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Volumn 15, Issue 8, 2016, Pages 989-1007

Current state in the development of candidate therapeutic HPV vaccines

Author keywords

Adjuvant; Cervical cancer; Clinical trials; Combinatorial approach; HPV; HPV E6; HPV E7; Human papillomavirus; Immunotherapy; Therapeutic vaccines

Indexed keywords

BACTERIAL VECTOR; DENDRITIC CELL VACCINE; DNA VACCINE; IMMUNOMODULATING AGENT; IMMUNOSTIMULATING AGENT; NUCLEIC ACID; PEPTIDE; PROTEIN; RNA VACCINE; TUMOR CELL VACCINE; VIRUS VECTOR; WART VIRUS VACCINE;

EID: 84961211668     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.2016.1157477     Document Type: Article
Times cited : (97)

References (149)
  • 1
    • 84957431097 scopus 로고    scopus 로고
    • The burden of HPV-associated anogenital cancers
    • K.Wakeham, K.Kavanagh The burden of HPV-associated anogenital cancers. Curr Oncol Rep. 2014;16(9):402.
    • (2014) Curr Oncol Rep , vol.16 , Issue.9 , pp. 402
    • Wakeham, K.1    Kavanagh, K.2
  • 2
    • 84875321843 scopus 로고    scopus 로고
    • Global burden of human papillomavirus and related diseases
    • D.Forman, C.de Martel, C.J.Lacey. et al. Global burden of human papillomavirus and related diseases. Vaccine. 2012;30(Suppl 5):F12–23.
    • (2012) Vaccine , vol.30 , pp. F12-F23
    • Forman, D.1    de Martel, C.2    Lacey, C.J.3
  • 3
    • 84954532413 scopus 로고    scopus 로고
    • HPV-associated head and neck cancer: unique features of epidemiology and clinical management
    • J.H.Maxwell, J.R.Grandis, R.L.Ferris. HPV-associated head and neck cancer: unique features of epidemiology and clinical management. Annu Rev Med. 2015;67:91–101.
    • (2015) Annu Rev Med , vol.67 , pp. 91-101
    • Maxwell, J.H.1    Grandis, J.R.2    Ferris, R.L.3
  • 4
    • 84876062521 scopus 로고    scopus 로고
    • Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer–systematic review and meta-analysis of trends by time and region
    • H.Mehanna, T.Beech, T.Nicholson, et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer–systematic review and meta-analysis of trends by time and region. Head Neck. 2013;35(5):747–755.
    • (2013) Head Neck , vol.35 , Issue.5 , pp. 747-755
    • Mehanna, H.1    Beech, T.2    Nicholson, T.3
  • 5
    • 73849109445 scopus 로고    scopus 로고
    • Currently approved prophylactic HPV vaccines
    • D.M.Harper. Currently approved prophylactic HPV vaccines. Expert Rev Vaccines. 2009;8(12):1663–1679.
    • (2009) Expert Rev Vaccines , vol.8 , Issue.12 , pp. 1663-1679
    • Harper, D.M.1
  • 6
    • 84959113972 scopus 로고    scopus 로고
    • Safety and efficacy data on vaccines and immunization to human papillomavirus
    • N.Kash, M.A.Lee, R.Kollipara, et al. Safety and efficacy data on vaccines and immunization to human papillomavirus. J Clin Med. 2015;4(4):614–633.
    • (2015) J Clin Med , vol.4 , Issue.4 , pp. 614-633
    • Kash, N.1    Lee, M.A.2    Kollipara, R.3
  • 7
    • 79954477058 scopus 로고    scopus 로고
    • Prophylactic HPV vaccines: current knowledge of impact on gynecologic premalignancies
    • D.M.Harper, K.B.Williams. Prophylactic HPV vaccines: current knowledge of impact on gynecologic premalignancies. Discov Med. 2010;10(50):7–17.
    • (2010) Discov Med , vol.10 , Issue.50 , pp. 7-17
    • Harper, D.M.1    Williams, K.B.2
  • 8
    • 84870419307 scopus 로고    scopus 로고
    • Emerging human papillomavirus vaccines
    • B.Ma, B.Maraj, N.P.Tran, et al. Emerging human papillomavirus vaccines. Expert Opin Emerg Drugs. 2012;17(4):469–492.
    • (2012) Expert Opin Emerg Drugs , vol.17 , Issue.4 , pp. 469-492
    • Ma, B.1    Maraj, B.2    Tran, N.P.3
  • 9
    • 0027468148 scopus 로고
    • Natural history of cervical intraepithelial neoplasia: a critical review
    • A.G.Ostor. Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol. 1993;12(2):186–192.
    • (1993) Int J Gynecol Pathol , vol.12 , Issue.2 , pp. 186-192
    • Ostor, A.G.1
  • 10
  • 11
    • 0033572319 scopus 로고    scopus 로고
    • Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes
    • R.Klaes, S.M.Woerner, R.Ridder, et al. Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res. 1999;59(24):6132–6136.
    • (1999) Cancer Res , vol.59 , Issue.24 , pp. 6132-6136
    • Klaes, R.1    Woerner, S.M.2    Ridder, R.3
  • 12
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: from basic studies to clinical application
    • H.zur Hausen. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002;2(5):342–350.
    • (2002) Nat Rev Cancer , vol.2 , Issue.5 , pp. 342-350
    • zur Hausen, H.1
  • 13
    • 84951325997 scopus 로고    scopus 로고
    • Model systems of human papillomavirus-associated disease
    • J.Doorbar. Model systems of human papillomavirus-associated disease. J Pathol. 2016;238(2):166–179.
    • (2016) J Pathol , vol.238 , Issue.2 , pp. 166-179
    • Doorbar, J.1
  • 14
    • 33646596267 scopus 로고    scopus 로고
    • Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer
    • H.Arias-Pulido, C.L.Peyton, N.E.Joste, et al. Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer. J Clin Microbiol. 2006;44(5):1755–1762.
    • (2006) J Clin Microbiol , vol.44 , Issue.5 , pp. 1755-1762
    • Arias-Pulido, H.1    Peyton, C.L.2    Joste, N.E.3
  • 15
    • 34547099574 scopus 로고    scopus 로고
    • Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?
    • M.Pett, N.Coleman. Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis? J Pathol. 2007;212(4):356–367.
    • (2007) J Pathol , vol.212 , Issue.4 , pp. 356-367
    • Pett, M.1    Coleman, N.2
  • 16
    • 77952821748 scopus 로고    scopus 로고
    • In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis
    • E.Gray, M.R.Pett, D.Ward, et al. In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis. Cancer Res. 2010;70(10):4081–4091.
    • (2010) Cancer Res , vol.70 , Issue.10 , pp. 4081-4091
    • Gray, E.1    Pett, M.R.2    Ward, D.3
  • 17
    • 84875865996 scopus 로고    scopus 로고
    • HPV-16 E6 and E7 protein T cell epitopes prediction analysis based on distributions of HLA-A loci across populations: an in silico approach
    • Y.Yao, W.Huang, X.Yang, et al. HPV-16 E6 and E7 protein T cell epitopes prediction analysis based on distributions of HLA-A loci across populations: an in silico approach. Vaccine. 2013;31(18):2289–2294.
    • (2013) Vaccine , vol.31 , Issue.18 , pp. 2289-2294
    • Yao, Y.1    Huang, W.2    Yang, X.3
  • 18
    • 0027320440 scopus 로고
    • Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
    • M.C.Feltkamp, H.L.Smits, M.P.Vierboom, et al. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur J Immunol. 1993;23(9):2242–2249.
    • (1993) Eur J Immunol , vol.23 , Issue.9 , pp. 2242-2249
    • Feltkamp, M.C.1    Smits, H.L.2    Vierboom, M.P.3
  • 19
    • 77956527183 scopus 로고    scopus 로고
    • A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers
    • A.B.Riemer, D.B.Keskin, G.Zhang, et al. A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers. J Biol Chem. 2010;285(38):29608–29622.
    • (2010) J Biol Chem , vol.285 , Issue.38 , pp. 29608-29622
    • Riemer, A.B.1    Keskin, D.B.2    Zhang, G.3
  • 20
    • 84931750120 scopus 로고    scopus 로고
    • Identification of human papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes
    • A.Kumar, S.Hussain, I.S.Yadav, et al. Identification of human papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes. J Virol Methods. 2015;218:51–58.
    • (2015) J Virol Methods , vol.218 , pp. 51-58
    • Kumar, A.1    Hussain, S.2    Yadav, I.S.3
  • 21
    • 24644518036 scopus 로고    scopus 로고
    • Vaccines against human papillomavirus and cervical cancer: promises and challenges
    • A.Mahdavi, B.J.Monk. Vaccines against human papillomavirus and cervical cancer: promises and challenges. Oncologist. 2005;10(7):528–538.
    • (2005) Oncologist , vol.10 , Issue.7 , pp. 528-538
    • Mahdavi, A.1    Monk, B.J.2
  • 22
    • 80053211234 scopus 로고    scopus 로고
    • New approaches to immunotherapy for HPV associated cancers
    • A.-S.Bergot, A.Kassianos, I.H.Frazer, et al. New approaches to immunotherapy for HPV associated cancers. Cancers (Basel). 2011;3(3):3461–3495.
    • (2011) Cancers (Basel) , vol.3 , Issue.3 , pp. 3461-3495
    • Bergot, A.-S.1    Kassianos, A.2    Frazer, I.H.3
  • 23
    • 50849136160 scopus 로고    scopus 로고
    • Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors
    • D.A.Sewell, Z.K.Pan, Y.Paterson. Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors. Vaccine. 2008;26(41):5315–5320.
    • (2008) Vaccine , vol.26 , Issue.41 , pp. 5315-5320
    • Sewell, D.A.1    Pan, Z.K.2    Paterson, Y.3
  • 24
    • 2342560473 scopus 로고    scopus 로고
    • An inducible surface presentation system improves cellular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci
    • L.G.Bermudez-Humaran, N.G.Cortes-Perez, Y.Le Loir, et al. An inducible surface presentation system improves cellular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci. J Med Microbiol. 2004;53(Pt 5):427–433.
    • (2004) J Med Microbiol , vol.53 , pp. 427-433
    • Bermudez-Humaran, L.G.1    Cortes-Perez, N.G.2    Le Loir, Y.3
  • 25
    • 17444425389 scopus 로고    scopus 로고
    • Cell-surface display of E7 antigen from human papillomavirus type-16 in Lactococcus lactis and in Lactobacillus plantarum using a new cell-wall anchor from lactobacilli
    • N.G.Cortes-Perez, V.Azevedo, J.M.Alcocer-Gonzalez, et al. Cell-surface display of E7 antigen from human papillomavirus type-16 in Lactococcus lactis and in Lactobacillus plantarum using a new cell-wall anchor from lactobacilli. J Drug Target. 2005;13(2):89–98.
    • (2005) J Drug Target , vol.13 , Issue.2 , pp. 89-98
    • Cortes-Perez, N.G.1    Azevedo, V.2    Alcocer-Gonzalez, J.M.3
  • 26
    • 77949652815 scopus 로고    scopus 로고
    • Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7
    • K.Adachi, K.Kawana, T.Yokoyama, et al. Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7. Vaccine. 2010;28(16):2810–2817.
    • (2010) Vaccine , vol.28 , Issue.16 , pp. 2810-2817
    • Adachi, K.1    Kawana, K.2    Yokoyama, T.3
  • 28
    • 0037424109 scopus 로고    scopus 로고
    • Enhancing the immunogenicity of bioengineered Listeria monocytogenes by passaging through live animal hosts
    • C.Peters, Y.Paterson. Enhancing the immunogenicity of bioengineered Listeria monocytogenes by passaging through live animal hosts. Vaccine. 2003;21(11–12):1187–1194.
    • (2003) Vaccine , vol.21 , Issue.11-12 , pp. 1187-1194
    • Peters, C.1    Paterson, Y.2
  • 29
    • 84964314044 scopus 로고    scopus 로고
    • Episomal expression of truncated listeriolysin O in LmddA-LLO-E7 vaccine enhances antitumor efficacy by preferentially inducing expansions of CD4+FoxP3- and CD8+ T cells
    • Z.Chen, L.Ozbun, N.Chong, et al. Episomal expression of truncated listeriolysin O in LmddA-LLO-E7 vaccine enhances antitumor efficacy by preferentially inducing expansions of CD4+FoxP3- and CD8+ T cells. Cancer Immunol Res. 2014;2(9):911–922.
    • (2014) Cancer Immunol Res , vol.2 , Issue.9 , pp. 911-922
    • Chen, Z.1    Ozbun, L.2    Chong, N.3
  • 30
    • 0031442052 scopus 로고    scopus 로고
    • Oral somatic transgene vaccination using attenuated S. typhimurium
    • A.Darji, C.A.Guzman, B.Gerstel, et al. Oral somatic transgene vaccination using attenuated S. typhimurium. Cell. 1997;91(6):765–775.
    • (1997) Cell , vol.91 , Issue.6 , pp. 765-775
    • Darji, A.1    Guzman, C.A.2    Gerstel, B.3
  • 31
    • 10244250350 scopus 로고    scopus 로고
    • Induction of an antibody response in mice against human papillomavirus (HPV) type 16 after immunization with HPV recombinant Salmonella strains
    • M.R.Krul, E.J.Tijhaar, J.A.Kleijne, et al. Induction of an antibody response in mice against human papillomavirus (HPV) type 16 after immunization with HPV recombinant Salmonella strains. Cancer Immunol Immunothe CII. 1996;43(1):44–48.
    • (1996) Cancer Immunol Immunothe CII , vol.43 , Issue.1 , pp. 44-48
    • Krul, M.R.1    Tijhaar, E.J.2    Kleijne, J.A.3
  • 32
    • 34247626477 scopus 로고    scopus 로고
    • Vaccination with an adenoviral vector expressing calreticulin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumors in mice
    • J.G.Gomez-Gutierrez, K.G.Elpek, R.Montes de Oca-Luna, et al. Vaccination with an adenoviral vector expressing calreticulin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumors in mice. Cancer Immunol Immunother CII. 2007;56(7):997–1007.
    • (2007) Cancer Immunol Immunother CII , vol.56 , Issue.7 , pp. 997-1007
    • Gomez-Gutierrez, J.G.1    Elpek, K.G.2    Montes de Oca-Luna, R.3
  • 33
    • 0033994625 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer
    • D.W.Liu, Y.P.Tsao, J.T.Kung, et al. Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer. J Virol. 2000;74(6):2888–2894.
    • (2000) J Virol , vol.74 , Issue.6 , pp. 2888-2894
    • Liu, D.W.1    Tsao, Y.P.2    Kung, J.T.3
  • 34
    • 0344665668 scopus 로고    scopus 로고
    • Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes
    • M.C.Cassetti, S.P.McElhiney, V.Shahabi, et al. Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes. Vaccine. 2004;22(3–4):520–527.
    • (2004) Vaccine , vol.22 , Issue.3-4 , pp. 520-527
    • Cassetti, M.C.1    McElhiney, S.P.2    Shahabi, V.3
  • 35
    • 84984552535 scopus 로고    scopus 로고
    • Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin
    • C.-J.Hsieh, T.W.Kim, C.-F.Hung, et al. Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin. Vaccine. 2004;22(29–30):3993–4001.
    • (2004) Vaccine , vol.22 , Issue.29-30 , pp. 3993-4001
    • Hsieh, C.-J.1    Kim, T.W.2    Hung, C.-F.3
  • 36
    • 15844365301 scopus 로고    scopus 로고
    • A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer
    • L.K.Borysiewicz, A.Fiander, M.Nimako, et al. A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer. Lancet. 1996;347(9014):1523–1527.
    • (1996) Lancet , vol.347 , Issue.9014 , pp. 1523-1527
    • Borysiewicz, L.K.1    Fiander, A.2    Nimako, M.3
  • 37
    • 0034802089 scopus 로고    scopus 로고
    • Regression of established human papillomavirus type 16 (HPV-16) immortalized tumors in vivo by vaccinia viruses expressing different forms of HPV-16 E7 correlates with enhanced CD8(+) T-cell responses that home to the tumor site
    • A.Lamikanra, Z.K.Pan, S.N.Isaacs, et al. Regression of established human papillomavirus type 16 (HPV-16) immortalized tumors in vivo by vaccinia viruses expressing different forms of HPV-16 E7 correlates with enhanced CD8(+) T-cell responses that home to the tumor site. J Virol. 2001;75(20):9654–9664.
    • (2001) J Virol , vol.75 , Issue.20 , pp. 9654-9664
    • Lamikanra, A.1    Pan, Z.K.2    Isaacs, S.N.3
  • 38
    • 67649385980 scopus 로고    scopus 로고
    • The expression of the soluble isoform of hFlt3 ligand by recombinant vaccinia virus enhances immunogenicity of the vector
    • K.Zurkova, K.Babiarova, P.Hainz, et al. The expression of the soluble isoform of hFlt3 ligand by recombinant vaccinia virus enhances immunogenicity of the vector. Oncol Rep. 2009;21(5):1335–1343.
    • (2009) Oncol Rep , vol.21 , Issue.5 , pp. 1335-1343
    • Zurkova, K.1    Babiarova, K.2    Hainz, P.3
  • 39
    • 26444607877 scopus 로고    scopus 로고
    • Low-dose adenovirus vaccine encoding chimeric hepatitis B virus surface antigen-human papillomavirus type 16 E7 proteins induces enhanced E7-specific antibody and cytotoxic T-cell responses
    • A.Baez-Astua, E.Herraez-Hernandez, N.Garbi, et al. Low-dose adenovirus vaccine encoding chimeric hepatitis B virus surface antigen-human papillomavirus type 16 E7 proteins induces enhanced E7-specific antibody and cytotoxic T-cell responses. J Virol. 2005;79(20):12807–12817.
    • (2005) J Virol , vol.79 , Issue.20 , pp. 12807-12817
    • Baez-Astua, A.1    Herraez-Hernandez, E.2    Garbi, N.3
  • 40
    • 79953177481 scopus 로고    scopus 로고
    • Role of regulatory T-cells in immunization strategies involving a recombinant alphavirus vector system
    • M.Walczak, J.Regts, A.J.van Oosterhout, et al. Role of regulatory T-cells in immunization strategies involving a recombinant alphavirus vector system. Antivir Ther. 2011;16(2):207–218.
    • (2011) Antivir Ther , vol.16 , Issue.2 , pp. 207-218
    • Walczak, M.1    Regts, J.2    van Oosterhout, A.J.3
  • 41
    • 30744459371 scopus 로고    scopus 로고
    • Induction of human papilloma virus E6/E7-specific cytotoxic T-lymphocyte activity in immune-tolerant, E6/E7-transgenic mice
    • A.Riezebos-Brilman, J.Regts, E.-J.Freyschmidt, et al. Induction of human papilloma virus E6/E7-specific cytotoxic T-lymphocyte activity in immune-tolerant, E6/E7-transgenic mice. Gene Ther. 2005;12(18):1410–1414.
    • (2005) Gene Ther , vol.12 , Issue.18 , pp. 1410-1414
    • Riezebos-Brilman, A.1    Regts, J.2    Freyschmidt, E.-J.3
  • 42
    • 58149510113 scopus 로고    scopus 로고
    • Augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by co-expression of interleukin-12
    • A.Riezebos-Brilman, J.Regts, M.Chen, et al. Augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by co-expression of interleukin-12. Vaccine. 2009;27(5):701–707.
    • (2009) Vaccine , vol.27 , Issue.5 , pp. 701-707
    • Riezebos-Brilman, A.1    Regts, J.2    Chen, M.3
  • 43
    • 84934444902 scopus 로고    scopus 로고
    • Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines
    • P.P.Ip, A.Boerma, M.Walczak, et al. Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines. Gene Ther. 2015;22(7):560–567.
    • (2015) Gene Ther , vol.22 , Issue.7 , pp. 560-567
    • Ip, P.P.1    Boerma, A.2    Walczak, M.3
  • 44
    • 84869491956 scopus 로고    scopus 로고
    • Successful therapeutic vaccination with integrase defective lentiviral vector expressing nononcogenic human papillomavirus E7 protein
    • F.Grasso, D.R.Negri, S.Mochi, et al. Successful therapeutic vaccination with integrase defective lentiviral vector expressing nononcogenic human papillomavirus E7 protein. Journal International du Cancer [Int J Cancer]. 2013;132(2):335–344.
    • (2013) Journal International du Cancer [Int J Cancer] , vol.132 , Issue.2 , pp. 335-344
    • Grasso, F.1    Negri, D.R.2    Mochi, S.3
  • 45
    • 68249122152 scopus 로고    scopus 로고
    • Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer
    • C.-L.Chang, B.Ma, X.Pang, et al. Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer. Mol Ther J Am Soc Gene Ther. 2009;17(8):1365–1372.
    • (2009) Mol Ther J Am Soc Gene Ther , vol.17 , Issue.8 , pp. 1365-1372
    • Chang, C.-L.1    Ma, B.2    Pang, X.3
  • 47
    • 76849115615 scopus 로고    scopus 로고
    • Perspectives for preventive and therapeutic HPV vaccines
    • K.Lin, K.Doolan, C.-F.Hung, et al. Perspectives for preventive and therapeutic HPV vaccines. J Formosan Med Assoc = Taiwan Yi Zhi. 2010;109(1):4–24.
    • (2010) J Formosan Med Assoc = Taiwan Yi Zhi , vol.109 , Issue.1 , pp. 4-24
    • Lin, K.1    Doolan, K.2    Hung, C.-F.3
  • 48
    • 84940570811 scopus 로고    scopus 로고
    • Immune therapy for human papillomaviruses-related cancers
    • R.Rosales, C.Rosales. Immune therapy for human papillomaviruses-related cancers. World J Clin Oncol. 2014;5(5):1002–1019.• A comprehensive review for various preventative and therapeutic strategies against HPV-associated diseases.
    • (2014) World J Clin Oncol , vol.5 , Issue.5 , pp. 1002-1019
    • Rosales, R.1    Rosales, C.2
  • 50
    • 42149123438 scopus 로고    scopus 로고
    • Therapeutic human papillomavirus vaccines: current clinical trials and future directions
    • C.-F.Hung, B.Ma, A.Monie, et al. Therapeutic human papillomavirus vaccines: current clinical trials and future directions. Expert Opin Biol Ther. 2008;8(4):421–439.
    • (2008) Expert Opin Biol Ther , vol.8 , Issue.4 , pp. 421-439
    • Hung, C.-F.1    Ma, B.2    Monie, A.3
  • 51
    • 3142704466 scopus 로고    scopus 로고
    • Comparison of HPV DNA vaccines employing intracellular targeting strategies
    • J.W.Kim, C.F.Hung, J.Juang, et al. Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther. 1011-1018;11(12):2004.
    • Gene Ther , vol.11 , Issue.12 , pp. 2004
    • Kim, J.W.1    Hung, C.F.2    Juang, J.3
  • 52
    • 0030820743 scopus 로고    scopus 로고
    • Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes
    • T.M.Fu, J.B.Ulmer, M.J.Caulfield, et al. Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol Med. 1997;3(6):362–371.
    • (1997) Mol Med , vol.3 , Issue.6 , pp. 362-371
    • Fu, T.M.1    Ulmer, J.B.2    Caulfield, M.J.3
  • 53
    • 0032555907 scopus 로고    scopus 로고
    • Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization
    • A.Porgador, K.R.Irvine, A.Iwasaki, et al. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med. 1998;188(6):1075–1082.
    • (1998) J Exp Med , vol.188 , Issue.6 , pp. 1075-1082
    • Porgador, A.1    Irvine, K.R.2    Iwasaki, A.3
  • 54
    • 0032526344 scopus 로고    scopus 로고
    • Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen-presenting cells
    • M.A.Chattergoon, T.M.Robinson, J.D.Boyer, et al. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen-presenting cells. J Immunol. 1998;160(12):5707–5718.
    • (1998) J Immunol , vol.160 , Issue.12 , pp. 5707-5718
    • Chattergoon, M.A.1    Robinson, T.M.2    Boyer, J.D.3
  • 55
    • 0034283956 scopus 로고    scopus 로고
    • Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice
    • M.Dupuis, K.Denis-Mize, C.Woo, et al. Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J Immunol. 2000;165(5):2850–2858.
    • (2000) J Immunol , vol.165 , Issue.5 , pp. 2850-2858
    • Dupuis, M.1    Denis-Mize, K.2    Woo, C.3
  • 56
    • 34247188123 scopus 로고    scopus 로고
    • Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells
    • S.W.Tsen, A.H.Paik, C.-F.Hung, et al. Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells. Expert Rev Vaccines. 2007;6(2):227–239.
    • (2007) Expert Rev Vaccines , vol.6 , Issue.2 , pp. 227-239
    • Tsen, S.W.1    Paik, A.H.2    Hung, C.-F.3
  • 57
    • 0036204348 scopus 로고    scopus 로고
    • Cancer immunotherapy using Sindbis virus replicon particles encoding a VP22-antigen fusion
    • W.-F.Cheng, C.-F.Hung, K.-F.Hsu, et al. Cancer immunotherapy using Sindbis virus replicon particles encoding a VP22-antigen fusion. Hum Gene Ther. 2002;13(4):553–568.
    • (2002) Hum Gene Ther , vol.13 , Issue.4 , pp. 553-568
    • Cheng, W.-F.1    Hung, C.-F.2    Hsu, K.-F.3
  • 58
    • 0030813127 scopus 로고    scopus 로고
    • Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus
    • P.Berglund, M.Quesada-Rolander, P.Putkonen, et al. Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus. AIDS Res Hum Retroviruses. 1997;13(17):1487–1495.
    • (1997) AIDS Res Hum Retroviruses , vol.13 , Issue.17 , pp. 1487-1495
    • Berglund, P.1    Quesada-Rolander, M.2    Putkonen, P.3
  • 59
    • 0035077790 scopus 로고    scopus 로고
    • Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen
    • K.F.Hsu, C.F.Hung, W.F.Cheng, et al. Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen. Gene Ther. 2001;8(5):376–383.
    • (2001) Gene Ther , vol.8 , Issue.5 , pp. 376-383
    • Hsu, K.F.1    Hung, C.F.2    Cheng, W.F.3
  • 60
    • 1242273662 scopus 로고    scopus 로고
    • Enhancement of suicidal DNA vaccine potency by delaying suicidal DNA-induced cell death
    • T.W.Kim, C.-F.Hung, J.Juang, et al. Enhancement of suicidal DNA vaccine potency by delaying suicidal DNA-induced cell death. Gene Ther. 2004;11(3):336–342.
    • (2004) Gene Ther , vol.11 , Issue.3 , pp. 336-342
    • Kim, T.W.1    Hung, C.-F.2    Juang, J.3
  • 61
    • 0034001812 scopus 로고    scopus 로고
    • Stable high-level expression of heterologous genes in vitro and in vivo by noncytopathic DNA-based Kunjin virus replicon vectors
    • A.N.Varnavski, P.R.Young, A.A.Khromykh. Stable high-level expression of heterologous genes in vitro and in vivo by noncytopathic DNA-based Kunjin virus replicon vectors. J Virol. 2000;74(9):4394–4403.
    • (2000) J Virol , vol.74 , Issue.9 , pp. 4394-4403
    • Varnavski, A.N.1    Young, P.R.2    Khromykh, A.A.3
  • 62
    • 1342321892 scopus 로고    scopus 로고
    • Recombinant Kunjin virus replicon vaccines induce protective T-cell immunity against human papillomavirus 16 E7-expressing tumour
    • K.A.Herd, T.Harvey, A.A.Khromykh, et al. Recombinant Kunjin virus replicon vaccines induce protective T-cell immunity against human papillomavirus 16 E7-expressing tumour. Virology. 2004;319(2):237–248.
    • (2004) Virology , vol.319 , Issue.2 , pp. 237-248
    • Herd, K.A.1    Harvey, T.2    Khromykh, A.A.3
  • 63
    • 84908060936 scopus 로고    scopus 로고
    • Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive(R)) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer
    • M.Sebastian, A.Papachristofilou, C.Weiss, et al. Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive(R)) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer. BMC Cancer. 2014;14:748.
    • (2014) BMC Cancer , vol.14 , pp. 748
    • Sebastian, M.1    Papachristofilou, A.2    Weiss, C.3
  • 64
    • 16544381246 scopus 로고    scopus 로고
    • Adjuvant effect of dendritic cells transduced with recombinant vaccinia virus expressing HPV16-E7 is inhibited by co-expression of IL12
    • J.Mackova, L.Kutinova, P.Hainz, et al. Adjuvant effect of dendritic cells transduced with recombinant vaccinia virus expressing HPV16-E7 is inhibited by co-expression of IL12. Int J Oncol. 2004;24(6):1581–1588.
    • (2004) Int J Oncol , vol.24 , Issue.6 , pp. 1581-1588
    • Mackova, J.1    Kutinova, L.2    Hainz, P.3
  • 65
    • 0034061398 scopus 로고    scopus 로고
    • Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity
    • T.L.Wang, M.Ling, I.M.Shih, et al. Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity. Gene Ther. 2000;7(9):726–733.
    • (2000) Gene Ther , vol.7 , Issue.9 , pp. 726-733
    • Wang, T.L.1    Ling, M.2    Shih, I.M.3
  • 66
    • 44649170385 scopus 로고    scopus 로고
    • Whole tumor antigen vaccination using dendritic cells: comparison of RNA electroporation and pulsing with UV-irradiated tumor cells
    • F.Benencia, M.C.Courreges, G.Coukos. Whole tumor antigen vaccination using dendritic cells: comparison of RNA electroporation and pulsing with UV-irradiated tumor cells. J Transl Med. 2008;6:21.
    • (2008) J Transl Med , vol.6 , pp. 21
    • Benencia, F.1    Courreges, M.C.2    Coukos, G.3
  • 67
    • 0033559604 scopus 로고    scopus 로고
    • Induction of specific CD8+ T-lymphocyte responses using a human papillomavirus-16 E6/E7 fusion protein and autologous dendritic cells
    • M.Murakami, K.J.Gurski, F.M.Marincola, et al. Induction of specific CD8+ T-lymphocyte responses using a human papillomavirus-16 E6/E7 fusion protein and autologous dendritic cells. Cancer Res. 1999;59(6):1184–1187.
    • (1999) Cancer Res , vol.59 , Issue.6 , pp. 1184-1187
    • Murakami, M.1    Gurski, K.J.2    Marincola, F.M.3
  • 68
    • 19644396618 scopus 로고    scopus 로고
    • Vaccination with dendritic cells transfected with BAK and BAX siRNA enhances antigen-specific immune responses by prolonging dendritic cell life
    • S.Peng, T.W.Kim, J.H.Lee, et al. Vaccination with dendritic cells transfected with BAK and BAX siRNA enhances antigen-specific immune responses by prolonging dendritic cell life. Hum Gene Ther. 2005;16(5):584–593.
    • (2005) Hum Gene Ther , vol.16 , Issue.5 , pp. 584-593
    • Peng, S.1    Kim, T.W.2    Lee, J.H.3
  • 69
    • 59649107188 scopus 로고    scopus 로고
    • Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8(+) T cell-mediated cell death
    • J.H.Kim, T.H.Kang, K.H.Noh, et al. Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8(+) T cell-mediated cell death. Immunol Lett. 2009;122(1):58–67.
    • (2009) Immunol Lett , vol.122 , Issue.1 , pp. 58-67
    • Kim, J.H.1    Kang, T.H.2    Noh, K.H.3
  • 70
    • 0037472447 scopus 로고    scopus 로고
    • Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]: poly[C(12)U] (Ampligen R)
    • M.Adams, H.Navabi, B.Jasani, et al. Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]: poly[C(12)U] (Ampligen R). Vaccine. 2003;21(7–8):787–790.
    • (2003) Vaccine , vol.21 , Issue.7-8 , pp. 787-790
    • Adams, M.1    Navabi, H.2    Jasani, B.3
  • 71
    • 24944469645 scopus 로고    scopus 로고
    • Therapeutic vaccines for cervical cancer: dendritic cell-based immunotherapy
    • A.D.Santin, S.Bellone, J.J.Roman, et al. Therapeutic vaccines for cervical cancer: dendritic cell-based immunotherapy. Curr Pharm Des. 2005;11(27):3485–3500.
    • (2005) Curr Pharm Des , vol.11 , Issue.27 , pp. 3485-3500
    • Santin, A.D.1    Bellone, S.2    Roman, J.J.3
  • 72
    • 84930418638 scopus 로고    scopus 로고
    • The siRNA cocktail targeting interleukin 10 receptor and transforming growth factor-beta receptor on dendritic cells potentiates tumour antigen-specific CD8(+) T cell immunity
    • Y.-H.Ahn, S.-O.Hong, J.H.Kim, et al. The siRNA cocktail targeting interleukin 10 receptor and transforming growth factor-beta receptor on dendritic cells potentiates tumour antigen-specific CD8(+) T cell immunity. Clin Exp Immunol. 2015;181(1):164–178.
    • (2015) Clin Exp Immunol , vol.181 , Issue.1 , pp. 164-178
    • Ahn, Y.-H.1    Hong, S.-O.2    Kim, J.H.3
  • 73
    • 3843108120 scopus 로고    scopus 로고
    • Treatment of minimal residual disease after surgery or chemotherapy in mice carrying HPV16-associated tumours: Cytokine and gene therapy with IL-2 and GM-CSF
    • R.Mikyskova, M.Indrova, J.Simova, et al. Treatment of minimal residual disease after surgery or chemotherapy in mice carrying HPV16-associated tumours: Cytokine and gene therapy with IL-2 and GM-CSF. Int J Oncol. 2004;24(1):161–167.
    • (2004) Int J Oncol , vol.24 , Issue.1 , pp. 161-167
    • Mikyskova, R.1    Indrova, M.2    Simova, J.3
  • 74
    • 0034063322 scopus 로고    scopus 로고
    • Antigen-specific cancer immunotherapy using a GM-CSF secreting allogeneic tumor cell-based vaccine
    • E.Y.Chang, C.H.Chen, H.Ji, et al. Antigen-specific cancer immunotherapy using a GM-CSF secreting allogeneic tumor cell-based vaccine. Journal International du Cancer [Int J Cancer]. 2000;86(5):725–730.
    • (2000) Journal International du Cancer [Int J Cancer] , vol.86 , Issue.5 , pp. 725-730
    • Chang, E.Y.1    Chen, C.H.2    Ji, H.3
  • 75
    • 0029047540 scopus 로고
    • Immunologic adjuvants for modern vaccine formulations
    • F.R.Vogel. Immunologic adjuvants for modern vaccine formulations. Ann N Y Acad Sci. 1995;754:153–160.
    • (1995) Ann N Y Acad Sci , vol.754 , pp. 153-160
    • Vogel, F.R.1
  • 76
    • 84940026134 scopus 로고    scopus 로고
    • Vaccines, adjuvants and autoimmunity
    • L.E.Guimaraes, B.Baker, C.Perricone, et al., Vaccines, adjuvants and autoimmunity. Pharmacol Res. 2015;100:190–209.• A detailed review discussing the mechanism, advantages, and drawbacks of adjuvants.
    • (2015) Pharmacol Res , vol.100 , pp. 190-209
    • Guimaraes, L.E.1    Baker, B.2    Perricone, C.3
  • 77
    • 0142058176 scopus 로고    scopus 로고
    • Recent advances in the discovery and delivery of vaccine adjuvants
    • D.T.O’Hagan, N.M.Valiante. Recent advances in the discovery and delivery of vaccine adjuvants. Nat Rev Drug Discov. 2003;2(9):727–735.
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.9 , pp. 727-735
    • O’Hagan, D.T.1    Valiante, N.M.2
  • 78
    • 0034788572 scopus 로고    scopus 로고
    • Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen
    • W.F.Cheng, C.F.Hung, C.Y.Chai, et al. Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. J Clin Invest. 2001;108(5):669–678.
    • (2001) J Clin Invest , vol.108 , Issue.5 , pp. 669-678
    • Cheng, W.F.1    Hung, C.F.2    Chai, C.Y.3
  • 79
    • 85027956886 scopus 로고    scopus 로고
    • Co-administration with DNA encoding papillomavirus capsid proteins enhances the antitumor effects generated by therapeutic HPV DNA vaccination
    • B.Yang, A.Yang, S.Peng, et al. Co-administration with DNA encoding papillomavirus capsid proteins enhances the antitumor effects generated by therapeutic HPV DNA vaccination. Cell Biosci. 2015;5:35.
    • (2015) Cell Biosci , vol.5 , pp. 35
    • Yang, B.1    Yang, A.2    Peng, S.3
  • 80
    • 2642545654 scopus 로고    scopus 로고
    • A DNA vaccine co-expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T-cell immune response
    • T.W.Kim, C.-F.Hung, M.Zheng, et al. A DNA vaccine co-expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T-cell immune response. J Biomed Sci. 2004;11(4):493–499.
    • (2004) J Biomed Sci , vol.11 , Issue.4 , pp. 493-499
    • Kim, T.W.1    Hung, C.-F.2    Zheng, M.3
  • 81
    • 84943583779 scopus 로고    scopus 로고
    • Ubiquitin-like molecule ISG15 acts as an immune adjuvant to enhance antigen-specific CD8 T-cell tumor immunity
    • D.O.Villarreal, M.C.Wise, R.J.Siefert, et al. Ubiquitin-like molecule ISG15 acts as an immune adjuvant to enhance antigen-specific CD8 T-cell tumor immunity. Mol Ther J Am Soc Gene Ther. 2015;23:1653–1662.
    • (2015) Mol Ther J Am Soc Gene Ther , vol.23 , pp. 1653-1662
    • Villarreal, D.O.1    Wise, M.C.2    Siefert, R.J.3
  • 82
    • 84929288176 scopus 로고    scopus 로고
    • A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile
    • R.Heidenreich, E.Jasny, A.Kowalczyk, et al. A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile. Journal International du Cancer [Int J Cancer]. 2015;137(2):372–384.
    • (2015) Journal International du Cancer [Int J Cancer] , vol.137 , Issue.2 , pp. 372-384
    • Heidenreich, R.1    Jasny, E.2    Kowalczyk, A.3
  • 83
    • 0034003977 scopus 로고    scopus 로고
    • Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies of HPV-16 E7-expressing DNA vaccines
    • C.H.Chen, T.L.Wang, C.F.Hung, et al. Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies of HPV-16 E7-expressing DNA vaccines. Vaccine. 2000;18(19):2015–2022.
    • (2000) Vaccine , vol.18 , Issue.19 , pp. 2015-2022
    • Chen, C.H.1    Wang, T.L.2    Hung, C.F.3
  • 84
    • 2942566291 scopus 로고    scopus 로고
    • DNA vaccines against the human papillomavirus type 16 E6 or E7 oncoproteins
    • A.P.Wlazlo, H.Deng, W.Giles-Davis, et al. DNA vaccines against the human papillomavirus type 16 E6 or E7 oncoproteins. Cancer Gene Ther. 2004;11(6):457–464.
    • (2004) Cancer Gene Ther , vol.11 , Issue.6 , pp. 457-464
    • Wlazlo, A.P.1    Deng, H.2    Giles-Davis, W.3
  • 85
    • 16244381453 scopus 로고    scopus 로고
    • Combined immunization with DNA and transduced tumor cells expressing mouse GM-CSF or IL-2
    • S.Rittich, M.Duskova, J.Mackova, et al. Combined immunization with DNA and transduced tumor cells expressing mouse GM-CSF or IL-2. Oncol Rep. 2005;13(2):311–317.
    • (2005) Oncol Rep , vol.13 , Issue.2 , pp. 311-317
    • Rittich, S.1    Duskova, M.2    Mackova, J.3
  • 86
    • 0142182009 scopus 로고    scopus 로고
    • Boosting with recombinant vaccinia increases HPV-16 E7-Specific T cell precursor frequencies and antitumor effects of HPV-16 E7-expressing Sindbis virus replicon particles
    • C.-T.Lin, C.-F.Hung, J.Juang, et al. Boosting with recombinant vaccinia increases HPV-16 E7-Specific T cell precursor frequencies and antitumor effects of HPV-16 E7-expressing Sindbis virus replicon particles. Mol Ther J Am Soc Gene Ther. 2003;8(4):559–566.
    • (2003) Mol Ther J Am Soc Gene Ther , vol.8 , Issue.4 , pp. 559-566
    • Lin, C.-T.1    Hung, C.-F.2    Juang, J.3
  • 87
    • 28944446238 scopus 로고    scopus 로고
    • Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara
    • J.Mackova, J.Stasikova, L.Kutinova, et al. Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara. Cancer Immunol Immunother CII. 2006;55(1):39–46.
    • (2006) Cancer Immunol Immunother CII , vol.55 , Issue.1 , pp. 39-46
    • Mackova, J.1    Stasikova, J.2    Kutinova, L.3
  • 88
    • 0030950036 scopus 로고    scopus 로고
    • Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules
    • F.Y.Yue, R.Dummer, R.Geertsen, et al. Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules. Journal International du Cancer [Int J Cancer]. 1997;71(4):630–637.
    • (1997) Journal International du Cancer [Int J Cancer] , vol.71 , Issue.4 , pp. 630-637
    • Yue, F.Y.1    Dummer, R.2    Geertsen, R.3
  • 89
    • 0034770605 scopus 로고    scopus 로고
    • Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells
    • L.Gorelik, R.A.Flavell. Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med. 1118-1122;7(10):2001.
    • Nat Med , vol.7 , Issue.10 , pp. 2001
    • Gorelik, L.1    Flavell, R.A.2
  • 90
    • 58149503751 scopus 로고    scopus 로고
    • Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4+CD25+ T regulatory cells
    • C.-M.Chuang, T.Hoory, A.Monie, et al. Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4+CD25+ T regulatory cells. Vaccine. 2009;27(5):684–689.
    • (2009) Vaccine , vol.27 , Issue.5 , pp. 684-689
    • Chuang, C.-M.1    Hoory, T.2    Monie, A.3
  • 91
    • 84942980828 scopus 로고    scopus 로고
    • An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression
    • A.E.Rice, Y.E.Latchman, J.P.Balint, et al. An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression. Cancer Gene Ther. 2015;22:454–462.
    • (2015) Cancer Gene Ther , vol.22 , pp. 454-462
    • Rice, A.E.1    Latchman, Y.E.2    Balint, J.P.3
  • 92
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
    • H.Yu, M.Kortylewski, D.Pardoll. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol. 2007;7(1):41–51.
    • (2007) Nat Rev Immunol , vol.7 , Issue.1 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 93
    • 0842286646 scopus 로고    scopus 로고
    • IDO and tolerance to tumors
    • D.H.Munn, A.L.Mellor. IDO and tolerance to tumors. Trends Mol Med. 2004;10(1):15–18.
    • (2004) Trends Mol Med , vol.10 , Issue.1 , pp. 15-18
    • Munn, D.H.1    Mellor, A.L.2
  • 94
    • 12144285871 scopus 로고    scopus 로고
    • Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege
    • N.Rubinstein, M.Alvarez, N.W.Zwirner, et al. Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege. Cancer Cell. 2004;5(3):241–251.
    • (2004) Cancer Cell , vol.5 , Issue.3 , pp. 241-251
    • Rubinstein, N.1    Alvarez, M.2    Zwirner, N.W.3
  • 95
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • V.Groh, J.Wu, C.Yee, et al. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature. 2002;419(6908):734–738.
    • (2002) Nature , vol.419 , Issue.6908 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3
  • 96
    • 33745258657 scopus 로고    scopus 로고
    • Tumor-driven evolution of immunosuppressive networks during malignant progression
    • R.Kim, M.Emi, K.Tanabe, et al. Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Res. 2006;66(11):5527–5536.
    • (2006) Cancer Res , vol.66 , Issue.11 , pp. 5527-5536
    • Kim, R.1    Emi, M.2    Tanabe, K.3
  • 97
    • 0037387334 scopus 로고    scopus 로고
    • Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review
    • K.N.Prasad, B.Kumar, X.-D.Yan, et al. Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. J Am Coll Nutr. 2003;22(2):108–117.
    • (2003) J Am Coll Nutr , vol.22 , Issue.2 , pp. 108-117
    • Prasad, K.N.1    Kumar, B.2    Yan, X.-D.3
  • 98
    • 84904989729 scopus 로고    scopus 로고
    • Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8 + T cell-mediated antitumor effects
    • T.H.Kang, J.Knoff, W.H.Yeh, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8 + T cell-mediated antitumor effects. Plos One. 2014;9(7):e103562.
    • (2014) Plos One , vol.9 , Issue.7 , pp. 103562
    • Kang, T.H.1    Knoff, J.2    Yeh, W.H.3
  • 99
    • 84942877676 scopus 로고    scopus 로고
    • Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine
    • T.Bartkowiak, S.Singh, G.Yang, et al. Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine. Proc Natl Acad Sci U S A. 2015;112(38):E5290–5299.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.38 , pp. E5290-E5299
    • Bartkowiak, T.1    Singh, S.2    Yang, G.3
  • 100
    • 84885329272 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor AR-42 enhances E7-specific CD8(+) T cell-mediated antitumor immunity induced by therapeutic HPV DNA vaccination
    • S.Y.Lee, Z.Huang, T.H.Kang, et al. Histone deacetylase inhibitor AR-42 enhances E7-specific CD8(+) T cell-mediated antitumor immunity induced by therapeutic HPV DNA vaccination. J Mol Med (Berl). 2013;91(10):1221–1231.
    • (2013) J Mol Med (Berl) , vol.91 , Issue.10 , pp. 1221-1231
    • Lee, S.Y.1    Huang, Z.2    Kang, T.H.3
  • 101
    • 84908679370 scopus 로고    scopus 로고
    • Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFNgamma
    • R.-S.Soong, L.Song, J.Trieu, et al. Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFNgamma. Clin Cancer Res Off J Amer Assoc Cancer Res. 2014;20(21):5456–5467.• This study demonstrated the immune recruitment effect of local adjuvant application.
    • (2014) Clin Cancer Res Off J Amer Assoc Cancer Res , vol.20 , Issue.21 , pp. 5456-5467
    • Soong, R.-S.1    Song, L.2    Trieu, J.3
  • 102
    • 84924988121 scopus 로고    scopus 로고
    • Local administration of granulocyte macrophage colony-stimulating factor induces local accumulation of dendritic cells and antigen-specific CD8+ T cells and enhances dendritic cell cross-presentation
    • S.-J.Lee, L.Song, M.-C.Yang, et al. Local administration of granulocyte macrophage colony-stimulating factor induces local accumulation of dendritic cells and antigen-specific CD8+ T cells and enhances dendritic cell cross-presentation. Vaccine. 2015;33(13):1549–1555.
    • (2015) Vaccine , vol.33 , Issue.13 , pp. 1549-1555
    • Lee, S.-J.1    Song, L.2    Yang, M.-C.3
  • 103
    • 67649506210 scopus 로고    scopus 로고
    • Treatment with demethylating agent, 5-aza-2ʹ-deoxycytidine enhances therapeutic HPV DNA vaccine potency
    • D.Lu, T.Hoory, A.Monie, et al. Treatment with demethylating agent, 5-aza-2ʹ-deoxycytidine enhances therapeutic HPV DNA vaccine potency. Vaccine. 2009;27(32):4363–4369.
    • (2009) Vaccine , vol.27 , Issue.32 , pp. 4363-4369
    • Lu, D.1    Hoory, T.2    Monie, A.3
  • 104
    • 33846697356 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination
    • T.H.Kang, J.H.Lee, C.K.Song, et al. Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer Res. 2007;67(2):802–811.
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 802-811
    • Kang, T.H.1    Lee, J.H.2    Song, C.K.3
  • 105
    • 33846302030 scopus 로고    scopus 로고
    • Therapeutic synergy of human papillomavirus E7 subunit vaccines plus cisplatin in an animal tumor model: causal involvement of increased sensitivity of cisplatin-treated tumors to CTL-mediated killing in therapeutic synergy
    • S.H.Bae, Y.-J.Park, J.-B.Park, et al. Therapeutic synergy of human papillomavirus E7 subunit vaccines plus cisplatin in an animal tumor model: causal involvement of increased sensitivity of cisplatin-treated tumors to CTL-mediated killing in therapeutic synergy. Clin Cancer Res Off J Amer Assoc Cancer Res. 2007;13(1):341–349.
    • (2007) Clin Cancer Res Off J Amer Assoc Cancer Res , vol.13 , Issue.1 , pp. 341-349
    • Bae, S.H.1    Park, Y.-J.2    Park, J.-B.3
  • 106
    • 34547133955 scopus 로고    scopus 로고
    • Increased sensitivity of radiated murine cervical cancer tumors to E7 subunit vaccine-driven CTL-mediated killing induces synergistic anti-tumor activity
    • G.W.Ye, J.-B.Park, Y.-J.Park, et al. Increased sensitivity of radiated murine cervical cancer tumors to E7 subunit vaccine-driven CTL-mediated killing induces synergistic anti-tumor activity. Mol Ther J Am Soc Gene Ther. 2007;15(8):1564–1570.
    • (2007) Mol Ther J Am Soc Gene Ther , vol.15 , Issue.8 , pp. 1564-1570
    • Ye, G.W.1    Park, J.-B.2    Park, Y.-J.3
  • 107
    • 48149087775 scopus 로고    scopus 로고
    • Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination
    • C.-W.Tseng, A.Monie, C.-Y.Wu, et al. Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination. J Mol Med (Berl). 2008;86(8):899–908.
    • (2008) J Mol Med (Berl) , vol.86 , Issue.8 , pp. 899-908
    • Tseng, C.-W.1    Monie, A.2    Wu, C.-Y.3
  • 108
    • 61349201441 scopus 로고    scopus 로고
    • Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts
    • C.-W.Tseng, C.Trimble, Q.Zeng, et al. Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts. Cancer Immunol Immunother CII. 2009;58(5):737–748.
    • (2009) Cancer Immunol Immunother CII , vol.58 , Issue.5 , pp. 737-748
    • Tseng, C.-W.1    Trimble, C.2    Zeng, Q.3
  • 109
    • 67651100519 scopus 로고    scopus 로고
    • Combination of apigenin treatment with therapeutic HPV DNA vaccination generates enhanced therapeutic antitumor effects
    • C.-M.Chuang, A.Monie, A.Wu, et al. Combination of apigenin treatment with therapeutic HPV DNA vaccination generates enhanced therapeutic antitumor effects. J Biomed Sci. 2009;16:49.
    • (2009) J Biomed Sci , vol.16 , pp. 49
    • Chuang, C.-M.1    Monie, A.2    Wu, A.3
  • 110
    • 34248226610 scopus 로고    scopus 로고
    • Apigenin and cancer chemoprevention: progress, potential and promise (review)
    • D.Patel, S.Shukla, S.Gupta. Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol. 2007;30(1):233–245.
    • (2007) Int J Oncol , vol.30 , Issue.1 , pp. 233-245
    • Patel, D.1    Shukla, S.2    Gupta, S.3
  • 111
    • 47649133239 scopus 로고    scopus 로고
    • Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects
    • C.W.Tseng, A.Monie, C.Trimble, et al. Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects. Vaccine. 2008;26(34):4314–4319.
    • (2008) Vaccine , vol.26 , Issue.34 , pp. 4314-4319
    • Tseng, C.W.1    Monie, A.2    Trimble, C.3
  • 112
    • 84893451828 scopus 로고    scopus 로고
    • Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors
    • C.-Y.Wu, L.-H.Yang, H.-Y.Yang, et al. Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors. Clin Cancer Res Off J Amer Assoc Cancer Res. 2014;20(3):644–657.•• This study suggested that radiotherapy converts the radiated tumor site to favor the generation of immune responses elicited by therapeutic vaccines.
    • (2014) Clin Cancer Res Off J Amer Assoc Cancer Res , vol.20 , Issue.3 , pp. 644-657
    • Wu, C.-Y.1    Yang, L.-H.2    Yang, H.-Y.3
  • 113
    • 84872485478 scopus 로고    scopus 로고
    • Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine
    • S.Peng, S.Lyford-Pike, B.Akpeng, et al. Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine. Cancer Immunol Immunother CII. 2013;62(1):171–182.
    • (2013) Cancer Immunol Immunother CII , vol.62 , Issue.1 , pp. 171-182
    • Peng, S.1    Lyford-Pike, S.2    Akpeng, B.3
  • 114
    • 84920458125 scopus 로고    scopus 로고
    • Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer
    • S.Peng, J.W.Wang, B.Karanam, et al. Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer. Plos One. 2015;10(1):e116389.
    • (2015) Plos One , vol.10 , Issue.1 , pp. 116389
    • Peng, S.1    Wang, J.W.2    Karanam, B.3
  • 115
    • 84879555379 scopus 로고    scopus 로고
    • Intratumoral injection of therapeutic HPV vaccinia vaccine following cisplatin enhances HPV-specific antitumor effects
    • S.Y.Lee, T.H.Kang, J.Knoff, et al. Intratumoral injection of therapeutic HPV vaccinia vaccine following cisplatin enhances HPV-specific antitumor effects. Cancer Immunology, Immunotherapy: CII. 2013;62(7):1175–1185.
    • (2013) Cancer Immunology, Immunotherapy: CII , vol.62 , Issue.7 , pp. 1175-1185
    • Lee, S.Y.1    Kang, T.H.2    Knoff, J.3
  • 116
    • 10744223658 scopus 로고    scopus 로고
    • Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe
    • C.Trimble, C.-T.Lin, C.-F.Hung, et al. Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe. Vaccine. 2003;21(25–26):4036–4042.
    • (2003) Vaccine , vol.21 , Issue.25-26 , pp. 4036-4042
    • Trimble, C.1    Lin, C.-T.2    Hung, C.-F.3
  • 117
    • 0032692821 scopus 로고    scopus 로고
    • Immunization of animals: from DNA to the dinner plate
    • L.A.Babiuk, H.van Drunen Littel-van den, S.L.Babiuk. Immunization of animals: from DNA to the dinner plate. Vet Immunol Immunopathol. 1999;72(1–2):189–202.
    • (1999) Vet Immunol Immunopathol , vol.72 , Issue.1-2 , pp. 189-202
    • Babiuk, L.A.1    van Drunen, H.2    Babiuk, S.L.3
  • 118
    • 68349152636 scopus 로고    scopus 로고
    • Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery
    • S.R.Best, S.Peng, C.-M.Juang, et al. Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery. Vaccine. 2009;27(40):5450–5459.
    • (2009) Vaccine , vol.27 , Issue.40 , pp. 5450-5459
    • Best, S.R.1    Peng, S.2    Juang, C.-M.3
  • 119
    • 64749089694 scopus 로고    scopus 로고
    • Femtosecond laser treatment enhances DNA transfection efficiency in vivo
    • S.W.Tsen, C.-Y.Wu, A.Meneshian, et al. Femtosecond laser treatment enhances DNA transfection efficiency in vivo. J Biomed Sci. 2009;16:36.
    • (2009) J Biomed Sci , vol.16 , pp. 36
    • Tsen, S.W.1    Wu, C.-Y.2    Meneshian, A.3
  • 120
    • 0036091223 scopus 로고    scopus 로고
    • Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101
    • B.Klencke, M.Matijevic, R.G.Urban, et al. Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101. Clin Cancer Res Off J Amer Assoc Cancer Res. 2002;8(5):1028–1037.
    • (2002) Clin Cancer Res Off J Amer Assoc Cancer Res , vol.8 , Issue.5 , pp. 1028-1037
    • Klencke, B.1    Matijevic, M.2    Urban, R.G.3
  • 121
    • 84908589994 scopus 로고    scopus 로고
    • Enhancing efficacy of anticancer vaccines by targeted delivery to tumor-draining lymph nodes
    • L.Jeanbart, M.Ballester, A.de Titta, et al. Enhancing efficacy of anticancer vaccines by targeted delivery to tumor-draining lymph nodes. Cancer Immunol Res. 2014;2(5):436–447.
    • (2014) Cancer Immunol Res , vol.2 , Issue.5 , pp. 436-447
    • Jeanbart, L.1    Ballester, M.2    de Titta, A.3
  • 122
    • 84934439485 scopus 로고    scopus 로고
    • Intravaginal HPV DNA vaccination with electroporation induces local CD8+ T-cell immune responses and antitumor effects against cervicovaginal tumors
    • Y.Sun, S.Peng, J.Qiu, et al. Intravaginal HPV DNA vaccination with electroporation induces local CD8+ T-cell immune responses and antitumor effects against cervicovaginal tumors. Gene Ther. 2015;22(7):528–535.•• This study demonstrated that local administration of the therapeutic vaccine lead to more potent local immune responses and antitumor effects.
    • (2015) Gene Ther , vol.22 , Issue.7 , pp. 528-535
    • Sun, Y.1    Peng, S.2    Qiu, J.3
  • 123
    • 67349153373 scopus 로고    scopus 로고
    • The first clinical use of a live-attenuated Listeria monocytogenes vaccine: a Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix
    • P.C.Maciag, S.Radulovic, J.Rothman. The first clinical use of a live-attenuated Listeria monocytogenes vaccine: a Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix. Vaccine. 2009;27(30):3975–3983.
    • (2009) Vaccine , vol.27 , Issue.30 , pp. 3975-3983
    • Maciag, P.C.1    Radulovic, S.2    Rothman, J.3
  • 124
    • 84907997134 scopus 로고    scopus 로고
    • Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients
    • K.Kawana, K.Adachi, S.Kojima, et al. Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients. Vaccine. 2014;32(47):6233–6239.
    • (2014) Vaccine , vol.32 , Issue.47 , pp. 6233-6239
    • Kawana, K.1    Adachi, K.2    Kojima, S.3
  • 125
    • 79551485967 scopus 로고    scopus 로고
    • Regression of high-grade cervical intraepithelial neoplasia with TG4001 targeted immunotherapy
    • J.-L.Brun, V.Dalstein, J.Leveque, et al. Regression of high-grade cervical intraepithelial neoplasia with TG4001 targeted immunotherapy. Am J Obstet Gynecol. 2011;204(2):169 e161–168.
    • (2011) Am J Obstet Gynecol , vol.204 , Issue.2 , pp. 161-168
    • Brun, J.-L.1    Dalstein, V.2    Leveque, J.3
  • 126
    • 2442515370 scopus 로고    scopus 로고
    • Therapeutic vaccination with MVA E2 can eliminate precancerous lesions (CIN 1, CIN 2, and CIN 3) associated with infection by oncogenic human papillomavirus
    • C.M.Corona Gutierrez, A.Tinoco, T.Navarro, et al. Therapeutic vaccination with MVA E2 can eliminate precancerous lesions (CIN 1, CIN 2, and CIN 3) associated with infection by oncogenic human papillomavirus. Hum Gene Ther. 2004;15(5):421–431.
    • (2004) Hum Gene Ther , vol.15 , Issue.5 , pp. 421-431
    • Corona Gutierrez, C.M.1    Tinoco, A.2    Navarro, T.3
  • 127
    • 33846900938 scopus 로고    scopus 로고
    • MVA E2 recombinant vaccine in the treatment of human papillomavirus infection in men presenting intraurethral flat condyloma: a phase I/II study
    • Y.C.A.Albarran, A.De La Garza, B.J.Cruz Quiroz, et al. MVA E2 recombinant vaccine in the treatment of human papillomavirus infection in men presenting intraurethral flat condyloma: a phase I/II study. Biodrugs Clin Immunotherapeutics Biopharmaceuticals Gene Ther. 2007;21(1):47–59.
    • (2007) Biodrugs Clin Immunotherapeutics Biopharmaceuticals Gene Ther , vol.21 , Issue.1 , pp. 47-59
    • Albarran, Y.C.A.1    De La Garza, A.2    Cruz Quiroz, B.J.3
  • 128
    • 84918815228 scopus 로고    scopus 로고
    • Regression of human papillomavirus intraepithelial lesions is induced by MVA E2 therapeutic vaccine
    • R.Rosales, M.Lopez-Contreras, C.Rosales, et al. Regression of human papillomavirus intraepithelial lesions is induced by MVA E2 therapeutic vaccine. Hum Gene Ther. 2014;25(12):1035–1049.•• A phase III clinical trial to test the efficacy of therapeutic HPV vaccines in high grade CIN patients.
    • (2014) Hum Gene Ther , vol.25 , Issue.12 , pp. 1035-1049
    • Rosales, R.1    Lopez-Contreras, M.2    Rosales, C.3
  • 129
    • 70350772293 scopus 로고    scopus 로고
    • Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
    • G.G.Kenter, M.J.Welters, A.R.Valentijn, et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med. 2009;361(19):1838–1847.
    • (2009) N Engl J Med , vol.361 , Issue.19 , pp. 1838-1847
    • Kenter, G.G.1    Welters, M.J.2    Valentijn, A.R.3
  • 130
    • 84866538193 scopus 로고    scopus 로고
    • A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions
    • P.J.De Vos Van Steenwijk, T.H.Ramwadhdoebe, M.J.Lowik, et al. A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions. Cancer Immunol Immunother CII. 2012;61(9):1485–1492.
    • (2012) Cancer Immunol Immunother CII , vol.61 , Issue.9 , pp. 1485-1492
    • De Vos Van Steenwijk, P.J.1    Ramwadhdoebe, T.H.2    Lowik, M.J.3
  • 131
    • 84875689800 scopus 로고    scopus 로고
    • HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial
    • M.I.Van Poelgeest, M.J.Welters, E.M.Van Esch, et al. HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial. J Transl Med. 2013;11:88.
    • (2013) J Transl Med , vol.11 , pp. 88
    • Van Poelgeest, M.I.1    Welters, M.J.2    Van Esch, E.M.3
  • 132
    • 84894436852 scopus 로고    scopus 로고
    • The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study
    • P.J.de Vos van Steenwijk, M.I.Van Poelgeest, T.H.Ramwadhdoebe, et al. The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study. Cancer Immunol Immunother CII. 2014;63(2):147–160.
    • (2014) Cancer Immunol Immunother CII , vol.63 , Issue.2 , pp. 147-160
    • de Vos van Steenwijk, P.J.1    Van Poelgeest, M.I.2    Ramwadhdoebe, T.H.3
  • 133
    • 84925511280 scopus 로고    scopus 로고
    • A phase I dose escalation trial of MAGE-A3- and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN)
    • D.P.Zandberg, S.Rollins, O.Goloubeva, et al. A phase I dose escalation trial of MAGE-A3- and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). Cancer Immunol Immunother CII. 2015;64(3):367–379.
    • (2015) Cancer Immunol Immunother CII , vol.64 , Issue.3 , pp. 367-379
    • Zandberg, D.P.1    Rollins, S.2    Goloubeva, O.3
  • 134
    • 0037019901 scopus 로고    scopus 로고
    • Enhancement of human papillomavirus (HPV) type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine
    • A.de Jong, T.O’Neill, A.Y.Khan, et al. Enhancement of human papillomavirus (HPV) type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine. Vaccine. 2002;20(29–30):3456–3464.
    • (2002) Vaccine , vol.20 , Issue.29-30 , pp. 3456-3464
    • de Jong, A.1    O’Neill, T.2    Khan, A.Y.3
  • 135
    • 77950370339 scopus 로고    scopus 로고
    • Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia
    • S.Daayana, E.Elkord, U.Winters, et al. Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia. Br J Cancer. 2010;102(7):1129–1136.
    • (2010) Br J Cancer , vol.102 , Issue.7 , pp. 1129-1136
    • Daayana, S.1    Elkord, E.2    Winters, U.3
  • 136
    • 2442540185 scopus 로고    scopus 로고
    • Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7)
    • E.J.Davidson, R.L.Faulkner, P.Sehr, et al. Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). Vaccine. 2004;22(21–22):2722–2729.
    • (2004) Vaccine , vol.22 , Issue.21-22 , pp. 2722-2729
    • Davidson, E.J.1    Faulkner, R.L.2    Sehr, P.3
  • 137
    • 2442598033 scopus 로고    scopus 로고
    • Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination
    • L.J.Smyth, M.I.Van Poelgeest, E.J.Davidson, et al. Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination. Clin Cancer Res an Off J Amer Assoc Cancer Res. 2004;10(9):2954–2961.
    • (2004) Clin Cancer Res an Off J Amer Assoc Cancer Res , vol.10 , Issue.9 , pp. 2954-2961
    • Smyth, L.J.1    Van Poelgeest, M.I.2    Davidson, E.J.3
  • 138
    • 84893856633 scopus 로고    scopus 로고
    • Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions
    • L.Maldonado, J.E.Teague, M.P.Morrow, et al. Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions. Sci Transl Med. 2014;6(221):221ra213.
    • (2014) Sci Transl Med , vol.6 , Issue.221
    • Maldonado, L.1    Teague, J.E.2    Morrow, M.P.3
  • 139
    • 84921357729 scopus 로고    scopus 로고
    • Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients
    • T.J.Kim, H.T.Jin, S.Y.Hur, et al. Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients. Nat Commun. 2014;5:5317.
    • (2014) Nat Commun , vol.5 , pp. 5317
    • Kim, T.J.1    Jin, H.T.2    Hur, S.Y.3
  • 140
    • 84867437406 scopus 로고    scopus 로고
    • Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses
    • M.L.Bagarazzi, J.Yan, M.P.Morrow, et al. Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses. Sci Transl Med. 2012;4(155):155ra138.
    • (2012) Sci Transl Med , vol.4 , Issue.155
    • Bagarazzi, M.L.1    Yan, J.2    Morrow, M.P.3
  • 141
    • 84947869406 scopus 로고    scopus 로고
    • Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial
    • C.L.Trimble, M.P.Morrow, K.A.Kraynyak, et al. Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. Lancet. 2015;386(10008):2078–2088.
    • (2015) Lancet
    • Trimble, C.L.1    Morrow, M.P.2    Kraynyak, K.A.3
  • 142
    • 38849136611 scopus 로고    scopus 로고
    • Human papillomavirus type 16 and 18 E7-pulsed dendritic cell vaccination of stage IB or IIA cervical cancer patients: a phase I escalating-dose trial
    • A.D.Santin, S.Bellone, M.Palmieri, et al. Human papillomavirus type 16 and 18 E7-pulsed dendritic cell vaccination of stage IB or IIA cervical cancer patients: a phase I escalating-dose trial. J Virol. 2008;82(4):1968–1979.
    • (2008) J Virol , vol.82 , Issue.4 , pp. 1968-1979
    • Santin, A.D.1    Bellone, S.2    Palmieri, M.3
  • 143
    • 84905971158 scopus 로고    scopus 로고
    • Development and clinical evaluation of dendritic cell vaccines for HPV related cervical cancer–a feasibility study
    • P.Ramanathan, S.Ganeshrajah, R.K.Raghanvan, et al. Development and clinical evaluation of dendritic cell vaccines for HPV related cervical cancer–a feasibility study. Asian Pacific J Cancer Prev APJCP. 2014;15(14):5909–5916.
    • (2014) Asian Pacific J Cancer Prev APJCP , vol.15 , Issue.14 , pp. 5909-5916
    • Ramanathan, P.1    Ganeshrajah, S.2    Raghanvan, R.K.3
  • 144
    • 0035576230 scopus 로고    scopus 로고
    • Two Listeria monocytogenes vaccine vectors that express different molecular forms of human papilloma virus-16 (HPV-16) E7 induce qualitatively different T cell immunity that correlates with their ability to induce regression of established tumors immortalized by HPV-16
    • G.R.Gunn, A.Zubair, C.Peters, et al. Two Listeria monocytogenes vaccine vectors that express different molecular forms of human papilloma virus-16 (HPV-16) E7 induce qualitatively different T cell immunity that correlates with their ability to induce regression of established tumors immortalized by HPV-16. J Immunol. 2001;167(11):6471–6479.
    • (2001) J Immunol , vol.167 , Issue.11 , pp. 6471-6479
    • Gunn, G.R.1    Zubair, A.2    Peters, C.3
  • 145
    • 0033863174 scopus 로고    scopus 로고
    • A recombinant vaccinia virus containing the papilloma E2 protein promotes tumor regression by stimulating macrophage antibody-dependent cytotoxicity
    • C.Rosales, V.V.Graham, G.A.Rosas, et al. A recombinant vaccinia virus containing the papilloma E2 protein promotes tumor regression by stimulating macrophage antibody-dependent cytotoxicity. Cancer Immunol Immunother CII. 2000;49(7):347–360.
    • (2000) Cancer Immunol Immunother CII , vol.49 , Issue.7 , pp. 347-360
    • Rosales, C.1    Graham, V.V.2    Rosas, G.A.3
  • 146
    • 0036644556 scopus 로고    scopus 로고
    • Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides
    • S.Zwaveling, S.C.Ferreira Mota, J.Nouta, et al. Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides. J Immunol. 2002;169(1):350–358.
    • (2002) J Immunol , vol.169 , Issue.1 , pp. 350-358
    • Zwaveling, S.1    Ferreira Mota, S.C.2    Nouta, J.3
  • 147
    • 0035859303 scopus 로고    scopus 로고
    • Pre-clinical safety and efficacy of TA-CIN, a recombinant HPV16 L2E6E7 fusion protein vaccine, in homologous and heterologous prime-boost regimens
    • S.H.van der Burg, K.M.Kwappenberg, T.O’Neill, et al. Pre-clinical safety and efficacy of TA-CIN, a recombinant HPV16 L2E6E7 fusion protein vaccine, in homologous and heterologous prime-boost regimens. Vaccine. 2001;19(27):3652–3660.
    • (2001) Vaccine , vol.19 , Issue.27 , pp. 3652-3660
    • van der Burg, S.H.1    Kwappenberg, K.M.2    O’Neill, T.3
  • 148
    • 50849116106 scopus 로고    scopus 로고
    • Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques
    • J.Yan, K.Harris, A.S.Khan, et al. Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques. Vaccine. 2008;26(40):5210–5215.
    • (2008) Vaccine , vol.26 , Issue.40 , pp. 5210-5215
    • Yan, J.1    Harris, K.2    Khan, A.S.3
  • 149
    • 57649210510 scopus 로고    scopus 로고
    • Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen
    • J.Yan, D.K.Reichenbach, N.Corbitt, et al. Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen. Vaccine. 2009;27(3):431–440.
    • (2009) Vaccine , vol.27 , Issue.3 , pp. 431-440
    • Yan, J.1    Reichenbach, D.K.2    Corbitt, N.3


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