Elevation of CpG frequencies in influenza a genome attenuates pathogenicity but enhances host response to infection

eLife

Volumn 5, Issue FEBRUARY2016, 2016, Pages

  Gaunt, Eleanor ^a   Wise, Helen M ^a,c   Zhang, Huayu ^a   Lee, Lian N ^b   Atkinson, Nicky J ^a   Nicol, Marlynne Quigg ^a   Highton, Andrew J ^b   Klenerman, Paul ^b   Beard, Philippa M ^a   Dutia, Bernadette M ^a   Digard, Paul ^a   Simmonds, Peter ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CPG ISLAND; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; GENE FREQUENCY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLUENZA A; INFLUENZA A VIRUS; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS NEUTRALIZATION; VIRUS REPLICATION; VIRUS VIRULENCE; ADAPTIVE IMMUNITY; ANIMAL; DISEASE MODEL; GENETICS; GENOME; IMMUNOLOGY; INNATE IMMUNITY; LUNG; ORTHOMYXOVIRUS INFECTION; PATHOLOGY; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX; VIROLOGY; VIRULENCE; VIRUS LOAD;

ADAPTIVE IMMUNITY; ANIMALS; CPG ISLANDS; DISEASE MODELS, ANIMAL; GENOME; IMMUNITY, INNATE; INFLUENZA A VIRUS; LUNG; MICE; ORTHOMYXOVIRIDAE INFECTIONS; SEVERITY OF ILLNESS INDEX; VIRAL LOAD; VIRULENCE; VIRUS REPLICATION;

EID: 84961279204     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.12735     Document Type: Article

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