fallon, Kenneth B ^ab   Farlow, Martin R ^an   Ferris, Steven ^ao   Foroud, Tatiana M ^an   Frosch, Matthew P ^r   Galasko, Douglas R ^ap   Ganguli, Mary ^aq   Gearing, Marla ^ar,as   Geschwind, Daniel H ^at   Ghetti, Bernardino ^an   Gilbert, John R ^m   Gilman, Sid ^d   Glass, Jonathan D ^ar   Graff Radford, Neill R ^aa,al   Green, Robert C ^au   Growdon, John H ^r   Hakonarson, Hakon ^av   Hamilton Nelson, Kara L ^m   Hamilton, Ronald L ^aq   Hardy, John ^aw   Harrell, Lindy E ^ad   Head, Elizabeth ^ax   Honig, Lawrence S ^ay   Huentelman, Matthew J ^ae   Hulette, Christine M ^v   Hyman, Bradley T ^r   Jarvik, Gail P ⁿ   Jicha, Gregory A ^ax   Jin, Lee Way ^ah   Kamboh, M Ilyas ^j   Karydas, Anna ^u   Kauwe, John S K ^az   Kaye, Jeffrey A ^ba,bb   Kim, Ronald ^af   Koo, Edward H ^ap   Kowall, Neil W ^h   Kramer, Joel H ^u   Kramer, Patricia ^ba,bc   Kukull, Walter A ⁿ   LaFerla, Frank M ^af   Lah, James J ^ar   Larson, Eric B ^n,bd   Leverenz, James B ⁿ   Levey, Allan I ^ar   Li, Ge ^be   Lin, Chiao Feng ^g   Lieberman, Andrew P ^d   Lopez, Oscar L ^j   Lunetta, Kathryn L ^bf   Lyketsos, Constantine G ^c   Mack, Wendy J ^ac   Marson, Daniel C ^ad   Martin, Eden R ^m   Martiniuk, Frank ^ao   Mash, Deborah C ^m   Masliah, Eliezer ^ap,bg   McCormick, Wayne C ⁿ   McCurry, Susan M ⁿ   McDavid, Andrew N ^y   McKee, Ann C ^h   Mesulam, Marsel ^bh   Miller, Bruce L ^u   Miller, Carol A ^bi   Miller, Joshua W ^ah   Montine, Thomas J ⁿ   Morris, John C ^a,w   Murrell, Jill R ^an   Myers, Amanda J ^m   Naj, Adam C ^m   Olichney, John M ^ah   Pankratz, Vernon S ^s   Parisi, Joseph E ^s   Peskind, Elaine ^be   Petersen, Ronald C ^s   Pierce, Aimee ^af   Poon, Wayne W ^aj   Potter, Huntington ^x   Quinn, Joseph F ^ba   Raj, Ashok ^x   Rajbhandary, Ruchita A ^m   Raskind, Murray ^be   Reiman, Eric M ^ae,bj,bk,bl   Reisberg, Barry ^ao   Reitz, Christiane ^ay,bm   Ringman, John M ^f   Roberson, Erik D ^ad   Rogaeva, Ekaterina ^bn   Rosen, Howard J ^u   Rosenberg, Roger N ^bo   Sano, Mary ^b   Saykin, Andrew J ^an   Schneider, Julie A ^k   Schneider, Lon S ^ac   Seeley, William W ^u   Smith, Amanda G ^x   Sonnen, Joshua A ⁿ   Spina, Salvatore ^an   Stern, Robert A ^h   Tanzi, Rudolph E ^r   Trojanowski, John Q ^g   Troncoso, Juan C ^c   Tsuang, Debby W ^be   Valladares, Otto ^g   Van Deerlin, Vivianna M ^g   Van Eldik, Linda J ^ax   Vardarajan, Badri N ^h   Vinters, Harry V ^f   Vonsattel, Jean Paul ^ay   Weintraub, Sandra ^bh   Welsh Bohmer, Kathleen A ^v   Williamson, Jennifer ^ay   Woltjer, Randall L ^ba   Wright, Clinton B ^m   Younkin, Steven G ^aa   Yu, Chang En ⁿ   Yu, Lei ^k   more..

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^j UNIVERSITY OF PITTSBURGH   (United States)

^k RUSH UNIVERSITY MEDICAL CENTER   (United States)

^l SUN HEALTH RESEARCH INSTITUTE   (United States)

^m UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

ⁿ UNIVERSITY OF WASHINGTON   (United States)

^o RUSH UNIVERSITY MEDICAL CENTER   (United States)

^p NORTHWESTERN UNIVERSITY   (United States)

^q HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^r MASSACHUSETTS GENERAL HOSPITAL   (United States)

^s MAYO CLINIC   (United States)

^t SWEDISH MEDICAL CENTER   (United States)

^u UNIVERSITY OF CALIFORNIA   (United States)

^v DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^w WASHINGTON UNIVERSITY   (United States)

^x UNIVERSITY OF SOUTH FLORIDA   (United States)

^y Fred Hutchinson Cancer Research Center   (United States)

^z VANDERBILT UNIVERSITY   (United States)

^aa MAYO GRADUATE SCHOOL   (United States)

^ab University of Alabama at Birmingham   (United States)

^ac UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^ad The University of Alabama at Birmingham   (United States)

^ae TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^af UNIVERSITY OF CALIFORNIA   (United States)

^ag BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^ah UNIVERSITY OF CALIFORNIA   (United States)

^ai UNIVERSITY OF VIRGINIA   (United States)

^aj UNIVERSITY OF CALIFORNIA   (United States)

^ak MOUNT SINAI MEDICAL CENTER   (United States)

^al MAYO CLINIC   (United States)

^am RUSH UNIVERSITY MEDICAL CENTER   (United States)

^an INDIANA UNIVERSITY   (United States)

^ao NEW YORK UNIVERSITY   (United States)

^ap UNIVERSITY OF CALIFORNIA   (United States)

^aq UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^ar EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^as EMORY UNIVERSITY   (United States)

^at UNIVERSITY OF CALIFORNIA   (United States)

^au HARVARD MEDICAL SCHOOL   (United States)

^av CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^aw UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ax UNIVERSITY OF KENTUCKY   (United States)

^ay Och Spine at New York Presbyterian Hospitals   (United States)

^az BRIGHAM YOUNG UNIVERSITY   (United States)

^ba OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^bb PORTLAND VA MEDICAL CENTER   (United States)

^bc OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^bd GROUP HEALTH RESEARCH INSTITUTE   (United States)

^be UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^bf BOSTON UNIVERSITY   (United States)

^bg UNIVERSITY OF CALIFORNIA   (United States)

^bh NORTHWESTERN UNIVERSITY   (United States)

^bi UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^bj ARIZONA ALZHEIMER S CONSORTIUM   (United States)

^bk BANNER ALZHEIMER S INSTITUTE   (United States)

^bl UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^bm Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^bn UNIVERSITY OF TORONTO   (Canada)

^bo UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; CELF1 GENE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; GATS GENE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; HUMAN; MICROGLIA; MTCH2 GENE; PILRB GENE; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; ZCWPW1 GENE; AGED; BRAIN; CASE CONTROL STUDY; FEMALE; GENETIC DATABASE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MALE; METABOLISM; MIDDLE AGED; ONSET AGE; RISK FACTOR; VERY ELDERLY;

CARRIER PROTEIN; CELF1 PROTEIN; CELF1 PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; MTCH2 PROTEIN, HUMAN; PILRB PROTEIN, HUMAN; ZINC FINGER PROTEIN;

AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; CASE-CONTROL STUDIES; CELF1 PROTEIN; DATABASES, GENETIC; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RECEPTORS, IMMUNOLOGIC; RISK FACTORS; ZINC FINGERS;

EID: 84961279376     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148717     Document Type: Article

References (38)

1. Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 2014; 83(1):11-26. doi: 10.1016/j.neuron.2014.05.041 PMID: 24991952; PubMed Central PMCID: PMC4120741.
2. Guerreiro RJ, Gustafson DR, Hardy J. The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. Neurobiol Aging. 2012; 33(3):437-56. Epub 2010/07/03. doi: 10.1016/j. neurobiolaging.2010.03.025 PMID: 20594621; PubMed Central PMCID: PMC2980860.
3. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008; 83(5):623-32. Epub 2008/11/04. doi: 10.1016/j.ajhg.2008.10.008 PMID: 18976728; PubMed Central PMCID: PMC2668052.
4. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet. 2009; 41(10):1088-93. PMID: 19734902. doi: 10.1038/ng.440
5. Lambert J-C, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet. 2009; 41 (10):1094-9. PMID: 19734903. doi: 10.1038/ng.439
6. Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. Jama. 2010; 303(18):1832-40. Epub 2010/05/13. doi: 10.1001/jama.2010.574 PMID: 20460622; PubMed Central PMCID: PMC2989531.
7. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J-C, Carrasquillo MM, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011; 43(5):429-35. PMID: 21460840. doi: 10.1038/ng.803
8. Naj AC, Jun G, Beecham GW, Wang L-S, Vardarajan BN, Buros J, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011; 43(5):436-41. PMID: 21460841. doi: 10.1038/ng.801
9. Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013. Epub 2013/10/29. doi: 10.1038/ng.2802 PMID: 24162737.
10. Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS One. 2014; 9(6):e94661. doi: 10.1371/journal.pone.0094661 PMID: 24922517; PubMed Central PMCID: PMC4055488.
11. Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013; 78(4):631-43. Epub 2013/04/30. doi: 10.1016/j.neuron.2013.04.014 PMID: 23623698; PubMed Central PMCID: PMC3706457.
12. Xiao Q, Gil SC, Yan P, Wang Y, Han S, Gonzales E, et al. Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. J Biol Chem. 2012; 287(25):21279-89. Epub 2012/04/28. doi: 10. 1074/jbc.M111.338376 PMID: 22539346; PubMed Central PMCID: PMC3375549.
13. Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV, et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry. 2013; 18(11):1225-34. Epub 2013/02/13. doi: 10.1038/mp.2013.1 PMID: 23399914; PubMed Central PMCID: PMC3807661.
14. Malik M, Simpson JF, Parikh I, Wilfred BR, Fardo DW, Nelson PT, et al. CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. J Neurosci. 2013; 33(33):13320-5. Epub 2013/08/16. doi: 10.1523/JNEUROSCI.1224-13.2013 PMID: 23946390; PubMed Central PMCID: PMC3742922.
15. Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. PLoS One. 2012; 7(11):e50976. Epub 2012/12/12. doi: 10.1371/journal.pone.0050976 PMID: 23226438; PubMed Central PMCID: PMC3511432.
16. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012; 79(3):221-8. Epub 2012/06/23. doi: 10.1212/WNL.0b013e3182605801 PMID: 22722634; PubMed Central PMCID: PMC3398432.
17. Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, et al. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Ann Hum Genet. 2013; 77(2):85-105. doi: 10.1111/ahg.12000 PMID: 23360175; PubMed Central PMCID: PMC3578142.
18. Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome research. 2012; 22(9):1790-7. doi: 10. 1101/gr.137323.112 PMID: 22955989; PubMed Central PMCID: PMC3431494.
19. Rosenthal SL, Barmada MM, Wang X, Demirci FY, Kamboh MI. Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings. PLoS One. 2014; 9(4):e95152. doi: 10.1371/journal.pone.0095152 PMID: 24743338; PubMed Central PMCID: PMC3990600.
20. Ramasamy A, Trabzuni D, Guelfi S, Varghese V, Smith C, Walker R, et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat Neurosci. 2014; 17(10):1418-28. doi: 10.1038/nn.3801 PMID: 25174004.
21. Gibbs JR, van der Brug MP, Hernandez DG, Traynor BJ, Nalls MA, Lai SL, et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet. 2010; 6(5): e1000952. doi: 10.1371/journal.pgen.1000952 PMID: 20485568; PubMed Central PMCID: PMC2869317.
22. Zou F, Chai HS, Younkin CS, Allen M, Crook J, Pankratz VS, et al. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet. 2012; 8(6): e1002707. doi: 10.1371/journal.pgen.1002707 PMID: 22685416; PubMed Central PMCID: PMC3369937.
23. Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, et al. An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex. J Neurosci. 2014; 34(36):11929-47. doi: 10.1523/JNEUROSCI.1860-14.2014 PMID: 25186741; PubMed Central PMCID: PMC4152602.
24. Mousseau DD, Banville D, L'Abbe D, Bouchard P, Shen SH. PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. J Biol Chem. 2000; 275(6):4467-74. PMID: 10660620.
25. Wunderlich P, Glebov K, Kemmerling N, Tien NT, Neumann H, Walter J. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) by ectodomain shedding and gamma-secretase dependent intramembranous cleavage. J Biol Chem. 2013. Epub 2013/10/01. doi: 10.1074/jbc.M113.517540 PMID: 24078628.
26. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, et al. TREM2 variants in Alzheimer's disease. N Engl J Med. 2013; 368(2):117-27. Epub 2012/11/16. doi: 10.1056/NEJMoa1211851 PMID: 23150934; PubMed Central PMCID: PMC3631573.
27. Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol. 2003; 3(6):445-53. Epub 2003/05/31. doi: 10.1038/nri1106 PMID: 12776204.
28. Shiratori I, Ogasawara K, Saito T, Lanier LL, Arase H. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med. 2004; 199(4):525-33. doi: 10.1084/jem.20031885 PMID: 14970179; PubMed Central PMCID: PMC2211832.
29. Lu Q, Lu G, Qi J, Wang H, Xuan Y, Wang Q, et al. PILRalpha and PILRbeta have a siglec fold and provide the basis of binding to sialic acid. Proc Natl Acad Sci U S A. 2014; 111(22):8221-6. doi: 10.1073/pnas.1320716111 PMID: 24843130; PubMed Central PMCID: PMC4050567.
30. Zeller T, Wild P, Szymczak S, Rotival M, Schillert A, Castagne R, et al. Genetics and beyond-the transcriptome of human monocytes and disease susceptibility. PLoS One. 2010; 5(5):e10693. doi: 10. 1371/journal.pone.0010693 PMID: 20502693; PubMed Central PMCID: PMC2872668.
31. Katz C, Zaltsman-Amir Y, Mostizky Y, Kollet N, Gross A, Friedler A. Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway. J Biol Chem. 2012; 287(18):15016-23. doi: 10. 1074/jbc.M111.328377 PMID: 22416135; PubMed Central PMCID: PMC3340256.
32. Xu Xuemin S Y-c, Gao Wei, Mao Guozhang, Zhao Guojun, Agrawal Sudesh, Chisolm Guy M., Sui Dexin, and Cui Mei-Zhen The Novel Presenilin-1-associated Protein Is a Proapoptotic Mitochondrial Protein J Biol Chem. 2002; 277:48913-22. doi: 10.1074/jbc.M209613200 PMID: 12377771
33. Xu X, Shi Y, Wu X, Gambetti P, Sui D, Cui MZ. Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1. J Biol Chem. 1999; 274(46):32543-6. PMID: 10551805.
34. Woulfe JM, Hammond R, Richardson B, Sooriabalan D, Parks W, Rippstein P, et al. Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease. Brain Pathol. 2002; 12(3):300-7. PMID: 12146798.
35. D'Angelo MA, Raices M, Panowski SH, Hetzer MW. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 2009; 136(2):284-95. doi: 10.1016/j. cell.2008.11.037 PMID: 19167330; PubMed Central PMCID: PMC2805151.
36. Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science. 2014; 344(6183):519-23. doi: 10. 1126/science.1249547 PMID: 24786080.
37. Myers AJ, Gibbs JR, Webster JA, Rohrer K, Zhao A, Marlowe L, et al. A survey of genetic human cortical gene expression. Nat Genet. 2007; 39(12):1494-9. PMID: 17982457.
38. Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci U S A. 2008; 105(11):4441-6. doi: 10.1073/pnas.0709259105 PMID: 18332434; PubMed Central PMCID: PMC2393743.